Neftekamsk, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
A special place in the pathogenesis of recurrent aphthous stomatitis is occupied by the state of local immunity, which can affect the clinical course and prognosis of chronic diseases of the oral mucosa. The inflammatory process in recurrent aphthous stomatitis is initiated by stimulation of keratinocytes of the oral mucosa by a currently unknown antigen, which leads to stimulation of T-lymphocytes and the release of cytokines and various interleukins. Cytokines are the main nonspecific humoral factor of immunity, providing the initiation and development of an inflammatory response during the development of a protective immune response. A huge number of works are devoted to the study of cytokine status in recurrent aphthous stomatitis, which plays one of the key roles in the pathogenesis of the disease. However, most of the studies were conducted in patients over the age of 18, in addition, the results obtained are contradictory. This determined the purpose of this study – to assess the cytokine status of oral fluid in children with recurrent aphthous stomatitis. The study examined 70 children who were divided into 2 groups. The main group consisted of 45 children aged 7 to 14 years, patients with recurrent aphthous stomatitis, during the relapse of the disease. The main group was divided into 2 subgroups: A – 20 children with the duration of recurrent aphthous stomatitis up to 5 years, group B – 25 children with the duration of recurrent aphthous stomatitis more than 5 years. All patients in the main group had concomitant diseases, in most cases, diseases of the gastrointestinal tract. The control group consisted of 25 practically healthy children without recurrent aphthous stomatitis. In children with recurrent aphthous stomatitis in the oral fluid, a significant increase in the concentration of the anti-inflammatory cytokine TNF-α and a decrease in the concentration of IL-10, an imbalance in the level of IL-2 depending on the duration of the disease, as evidenced by a pronounced inflammatory process of the oral mucosa with epithelial destruction.
recurrent aphthous stomatitis, oral mucosa, cytokines, interleukins, inflammatory process, oral fluid, pathogenesis, local immunity
1. Belenguer-Guallar I., Jiménez-Soriano Y., Claramunt-Lozano A. Treatment of recurrent aphthous stomatitis. A literature review // J Clin Exp Dent. - 2014;6(2):e168-e174. doi:https://doi.org/10.4317/jced.51401
2. Edgar N.R., Saleh D., Miller R.A. Recurrent Aphthous Stomatitis: A Review // J Clin Aesthet Dermatol. - 2017;10(3):26-36. Epub 2017 Mar 1. PMID: 28360966.
3. Chiang C.P., Yu-Fong Chang J., Wang Y.P., Wu Y.H., Wu Y.C., Sun A. Recurrent aphthous stomatitis - etiology, serum autoantibodies, anemia, hematinic deficiencies, and management // J Formos Med Assoc. - 2019;118:1279-1289. doi:https://doi.org/10.1016/j.jfma.2018.10.023.
4. Alli B.Y., Erinoso O.A., Olawuyi A.B. Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: a systematic review // J Oral Pathol Med. - 2019;48(5):358-364. doi:https://doi.org/10.1111/jop.12845.
5. Rabinovich O.F., Abramova E.S., Umarova K.V., Rabinovich I.M. Aspekty etiologii i patogeneza recidiviruyuschego aftoznogo stomatita. Klinicheskaya stomatologiya. 2015;4(76):8-13. [O.F. Rabinovich, E.S. Abramova, K.V. Umarova, I.M. Rabinovich. Aetiology and pathogenesis of recurrent ulcerative stomatitis. Clinical Dentistry. 2015;4(76):8-13. (In Russ.)]. https://elibrary.ru/item.asp?id=25136352
6. Gileva O.S., Libik T.V., Pozdnyakova A.A. i dr. Zabolevaniya slizistoy obolochki polosti rta: metody diagnostiki i lecheniya. Dental Forum. 2019;1(72):27-36. [O.S. Gileva, T.V. Libik, A.A. Pozdnyakova et. al. Oral mucosal diseases: methods of diagnosis and treatment. Dental Forum. 2019;1(72):27-36. (In Russ.)]. https://elibrary.ru/item.asp?id=37307583
7. Xu K., Zhou C., Huang F. et al. Relationship between dietary factors and recurrent aphthous stomatitis in China: a cross-sectional study // Journal of International Medical Research. - 2021;49(5). doihttps://doi.org/10.1177/03000605211017724
8. Bilodeau E.A., Lalla R.V. Recurrent oral ulceration: Etiology, classification, management, and diagnostic algorithm // Periodontol 2000. - 2019;80:49-60. 1doi:0.1111/prd.12262.
9. Queiroz S., Silva M., Medeiros A.M.C. et al. Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis // An Bras Dermatol. - 2018;93:341-346.https://doi.org/10.1590/abd1806-4841.20186228.
10. Boza-Oreamuno Y.V., Rugama-Flores M.F. Recurrent Aphthous Stomatitis and Nutritional Deficiencies: Report of Three Cases with Literature Review // Odovtos. - 2019;21(3):33-43. http://dx.doi.org/10.15517/ijds.v0i0.37071
11. Cheng B., Zeng X., Liu S. et al. The efficacy of probiotics in management of recurrent aphthous stomatitis: a systematic review and meta-analysis // Sci Rep. - 2020;10. https://doi.org/10.1038/s41598-020-78281-7
12. Leccese P., Alpsoy E. Behçet's Disease: An Overview of Etiopathogenesis // Front Immunol. - 2019;10:1067. doi:https://doi.org/10.3389/fimmu.2019.01067
13. Tong B., Liu X., Xiao J., Su G. Immunopathogenesis of Behcet's Disease // Front Immunol. - 2019;10:665. doi:https://doi.org/10.3389/fimmu.2019.00665
14. Borisova E.G., Komova A.A., Verbickiy E.S., Idris A.Ya. Gal'vanoz polosti rta. Problemy stomatologii. 2019;15(1):5-9. [E.G. Borisova, A.A. Komova, E.S. Verbitsky, A.Ya. Idris. Galvanosis of the oral cavity. Actual problems in dentistry. 2019;15(1):5-9. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37602572
15. Novak T., Hamedi M., Bergmeier L.A., Fortune F., Hagi-Pavli E. Saliva and Serum Cytokine Profiles During Oral Ulceration in Behçet's Disease // Front Immunol. - 2021;22;12:724900. doi:https://doi.org/10.3389/fimmu.2021.724900.
16. Hernández-Olivos R., Muñoz M., Núñez E. et al. Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria // Sci Rep. - 2021;11:15646. https://doi.org/10.1038/s41598-021-95228-8
17. Sitdikova O.F., Kabirova M.F., Gubina O.F. Znachenie citokinov rotovoy zhidkosti i parodontopatogennoy mikrobioty v razvitii gingivita na fone psihoemocional'nogo stressa u kursantov vedomstvennogo instituta. Problemy stomatologii. 2021;3:40-47. [O.F. Sitdikova, M.F. Kabirova, O.F. Gubina. The significance of oral fluid cytokines and periodontopathogenic microbiota in the development of gingivitis against the background of psycho-emotional stress in cadets of a departmental institute. Actual problems in dentistry. 2021;3:40-47. (In Russ.)]. DOI: https://doi.org/10.18481/2077-7566-21-17-3-40-47
18. Meircurius Dwi Condro Surboyo, Rizky Merdietio Boedi, Ninuk Hariyani, Arvind Babu Rajendra Santosh, Ida Bagus Pramana Putra Manuaba, Pamela Handy Cecilia, I Gusti Agung Dyah Ambarawati, Adiastuti Endah Parmadiati, Diah Savitri Ernawati, The expression of TNF-α in recurrent aphthous stomatitis: A systematic review and meta-analysis // Cytokine. - 2022;157:155946. doi:https://doi.org/10.1016/j.cyto.2022.
19. Bhosale S.S., Rajput B.S., Takkar H., Bhagat S.V., Vagger R.M., Shaikh M.I.K. Establishment of Role of IL-2, IL-10 and IL-12 in Patients with Recurrent Aphthous Stomatitis-A Clinical Study // The Journal of Contemporary Dental Practice. - 2018;19(10):1242-1245. PMID: 30498180
20. Boras V.V. et al. Salivary interleukin-6 and tumor necrosis factoralpha in patients with recurrent aphthous ulceration // J. Oral Pathol. Med. - 2006;35(4):241-243. doi:https://doi.org/10.1111/j.1600-0714.2006.00404.x.
21. Abdel-Haq A. et al. Interleukin-6 and neopterin levels in the serum and saliva of patients with Lichen planus and oral Lichen planus // J. Oral Pathol. Med. - 2014;43(10):734-739. doi:https://doi.org/10.1111/jop.12199.
22. Boronat-Catalá M. et al. Salivary and crevicular fluid interleukins in gingivitis // J. Clin. Exp. Dent. - 2014;6(2):e175-179. doi:https://doi.org/10.4317/jced.51403.
23. Shirzaiy M., Neshat F. Salivary interleukin 2 levels in patients with recurrent aphthous stomatitis during active ulcerative and healing period // J Res Dent Sci. - 2022;19(2):112-118. http://jrds.ir/article-1-1270-en.html
24. Sadeq Ali Al-Maweri, Nader Alaizari, Rawan Hejji Alanazi, Sajna Ashraf, Rania Hejji Alanazi, Hesham Mohammed Al-Sharani, Esam Halboub, Efficacy of hyaluronic acid for recurrent aphthous stomatitis: a systematic review of clinical trials // Clinical Oral Investigations. - 2021. doihttps://doi.org/10.1007/s00784-021-04180-4.
25. Ang Z. et al. Comparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis (RAS)-affected patients // BMC Oral Health. - 2020;20:128. https://doi.org/10.1186/s12903-020-01115-5 (2020).
26. Nikitina E.A., Borisova E.G. Tradicionnye metodiki terapii hronicheskogo recidiviruyuschego aftoznogo stomatita. Problemy stomatologii. 2021;1:26-31. [E.A. Nikitina, E.G. Borisova. Traditional methods of treatment of chronic recurrent aphthous stomatitis. Actual problems in dentistry. 2021;1:26-31. (In Russ.)]. https://doi.org/10.18481/2077-7566-20-17-1-26-31
