PATHOGENETIC PARALLELS OF OSTEOPOROSIS AND CHRONIC PERIODONTITIS. LITERATURE REVIEW
Abstract and keywords
Abstract (English):
Subject. Parallels in the pathogenesis of two severe diseases of the modern era, osteoporosis and periodontitis. Objectives. To review domestic and international research on pathogenetic relationship between osteoporosis and periodontal pathology. Methodology. In topic generalization, the review of publications (since 2016) available on PubMed, eLIBRARY, Web of Science, Scopus by keywords is made. Conclusion. Research studies have shown that bone tissue in the orofacial region, though lesser than bones of axial skeleton, tends to develop osteoporosis. That is why patients with osteoporosis are recommended regular periodontal maintenance visits, especially when periodontal disease is diagnosed at the appointment or during the complex rehabilitation program for patients in osteoplastic and maxillofacial reconstructive surgery. Future controlled longitudinal studies may be useful in research of this relationship based on the features of osteogenesis in the both diseases. This literature review helps to develop modern views of pathogenetic relationship between osteoporosis and periodontitis, evaluate general risk factors, promote understanding of tools in the diagnostic process and interpretation of results. Moreover, with the help of this paper by knowing the cell and molecular structure of bone tissue and mechanisms of bone remodeling a dental practitioner can arrange a personalized follow-up strategy for patients in the risk group for the above two diseases timely engaging general practitioners in interdisciplinary and complex therapy of patients with periodontal pathology.

Keywords:
osteoporosis, chronic periodontitis, inflammatory maxillary bone destruction, vitamin D deficiency
References

1. Grebennikova T.A., Belaya Zh.E., Rozhinskaya L.Ya., Mel'nichenko G.A. Kanonicheskiy signal'nyy put' Wnt/β-katenin: ot istorii otkrytiya do klinicheskogo primeneniya. Terapevticheskiy arhiv. 2016;88(10):74-81. [T.A. Grebennikova, Zh.E. Belaia, L.Ya. Rozhinskaia, G.A. Melnichenko. The canonical Wnt/β-catenin pathway: From the history of its discovery to clinical application. Therapeutic archive. 2016;88(10):74-81. (In Russ.)]. https://doi.org/10.17116/terarkh201688674-81

2. Dreval' A.V., Kryukova I.V., Barsukov I.A. Tevosyan L.H. Vnekostnye effekty vitamina D (obzor literatury). RMZh. 2017;1:53-59. [A.V. Dreval, I.V. Krukova, I.A. Barsukov, L.Kh. Tevosjan. Ectostical effects of vitamin D (literature review). RMZ. 2017;1:53-59. (In Russ.)]. https://www.elibrary.ru/item.asp?id=30743131

3. Klinicheskie rekomendacii. Osteoporoz. 2021. (24.04.2021). Utverzhdeny Minzdravom. [Clinical practice guidelines. Osteoporosis. 2021. (24.04.2021). Approved by Ministry of Health. (In Russ.)]. https://diseases.medelement.com/disease/osteoporoz-kp-rf-2021/16662

4. Iordanishvili A.K., Zuykova M.A., Udal'cova N.A., Hromova E.A., Prisyazhnyuk O.V. Osobennosti individual'noy gigieny polosti rta v podderzhanii stomatologicheskogo zdorov'ya pri gingivite u lic s saharnym diabetom 2-go tipa. Rossiyskaya stomatologiya. 2019;12(1):9-13. [A.K. Iordanishivili, M.A. Zuykova, N.A. Udaltsova, E.A. Khromova, O.V. Prisyazhnyuk. Features personal oral hygiene in supporting dental health gingivitis in persons with type 2 diabetes. Russian Dentistry. 2019;12(1):9-13. (In Russ.)]. https://doi.org/10.17116/rosstomat2019120119

5. Kas'yanova A.N., Dolbnya S.V., Kur'yaninova V.A. Vitamin D i ego biologicheskaya rol' v organizme. Vestnik molodogo uchenogo. 2016;1:6-13. [A.N. Kasjanova, S.V. Dolbnja, V.A. Kurjaninova. Vitamin D and its biological role in the body. Young Scientist Journal. 2016;1:6-13. (In Russ.)]. https://www.elibrary.ru/item.asp?id=26320238

6. Lucenko A.S., Rozhinskaya L.Ya., Toropcova N.V., Belaya Zh.E. Rol' i mesto preparatov kal'ciya i vitamina D dlya profilaktiki i lecheniya osteoporoza. Profilakticheskaya deyatel'nost' i ee zakonodatel'noe i normativnoe pravovoe obespechenie. Osteoporoz i osteopatii. 2017;2(20):69-75. [A.S. Lutsenko, L.Ya. Rozhinskaya, N.V. Toroptsova, Zh.E. Belaya. Role and application of calcium and vitamin D medications for osteoporosis prophylaxis and treatment. Osteoporosis and Osteopathy. 2017;2(20):69-75. (In Russ.)]. doi:https://doi.org/10.14341/osteo9523

7. Muzykin M.I., Iordanishvili A.K. Model' sanogeneza postekstrakcionnoy regeneracii kostnoy tkani chelyustey. Ekologiya cheloveka. 2020;8:40-48. [M.I. Muzykin, A.K. Iordanishvili. Postextraction regeneration of jaw bone sanogenesis model. Human Ecology. 2020;8:40-48. (In Russ.)]. doi: 10.33396 / 1728-0869-2020-8-40-48

8. Nurullina G.M., Ahmadullina G.A. Kostnoe remodelirovanie v norme i pri pervichnom osteoporoze: znachenie markerov kostnogo remodelirovaniya. Arhiv vnutrenney mediciny. 2018;8(2):100-110. [G.M. Nurullina, G.I. Akhmadullina. Bone remodeling in norm and in primary osteoporosis: the significance of bone remodeling markers. Archives of Internal Medicine. 2018;8(2):100-110. (In Russ.)]. https://doi.org/10.20514/2226-6704-2018-8-2-100-110

9. Ostrovskaya L.Yu., Zaharova N.B., Budyleva A.P., Bulkina N.V. Znachenie lokal'nogo deystviya vitamina D na immunnuyu sistemu parodonta (obzor). Stomatologiya. 2019;1:41-47. [L.Yu. Ostrovskaya, N.B. Zakharova, A.P. Budyleva, N.V. Bulkina. Significance of local effects of vitamin D on periodontium immune system (review). Dentistry. 2019;1:41-47. (In Russ.)]. doi:https://doi.org/10.17116/stomat202110006129

10. Pestrikova T.Yu., Yachinskaya T.V. Sovremennyy vzglyad na etiologiyu, patogenez, diagnostiku, profilaktiku i lechenie deficita vitamina D u zhenschin v postmenopauze (obzor literatury). Ginekologiya. 2016;1:19-23. [T.Yu. Pestrikova, T.V. Yachinskaya. Modern view on etiology, pathogenesis, prophylaxis and treatment of vitamin D deficiency for postmenopausal women (literature review). Gynecology. 2016;1:19-23. (In Russ.)]. https://gynecology.orscience.ru/2079-5831/article/view/28502

11. Solyanova N.A., Senchukova O.V., Kurilo I.N. Posledstviya deficita vitamina D u lyudey starshih vozrastov. Sovremennye problemy nauki i obrazovaniya. 2015;4:12-17. [N.A. Solyanova, O.V. Senchugova, I.N. Kurilo. Consequences of deficiency of vitamin D at people of advanced ages. Modern Problems of Science and Education. 2015;4:12-17. (In Russ.)]. https://www.elibrary.ru/item.asp?id=23940139

12. Timofeev E.V., Belousova T.I., Vyutrih E.V. i dr. Mineral'naya plotnost' kostnoy tkani i laboratornye markery kostnogo metabolizma u molodyh muzhchin s marfanoidnoy vneshnost'yu. Pediatr. 2017;8(6):42-49. [E.V. Timofeev, T.I. Belousova, E.V. Vutrih et al. Bone mineral density and bone metabolic markers in laboratory in men with marfanoid habitus. Pediatrician. 2017;8(6):42-49. (In Russ.)]. doi:https://doi.org/10.17816/PED8642-49

13. Sablina S.N., Elovikova T.M., Grigor'ev S.S. Rol' vitamina D v podderzhanii zdorov'ya polosti rta (literaturnyy obzor). Problemy stomatologii. 2020;16(4):25-34. [S.N. Sablina, T.M. Elovikova, S.S. Grigoriev. The role of vitamin D in maintaining oral health (literature review). Actual Problems in Dentistry. 2020;16(4):25-34. (In Russ.)]. https://doi.org/10.18481/2077-7566-20-16-4-25-34

14. Sablina S.N., Elovikova T.M., Grigor'ev S.S., Koscheev A.S. Klinicheskie parametry sostoyaniya polosti rta u zhenschin postmenopauzal'nogo perioda pri kursovom primenenii nesteroidnogo protivovospalitel'nogo preparata. Stomatologiya. 2021;100(6):29-34. [S.N. Sablina, T.M. Elovikova, S.S. Grigorjev, A.S. Koshcheev. Clinical parameters of the oral cavity in postmenopausal women during the course of a nonsteroidal anti-inflammatory drug. Dentistry. 2021;100(6):29-34. (In Russ.)]. https://doi.org/10.17116/stomat202110006129

15. Sablina S.N., Elovikova T.M., Grigor'ev S.S., Dorohina K.R. i dr. Primenenie nesteroidnyh protivovospalitel'nyh preparatov pri parodontal'noy terapii pacientov s komorbidnoy patologiey. Problemy stomatologii. 2021;17(4):13-19. [S.N. Sablina, T.M. Elovikova, S.S. Grigorjev, K.R. Dorokhina et al. Use of non-steroidal anti-inflammatory drugs on periodontal therapy in patients with comorbid pathology. Actual Problems in Dentistry. 2021;17(4):13-19. (In Russ.)]. doi:https://doi.org/10.18481/2077 7566 21 17 4-13-19

16. Ushakov R.V., Gerasimova T.P. Mehanizmy tkanevoy destrukcii pri parodontite. Stomatologiya. 2017;96(4):63-66. [R.V. Ushakov, T.P. Gerasimova. Mechanisms of tissue destruction in periodontal disease. Dentistry. 2017;96(4):63-66. (In Russ.)]. https://doi.org/10.17116/stomat201796463-66

17. Cepov L.M., Cepov E.L., Cepov A.L. Sochetannaya patologiya: vospalitel'nye zabolevaniya parodonta, osteoporoz, deficit vitamina D (obzor literatury). Parodontologiya. 2016;4:5-9. [L.M. Tsepov, E.L. Tsepov, A.L. Tsepov. Comorbidity: inflammatory periodontal diseases, osteoporosis, vitamin D deficiency (a review of the literature). Periodontology. 2016;4:5-9. (In Russ.)]. doi:https://doi.org/10.17116/stomat202110006129

18. Alarkawi D., Bliuc D., Nguyen T.V., Eisman J.A., Center J.R. Contribution of lumbar spine BMD to fracture risk in individuals with T-score discordance // J Bone Miner Res. – 2016;31(2):274-280. https://doi.org/10.1002/jbmr.2611

19. Albandar J.M., Susin C., Hughes F.J. Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: case definitions and diagnostic considerations // J Clin Periodontol. – 2018;45(20):S171-S189.https://doi.org/10.1111/jcpe.12947

20. Afaf Zia, Hakim S., Khan A.U., Bey A., Ateeq H., Parveen S., Khalid S., Yusufi F.N.K. Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome // Journal of Bone and Mineral Metabolism. – 2022. https://doi.org/10.1007/s00774-021-01302-6

21. Asif S., Ahmad B., Hamza S.A., Taib H., Kassim N.K., Zainuddin S.L.A. Investigation of Salivary RANKL and OPG Levels in Periodontitis Patients at Hospital Universiti Sains Malaysia // Eur J Dent. – 2021;27. doi:https://doi.org/10.1055/s-0041-1731930.

22. Arioka M., Zhang X., Li Z., Tulu U.S. Osteoporotic changes in the periodontium impair alveolar bone healing // J Dental Res. – 2019;98(4):450-458. doi:https://doi.org/10.1177/0022034518818456.

23. Ayed M.S., Alsharif A.F., Divakar D.D., Jhugroo C., Alosaimi B., Mustafa M. Evaluating the possible association between systemic osteoporosis and periodontal disease progression in postmenopausal women // Dis Mon. – 2019;65(6):193-215. https://doi.org/10.1016/j.disamonth.2018.11.001

24. Bui F.Q., Almeida-da-Silva C.L.C., Huynh B., Trinh A., Liu J., Woodward J., Asadi H., Ojcius D.M. Association between periodontal pathogens and systemic disease // Biomed J. – 2019;42(1):27-35. doi:https://doi.org/10.1016/j.bj.2018.12. 001

25. Buset S.L., Walter C., Friedmann A., Weiger R., Borgnakke W.S., Zitzmann N.U. Are periodontal diseases really silent? A systematic review of their effect on quality of life // J. Clin. Periodontol. – 2016;43:333-344. doi:https://doi.org/10.1111/jcpe.12517.

26. Hajishengallis G., Diaz P.I. Porphyromonas gingivalis: Immune subversion activities and role in periodontal dysbiosis // Current oral health reports. – 2020;7(1):12-21. https://doi.org/10.1007/s40496-020-00249-3

27. Hong S.J., Yang B.E., Yoo D.M., Kim S.J., Choi H.G., Byun S.H. Analysis of the relationship between periodontitis and osteoporosis/fractures: a cross-sectional study // BMC Oral Health. – 2021;21(1):125. doi:https://doi.org/10.1186/s12903-021-01496-1

28. Cheng W.C., van Asten S.D., Burns L.A., Evans H.G., Walter G.J., Hashim A., Hughes F.J., Taams L.S. Periodontitis-associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14(+) monocytes leading to enhanced Th17/IL-17 responses // Eur J Immunol. – 2016;46(9):2211-2221. doi:https://doi.org/10.1002/eji.201545871.

29. Chapple I.L.C., Bouchard P., Cagetti M.G., Campus G., Carra M.C., Cocco F., Nibali L., Hujoel P., Laine M.L., Lingstrom P. et al. Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: Consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases // J. Clin. Periodontol. – 2017;44:39-51. doi:https://doi.org/10.1111/jcpe.12685

30. Flyvbjerg A., Nielsen C.H., Hansen P.R. Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician // J Oral Microbiol. – 2017;14;9(1):1332710. doi:https://doi.org/10.1080/20002297.2017.1332710

31. Gomes‐Filho I.S., Cruz S.S.D., Trindade S.C., Passos‐Soares J.D.S., Carvalho‐Filho P.C., Figueiredo A.C.M.G., Lyrio A.O., Hintz A.M., Pereira M.G., Scannapieco F. Periodontitis and respiratory diseases: A systematic review with meta‐analysis // Oral Diseases. – 2020;26(2):439-446. doi:https://doi.org/10.1111/odi.13228.27

32. Qasim S.S.B., Al-Otaibi D., Al-Jasser R., Gul S.S., Zafar M.S. An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases // Int J Mol Sci. – 2020;28;21(11):3829. doi:https://doi.org/10.3390/ijms21113829.

33. Hernandez-Vigueras S., Martinez-Garriga B., Sanchez M.C., Sanz M., Estrugo-Devesa A., Vinuesa T., Lopez-Lopez J., Vinas M. Oral microbiota, periodontal status, and osteoporosis in postmenopausal females // J Periodontol. – 2016;87(2):124-133. doi:https://doi.org/10.1902/jop.2015.150365

34. Jonasson G., Rythén M. Alveolar bone loss in osteoporosis: a loaded and cellular affair? // Clin Cosmet Investig Dent. – 2016;13;8:95-103. doi:https://doi.org/10.2147/CCIDE.S92774.

35. Kassebaum N.J., Smith A.G.C., Bernabe E., Fleming T.D., Reynolds A.E., Vos T., Murray C.J.L., Marcenes W. Collaborators GBDOH: Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990–2015: a systematic analysis for the global burden of diseases, injuries, and risk factors // J Dent Res. – 2017;96(4):380-387. doi:https://doi.org/10.1177/0022034517693566

36. Kim Y., Han B.G., KoGES Group Cohort profile: the Korean Genome and Epidemiology Study (KoGES) consortium // Int J Epidemiol. – 2017;46(4):1350. doi:https://doi.org/10.1093/ije/dyx105.

37. Leslie W.D., Shevroja E., Johansson H., McCloskey E.V., Harvey N.C., Kanis J.A., Hans D. Risk-equivalent T-score adjustment for using lumbar spine trabecular bone score (TBS): the Manitoba BMD registry // Osteoporos Int. – 2018;29(3):751-758. doi:https://doi.org/10.1007/s00198-018-4405-0.

38. Manolagas S.C. The quest for osteoporosis mechanisms and rational therapies: how far we've come, how much further we need to go // J Bone Miner Res. – 2018;33(3):371-385. doi:https://doi.org/10.1002/jbmr.3400

39. Mongkornkarn S., Suthasinekul R., Sritara C., Lertpimonchai A., Tamsailom S., Udomsak A. Significant association between skeletal bone mineral density and moderate to severe periodontitis in fair oral hygiene individuals // J Investig Clin Dent. – 2019;10(4):e12441. doi:https://doi.org/10.1111/jicd.12441

40. Miralda I., Uriarte S.M. Periodontal Pathogens' strategies disarm neutrophils to promote dysregulated inflammation // Molecular oral microbiology. – 2021;36(2):103-120. https://doi.org/10.1111/omi.12321

41. Napeñas J.J., Brennan M.T., Elad S. Oral Manifestations of Systemic Diseases // Dermatol. Clin. – 2020;38(4):495-505. doi:https://doi.org/10.1016/j.det.2020.05.010

42. Olsen I., Yilmaz Ö. Subversion of inflammasome activity by Porphyromonas gingivalis in periodontitis and associated systemic diseases // J Oral Microbiol. – 2016;8:30385. http://dx.doi.org/10.3402/jom.v8.30385.

43. Passos-Soares J.S., Vianna M.I.P., Gomes-Filho I.S., Cruz S.S., Barreto M.L., Adan L.F., Rosing C.K., Trindade S.C., Cerqueira E.M.M., Scannapieco F.A. Association between osteoporosis treatment and severe periodontitis in postmenopausal women // Menopause. – 2017;24(7):789-795. doi:https://doi.org/10.1097/GME.0000000000000830.

44. Penoni D.C., Torres S.R., Farias M.L., Fernandes T.M., Luiz R.R., Leao A.T. Association of osteoporosis and bone medication with the periodontal condition in elderly women // Osteoporos Int. – 2016;27(5):1887-1896. doi:https://doi.org/10.1007/s00198-015-3437-y

45. Richa R.Y., Puranik M.P., Shrivastava A. Association between osteoporosis and periodontal disease among postmenopausal Indian women // J Investig Clin Dent. – 2017;8(3). doi:https://doi.org/10.1111/jicd.12223

46. Shuai Xu, Gang Zhang, Jun‐feng Guo, Ying‐hui Tan. Associations between osteoporosis and risk of periodontitis: A pooled analysis of observational studies // Oral Diseases. – 2020;27(2):257-369. doi:https://doi.org/10.1111/odi.13531

47. Turck D., Bresson J.L., Burlingame B., Dean T., Fairweather-Tait S., Heinonen M., Hirsch-Ernst K.I., Mangelsdorf I., McArdle H.J., Naska A. et al. Update of the tolerable upper intake level for vitamin D for infants // EFSA J. – 2018;16:110-118. doi:https://doi.org/10.2903/j.efsa.2018.5365.

48. Uwitonze A.M., Murererehe J., Ineza M.C., Harelimana E.I., Nsabimana U., Uwambaye P., Gatarayiha A., Haq A., Razzaque M.S. Effects of vitamin D status on oral health // J. Steroid Biochem. Mol. Biol. – 2018;175:190-194. doi:https://doi.org/10.1016/j.jsbmb.2017.01.020.

49. Xiao W., Li S., Pacios S., Wang Y., Graves D.T. Bone Remodeling Under Pathological Conditions // Front Oral Biol. – 2016;18:17-27. doi:https://doi.org/10.1159/000351896

50. Yoon H. Kang, Francois Berthiaume. Periodontitis: Clinical Aspects, Pathophysiology, Experimental Approaches and Emerging Therapies // Nano LIFE. – 2021. https://doi.org/10.1142/S1793984421300065

51. Watt R.G., Daly B., Allison P., Macpherson L.M.D., Venturelli R., Listl S., Weyant R.J., Mathur M.R., Guarnizo-Herreño C.C., Celeste R.K. et al. Ending the neglect of global oral health: Time for radical action // Lancet. – 2019;394:261-272. doi:https://doi.org/10.1016/S0140-6736(19)31133-X

52. Wang Z.M., Luo J.Q., Xu L.Y. et al. Harnessing low-density lipoprotein receptor protein 6 (LRP) genetic variation and Wnt signaling for innovative diagnostics in complex diseases // Pharmacogenomics J. – 2018;18:351-358. https://doi.org/10.1038/tpj.2017.28

53. Wang C.J., McCauley L.K. Osteoporosis and Periodontitis // Current osteoporosis reports. – 2016;14(6):284-291. https://doi.org/10.1007/s11914-016-0330-3


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