employee
Perm, Perm, Russian Federation
Perm', Perm, Russian Federation
employee
Perm, Perm, Russian Federation
employee
Perm, Perm, Russian Federation
employee
Perm, Perm, Russian Federation
employee
Perm, Perm, Russian Federation
UDK 616.31 Стоматология. Заболевания ротовой полости и зубов
The replacement and restoration of defects in the mandible has remained relevant for several decades. The choice of graft, its positioning, and fixation methods are primarily aimed at optimizing the recovery time and quality of life for patients. Optimizing timelines when using foreign materials is possible through the development of an optimal implant design, with its inertness optimizing morphological processes at the interface with the host bone, which is one of the main issues to be studied in a group of patients who are unable to use autotransplants for reconstruction. The morphological aspects of regeneration, osteointegration, and other factors in their use for this category of patients are fundamental and of particular significance. The aim of the study was to create an experimental model to investigate the morphological aspects of the regenerative activity of bone tissue at the interface with an orthotopic implant made of carbon-carbon composite and to detail the features of osteointegration. As a result, morphological data were analyzed at the interface of the implant-bone block using the carbon-carbon composite “Uglekon M”. The experiment was conducted on 10 male pigs of the “Landras” breed, kept under identical conditions and feeding, in accordance with the European Convention for the Protection of Vertebrate Animals used for Experimental or Other Scientific Purposes, and approved by the decision of the ethical committee of the PGMU named after Academician E.A. Wagner. A 5 cm incision was made in the submandibular area under combined anesthesia, creating a defect of at least 1.5x2.0 cm, which was simultaneously replaced with an implant made of carbon-carbon composite material. Material for morphological analysis was collected on days 180 and 270 without removing the animals from the experiment. Bone tissue regeneration was characterized by the formation of coarse-fibrous bone around the perimeter, followed by its replacement with morphological structures that closely resemble the outer cortical plate. Actively filling the undercuts and voids on the surface of the transplant, the newly formed bone conglomerate achieved maximum congruence with the articulating surfaces across the entire area of the transplant, which was particularly evident in animals with asymmetric shapes and sizes of the restored defects.
carbon-carbon composite materials, implant, mandibular defect, osseointegration, reparative processes
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