Volgograd, Volgograd, Russian Federation
Volgograd, Volgograd, Russian Federation
Volgograd, Russian Federation
from 01.01.2018 until now
Volgograd, Volgograd, Russian Federation
Volgograd, Volgograd, Russian Federation
Volgograd, Russian Federation
OKSO 31.02.05 Стоматология ортопедическая
BBK 566 Стоматология
Subject. Lichen planus (LP) is one of the most common pathologies of the oral mucosa (OM). The optimization of LP treatment retains its relevance and significance. The methods of physiotherapy have proven themselves well, as an addition to basic treatment plan. Cryotherapy is of special interest to doctors, because this procedure can have analgesic, anti-inflammatory and reparative effects. Objectives. To evaluate the dynamics of clinical scores of the oral mucosa state in patients with LP if used local hypothermia. Methodology. 21 patients with bullous and erosive-ulcerative clinical forms of LP were examined and treated, who were prescribed comprehensive treatment, including local hypothermia (3 procedures). Examination and evaluation of the oral mucosa condition of patients were carried out before treatment, 3, 7 and 14 days after its start. A specially designed scoring system was used to study the timing of arresting of inflammation symptoms (pain, hyperemia, swelling) and the dynamics of the erosive lesions epithelialization. The intensity of the pain syndrome was assessed using a visual analogue scale (VAS). Results. The positive dynamics was registered by the 3rd day of therapy: there was a significant decrease in hyperemia and swelling symptoms of the affected areas of the oral mucosa, compared with the scores registered before treatment (p < 0.05). The epithelialization of erosive lesions proceeded at a good speed, which was associated with the normalization of tissue microcirculation. Similar trends were noted at all follow-up periods: a statistically significant difference in these clinical indicators persisted throughout the entire treatment period (p < 0.05). Against the background of arresting of inflammation symptoms, the level of pain response of patients also decreased, up to the disappearance of pain by the 14th day of observation in 66.7% of patients. Conclusions. The local hypothermia technique is a minimally invasive and painless procedure that is well tolerated by patients with oral lichen planus. Cryotherapy has demonstrated its high clinical efficiency, which allows expanding the indications for its usage in dental practice.
local hypothermia, oral lichen planus, oral mucosa. cryotherapy, physiotherapy
1. Levin M., Mal'kevich L., Danilova L. Krioterapiya: sostoyanie i perspektivy. Nauka i innovacii. 2018;4(183):72-75. [M. Levin, L. Malkevich, L. Danilova. Cryotherapy: current state and prospects. Science and innovation. 2018;4(183):72-75. (In Russ.)]. https://elibrary.ru/item.asp?id = 35198761
2. Nikitenko P.I., Gordeychuk T.V., Tabunov S.N., Kashickiy E.S. Issledovanie vliyaniya krioterapii na fiziologicheskie osobennosti cheloveka. Novosti mediko-biologicheskih nauk. 2017;1(15):62-65. [P.I. Nikitenko, T.V. Gordechchuk, SN Tabunov, E.S. Kashitsky. Research of influence of cryotherapy on physiological features of human. News of Biomedical Sciences. 2017;1(15):62-65. (In Russ.)]. https://elibrary.ru/item.asp?id = 29811211
3. Pavlov A.V., Maskin S.S., Igolkina L.A. Kriovozdeystvie v lechenii gnoynyh zabolevaniy kozhi i podkozhnoy kletchatki. Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta. 2018;1(65):3-9. [A.V.Pavlov, S.S. Maskin, L.A. Igolkina. Local cryotherapy in treatment of purulent skin diseases and subcutaneous tissue. Journal of Volgograd State Medical University. 2018;1(65):3-9. (In Russ.)]. https://elibrary.ru/item.asp?id = 32723457
4. Sakovec T.G., Barysheva E.N. Osobennosti primeneniya krioterapii. Vestnik sovremennoy klinicheskoy mediciny. 2020;6(13):57-61. [T.G. Sakovets, E.N. Barysheva. Cryotherapy application specifics. The Bulletin of Contemporary Clinical Medicine. 2020;6(13):57-61. (In Russ.)]. https://doi.org/10.20969/VSKM.2020.13(6).57-61
5. Serikova O.V. Fizicheskie metody v lechenii pacientov s proyavleniyami krasnogo ploskogo lishaya na slizistoy obolochke polosti rta. Sovremennaya nauka: aktual'nye problemy teorii i praktiki. Seriya: Estestvennye i tehnicheskie nauki. 2021;9:140-144. [O.V. Serikova. Physical methods in the treatment of patients with manifestations of lichen planus on the oral mucosa. Magazine "Modern Science: actual problems of theory & practice". 2021;9:140-144. (In Russ.)]. https://doi.org/10.37882/2223-2966.2021.09.24
6. Fedotova Yu.M. Sravnitel'naya harakteristika effektivnosti bioadgezivnyh preparatov v kompleksnom lechenii bol'nyh krasnym ploskim lishaem polosti rta : diss. … kandidata medicinskih nauk. Volgogradskiy gosudarstvennyy medicinskiy universitet. Volgograd, 2020. [Yu.M. Fedotova. Comparative characteristics of the effectiveness of bioadhesive drugs in the complex treatment of patients with lichen planus of the oral cavity: diss. ... candidate of medical sciences. [Volgograd State Medical University.] Volgograd, 2020. (In Russ.)]. https://elibrary.ru/item.asp?id = 47343191
7. Shitc D.V., Torshina I.E., Nekrasova N.V., Bus'ko T.M. Opyt primeneniya eksimernoy lampy, osnaschennoy sistemoy kontrolya UVB dozy, v dermatologii. Biomedical Photonics. 2020;1(9):21-26. [D.V. Schitz, I.E. Torshina, N.V. Nekrasova, T.M. Busko. Experience of using an excimer lamp equipped with UVB dose control system in dermatology. Biomedical Photonics. 2020;1(9):21-26 (In Russ.)]. https://doi.org/10.24931/2413-9432-2020-9-1-21-26
8. Correa M.E.P., Cheng K.K.F., Chiang K., Kandwal A., Loprinzi C.L., Mori T., Potting C., Rouleau T., Toro J.J., Ranna V., Vaddi A., Peterson D.E., Lalla R.V., Bossi P., Elad S. Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines // Supportive Care in Cancer. - 2020;5(28):2449-2456. https://doi.org/10.1007/s00520-019-05217-x
9. Guseynov N.A., Ivashkevich S.G., Boyko E.M. Physiological features of cells and microvasculature under the local hypothermia influence // RUDN Journal of Medicine. - 2022;1(26):34-41. https://doi.org/10.22363/2313-0245-2022-26-1-34-41
10. Shin N., Kang Y. The effects of oral cryotherapy on oral mucositis, reactive oxygen series, inflammatory cytokines, and oral comfort in gynecologic cancer patients undergoing chemotherapy: a randomized controlled trial // Journal of Korean Academy of Nursing. - 2019;2(49):149-160. https://doi.org/10.4040/jkan.2019.49.2.149