from 01.01.2003 until now
Voronezh, Voronezh, Russian Federation
from 01.01.2018 until now
Voronezh, Voronezh, Russian Federation
from 01.01.2015 until now
Voronezh, Russian Federation
Voronezh, Voronezh, Russian Federation
Voronezh, Voronezh, Russian Federation
UDK 61 Медицина. Охрана здоровья
GRNTI 76.29 Клиническая медицина
OKSO 31.08.69 Челюстно-лицевая хирургия
OKSO 31.08.74 Стоматология хирургическая
BBK 566 Стоматология
BISAC MED016050 Dentistry / Oral Surgery
Subject. It is important to develop methods for the diagnosis and treatment of secondary destructive parotitis (SDP) depending on the form of the disease. A working classification of SDP is proposed. The aim of the study is to improve the diagnosis of SDP by developing a program for early detection and differential diagnosis of forms of diseases. Methodology. The basis of this work was the examination and treatment of 287 patients with various forms of destructive parotitis. Results. In 103 patients with SDP, the disease occurred as a monoabsccess and with the formation of multiple small-focal abscesses. Changes in indicators of metabolic processes, hemostasis and immunity did not exceed the limits of possible physiological fluctuations. In 62 patients with phlegmonous form of SDP, a significant decrease in total serum protein was observed (by 8%). When combined with SDP and pancreatic pathology, the level of amylase increased 3 to 4 times. Of the 122 patients with SDP 14% were dominated by alterations in the local inflammatory response and the development of general complications in the form of sepsis. There are two main states of life support systems: unstable compensation and decompensation. Conclusions. Clinical and laboratory manifestations of SDP dictate the expediency of identifying the main forms of the course of the disease which are characterized by certain clinical and laboratory data. Given the real threat of the spread of acute inflammatory process, the development of local and general complications, treatment of SDP should be performed only in a specialized maxillofacial hospital.
acute parotitis, secondary destructive parotitis, sialoadenitis, phlegmon, abscess, purulent-necrotic inflammation, endogenous intoxication syndrome, immunodeficiency, inflammatory reaction, inflammatory complications
1. Gubin M.A., Haritonov Yu.M., Kikov R.N. O problemah diagnostiki vtorichnogo destruktivnogo parotita. Nauchnyy posyl vysshey shkoly - real'nye dostizheniya prakticheskogo zdravoohraneniya, posvyaschennyy 30-letiyu stomatologicheskogo fakul'teta Privolzhskogo issledovatel'skogo medicinskogo universiteta: sbornik nauchnyh trudov. Nizhniy Novgorod. 2018: 271-278. [M.A. Gubin, Yu.M. Kharitonov, R.N. Kikov. On the problems of diagnostics of secondary destructive mumps. The scientific message of the higher school is the real achievements of practical health care, dedicated to the 30th anniversary of the dental faculty of the Volga Research Medical University: a collection of scientific papers. Nizhny Novgorod. 2018: 271-278. (In Russ.)].
2. Dregalkina A.A., Shimova M.E., Shneyder O.L. Vospalitel'nye zabolevaniya chelyustno-licevoy oblasti. Sovremennye osobennosti klinicheskogo techeniya, principy diagnostiki i lecheniya. Uchebnoe posobie. Ekaterinburg. UGMU. «Tirazh». 2020:108. [A.A. Dregalkina, M.E. Shimova, O.L. Shneider. Inflammatory diseases of the maxillofacial region. Modern features of the clinical course, the principles of diagnosis and treatment. Tutorial. Ekaterinburg. UGMU. "Circulation". 2020:108. (In Russ.)].
3. Klinovskaya A.S., Smyslenova M.V., Gurgenadze A.P., Abraamyan K.D., Volozhin G.A. Hronicheskiy nespecificheskiy parenhimatoznyy parotit. Klinicheskiy sluchay. Stomatologiya detskogo vozrasta i profilaktika. 2019; 19; 4 (72):77-80. [A.S. Klinovskaya, M.V. Smyslenova, A.P. Gurgenadze, K.D. Abrahamyan, G.A. Volozhin. Chronic nonspecific parenchymal parotitis. Clinical case. Pediatric dentistry and prevention. 2019;19;4 (72):77-80. (In Russ.)]. https://www.elibrary.ru/item.asp?id=42490599
4. Klyaritskaya I.L., Krivoy V.V., Rabotyagova Yu.S., Starosek V.N., Bobko O.V. Sravnitel'naya harakteristika metodov diagnostiki ostrogo i hronicheskogo pankreatita. Krymskiy terapevticheskiy zhurnal. 2014; 1 (22):147-157. [I.L. Klyaritskaya, V.V. Krivoy, Yu.S. Rabotyagova, V.N. Starosek, O.V. Bobko. Comparative characteristics of diagnostic methods for acute and chronic pancreatitis. Crimean therapeutic journal. 2014; 1 (22):147-157. (In Russ.)]. https://www.elibrary.ru/item.asp?id=22889747
5. Korotkih N.G., Petrov B.V., Stepanov I.V., Morozov A.N. Differencial'naya diagnostika vospalitel'nyh zabolevaniy chelyustno-licevoy oblasti. Uchebno-metodicheskoe posobie po hirurgicheskoy stomatologii dlya studentov stomatologicheskih fakul'tetov medicinskih VUZov. Voronezh. 2005:71. [N.G. Korotkikh, B.V. Petrov, I.V. Stepanov, A.N. Morozov. Differential diagnosis of inflammatory diseases of the maxillofacial region. Teaching aid on surgical dentistry for students of dental faculties of medical universities. Voronezh. 2005:71. (In Russ.)].
6. Nikitina N.V., Aleksandrov A.V., Alehina I.Yu., Levkina M.V., Aleksandrova N.V. i dr. Kliniko-immunologicheskaya diagnostika porazheniya slyunnyh zhelez pri revmatoidnom artrite. Sovremennye problemy nauki i obrazovaniya. 2019; 3:170. [N.V. Nikitina, A.V. Aleksandrov, I.Yu. Alekhina, M.V. Levkina, N.V. Alexandrova et al. Clinical and immunological diagnosis of lesions of the salivary glands in rheumatoid arthritis. Modern problems of science and education. 2019; 3:170. (In Russ.)].
7. Sidnenko D.I. Vospalenie slyunnyh zhelez u studentov stavropol'skogo kraya i profilaktika. Materialy II nauchno-prakticheskoy konferencii «Sovremennye problemy mediciny i farmacii». 2017:84-88. [D. I. Sidnenko. Inflammation of the salivary glands in students of the Stavropol Territory and prevention. Materials of the II scientific-practical conference "Modern problems of medicine and pharmacy". 2017:84-88. (In Russ.)].
8. Skutova V.A., Danilov A.I., Feoktistova Zh.A. Ostryy pankreatit: aktual'nye voprosy diagnostiki i kompleksnogo lecheniya. Vestnik Smolenskoy gosudarstvennoy medicinskoy akademii. 2016; 15; 2:78-84. [V.A. Skutova, A.I. Danilov, Zh.A. Feoktistova. Acute pancreatitis: topical issues of diagnosis and complex treatment. Bulletin of the Smolensk State Medical Academy. 2016; 15; 2:78-84. (In Russ.)].
9. Ternovoy D.A. Osobennosti sistemnogo vospalitel'nogo otveta i dinamika mikrobiocenoza ran v zavisimosti ot sposoba vedeniya ranevogo processa. Sbornik 72-y mezhvuzovskoy (VII Vserossiyskoy) itogovoy nauchnoy studencheskoy konferencii s mezhdunarodnym uchastiem. 2018:224. [D.A. Ternovoy. Features of the systemic inflammatory response and the dynamics of the microbiocenosis of wounds, depending on the method of conducting the wound process. Collection of the 72nd interuniversity (VII All-Russian) final scientific student conference with international participation. 2018:224. (In Russ.)].
10. Fomichev E.V., Saleh A., Yakovlev A.T., Efimova E.V. Kliniko-immunologicheskie osobennosti atipichno tekuschih flegmon chelyustno-licevoy oblasti. Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta. 2010; 2 (34):49-51. [E.V. Fomichev, A. Salekh, A.T. Yakovlev, E.V. Efimova. Clinical and immunological features of atypically flowing phlegmon of the maxillofacial region. Bulletin of the Volgograd State Medical University. 2010; 2 (34):49-51. (In Russ.)].
11. Shayahmetov D.B. Etiologiya. Zdravoohranenie Kyrgyzstana. 2014; 1:118-121. [D.B. Shayakhmetov. Etiology. Healthcare of Kyrgyzstan. 2014; 1:118-121. (In Russ.)]. https://www.elibrary.ru/item.asp?id=30541772
12. Yuy R.I., Mirzakulova U.R., Tyan D.S. Razrabotka sposoba neinvazivnoy citologicheskoy diagnostiki i monitoringa hronicheskogo parenhimatoznogo sialadenita v period obostreniya. Vestnik Kazahskogo nacional'nogo medicinskogo universiteta. 2017; 4:145-150. [R.I. Yuy, U.R. Mirzakulova, D.S. Tyan. Development of a method for non-invasive cytological diagnosis and monitoring of chronic parenchymal sialadenitis during an exacerbation. Bulletin of the Kazakh National Medical University. 2017; 4:145-150. (In Russ.)].
13. Abu-Taleb N.S.M., Abdel-Waheb N., Amer M.S. The Role of Magnetic Resonance Imaging and Magnetic Resonance Sialography in the Diagnosis of Various Salivary Gland Disorders: An Interobserver Agreement. // J Med Imaging Radiation Sciences. - 2014; 45:299.
14. Brook I. Acute bacterial suppurative parotitis: microbiology and management // J Craniofac Surg. - 2003; 14:37.
15. Chi T.H., Yuan C.H., Chen H.S. Parotid abscess: a retrospective study of 14 cases at a regional hospital in Taiwan // B-ENT. - 2014; 10:315.
16. Cohen M.A., Docktor J.W. Acute suppurative parotitis with spread to the deep neck spaces // Am J Emerg Med. - 1999; 17:46.
17. Dantes R., Mu Y., Belflower R., et al. National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011 // JAMA Intern Med. - 2013; 173:1970.
18. Fattahi T.T., Lyu P.E., Van Sickels J.E. et al. Management of acute suppurative parotitis // J Oral Maxillofac Surg. - 2002; 60 (4):446-448. doi: 10.1053.
19. Gubin M., Kharitonov Y., Kikov R., Oleynik O., Podoprigra A. et al. Early diagnosis of secondary destructive parotitis as prevention of a purulent-septic infection // Research journal of pharmaceutical, biological and chemical sciences. - 2018; 9; 6:697-703. doi:https://doi.org/10.1159/000334246
20. Kim Y.Y., Lee D.H., Yoon T.M. et al. Parotid abscess at a single institute in Korea // Medicine (Baltimore). - 2018; 97:1700.
21. Kondo N., Yoshihara T., Yamamura Y., Kusama K., Sakitani E. et al. Diagnostic and treatment effects of sialendoscopy for patients with swelling of the parotid gland when sialoliths are undetected with computed tomography // Auris Nasus Larynx. - 2018; 45 (4):880-884. doi:https://doi.org/10.1016/j.anl.2017.11.004.
22. Molina J.C., Altés J., Vera R., Vilamala A., Molina J.C. et al. Acute bacterial parotiditis due to methicillin-resistant Staphylococcus aureus in the institutionalized elderly //Enferm Infecc Microbiol Clin. - 2003; 21 (6):325-326.
23. Ogasawara N., Takano K.I., Kobayashi H. et al. HIV-associated cystic lesions of the parotid gland // Auris Nasus Larynx. - 2017; 44:126.
24. Reddy R., White D.R., Gillespie M.B. Obstructive parotitis secondary to an acute masseteric bend // J. Otorhinolaryngol. - 2012; 74 (1):12-15. doi:https://doi.org/10.1159/000334246
25. Tan V.E., Goh BS. Parotid abscess: a five-year review-clinical presentation, diagnosis and management // J Laryngol Otol. - 2007; 121:872.
