student
Ekaterinburg, Ekaterinburg, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
Subject. Individualized etiotropic prevention of caries in children using bacteriophages. The goal is to study the peculiarities of the carioprophylactic effect of bacteriophages that are part of the drug "Fagodent." Methodology. The study involved 30 somatically safe children of 7―12 years of age with equal gender distribution and a decompensated caries course. The intensity of caries was determined by the formula KPU+CP. Patients with confirmed cariogenic bacteria dysbiosis were selected according to the CRT-bacteria test (Ivoclar company) at CFU/ml≥105. The method involves the collection of stimulated saliva, inoculation and incubation in a thermostat at a temperature of 37 °C for 2 days, the analysis of the number of colonies on a standard scale. The Green―Vermillion Hygiene Index (OHI-S) was also taken into account with an average of 0.9, children with high rates were excluded from the study. Results. After the course administration of the drug, the colonization rate of the oral cavity with cariogenic microorganisms decreases, which is reflected in the decrease in the Green―Vermillion (OHI-S) hygiene indices from 0.9±0.14 to 0.5±0.1 (p<0.05) and the test CRT-bacteria (Ivoclar Vivadent) CFU / ml from ≥105 to ≤105 (p<0.05). Upon further observation, within 3 months after the course of phagotherapy, the levels of contamination of the oral cavity with cariogenic microorganisms and hygiene were reliably kept low. Hygienic indicators also changed after the administration of the drug “Fagodent”: the Green― Vermillion hygiene index significantly decreased from 0.9±0.14 to 0.5±0.1 after 2 weeks and to 0.7±0.1 after 3 months. Findings. Clinical studies have proven the effectiveness of the drug "Fagodent" based on bacteriophages in the complex treatment and prevention of dental caries. The proposed scheme for the individual use of the drug under the supervision of a doctor does not require special equipment, is simple to implement and shows high positive results, which allows us to recommend it for the prevention of caries in children.
bacteriophages, phagotherapy, multiple caries, rapid test, prevention of dental caries in children, cariogenic microorganisms, Phagodent
1. Kuzmina, E. M., Yanushevich, O. O., Kuzmina, I. N. (2019). Stomatologicheskaya zabolevayemost' naseleniya Rossii [Dental morbidity of the Russian population]. Moscow : MGMSU, 293. (In Russ.)
2. Ed. Kuzmina, E. M. (1999). Stomatologicheskaya zabolevayemost' naseleniya Rossii [Dental morbidity of the Russian population]. Moscow : Informelectro, 168. (In Russ.)
3. Ed. Kuzmina, E. M. (2009). Stomatologicheskaya zabolevayemost' naseleniya Rossii. Sostoyaniye tverdykh tkaney zubov. Rasprostranennost' zubochelyustnykh anomaliy. Potrebnost' v protezirovanii [Dental morbidity of the Russian population. Condition of the hard tissues of the teeth. Prevalence of dental anomalies. The need for prosthetics]. Moscow : Moscow state University of medicine, 232. (In Russ.)
4. Ioshchenko, E. S., Brusnitsyna, E. V., Zakirov, T. V., Ozhgikhina, N. V., Vorozhtsova, L. I. (2017). Analiz osnovnoy stomatologicheskoy zabolevayemosti detskogo naseleniya g. Yekaterinburga [Analysis of the main dental morbidity of the children's population of Yekaterinburg]. Problemy stomatologii [Actual problems in dentistry], 1, 110-113. (In Russ.)
5. Skripkina, G. I., Ekimov, E. V., Nikitin, Yu. B., Korshunov, A. P., Bernetsyan, T. L. (2020). Kolichestvennaya otsenka urovnya mtineralizuyushchego potentsiala rotovoy zhidkosti u detey [Quantitative assessment of the level of mtineralizing potential of oral fluid in children]. Problemy stomatologii [Actual problems in dentistry], 1, 127-132. (In Russ.)
6. Brusnitsyna, E. V., Zakirov, T. V., Kazantseva, E. M., Vorozhtsova, L. I., Petrov, I. A., Chernavsky, A. F. (2016). Stomatologicheskaya zabolevayemost' detskogo naseleniya g. Yekaterinburga [Dental morbidity of children in Yekaterinburg]. IV Vserossiyskoye rabocheye soveshchaniye po problemam fundamental'noy stomatologii Mezhdunarodnyy kongress «Stomatologiya Bol'shogo Urala 25-27 noyabrya 2015 god [IV all-Russian workshop on the problems of fundamental dentistry international Congress " Dentistry of the greater Urals, November 25-27, 2015], Yekaterinburg, 204-207. (In Russ.)
7. Shakovets, N. V. (2018). Rekomendatsii ekspertov VOZ 2017 goda po profilaktike kariyesa zubov u detey rannego vozrasta [Recommendations of who experts 2017 on the prevention of dental caries in young children]. Sovremennaya stomatologiya [Modern dentistry], 1, 3-8. (In Russ.)
8. Kuchmina, M. V., Turkina, A. Yu., Paramonov, Yu. O. (2018). Vozmozhnosti fagoterapii v stomatologii [Possibilities of phagotherapy in dentistry]. Rossiyskiy stomatologicheskiy zhurnal [Russian dental journal], 22, 2, 107-110. (In Russ.)
9. Zemlyanichenko, M. K., Lebedeva, S. N. (2011). Ispol'zovaniye khlorgeksidinsoderzhashchikh sredstv dlya profilaktiki stomatologicheskikh zabolevaniy [Use of chlorhexidine-containing agents for the prevention of dental diseases]. Saratovskiy nauchno-meditsinskiy zhurnal [Saratov scientific and medical journal], 7, 1, 15-19. (In Russ.)
10. (2013). The world health organization. Basic methods of oral health examination. 5th ed. Geneva : WHO, 2013.
11. Skripkina, G. I., Burnashova, T. I. (2018). Rezul'taty epidemiologicheskogo i sotsiologicheskogo obsledovaniya shkol'nikov, roditeley, pedagogov i meditsinskikh rabotnikov g. Omska [Results of epidemiological and sociological survey of schoolchildren, parents, teachers and medical workers of Omsk]. Stomatologiya detskogo vozrasta i profilaktika [Children's dentistry and prevention], 3 (66), 84-89. (In Russ.)
12. Zhirova, V. G., Demyanenko, S. A. (2017). Stomatologicheskoye zdorov'ye detey Kryma i puti yego sovershenstvovaniya [Dental health of children in Crimea and ways to improve it]. Stomatologiya detskogo vozrasta i profilaktika [Children's dentistry and prevention], 2 (61), 49-53. (In Russ.)
13. Suetenkov, D. E., Kharitonova, T. L., Danilov, A. N., Popkova, O. V., Kobets, A. V. (2019). Stomatologicheskaya zabolevayemost' detskogo naseleniya shkol'nogo vozrasta v Saratovskoy oblasti [Dental morbidity of school-age children in the Saratov region]. Klinicheskaya stomatologiya [Clinical dentistry], 1, 96-99. (In Russ.)
14. Kudrina, K. O., Sarap, L. R., Dmitrienko, N. Yu., Zeibert, A. Yu., Geghamyan, A. O. (2019). Otsenka stomatologicheskoy zabolevayemosti u detey shkol'nogo vozrasta g. Barnaula [Assessment of dental morbidity in school-age children of Barnaul]. Stomatologiya detskogo vozrasta i profilaktika [Children's dentistry and prevention], 2, 64-68. (In Russ.)
15. Sarap, L. R., Biryuk, T. V. (2007). Vliyaniye neblagopriyatnykh faktorov vneshney sredy na formirovaniye zubochelyustnykh anomaliy u detskogo naseleniya Altayskogo kraya [Influence of adverse environmental factors on the formation of dental anomalies in the children's population of the Altai territory]. Stomatologiya detskogo vozrasta i profilaktika [Children's dentistry and prevention], 2, 33-36. (In Russ.)
16. Zhilenko, O. G. (2006). Stomatologicheskoye zdorov'ye detey, prozhivayushchikh v ekologicheski neblagopriyatnykh rayonakh Altayskogo kraya : dis. … kand. med. nau [Dental health of children living in ecologically unfavorable areas of the Altai territory : dis. ... cand. .med. science]. Omsk, 158. (In Russ.)
17. Sarap, L. R., Zhilenko, O. G., Biryuk, T. V. (2010). Izucheniye stomatologicheskogo zdorov'ya detskogo naseleniya Altayskogo kraya v ramkakh kompleksnoy programmy «Stomatologicheskoye zdorov'ye naseleniya Altayskogo kraya» [Study of dental health of the children's population of the Altai territory in the framework of the comprehensive program "Dental health of the population of the Altai territory"]. Vestnik altayskoy nauki [Bulletin of the Altai science], 1, 22-26. (In Russ.)
18. Brusnitsyna, E. V., Zakirov, T. V., Ioshchenko, E. S., Ozhgikhina, N. V., ed. Mandra, Yu. V. (2019). Sravnitel'naya otsenka svoystv ftoridsoderzhashchikh lakov [Comparative assessment of properties of fluoride-containing lacquers]. Materialy Mezhdunarodnogo kongressa «Stomatologiya Bol'shogo Urala» : sbornik nauchnykh statey [Materials of the International Congress "Dentistry of the Greater Urals" : collection of scientific articles], Ekaterinburg : CIRCULATION, 16-17. (In Russ.)
19. Ozhgikhina, N. V., Zakirov, T. V., Ishchenko, E. S. (2014). Intensivnost' kariyesa i skorost' slyunootdeleniya u detey s sistemnoy gipoplaziyey emali postoyannykh zubov [Caries intensity and salivation rate in children with systemic hypoplasia of permanent teeth enamel]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 5. URL : http://www.science-education.ru/119-15227 (In Russ.)
20. Brusnitsyna, E. V., Zakirov, T. V., Ioshchenko, E. S., eds. Kiselnikov L. P., Drobotko, L. N (2014). Sravnitel'naya kharakteristika effektivnosti "ROCS medical minerals" i "GT Tooth mousse" pri sozrevanii prezhdevremenno prorezavshikhsya postoyannykh zubov [Comparative characteristics of the effectiveness of "ROX curative minerals" and "GT tooth mousse" in the maturation of prematurely erupted permanent teeth]. Stomatologiya detskogo vozrasta i profilaktika stomatologicheskikh zabolevaniy : sbornik trudov [Children's Dentistry and prevention of dental diseases. Proceedings], Moscow : Moscow state medical and dental University named after A. I. Evdokimov : Redmer publishing house, 213. (In Russ.)
21. Shakovets, N. V. (2016). Rezul'taty trekhletney profilaktiki kariyesa zubov u detey rannego vozrasta [Results of three-year prevention of dental caries in young children]. Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta [Bulletin of the Vitebsk state medical University], 15, 2, 23-27. (In Russ.)
22. Berezina, N. V., Khitrov, V. Yu., Sprenger, L. V. (2009). Primeneniye salfetok Spiffies dlya profilaktiki kariyesa zubov u detey rannego vozrasta [SP spiffies for the prevention of dental caries in young children]. Prakticheskaya meditsina [Practical medicine], 33, 24-29. (In Russ.)
23. Vranich, D. N., Maistorovich, M. (2010). Plidenta Pro-T-action: the new generation of toothpastes with probiotic lactobacillus shows excellent results! (results of clinical studies). Dent Res, 89, 175-177.
24. Li-Chuan, C., Chiung-Shin, H., Li Wei, OU.-Y., Shiao-Yu, L., Li-Chuan, Zh. (2011). Influence of probiotic Lactobacillus paracasei on bacterial cariesogenic flora. Klin oral invest, 15, 476479.
25. Kirillova, E. N., Tsarev, V. N., Kiselnikova, L. P., Artemova, V. O. (2009). Mikrobiologicheskiy monitoring sostoyaniya bioplenki zuba pri primenenii khlorgeksi-dina i ksilita v kompleksnom lechenii kariyesa u detey rannego vozrasta [Microbiological monitoring of the state of the tooth biofilm when using chlorhexidine and xylitol in the complex treatment of caries in young children]. Stomatologiya detskogo vozrasta i profilaktika [Stomatology of children's age and prevention], 2, 86-94. (In Russ.)
