Stavropol', Stavropol, Russian Federation
Stavropol', Stavropol, Russian Federation
Stavropol', Stavropol, Russian Federation
Stavropol', Stavropol, Russian Federation
Stavropol', Stavropol, Russian Federation
Stavropol', Stavropol, Russian Federation
Stavropol', Stavropol, Russian Federation
Subject. Periodontitis is an inflammatory and destructive process in periodontal tissues, the main etiological factor of which, according to modern concepts, is the microbial invasion of the gingival groove by qualitatively and quantitatively modified microorganisms of cervical plaque. Based on the etiopathogenetic bacterial-vascular mechanisms of the occurrence and progression of inflammatory and destructive periodontal diseases, the use of low-energy (low-intensity) laser exposure was included in all the algorithms for the comprehensive treatment of periodontitis that we studied. Objective: to study the effect of low-intensity laser radiation in combination with local non-steroidal anti-inflammatory drugs on the effectiveness of complex treatment of periodontitis. Methodology. The study involved 120 patients (60 men and 60 women), equally divided into four groups depending on the treatment performed. A randomized controlled trial with discrete longitudinal open observation was conducted. The therapy included the implementation of professional oral hygiene using an ultrasound apparatus, sandblasting, polishing all surfaces of the teeth, a hygiene lesson, recommendations. The methodology of pharmacological treatment was to perform the application of the anti-inflammatory drugs Oralsept and Arkoxia to the periodontal area for 15 minutes with a course of 10 procedures. In the second and fourth groups, low-energy laser exposure was performed using the Optodan apparatus in the second mode for 15 minutes. The course of therapy was 10 procedures. The clinical study was conducted according to generally accepted principles with mandatory x-ray control and an index assessment of the periodontal condition. Results. After a six-month observation period, in the first and third groups, there was a deterioration in both index and hemodynamic digital data, and in the second and fourth indicators remained at a fairly positive level, indicating the effectiveness of the therapy. Conclusions. The use of NLV increases the effectiveness of local exposure to non-steroidal anti-inflammatory drugs "Arkoxia" and "Oralsept" by 16 and 19 % respectively. The positive effect of NLV is maintained throughout the observation period.
inflammatory periodontal diseases, non-steroidal anti-inflammatory drugs, laser Doppler flowmetry, periodontitis, laser exposure
1. Borzikova, N. S. (2015). Markery vospalitelnykh protsessov pri boleznyakh parodonta [Markers of inflammatory processes in periodontal diseases]. MS [MS], 2. DOI:https://doi.org/10.21518/2079-701X-2015-2-78-79. (In Russ.)
2. Garazha, S. N., Grishilova, E. N., Khatsayeva, T. M., Demina, K. Yu., Batchayeva, D. D., Morgoyeva, Z. Z. (2013). Vliyaniye lecheniya parodontita immobilizovannymi protivovospalitelnymi preparatami na gemodinamiku v tkanyakh parodonta [Effect of periodontitis treatment with immobilized anti-inflammatory drugs on hemodynamics in periodontal tissues]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 5, 281-285. (In Russ.)
3. Demina, K. Yu., Grishilova, E. N., Brazhnikova, A. N., Garazha, S. N., Batchayeva, D. D., Gotlib, A. O., Garazha, N. N., Khachaturov, S. S. (2014). Vliyaniye fotodinamicheskoy terapii na gemodinamiku v tkanyakh parodonta pri lechenii khronicheskogo generalizovannogo parodontita [Effect of photodynamic therapy on hemodynamics in periodontal tissues in the treatment of chronic generalized periodontitis]. Fundamentalnyye issledovaniya [Fundamental Study], 10, 6, 1094-1097. (In Russ.)
4. Garazha, S. N., Grishilova, E. N., Demina, K. Yu., Batchayeva, D. D., Gotlib, A. O., Brazhnikova, A. N. (2015). Vliyaniye fotodinamicheskoy i lazernoy terapii na tsitokhimicheskiye pokazateli aktivnosti neytrofilnykh granulotsitov pri lechenii khronicheskogo gingivita [Effect of photodynamic and laser therapy on cytochemical parameters of neutrophil granulocytes activity in the treatment of chronic gingivitis]. Kubanskiy nauchnyy meditsinskiy vestnik [Kuban scientific medical Bulletin], 1, 34-37. (In Russ.)
5. Gazhva, S. I., Guluyev, R. S. (2012). Rasprostranennost i intensivnost vospalitelnykh zabolevaniy parodonta (obzor literatury) [Prevalence and intensity of inflammatory periodontal diseases (literature review)]. Obozreniye. Stomatologiya [Review. Dentistry], 1, 13-14. (In Russ.)
6. Dzyuba, E. V., Nagayeva, M. O., Zhdanova E. V. (2019). Rol immunologicheskikh protsessov v razvitii vospalitelnykh zabolevaniy parodonta i vozmozhnosti ikh korrektsii [The role of immunological processes in the development of inflammatory periodontal diseases and the possibility of their correction]. Problemy stomatologii [Problems of dentistry], 15, 2, 25-31. (In Russ.)
7. Zhulev, E. N., Kochubeynik, A. V., Kruglova, N. V., Sergeyeva, A. V., Prikhodko, M. I. (2019). Diagnosticheskiye kriterii pri planirovanii ortopedicheskogo lecheniya patsiyentov s vospalitelnymi zabolevaniyami parodonta [Diagnostic criteria for planning orthopedic treatment of patients with inflammatory periodontal diseases]. Problemy stomatologii [Problems of dentistry], 15, 2, 102-105. (In Russ.)
8. Zorina, O. A., Kulakov, A. A., Grudyanov, A. I. (2011). Mikrobiotsenoz polosti rta v norme i pri vospalitelnykh zabolevaniyakh parodonta [Microbiocenosis of the oral cavity in normal and inflammatory periodontal diseases]. Stomatologiya [Dentistry], 1, 73-78. (In Russ.)
9. Kovalevskiy, A. M., Kovalevskiy, V. A. (2017). Etiologiya i patogenez vospalitelnykh zabolevaniy parodonta (obzor literatury). Ch. I [Etiology and pathogenesis of inflammatory periodontal diseases (literature review). CH. I]. Institut stomatologii [Institute of dentistry], 4, 77, 88-90. (In Russ.)
10. Leus, P. A. (2007). Mikrobnyy biofilm na zubakh. Fiziologicheskaya rol i patogennoye znacheniye [Microbial biofilm on teeth. Physiological role and pathogenic significance]. Stomatologicheskiy zhurnal [Dental journal], 2, 100-111. (In Russ.)
11. Garazha, S. N., Zelenskaya, A. V., Grishilova, E. N., Batchayeva, D. D., Khatsayeva, T. M., Morgoyeva, Z. Z. (2013). Lecheniye vospalitelnykh zabolevaniy parodonta s ispolzovaniyem immobilizovannykh preparatov [Treatment of inflammatory periodontal diseases with the use of immobilized preparations]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 3, 140-145. (In Russ.)
12. Mamedov, R. M., Sadygova, N. N., Ibragimova, L. K. (2019). Optimizatsiya metodov profilaktiki i lecheniya vospalitelnykh zabolevaniy parodonta [Optimization of methods of prevention and treatment of inflammatory periodontal diseases]. Problemy stomatologii [Problems of dentistry], 15, 2, 114-121. (In Russ.)
13. Miklyayev, S. V., Leonova, O. M., Sushchenko, A. V. (2018). Analiz rasprostranennosti khronicheskikh vospalitelnykh zabolevaniy tkaney parodonta [Analysis of the prevalence of chronic inflammatory periodontal tissue diseases]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 2, URL: http://science-education.ru/ru/article/view?id=27454. (In Russ.)
14. Gazhva, S. I., Shmatova, S. O., Goryacheva, T. P., Khudoshin, S. V. (2014). Optimizatsiya metodov lecheniya parodontita legkoy i sredney stepeni tyazhesti s ispolzovaniyem FDT i lazernoy dekontaminatsii parodontalnykh karmanov [Optimization of methods of treatment of periodontitis of mild and moderate severity using PDT and laser decontamination of periodontal pockets]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 6, 17-18. (In Russ.)
15. Morgoyeva, Z. Z., Garazha, S. N., Grishilova, E. N., Garazha, N. N. (2014). Primeneniye immobilizovannogo ftorida olova v kompleksnom lechenii khronicheskogo generalizovannogo parodontita legkoy i sredney stepeni tyazhesti [The use of immobilized tin fluoride in the complex treatment of chronic generalized periodontitis of mild and moderate severity]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 1, 135-140. (In Russ.)
16. Zelenskaya, A. V., Shilova, S. G., Grishilova, E. N., Nekrasova, E. F. (2017). Protivovospalitelnaya effektivnost rastvorov ftorida olova [Anti-inflammatory efficacy of tin fluoride solutions]. Aktualnyye aspekty sovremennoy stomatologii i implantologii : materialy nauchno-prakticheskoy konferentsii [Topical aspects of sovremennoy dentistry as well as Implantology : materialy nauchno-prakticheskoy konferentsii], 342-345. (In Russ.)
17. Tsybikov, N. N., Domanova, E. T., Zobnin, V. V., Ignatov, M. Yu., Maslo, E. Yu., Isakova, N. V. (2012). Svoystva desnevoy zhidkosti pri ostrom gingivite i khronicheskom parodontite [Properties of gingival fluid in acute gingivitis and chronic periodontitis]. Rossiyskiy stomatologicheskiy zhurnal [Russian dental journal], 1, 45-49. (In Russ.)
18. Fuks, I., Kareva, Yu. A., Galizina, O. A., Tabolina, E. S. (2013). Sovremennyye aspekty etiologii i patogeneza zabolevaniy parodonta [Modern aspects of etiology and pathogenesis of periodontal diseases]. Ros. med.-biol. vestn. im. akad. I.P. Pavlova [Russian medico-biological Bulletin. academician I. p. Pavlov], 3, URL: https://cyberleninka.ru/article/n/sovremennye-aspekty-etiologii-i-patogeneza-zabolevaniy-parodonta. (In Russ.)
19. Garazha, S. N., Grishilova, E. N., Zelenskaya, A. V., Khachaturov, S. S., Bandurova, E. E., Demina, K. Yu. (2016). Patent na izobreteniye 2636185. Sposob lecheniya khronicheskogo generalizovannogo kataralnogo gingivita v stadii obostreniya [Patent for invention 2636185. Method of treatment of chronic generalized catarrhal gingivitis in the acute stage]. (In Russ.)
20. Tebloyeva, L. M., Gurevich, K. G. (2014). Faktory riska razvitiya khronicheskogo generalizovannogo parodontita [Risk factors for chronic generalized periodontitis]. Institut stomatologii [Institute of dentistry], 2, 54-56. (In Russ.)
21. Amkhadova, M. A., Garazha, S. N., Khubayev, Z. S. S., Grishilova, E. N., Khachaturov, S. S., Ilina, E. E., Khubayev, T. S. S. (2019). Effektivnost kompleksnoy terapii khronicheskogo generalizovannogo parodontita [Effectiveness of complex therapy of chronic generalized periodontitis]. Rossiyskiy stomatologicheskiy zhurnal [Russian dental journal], 23, 1, 7-9. (In Russ.)
22. Azarpazhooh, A., Shah P. S., Tenenbaum, H. C. (2010). The effect of photodynamic therapy for periodontitis: a systematic review and meta-analysis. J Periodontol, 81,4-14.
23. Masadeh, M. M., Gharaibeh, S. F., Alzoubi, K. H., Al-Azzam, S. I., Obeidat, W. M. (2013). Antimicrobial activity of common mouthwash solutions on multidrug-resistance bacterial biofilms. J Clin Med Res, 5, 389-394.
24. Kinane, D. F., Stathopoulou, P. G., Papapanou, P. N. (2017). Periodontal diseases. Nature Reviews Disease Primers, 22, 3, 225-237.
25. Papageorgiou, S. N., Hagner, M., Nogueira, A. V. B., Franke, A., Jäger, A., Deschner, J. (2017). Inflammatory bowel disease and oral health: systematic review and a meta-analysis. Journal of Clinical Periodontology, 44, 4, 382-393.
