employee
Baku, Azerbaijan
employee
Baku, Azerbaijan
Baku, Azerbaijan
Relevance. Medicines, taking into account the role of various microbial associations in the development of severe generalized forms of gingivitis and periodontitis, should have high antimicrobial activity, but their use can also cause growth inhibition and representatives of normal microflora. The purpose ― to evaluate the effectiveness of complex treatment of inflammatory periodontal diseases using new prophylactic agents. Material and research methods. For a comparative clinical and laboratory evaluation of the effectiveness of the therapeutic and prophylactic agents used, the patients were divided into 3 groups. With HGPLS - the control group - 18, in which treatment was limited only to hygienic education and the conduct of professional hygiene. The comparison group (20 people with CHPH) received treatment according to the generally accepted standard regimen and prescribed Curasept ADS 712 gel toothpaste. The main group (20 people with CHPH) received the standard therapy with Curaprox Enzycal toothpaste 1450ppm. Microbiological studies of a mixed oral fluid and clinical indices were performed in the work — the SBI bleeding index of the gingival sulcus (Muhlemann, 1971), Silness-Loe hygienic index (S-L, 1964). Evaluation of the cleansing, anti-inflammatory and hemostatic effects of the proposed medications was carried out before treatment and 1,3.6 months after treatment. Research results. The control group, the frequency of occurrence of A.actinomycetemcimitans and P.intermedia three months after the completion of treatment and preventive measures was 5.6 ± 5.4 and 11.1 ± 7.4 %, in the comparison group, where Curasept ADS toothpaste was administered 712, the indicators for the above bacteria dropped to zero. The detected values of the hygienic index three months after treatment in the main, control groups and in the comparison group, respectively, amounted to 1.12 ± 0.038; 1.30 ± 0.028 and 1.13 ± 0.041. In the long-term clinical observations in the main group, the values of the Conclusion. According to the data obtained, the use of Curaprox Enzycal paste with 3 enzymes and sodium fluoride in the minimum amount for use revealed its high prophylactic efficacy.
periodontitis, inflammation, microb, treatment, toothpaste
1. Gazhva, S. I., Guluyev, R. S. (2012). Rasprostranennost' i intensivnost' vospalitel'nykh zabolevaniy parodonta (obzor literatury) [Prevalence and intensity of inflammatory periodontal diseases (literature review)]. Obozreniye. Stomatologiya [Obozrenie. Dentistry], 1, 13-14. (In Russ.)
2. Gileva, O. S., Sadilova, A. V. (2013). Zabolevaniya parodonta u vich-infitsirovannykh bol'nykh: rasprostranennost' i osobennosti klinicheskikh proyavleniy v zavisimosti ot priverzhennosti antiretrovirusnoy terapii [Periodontal diseases in HIV-infected patients: prevalence and features of clinical manifestations depending on adherence to antiretroviral therapy]. Permskiy meditsinskiy zhurnal [Perm Medical Journal], 30, 2, 34-42. (In Russ.)
3. Goncharova, Ye. I. (2015). Preparaty lekarstvennykh rasteniy v lechenii zabolevaniy slizistoy obolochki rta [Preparations of medicinal plants in the treatment of diseases of the oral mucosa]. Rossiyskiy stomatologicheskiy zhurnal [Russian dental journal], 19, 4, 55-57. (In Russ.)
4. Yelovikova, T. M., Yermishina, Ye. YU., Belokonova, N. A. (2014). Klinicheskaya kharakteristika otechestvennoy lechebno-profilakticheskoy zubnoy pasty na osnove rastitel'nykh ekstraktov [Clinical characteristics of domestic therapeutic and prophylactic toothpaste based on plant extracts]. Parodontologiya [Periodontology], 2 (71), 68-71. (In Russ.)
5. Zorina, O. A., Kulakov, A. A., Grudyanov, A. I. (2011). Mikrobiotsenoz polosti rta v norme i pri vospalitel'nykh zabolevaniyakh parodonta [Microbiocenosis of the oral cavity in normal and inflammatory periodontal diseases]. Stomatologiya [Dentistry], 1, 73-78. (In Russ.)
6. Kuz'mina, I. N., Lapatina, A. V. (2009). Opyt primeneniya kompleksa lechebno-profilakticheskikh sredstv dlya profilaktiki stomatologicheskikh zabolevaniy [Experience in the use of complex therapeutic and prophylactic agents for the prevention of dental diseases]. Dental Forum [Dental Forum], 2, 33-39. (In Russ.)
7. Kunin, A. A., Korovkina, A. N., Oleynik, O. I. (2012). Effektivnost' vklyucheniya v skhemu kompleksnogo podbora sredstv gigiyeny pri nachal'nykh formakh vospalitel'nykh zabolevaniy parodonta fermentosoderzhashchikh zubnykh past [The effectiveness of the inclusion in the scheme of a comprehensive selection of hygiene products in the initial forms of inflammatory periodontal diseases of enzyme-containing toothpastes]. Institut Stomatologii [Institute of Dentistry], 1, 62-64. (In Russ.)
8. Leus, P. A. (2007). Mikrobnyy biofil'm na zubakh. Fiziologicheskaya rol' i patogennoye znacheniye [Microbial biofilm on the teeth. Physiological role and pathogenic value]. Stomatologicheskiy zhurnal [Dental Journal], 2, 100-111. (In Russ.)
9. Pavlovich, S. A. (2013). Mikrobiologiya s virusologiyey i immunologiyey : ucheb. posobiye [Microbiology with virology and immunology : studies. manual]. Minsk : Higher School, 3, 799. (In Russ.)
10. Tariko, O. S., Zholudev, S. Ye. (2010). Vliyaniye gigiyenicheskikh sredstv na mikrobnyy sostav polosti rta u patsiyentov s parodontitom sredney ili tyazheloy stepeni, pol'zuyushchikhsya kombi nirovannymi shiniruyushchimi konstruktsiyami [The effect of hygiene products on the microbial composition of the oral cavity in patients with moderate to severe periodontitis using a combination splinting structure]. Problemy stomatologii [Dentistry problems], 2, 48-52. (In Russ.)
11. Tebloyeva, L. M., Gurevich, K. G. (2014). Faktory riska razvitiya khronicheskogo generalizovannogo parodontita [Risk factors for the development of chronic generalized periodontitis]. Institut stomatologii [Institute of Dentistry], 2, 54-56. (In Russ.)
12. Yaseen, A., Algabri, R. S. (2015). Limited Evidence Suggests High Risk of Implant Failure Rates Among People With Generalized Aggressive Periodontitis. Journal of Evidence Based Dental Practice, 15, 4, 187-189.
13. Dorri, M., Sheiham, A., Watt, R. G. (2010). Modelling the factors influencing general and oral hygiene behaviours in adolescents. International Journal of Paediatric Dentistry, 20 (4), 261-269.
14. Eke, P. I., Dye, B. A., Wei, L. (2012). Periodontal Disease Surveillance workgroup. James Beck (University of North Carolina, Chapel Hill, USA), Gordon Douglass (Past President, American Academy of Periodontology), Roy Page (University of Washington). Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res, 914-920.
15. Hampton-Marcell, J. T., Lopez, J. V., Gilbert, J. A. (2017). The Human Microbiome: An Emerging Tool in Forensics. Microbial Biotechnology, 10, 2, 228-230.
16. Keestra, J. A., Grosjean, I., Coucke, W., Quirynen, M., Teughels, W. (2015). Non-surgical periodontal therapy with systemic antibiotics in patients with untreated aggressive periodontitis: A systematic review and meta-analysis. J. Periodontal Res, 50, 689-706.
17. Lasserre, J. F., Toma, S., Bourgeois, T., El Khatmaoui, H., Marichal, E., Brecx, M. C. (2016). Influence of low direct electric currents and chlorhexidine upon human dental biofilms. Clin. Exp. Dent. Res, 2, 146-154.
18. Kinane, D. F., Stathopoulou, P. G., Papapanou, P. N. (2017). Periodontal diseases. Nature Reviews Disease Primers, 22 (3), 225-237.
19. Marsh, P. D. (2012). Contemporary perspective on plaque control. British Dental Journal, 212, 601-606.
20. Monje, A., Alcoforado, G., Padial-Molina, M., Suarez, F., Lin, G.-H., Wang, H.-L. (2014). Generalized Aggressive Periodontitis as a Risk Factor for Dental Implant Failure: A Systematic Review and Meta-Analysis. Journal of Periodontology, 85, 10, 1398-1407.
21. Papageorgiou, S. N., Hagner, M., Nogueira, A. V. B., Franke, A., Jäger, A., Deschner, J. (2017). Inflammatory bowel disease and oral health: systematic review and a meta-analysis. Journal of Clinical Periodontology, 44 (4), 382-393.
22. Schonfeld, S. E. (2010). Strategies for managing periodontal inflammation. J.Calif. Dent. Assoc, 38 (4), 272-283.
23. Tabary, N., Chai, F., Blanchemain, N., Neut, C., Pauchet, L., Bertini, S., Delcourt-Debruyne, E., Hildebrand, H. F., Martel, B. (2014). A chlorhexidine-loaded biodegradable cellulosic device for periodontal pockets treatment. Acta Biomater, 10 (1), 318-329.
24. Wang, J., Wang, W., Jiang, X. et al. (2016). Alcohol consumption and risk of periodontitis: a meta-analysis. Journal of Clinical Periodontology, 43 (7), 572-583.
25. Weatherspoon, D. J., Borrell, L. N., Johnson, C. W., Mahasin, S. M,, Neighbors, H. W., Adar, S. D. (2016). Racial and Ethnic Differences in Self-Reported Periodontal Disease in the Multi-Ethnic Study of Atherosclerosis (MESA). Oral Health & Preventive Dentistry, 14, 3, 249.