CLINICAL EFFICACY OF DIFFERENTIATED PROTOCOLS FOR COMPREHENSIVE ORTHOPAEDIC REHABILITATION OF PATIENTS WITH TEMPOROMANDIBULAR JOINT DYSFUNCTION
Abstract and keywords
Abstract:
Relevance. Temporomandibular joint dysfunction is characterized by high prevalence, clinical polymorphism, and a substantial influence on the course of dental rehabilitation. A unified treatment sequence does not account for the differences between masticatory muscle myalgia, arthralgia, and intra-articular disorders without osteoarthrosis, which limits treatment effectiveness. Objective. To develop differentiated clinical protocols for comprehensive orthopaedic rehabilitation of patients with temporomandibular joint dysfunction depending on the subtype of pathology and to compare their clinical effectiveness with the standard treatment sequence. Materials and methods. A prospective controlled comparative clinical study included 90 patients randomized into 6 subgroups of 15 each: main and control subgroups for myalgia, arthralgia, and intra-articular disorders. In the main subgroups, treatment was performed according to differentiated protocols; in the control subgroups, a standard rehabilitation scheme was used. Pain intensity was assessed by the visual analogue scale, maximal mouth opening, frequency of painful episodes and forced treatment interruptions, treatment tolerance, adverse events, and surface electromyography parameters of the masticatory muscles. Results. Differentiated protocols provided greater pain reduction, faster restoration of mouth opening, lower frequency of painful episodes and forced interruptions, and more favorable electromyographic outcomes. Conclusion. The developed differentiated clinical protocols for comprehensive orthopaedic rehabilitation demonstrate statistically significant clinical superiority over the standard treatment sequence and provide more complete restoration of the functional state of the masticatory apparatus in patients with different subtypes of temporomandibular joint dysfunction.

Keywords:
temporomandibular joint dysfunction, orthopaedic rehabilitation, myalgia, arthralgia, intra-articular disorders, visual analogue scale, electromyography, differentiated protocols
References

1. Dworkin S.F. Research diagnostic criteria for temporomandibular disorders: current status & future relevance. Journal of oral rehabilitation. 2010;37(10):734-743. https://doi.org/10.1111/j.1365-2842.2010.02090.x

2. Kapos F.P., Exposto F.G., Oyarzo J.F., Durham J. Temporomandibular disorders: a review of current concepts in aetiology, diagnosis and management. Oral surgery. 2020;13(4):321-334. https://doi.org/10.1111/ors.12473

3. Zieliński G., Pająk-Zielińska B., Ginszt M. A Meta-Analysis of the Global Prevalence of Temporomandibular Disorders. Journal of clinical medicine. 2024;13(5):1365. https://doi.org/10.3390/jcm13051365

4. González-Sánchez B., García Monterey P., Ramírez-Durán M.D.V., Garrido-Ardila E.M., Rodríguez-Mansilla J., Jiménez-Palomares M. Temporomandibular Joint Dysfunctions: A Systematic Review of Treatment Approaches. Journal of clinical medicine. 2023;12(12):4156. https://doi.org/10.3390/jcm12124156

5. Orzeszek S., Waliszewska-Prosol M., Ettlin D., Seweryn P., Straburzynski M., Martelletti P. et al. Efficiency of occlusal splint therapy on orofacial muscle pain reduction: a systematic review. BMC Oral Health. 2023;23(1):180. https://doi.org/10.1186/s12903-023-02897-0

6. Albagieh H., Alomran I., Binakresh A., Alhatarisha N., Almeteb M., Khalaf Y. et al. Occlusal splints-types and effectiveness in temporomandibular disorder management. The Saudi dental journal. 2023;35(1):70–79. https://doi.org/10.1016/j.sdentj.2022.10.013

7. Sun X., Feng Y., Jiao Y., Liu W. Fully digital workflow for the fabrication of occlusal stabilization splints based on individual mandibular movement. Journal of Dentistry. 2024;141:104826. https://doi.org/10.1016/j.jdent.2023.104826

8. Pittari L., Paniura L., Bosco F., Tecco S. TMD management with full digital workflow: a beneficial clinical protocol. Journal of Dentistry. 2024;147:105187. https://doi.org/10.1016/j.jdent.2024.105187

9. Tecco S., Nota A., Pittari L., Clerici C., Mangano F., Gherlone E.F. Full-Digital Workflow for TMDs Management: A Case Series. Healthcare (Basel). 2023;11(6):790. https://doi.org/10.3390/healthcare11060790

10. Nickel J.C., Iwasaki L.R., Gonzalez Y.M., Gallo L.M., Yao H. Mechanobehavior and Ontogenesis of the Temporomandibular Joint. Journal of dental research. 2018;97(11):1185–1192. https://doi.org/10.1177/0022034518786469

11. Antonik P.M., Gvetadze R.Sh., Oganesyan A.S., Sarkisyan N.G. Cifrovoy protokol lecheniya pacientov s yavleniyami myshechno-sustavnoy disfunkcii: klinicheskiy sluchay. Parodontologiya. 2023;28(2):195–204. [Antonik P.M., Gvetadze R.Sh., Oganesyan A.S., Sarkisyan N.G. A digital workflow in the treatment of patients with temporomandibular joint disorders: a case report. Parodontologiya. 2023;28(2):195–204. (In Russ.)]. https://doi.org/10.33925/1683-3759-2023-28-2-195-204

12. Borodina I.D., Apresyan S.V., Stepanov A.G., Butkov D.S., Sanosyan G.V. Klinicheskaya effektivnost' okklyuzionnyh shin v lechenii pacientov s disfunkciey visochno-nizhnechelyustnogo sustava, oslozhnennoy bruksizmom. Stomatologiya. 2023;102(5):56–60. [Borodina I.D., Apresyan S.V., Stepanov A.G., Butkov D.S., Sanosyan G.V. Clinical efficiency of occlusive splints in the treatment of patients with temporomandibular joint dysfunction complicated by bruxism. Stomatology. 2023;102(5):56‑60. (In Russ.)]. https://doi.org/10.17116/stomat202310205156

13. Danilova M.A., Ishmurzin P.V. Podhody k lecheniyu pacientov s distal'noy okklyuziey, oslozhnennoy disfunkciey VNChS. Stomatologiya. 2023;102(1):41–45. [Danilova M.A., Ishmurzin P.V. Treatment approach to patients with distal malocclusion complicated by temporomandibular joint pain-dysfunction syndrome. Stomatology. 2023;102(1):41–45. (In Russ.)]. https://doi.org/10.17116/stomat202310201141

14. Dubova L.V., Stupnikov P.A., Stupnikov A.A., Burenchev D.V., Harchenko D.A. Obosnovanie primeneniya kompleksnogo cifrovogo diagnosticheskogo algoritma dlya obsledovaniya pacientov s myshechno-sustavnoy disfunkciey pri ispol'zovanii vnutrirotovogo okklyuzionnogo apparata. Parodontologiya. 2021;26(4):260-268. [Dubova L.V., Stupnikov P.A., Stupnikov A.A., Burenhcev D.V., Kharchenko D.A. The rationale for the algorithm of comprehensive digital diagnosis of patients with temporomandibular disorders using an intraoral occlusal appliance. Parodontologiya. 2021;26(4):260-268. (In Russ.)]. https://doi.org/10.33925/1683-3759-2021-26-4-260-268

15. Kosyreva T.F., Tuturov N.S., Kadbeh Imad, Lebedev V.G., Donskov D.V., Chhikvadze T.V. Diagnostika i lechenie disfunkcii VNChS s ispol'zovaniem cifrovyh tehnologiy. Stomatologiya dlya vseh. 2020;(3):56–61. [Kosyreva T.F., Tuturov N.S., Kadbekh Imad, Lebedev V.G., Donskov D.V., Chkhikvadze T.V. Diagnostics and treatment of temporomandibular joint dysfunctions using digital technologies. Stomatology for All / Int. Dental Review. 2020;(3):56–61. (In Russ.)]. https://doi.org/10.35556/IDR-2020-3(92)56-60

16. Ryahovskiy A.N. Virtual'noe pozicionirovanie nizhney chelyusti v central'noe sootnoshenie. Stomatologiya. 2021;100(4):104–108. [Ryahovsky A.N. Virtual positioning of the mandible to the position of the central relationship in a clinical example. Stomatology. 2021;100(4):104‑108. (In Russ.)]. https://doi.org/10.17116/stomat2021100041104

17. Ryahovskiy A.N., Boycova E.A. 3D-analiz visochno-nizhnechelyustnogo sustava i okklyuzionnyh vzaimootnosheniy na osnove komp'yuternogo virtual'nogo modelirovaniya. Stomatologiya. 2020;99(2):97–104. [Ryakhovskiy A.N., Boytsova E.A. 3D analysis of the temporomandibular joint and occlusal relationships based on computer virtual simulation. Stomatology. 2020;99(2):97–104. (In Russ.)]. https://doi.org/10.17116/stomat20209902197

18. Chhikvadze T.V., Bekreev V.V., Roschin E.M., Trufanov V.D., Yurkevich R.I., Ivanov S.Yu. Korrekciya vnutrennih narusheniy visochno-nizhnechelyustnogo sustava s ispol'zovaniem okklyuzionnyh shin, izgotovlennyh s pomosch'yu CAD/CAM-tehnologiy. Sovremennye tehnologii v medicine. 2019;11(3):111–116. [Chkhikvadze T.V., Bekreev V.V., Roshchin E.M., Trufanov V.D., Yurkevich R.I., Ivanov S.Yu. Correction of Internal Disorders of the Temporomandibular Joint Using Muscle Relaxation Splints Made with CAD/CAM Technologies. Sovremennye tehnologii v medicine. 2019;11(3):111–116. (In Russ.)]. https://doi.org/10.17691/stm2019.11.3.15

19. Chhikvadze T.V., Bekreev V.V. Okklyuzionnaya terapiya narusheniy funkcii visochno-nizhnechelyustnogo sustava. Vestnik Rossiyskogo universiteta druzhby narodov. Seriya: Medicina. 2018;22(4):387–401. [Chkhikvadze T.V., Bekreev V.V. Occlusive therapy of temporomandibular disorders. RUDN Journal of Medicine. 2018;22(4):387–401. (In Russ.)]. https://doi.org/10.22363/2313-0245-2018-22-4-387-401

20. Ovcharenko E.S., Lapina N.V., Voychenko A.A., Skorikova L.A., Nadtochiy A.V., Triandafilov S.A. Sovremennye aspekty mezhdisciplinarnogo podhoda k diagnostike i kompleksnoy vosstanovitel'noy terapii zhevatel'no-rechevogo apparata bol'nyh s neyromuskulyarnym disfunkcional'nym sindromom visochno-nizhnechelyustnogo sustava sistematicheskiy obzor. Mediko-farmacevticheskiy zhurnal "Pul's". 2023;25(6):74–83. [Ovcharenko E.S., Lapina N.V., Voychenko A.A., Skorikova L.A., Nadtochiy A.V., Triandafilov S.A. Modern aspects of an interdisciplinary approach to diagnostics and complex rehabilitation therapy of the mustering and speech apparatus in patients with neuromuscular dysfunctional syndrome of the temporomantomandibular joint systematic review. Medical & Pharmaceutical Journal «Pulse». 2023;25(6):74–83. (In Russ.)]. https://doi.org/10.26787/nydha-2686-6838-2023-25-6-74-83

21. Dolgalev A.A., Hristoforando D.Yu., Garus Ya.N., Ivenskiy V.N., Brazhnikova A.N., Horev O.Yu. i dr. Analiz apparatnyh metodov lecheniya pacientov s disfunkciey visochno-nizhnechelyustnogo sustava. Permskiy medicinskiy zhurnal. 2024;41(1):120–131. [Dolgalev A.A., Khristoforando D.Yu., Garus Ya.N., Ivensky V.N., Brazhnikova A.N., Khorev O.Y. et al. Analysis of hardware methods of treatment of patients with temporomandibular joint dysfunction. Perm Medical Journal. 2024;41(1):120–131. (In Russ.)]. https://doi.org/10.17816/pmj411120-131

22. Nachar'yan D.G., Apresyan S.V., Stepanov A.G., Moskovec O.O., Butkov D.S. Cifrovye protokoly kompleksnoy ortopedicheskoy reabilitacii pacientov s sindromom bolevoy disfunkcii visochno-nizhnechelyustnogo sustava (obzor literatury). Problemy stomatologii. 2025;21(2):37–42. [Nacharyan E.G., Apresyan S.S., Stepanov A.G., Moskovets O.O., Butkov D.S. Digital protocols for comprehensive orthopedic rehabilitation of patients with temporomandibular joint pain dysfunction syndrome. Actual problems in dentistry. 2025;21(2):37–42. (In Russ.)]. https://doi.org/10.18481/2077-7566-2025-21-2-37-42

23. Gauer R.L., Semidey M.J. Diagnosis and treatment of temporomandibular disorders. American Family Physician. 2015;91(6):378–386. https://www.aafp.org/pubs/afp/issues/2015/0315/p378.html

24. Apresyan S.V., Stepanov A.G., Nacharyan D.G., Moskovec O.O., Kopylov M.V., avtory; Federal'noe gosudarstvennoe avtonomnoe obrazovatel'noe uchrezhdenie vysshego obrazovaniya "Rossiyskiy universitet druzhby narodov imeni Patrisa Lumumby", patentoobladatel'. Prikusnoy blok dlya fiksacii chelyustey. Rossiyskaya Federaciya patent RU 2844632. Opubl. 04.08.2025, Byul. № 2. [Apresyan S.V., Stepanov A.G., Nacharyan D.G., Moskovets O.O., Kopylov M.V. inventors; Federalnoe gosudarstvennoe avtonomnoe obrazovatelnoe uchrezhdenie vysshego obrazovaniya "Rossijskij universitet druzhby narodov imeni Patrisa Lumumby"(RUDN), assignee. Bite block for fixation of jaws. Russian Federation patent RU 2844632. Date of publication: 04.08.2025, Bulletin No. 2]. https://elibrary.ru/item.asp?id=82764489

25. Apresyan S.V., Stepanov A.G., Nacharyan D.G., Moskovec O.O., Kopylov M.V. avtory; Federal'noe gosudarstvennoe avtonomnoe obrazovatel'noe uchrezhdenie vysshego obrazovaniya "Rossiyskiy universitet druzhby narodov imeni Patrisa Lumumby", patentoobladatel'. Sposob profilaktiki patologii visochno-nizhnechelyustnogo sustava vo vremya stomatologicheskogo lecheniya. Rossiyskaya Federaciya patent RU 2843790. Opubl. 18.07.2025, Byul. № 20. [Apresian S.V., Stepanov A.G., Nacharian D.G., Moskovets O.O., Kopylov M.V. inventors; Federalnoe gosudarstvennoe avtonomnoe obrazovatelnoe uchrezhdenie vysshego obrazovaniya "Rossijskij universitet druzhby narodov imeni Patrisa Lumumby"(RUDN), assignee. Method for prevention of temporomandibular joint pathology during dental treatment. Russian Federation patent RU 2843790. Date of publication: 18.07.2025, Bulletin No. 2]. https://elibrary.ru/item.asp?id=82661790


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