Cheboksary, Cheboksary, Russian Federation
graduate student from 01.01.1924 to 01.01.1927
Cheboksary, Cheboksary, Russian Federation
student
Cheboksary, Cheboksary, Russian Federation
VAK Russia 3.1.7
UDC 616.31
CSCSTI 76.29
The work is devoted to the analysis of the features of inflammatory periodontal diseases in children with autism spectrum disorders. The study was based on the data on the high prevalence of dental pathology in this group of patients and the lack of adapted clinical approaches to their management. The aim of the study was to summarize information on the pathogenetic, immunological, microbiological, and clinical mechanisms of periodontal lesions in children with autism spectrum disorders and to justify the need for modification of diagnostic and therapeutic strategies. The work was conducted in the form of an analytical review of scientific literature. The analysis included publications by Russian and foreign authors on the pathogenesis, clinical manifestations, diagnosis, and treatment of periodontal diseases in children with neurodevelopmental disorders. The methodological basis was based on a comparative analysis of clinical, laboratory, and microbiological data, as well as an assessment of current concepts of neuroimmune interaction. The review findings suggest that inflammatory periodontal diseases in children with autism spectrum disorders are influenced by a complex of factors, including impaired oral hygiene behavior, sensory hypersensitivity, changes in the immune response, and dysbiotic alterations in the oral microbiome. It has been shown that the combination of neuroinflammatory and immune disorders contributes to the chronification of the process and the formation of atypical clinical manifestations. The authors conclude that it is necessary to develop adapted diagnostic algorithms and individualized therapeutic programs based on an interdisciplinary approach and minimally invasive treatment methods, which will increase the effectiveness of prevention and treatment of periodontal diseases in this category of patients.
pediatric periodontology, periodontal diseases in children, autism spectrum disorders, neuroimmune mechanisms of inflammation, oral microbiome, behavioral dental features, adapted dental protocols
1. Agarkov N.M., Makaryan A.S., Gontareva I.S. Sovershenstvovanie diagnostiki hronicheskogo parodontita u detey. Infekciya i immunitet. 2020;10(3):558–564. [Agarkov N.M., Makaryan A.S., Gontareva I.S. Advancing diagnostics of chronic paradontitis in children. Russian Journal of Infection and Immunity. 2020;10(3):558–564. (In Russ.)]. https://doi.org/10.15789/2220-7619-ADO-1186
2. Bavykina I.A., Bavykin D.V. Osobennosti okazaniya stomatologicheskoy pomoschi detyam s rasstroystvami autisticheskogo spektra. Prikladnye informacionnye aspekty mediciny. 2022;25(2):43–47. [Bavykina I.A., Bavykin D.V. Features of dental care for children with autism spectrum disorders. Prikladnye informacionnye aspekty mediciny. 2022;25(2):43–47. (In Russ.)]. https://www.elibrary.ru/item.asp?id=49331253
3. Boyarkin V.S., Kapica I.G., Voronina T.A. Modelirovanie v eksperimente rasstroystv autisticheskogo spektra s ispol'zovaniem propionovoy kisloty. Patogenez. 2023;21(4):32–38. [Boyarkin V.S., Kapitsa I.G., Voronina T.A. Experimental modeling of autism spectrum disorders using propionic acid. Pathogenesis. 2023;21(4):32–38. (In Russ.)]. https://doi.org/10.25557/2310-0435.2023.04.32-38
4. Voytenko V.V., Podzorova E.A. Problemy stomatologicheskoy sanacii detey s rasstroystvami autisticheskogo spektra. Scientist. 2023;(2):165–167. [Voitenko V.V., Podzorova E.A. Problems of dental sanitation in children with autism spectrum disorders. Scientist. 2023;(2):165–167. (In Russ.)]. https://www.elibrary.ru/item.asp?id=50751009
5. Gaydomak K.I., Ekimov E.V. Osobennosti lecheniya i adaptacii detey s autisticheskimi rasstroystvami na stomatologicheskom prieme. Nauchnyy vestnik Omskogo gosudarstvennogo medicinskogo universiteta. 2022;2(4):40-48. [Gaydomak C.I., Ekimov E.V. Features of treatment and adaptation of children with autistic disorders at dental practices. Scientific Bulletin of the Omsk State Medical University.2022;2(4):40-48. (In Russ.)]. https://journals.eco-vector.com/2782-3024/article/view/623789
6. Efimova V.L., Kon'shina N.V. Neyrovospalitel'nye markery: poisk vzaimosvyazey s narusheniyami razvitiya i zdorov'ya detey. Mir nauki. Pedagogika i psihologiya. 2024;12(3):86. [Efimova V.L., Konshina N.V. Neuroinflammatory markers: search for relationships with developmental disorders and health of children. World of Science. Pedagogy and Psychology. 2024;12(3):86. (In Russ.)]. https://www.elibrary.ru/item.asp?id=71282401
7. Zozulya S.A., Nikitina S.G., Simonov A.N., Simashkova N.V., Klyushnik T.P. Predikciya urovnya postpristupnogo social'nogo funkcionirovaniya detey na osnove opredeleniya immunologicheskih pokazateley. Patogenez. 2022;20(3):44–51. [Zozulya S.A., Nikitina S.G., Simonov A.N., Simashkova N.V., Klyushnik T.P. Prediction of post-psychotic social functioning in children based on determination of immunological parameters. Pathogenesis. 2022;20(3):44–51. (In Russ.)]. https://www.elibrary.ru/item.asp?id=49602264
8. Indiaminova G.N. Optimizirovat' metodov profilaktiki kariesa u detey s zaderzhkoy umstvennogo razvitiya. Science and Education. 2024;5(9):149–154. [Indiaminova G.N. To optimize caries prevention methods in children with mental development retards. Science and Education. 2024;5(9):149–154. (In Russ.)]. https://openscience.uz/index.php/sciedu/article/view/7192
9. Kisel'nikova L.P., Gutnik A.A., Danilova I.G. Harakteristika faktorov mestnogo immuniteta polosti rta i vozmozhnosti ih korrekcii u pacientov s zabolevaniyami parodonta. Klinicheskaya stomatologiya. 2022;25(4);6-15. [Kiselnikova L.P., Gutnik A.A., Danilova I.G. Characteristics of the state of some local oral immunity factors and the possibility of their correction in patients with diseases of periodontal tissues. Clinical Dentistry (Russia). 2022;25(4);6-15. (In Russ.)]. https://doi.org/10.37988/1811-153X_2022_4_6
10. Kopeckiy I.S., Pobozh'eva L.V., Kopeckaya A.I., Shevelyuk Yu.V. Mikrobiom polosti rta. Rossiyskiy medicinskiy zhurnal. 2021;27(4):365-372. [Kopetsky I.S., Pobozhieva L.V., Kopetskaya A.I., Shevelyuk J.V. Oral microbiome. Russian Medicine. 2021;27(4):365-372. (In Russ.)]. https://doi.org/10.17816/0869-2106-2021-27-4-365-372
11. Natarova K.A., Semke A.V., Gutkevich E.V. Rasstroystva autisticheskogo spektra (kliniko-dinamicheskiy, regional'nyy i semeynyy aspekty). Tomsk: Ivan Fedorov; 2012. 192 p. [Natarova K.A., Semke A.V., Gutkevich E.V. Autism spectrum disorders (clinical, regional and family aspects). Tomsk: Ivan Fedorov; 2012. 192 p. (In Russ.)]. https://www.mental-health.ru/files/edu/monograph/self/005.pdf
12. Sabirova A.I., Mamytova A.B., Kydyralieva R.B., Mamasaliev Zh.M., Kasymalieva D.K. Rol' mikrobioma polosti rta v razvitii parodontita i kardiovaskulyarnoy patologii. Vestnik Kyrgyzsko-Rossiyskogo Slavyanskogo universiteta. 2024;24(1):84–90. [Sabirova A.I., Mamytova A.B., Kydyralieva R.B., Mamasaliev Zh.M., Kasymalieva D.K. The role of the oral microbiome in the development of periodontal tissue diseases and atherosclerotic-associated cardiovascular pathology. Vestnik Kyrgyzsko-Rossijskogo Slavânskogo Universiteta. 2024;24(1):84–90. (In Russ.)]. https://doi.org/10.36979/1694-500X-2024-24-1-84-90
13. Turdubekova A.N. Ocenka psihologicheskoy adaptacii detey na stomatologicheskom prieme. Scientist. 2023;(4):65–70. [Turdubekova A.N. Psychological adaptation of children at the dental appointment. Scientist. 2023;(4):65–70. (In Russ.)]. https://www.elibrary.ru/item.asp?id=60005491
14. Filippova N.V., Baryl'nik Yu.B. Neyrohimicheskie aspekty etiopatogeneza rasstroystv autisticheskogo spektra. Sibirskiy medicinskiy zhurnal (Irkutsk). 2013;123(8):11–15. [Filippova N.V., Barylnik J.B. Neurochemical aspects of the pathogenesis of autism spectrum disorders. Siberian Medical Journal (Irkutsk). 2013;123(8):11–15. (In Russ.)]. https://www.elibrary.ru/item.asp?id=21459585
15. Hudyakova M.I., Cherevko N.A., Skirnevskaya A.V., Rozenshteyn M.Yu., Rozenshteyn A.Z., Kondakov S.E. i dr. Pischevaya giperchuvstvitel'nost' u detey s rasstroystvom autisticheskogo spektra. Acta Biomedica Scientifica. 2019;4(5):60–67. [Khudyakova M.I., Cherevko N.A., Skirnevskaya A.V., Rozenshtein M.Yu., Rozenshtein A.Z., Kondakov S.E. et al. Features of food hypersensitivity in children with autism spectrum disorder. Acta Biomedica Scientifica. 2019;4(5):60–67. (In Russ.)]. https://doi.org/10.29413/ABS.2019-4.5.10
16. Carev V.N., Nikolaeva E.N., Ippolitov E.V. Parodontopatogennye bakterii - osnovnoy faktor vozniknoveniya i razvitiya parodontita. Zhurnal mikrobiologii, epidemiologii i immunobiologii. 2017;94(5):101-112. [Tsarev V.N., Nikolaeva E.N., Ippolitov E.V. Periodontophatogenic bacteria of the main factors of emergence and development of periodontitis. Journal of microbiology, epidemiology and immunobiology. 2017;94(5):101-112. (In Russ.)]. https://doi.org/10.36233/0372-9311-2017-5-101-112
17. Maenner M.J., Warren Z., Williams A.R., Amoakohene E., Bakian A.V., Bilder D.A. et al. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020. Morbidity and mortality weekly report. Surveillance summaries. 2023;72(2):1-14. https://doi.org/10.15585/mmwr.ss7202a1
18. Veseli A., Gjocaj M., Mrasori S., Veseli E., Behluli E., Veseli K. Oral-Health Considerations in Children with Autism Spectrum Disorder: A Narrative Review. International Journal of Biomedicine. 2025;15(3):441-445. https://doi.org/10.21103/Article15(3)_RA1
19. Prynda M., Pawlik A.A., Emich-Widera E., Kazek B., Mazur M., Niemczyk W. et al. Oral Hygiene Status in Children on the Autism Spectrum Disorder. Journal of clinical medicine. 2025;14(6):1868. https://doi.org/10.3390/jcm14061868
20. Sami W., Ahmad M.S., Shaik R.A., Miraj M., Ahmad S., Molla M. H. Oral Health Statuses of Children and Young Adults with Autism Spectrum Disorder: An Umbrella Review. Journal of clinical medicine. 2023;13(1):59. https://doi.org/10.3390/jcm13010059
21. Fakroon S., Arheiam A., Omar S. Dental caries experience and periodontal treatment needs of children with autistic spectrum disorder. European archives of paediatric dentistry. 2015;16(2):205-209. https://doi.org/10.1007/s40368-014-0156-6
22. Kim S., Lee H., Song J., Kum K.Y., Kim J.M. Oral microbiome-based evaluation of periodontal treatment responses in individuals with special health care needs: a longitudinal study. BMC Oral Health. 2026;26(1):222. https://doi.org/10.1186/s12903-025-07587-7
23. Farmani S., Ajami S., Babanouri N. Prevalence of Malocclusion and Occlusal Traits in Children with Autism Spectrum Disorders. Clinical, cosmetic and investigational dentistry. 2020;12:343-349. https://doi.org/10.2147/CCIDE.S262679
24. Naka S., Yamana A., Nakano K., Okawa R., Fujita K., Kojima A. et al. Distribution of periodontopathic bacterial species in Japanese children with developmental disabilities. BMC Oral Health. 2009;9:24. https://doi.org/10.1186/1472-6831-9-24
25. Jaber M.A. Dental caries experience, oral health status and treatment needs of dental patients with autism. Journal of applied oral science. 2011;19(3):212-217. https://doi.org/10.1590/s1678-77572011000300006
26. Stein Duker L.I., Como D.H., Jolette C., Vigen C., Gong C.L., Williams M.E. et al. Sensory Adaptations to Improve Physiological and Behavioral Distress During Dental Visits in Autistic Children: A Randomized Crossover Trial. JAMA network open. 2023;6(6):e2316346. https://doi.org/10.1001/jamanetworkopen.2023.16346
27. Martínez Pérez E., Adanero Velasco A., Gómez Clemente V., Miegimolle Herrero M., Planells Del Pozo P. Importance of Desensitization for Autistic Children in Dental Practice. Children (Basel). 2023;10(5):796. https://doi.org/10.3390/children10050796
28. Cermak S.A., Stein Duker L.I., Williams M.E., Dawson M.E., Lane C.J., Polido J.C. Sensory Adapted Dental Environments to Enhance Oral Care for Children with Autism Spectrum Disorders: A Randomized Controlled Pilot Study. Journal of autism and developmental disorders. 2015;45(9):2876-2888. https://doi.org/10.1007/s10803-015-2450-5
29. Ferrazzano G.F., Salerno C., Bravaccio C., Ingenito A., Sangianantoni G., Cantile T. Autism spectrum disorders and oral health status: review of the literature. European journal of paediatric dentistry. 2020;21(1):9-12. https://doi.org/10.23804/ejpd.2020.21.01.02
30. da Silva S.N., Gimenez T., Souza R.C., Mello-Moura A.C.V., Raggio D.P., Morimoto S. et al. Oral health status of children and young adults with autism spectrum disorders: systematic review and meta-analysis. International journal of paediatric dentistry. 2017;27(5):388-398. https://doi.org/10.1111/ipd.12274
