ASSESSMENT OF CLINICAL-LABORATORY CHANGES IN ORAL HEALTH INDICATORS IN PATIENTS WITH HAEMOPHILIA AGAINST THE BACKGROUND OF THE USE OF NEW THERAPEUTIC AND PREVENTIVE DENTAL PASTE

Rimma Fedorova; Oleg Oreshaka; Kirill Fedorov

doi:10.18481/2077-7566-2026-22-2-39-43

VAK Russia 3.1.7 UDC 616.31

2 more Collapse

ASSESSMENT OF CLINICAL-LABORATORY CHANGES IN ORAL HEALTH INDICATORS IN PATIENTS WITH HAEMOPHILIA AGAINST THE BACKGROUND OF THE USE OF NEW THERAPEUTIC AND PREVENTIVE DENTAL PASTE

Published in Actual problems in dentistry · Volume 22, Issue 2 · Pages 39–43 · Rubric: TERAPEUTIC DENTISTRY. ORIGINAL RESEARCH PAPERS

DOI: https://doi.org/10.18481/2077-7566-2026-22-2-39-43

Received: 17.06.2026 Accepted: 29.06.2026 Published: 29.06.2026 Language of publication: RUS

Authors

Rimma Fedorova

Oleg Oreshaka

Kirill Fedorov

Rimma Fedorova

Russian Federation

Oleg Oreshaka

Academic degree: doctor of medical sciences

Altai State Medical Universite Professor of the Department · Department of Orthopedic Dentistry · Russian Federation · Barnaul

Kirill Fedorov

Academic degree: candidate of medical sciences

Science rang: docent

Altai State Medical University Associate Professor · Department of Pediatric Dentistry · Russian Federation · Barnaul

ABSTRACT

Young haemophilia patients with a high incidence of caries, hard tooth tissue lesions, and gingival inflammation are prone to fear of bleeding during individual oral hygiene. This reduces hygiene effectiveness and results in unsatisfactory oral status, necessitating the development of specialised hygiene products. Subject. Toothpaste containing a special dye to improve cleaning quality and components aimed at reducing bleeding and inflammation. Objective. To evaluate the clinical and laboratory effectiveness of a new toothpaste used within a comprehensive dental protocol and its impact on oral tissues in young haemophilia patients. Methodology. An open controlled study was conducted. Subjects were divided into two parallel groups using stratified randomisation and pairwise matching. The observation group included 18 haemophilia patients aged 18-35 years who used an improved toothpaste (patented formulation). The comparison group comprised 18 individuals of the same age and gender with the same diagnosis who received a standard protocol approved by the Russian Dental Association. Assessed parameters: OHI-S index, SBI index, PMA index, mixed saliva pH, secretion rate, and viscosity. Measurements were taken at baseline, after 3 and 6 months. Statistical processing used Statistica version 10.0. Results. By the third month, use of the improved toothpaste in young haemophilia patients was associated with positive dynamics of OHI-S, SBI, and PMA indices regardless of disease severity. Additionally, pH shifted toward physiological values, saliva secretion rate increased, and viscosity decreased. No such changes occurred in the comparison group. Conclusion. Inclusion of the improved toothpaste in a prophylactic and therapeutic protocol for haemophilia patients aged 18–35 years achieves satisfactory or good oral hygiene, significant reduction of gingival bleeding, and decreased inflammation severity. Normalisation of mixed saliva (pH stabilization, increased secretion rate, reduced viscosity) was also observed. The most pronounced positive dynamics were noted in patients with more severe disease, making this approach particularly relevant.

KEYWORDS

advanced toothpaste, haemophilia, dental health, treatment effectiveness, patients with haemophilia

1. Aleksandrov M.T., Olesova V.N., Dmitrieva E.F., Namiot E.D., Artemova O.A., Ahmedov A.N. i dr. Problemnye voprosy ocenki gigienicheskogo sostoyaniya polosti rta i ih klinicheskoe reshenie. Stomatologiya. 2020;99(4):21-26. [Aleksandrov M.T., Olesova V.N., Dmitrieva E.F., Namiot E.D., Artyomova O.A., Akhmedov A.N. et al. Integrated assessment of hygienic condition of the oral cavity. Stomatology. 2020;99(4):21‑26. (In Russ.)]. https://doi.org/10.17116/stomat20209904121

2. Bessonova E.A., Kozlov M.E. Klinicheskaya ocenka effektivnosti zubnoy pasty, soderzhaschey citrat i laktat cinka, cetilpiridiniya hlorid, ekstrakt kory duba i sangvinarii, dlya snizheniya krovotochivosti desen. Medicinskiy alfavit. 2026;(1):77–80. [Bessonova E.A., Kozlov M.E. Clinical evaluation of the effectiveness of toothpaste containing zinc citrate and lactate, cetylpyridinium chloride, oak bark extract and sanguinaria to reduce bleeding gums. Medical alphabet. 2026;(1):77–80. (In Russ.)]. https://doi.org/10.33667/2078-5631-2026-1-77-80

3. Gromova S.N., Elikov A.V., Ogorodova N.Yu., Pyshkina O.A., Gromov Ya.P., Guzhavina N.A. i dr. Opyt ocenki gigienicheskoy effektivnosti detskih zubnyh past po biohimicheskim parametram smeshannoy slyuny. Stomatologiya detskogo vozrasta i profilaktika. 2022;22(2):133-142. [Gromova S.N., Elikov A.V., Ogorodova N.Yu., Pyshkina O.A., Gromov Ya.P., Guzhavina N.A. et al. Experience in the toothpaste’s hygienic effectiveness assessment by oral fluid biochemical parameters. Pediatric dentistry and dental prophylaxis. 2022;22(2):133-142 (In Russ.)]. https://doi.org/10.33925/1683-3031-2022-22-2-133-142

4. Popkova A.A., Postnikov M.A., Burakshaev S.A., Svechnikova M.V. Optimizaciya stomatologicheskogo lecheniya pacientov s gemofiliey. Aktual'nye problemy mediciny. 2024;47(3):328–335. [Popkova A.A., Postnikov M.A., Burakshaev S.A., Svechnikova M.V. 2024. Optimization of Dental Treatment of Patients with Hemophilia. Challenges in Modern Medicine. 2024;47(3):328–335. (In Russ.)]. https://doi.org/10.52575/2687-0940-2024-47-3-328-335

5. Ulitovskiy S.B., Orehova L.Yu., Kalinina O.V., Leont'ev A.A., Loboda E.S. Mirovoy opyt vnedreniya profilakticheskih programm v stomatologii. Parodontologiya. 2024;29(1):13-23. [Ulitovskiy S.B., Orekhova L.Y., Kalinina O.V., Leontev A.A., Loboda E.S. The world's experience of introducing prophylactic programs in dentistry. Parodontologiya. 2024;29(1):13-23. (In Russ.)]. https://doi.org/10.33925/1683-3759-2024-895

6. Fedorova R.K, Oreshaka O.V., Fedorov K.P. Ocenka effektivnosti special'no razrabotannoy zubnoy pasty v komplekse sovremennyh stomatologicheskih meropriyatiy u detey, stradayuschih gemofiliey. Problemy stomatologii. 2025;21(2):153-156. [Fedorova R.K., Oreshaka O.V., Fedorov K.P. Evaluation of the effectiveness of specially developed toothpaste in complex modern preventive measures for children suffering from haemophilia. Actual problems in dentistry. 2025;21(2):153-156. (In Russ.)]. https://doi.org/10.18481/2077-7566-2025-21-2-153-156

7. Florinskiy D.B., Zharkov P.A. Sovremennye podhody k lecheniyu gemofilii. Voprosy gematologii/onkologii i immunopatologii v pediatrii. 2020;19(3):131–138. [Florinskiy D.B., Zharkov P.A. Modern approaches in hemophilia therapy. Pediatric Hematology/Oncology and Immunopathology. 2020;19(3):131–138. (In Russ.)] https://doi.org/10.24287/1726-1708-2020-19-3-131-138

8. Sundaresan P.D., Kruger E., Lim M., McGeachie J., Tennant M. Dentistry for patients with haemophilia: Trialling a safe and economical change in management. Haemophilia. 2024;30(2):404-409. https://doi.org/10.1111/hae.14947

9. Desai S., Berry E., Unkel J., Reinhartz J., Reinhartz D. A case report of haemophilia: a review of haemophilia and oral health implications. British Dental Journal. 2023;234:92–95. https://doi.org/10.1038/s41415-023-5448-y

10. Kametani M., Akitomo T., Usuda M., Kusaka S., Asao Y., Nakano M. et al. Evaluation of periodontal status and oral health habits with continual dental support for young patients with hemophilia. Applied Sciences. 2024;14(4):1349. https://doi.org/10.3390/app14041349

This work is licensed under Creative Commons Attribution 4.0 International

JATS XML

Editor in Chief

Sergey Zholudev

zholudev_se@mail.ru

Deputy editor

Yuliya Mandra

jmandra@mail.ru

101

downloads

This work is licensed under Creative Commons Attribution 4.0 International Creative Commons

GOST

Fedorova R. K., Oreshaka O. V., Fedorov K. P. ASSESSMENT OF CLINICAL-LABORATORY CHANGES IN ORAL HEALTH INDICATORS IN PATIENTS WITH HAEMOPHILIA AGAINST THE BACKGROUND OF THE USE OF NEW THERAPEUTIC AND PREVENTIVE DENTAL PASTE // Actual problems in dentistry. 2026. no. 2. pp. 39-43. DOI: https://doi.org/10.18481/2077-7566-2026-22-2-39-43. (Date of access 04.11.2026).

MLA

Rimma Fedorova, Oreshaka O. V., Fedorov K. P.. "ASSESSMENT OF CLINICAL-LABORATORY CHANGES IN ORAL HEALTH INDICATORS IN PATIENTS WITH HAEMOPHILIA AGAINST THE BACKGROUND OF THE USE OF NEW THERAPEUTIC AND PREVENTIVE DENTAL PASTE." Actual problems in dentistry 22.2 (2026): 39-43. DOI: https://doi.org/10.18481/2077-7566-2026-22-2-39-43.

APA

Fedorova R. K., Oreshaka O. V., Fedorov K. P. (2026). ASSESSMENT OF CLINICAL-LABORATORY CHANGES IN ORAL HEALTH INDICATORS IN PATIENTS WITH HAEMOPHILIA AGAINST THE BACKGROUND OF THE USE OF NEW THERAPEUTIC AND PREVENTIVE DENTAL PASTE. Actual problems in dentistry, 22(2), 39-43. https://doi.org/10.18481/2077-7566-2026-22-2-39-43

Chicago

Rimma Fedorova, Oreshaka O. V., Fedorov K. P.. "ASSESSMENT OF CLINICAL-LABORATORY CHANGES IN ORAL HEALTH INDICATORS IN PATIENTS WITH HAEMOPHILIA AGAINST THE BACKGROUND OF THE USE OF NEW THERAPEUTIC AND PREVENTIVE DENTAL PASTE." Actual problems in dentistry 22, no. 2 (2026): 39-43. https://doi.org/10.18481/2077-7566-2026-22-2-39-43.

WIKI

{{cite journal | author = Fedorova R. K., Oreshaka O. V., Fedorov K. P. | title = ASSESSMENT OF CLINICAL-LABORATORY CHANGES IN ORAL HEALTH INDICATORS IN PATIENTS WITH HAEMOPHILIA AGAINST THE BACKGROUND OF THE USE OF NEW THERAPEUTIC AND PREVENTIVE DENTAL PASTE | journal = Actual problems in dentistry | year = 2026 | volume = 22 | issue = 2 | pages = 39-43 | doi = 10.18481/2077-7566-2026-22-2-39-43 }}

Copy

Export: BibTeX EndNote RefMan RusMARC

ASSESSMENT OF CLINICAL-LABORATORY CHANGES IN ORAL HEALTH INDICATORS IN PATIENTS WITH HAEMOPHILIA AGAINST THE BACKGROUND OF THE USE OF NEW THERAPEUTIC AND PREVENTIVE DENTAL PASTE

Confirmation