CLINICAL AND IMMUNOLOGIC ASPECTS IN THE SURGICAL TREATMENT OF PATIENTS WITH ORAL MUCOSAL HYPERKERATOSIS

Svetlana Tarasenko; Oksana Svitich; Viktoria Morozova; Mihail Stepanov; Svetlana Repina; Elizaveta Bystritskaya; Polina Kozlova; Ekaterina Meremianina

doi:10.18481/2077-7566-2024-20-3-117-123

VAK Russia 3.1.7 UDC 616.31

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CLINICAL AND IMMUNOLOGIC ASPECTS IN THE SURGICAL TREATMENT OF PATIENTS WITH ORAL MUCOSAL HYPERKERATOSIS

Published in Actual problems in dentistry · Volume 20, Issue 3 · Pages 117–123 · Rubric: SURGICAL DENTISTRY AND IMPLANTOLOGY

DOI: https://doi.org/10.18481/2077-7566-2024-20-3-117-123

Received: 27.10.2024 Accepted: 31.10.2024 Published: 31.10.2024 Language of publication: RUS

Authors

Svetlana Tarasenko

Oksana Svitich

Viktoria Morozova

Mihail Stepanov

et al.

Svetlana Repina

Elizaveta Bystritskaya

Polina Kozlova

Ekaterina Meremianina

Svetlana Tarasenko

Academic degree: doctor of medical sciences

Science rang: professor

First Moscow State Medical University named after I.M. Sechenov Head of Department · Department of Oral Surgery of Borovskiy Institute of Dentistry · Russian Federation · Moscow

Oksana Svitich

Academic degree: doctor of medical sciences

Science rang: corresponding member author.academy_titles.32

First Moscow State Medical University named after I.M. Sechenov Professor of the Department · Department of Microbiology, Virology and Immunology named after Academician A.A. Vorobyov · Russian Federation · Moscow

Viktoria Morozova

First Moscow State Medical University named after. I. M. Sechenova Assistant of the department · Department of Surgical Dentistry · Russian Federation · Moscow

Mihail Stepanov

Academic degree: candidate of medical sciences

First Moscow State Medical University named after I.M. Sechenov Associate Professor of the Department · Department of Surgical Dentistry · Russian Federation · Moscow

Svetlana Repina

Academic degree: candidate of medical sciences

First Moscow State Medical University named after I.M. Sechenov Associate Professor of the Department · Department of Surgical Dentistry · Russian Federation · Moscow

Elizaveta Bystritskaya

Research Institute of Vaccines and Serums named after I. I. Mechnikov Junior Researcher · Laboratory of Molecular Immunology · Russian Federation · Moscow

Polina Kozlova

First Moscow State Medical University named after I.M. Sechenov Russian Federation · Moscow

Ekaterina Meremianina

Academic degree: candidate of medical sciences

Research Institute of Vaccines and Serums named after I. I. Mechnikov Research Fellow · Laboratory of Molecular Immunology · Russian Federation · Moscow

ABSTRACT

Relevance. The relevance of the treatment of oral mucosa diseases is determined by their prevalence, propensity to progression and difficulties in early diagnosis. The article presents the results of surgical treatment of this category of patients using laser radiation with a wavelength of 1940 nm and determination of gene expression of immunologic factors. Purpose. To increase the efficiency of surgical treatment of oral mucosa hyperkeratosis by using the fiber laser LSP – «IRE-Polus». Materials and methods. Surgical treatment was performed on 30 patients (100%) with clinical diagnosis K13.2 Leukoplakia and other disturbances of oral epithelium, including tongue (25 patients) and L43.0 Lichen ruber planus hypertrophicus (5 patients). All patients were randomly divided into 2 groups: in the 1st group lesions were excised by fiber laser LSP – «IRE-Polus», in the 2nd group excision was performed by scalpel. Sampling for gene expression study of defensin beta 1 and IL-28B genes was performed after surgical intervention in all patients. Statistical analysis was carried out using the Mann–Whitney test. Results. The use of laser alteration leads to a decrease in pain intensity, collateral edema, and the timing of postoperative wound epithelialization. In the expression study of immunologic factors, there was no statistically significant difference in the expression of defensin beta 1 gene in both study groups, while an association was found between a high level of IL-28B gene expression and the development of inflammation when using the traditional method. Conclusion. The use of fiber lasers contributes to the improvement of treatment efficiency in patients with hyperkeratosis of the oral mucosa. When examining patients with hyperkeratosis, a significant 2.2-fold increase in IL-28B gene expression was found in the group of patients where the traditional method of treatment was applied (p < 0.05).

KEYWORDS

fiber lasers, hyperkeratosis, leukoplakia, red squamous lichen, oral mucosa, interleukin-28, defensin beta 1

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GOST

Tarasenko S. V., Svitich O. A., Morozova V. V., Stepanov M. A., Repina S. I., Bystritskaya E. P., Kozlova P. E., Meremianina E. A. CLINICAL AND IMMUNOLOGIC ASPECTS IN THE SURGICAL TREATMENT OF PATIENTS WITH ORAL MUCOSAL HYPERKERATOSIS // Actual problems in dentistry. 2024. no. 3. pp. 117-123. DOI: https://doi.org/10.18481/2077-7566-2024-20-3-117-123. (Date of access 23.10.2026).

MLA

Svetlana Tarasenko, Svitich O. A., Morozova V. V., Stepanov M. A., Repina S. I., Bystritskaya E. P., Kozlova P. E., Meremianina E. A.. "CLINICAL AND IMMUNOLOGIC ASPECTS IN THE SURGICAL TREATMENT OF PATIENTS WITH ORAL MUCOSAL HYPERKERATOSIS." Actual problems in dentistry 20.3 (2024): 117-123. DOI: https://doi.org/10.18481/2077-7566-2024-20-3-117-123.

APA

Tarasenko S. V., Svitich O. A., Morozova V. V., Stepanov M. A., Repina S. I., Bystritskaya E. P., Kozlova P. E., Meremianina E. A. (2024). CLINICAL AND IMMUNOLOGIC ASPECTS IN THE SURGICAL TREATMENT OF PATIENTS WITH ORAL MUCOSAL HYPERKERATOSIS. Actual problems in dentistry, 20(3), 117-123. https://doi.org/10.18481/2077-7566-2024-20-3-117-123

Chicago

Svetlana Tarasenko, Svitich O. A., Morozova V. V., Stepanov M. A., Repina S. I., Bystritskaya E. P., Kozlova P. E., Meremianina E. A.. "CLINICAL AND IMMUNOLOGIC ASPECTS IN THE SURGICAL TREATMENT OF PATIENTS WITH ORAL MUCOSAL HYPERKERATOSIS." Actual problems in dentistry 20, no. 3 (2024): 117-123. https://doi.org/10.18481/2077-7566-2024-20-3-117-123.

WIKI

{{cite journal | author = Tarasenko S. V., Svitich O. A., Morozova V. V., Stepanov M. A., Repina S. I., Bystritskaya E. P., Kozlova P. E., Meremianina E. A. | title = CLINICAL AND IMMUNOLOGIC ASPECTS IN THE SURGICAL TREATMENT OF PATIENTS WITH ORAL MUCOSAL HYPERKERATOSIS | journal = Actual problems in dentistry | year = 2024 | volume = 20 | issue = 3 | pages = 117-123 | doi = 10.18481/2077-7566-2024-20-3-117-123 }}

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