employee
Krasnodar, Krasnodar, Russian Federation
employee
Tuapse, Krasnodar, Russian Federation
UDC 616.31
Inflammatory diseases of the oral cavity, such as periodontitis and peri-implantitis, remain one of the leading causes of tooth loss and decreased quality of life for patients. Standard treatment methods focus on eliminating infection and inflammation; however, they do not always provide adequate restoration of the affected tissues. In this context, bioregenerative materials with anti-inflammatory and regenerative properties are gaining increasing attention as a promising tool in comprehensive therapy. This review is relevant in light of the growing number of studies devoted to the effectiveness of various biomaterials and the need for their systematic analysis. Objective. The aim of this study is to systematize existing data on bioregenerative materials, determine their regenerative potential, and analyze their advantages in the treatment of periodontitis and peri-implantitis. Methodology. The review was conducted in accordance with PRISMA guidelines. Literature searches were carried out in the PubMed, Cochrane Library, and Elibrary databases. The analysis included randomized controlled trials and meta-analyses that met the inclusion criteria. The Cochrane Risk of Bias tool was used to assess the quality of the studies. Results. Of the 404 publications identified, 24 studies were included in the final analysis. The main bioregenerative materials included were platelet-rich fibrin (PRF), hydrogels, bioactive glasses, and stem cells. PRF demonstrated high effectiveness in soft tissue healing and bone defect regeneration, while hydrogels were effective in reducing inflammatory processes. Clinical efficacy assessment showed significant improvements in probing depth and clinical attachment level. Conclusion. Bioregenerative materials have high potential in the comprehensive treatment of inflammatory oral diseases, providing anti-inflammatory and regenerative effects. However, further studies with larger sample sizes and long-term follow-up are necessary for their widespread implementation.
bioregenerative materials, platelet-rich fibrin (PRF), hydrogels, bioactive glass, stem cells, inflammatory oral diseases, periodontitis, peri-implantitis, tissue regeneration, systematic review
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