from 01.01.2023 to 01.01.2024
Vladivostok, Vladivostok, Russian Federation
Vladivostok, Vladivostok, Russian Federation
Vladivostok, Vladivostok, Russian Federation
Vladivostok, Vladivostok, Russian Federation
Vladivostok, Vladivostok, Russian Federation
UDK 616.31 Стоматология. Заболевания ротовой полости и зубов
GRNTI 76.29 Клиническая медицина
The subject of this article is a comprehensive analysis and evaluation of the various biochemical factors that influence the success of dental implant placement and function. The study aims are to identify and understand the following aspects: osseointegration processes, growth factors and cytokines, biocompatibility of materials and implants, ionic composition of the oral cavity, inflammatory processes, biochemical markers of recovery prediction. The aim is to study and characterize the biochemical factors influencing the durability of the implant construction and the integrative ability of implants. Research objectives: 1) to determine which biochemical factors are most important for successful dental implantation and can be used as predictors of osseointegration success. 2) explain the importance for a comprehensive approach and to show the importance of integrating data on the biochemical status of the patient into the overall picture of preoperative examination and subsequent monitoring to improve the long-term results of implant treatment. Methodology. A review of the literature on the subject for the last 10 years has been carried out, which allows to reveal correlations between biochemical processes and the success of dental implant surgeries. The mechanism of the impact of the biochemical composition of the oral cavity on the implant is considered. Results. Literature data indicate that biochemical processes play a crucial role in the process of osseointegration and maintenance of stable connection of the implant with the bone tissue. Optimization of these processes can significantly improve the success of dental implants. Conclusions. It was found that taking into account the biochemical factors influencing osseointegration, immune response and tissue reaction to implant materials helps to better understand the mechanisms related to implant biocompatibility with oral tissues for further successful implantation.
dental implants, osseointegration, biochemical factors, growth factors, cytokines, biocompatibility, osteoblasts and osteoclasts
1. Baranov S.R., Lyzo T.S., Korchagina A.A., Krylova A.S. razrabotka funkcional'noy modeli, opisyvayuschey vliyanie signal'nyh belkov na process osteointegracii. Prirodnye sistemy i resursy. 2020;3. [S.R. Baranov, T.S. Lyzo, A.A. Korchagina, A.S. Krylova. Development of functional model describing the implication of signal belks on the osteointegration process. Natural Systems and Resources. 2020;3. (In Russ.)]. https://cyberleninka.ru/article/n/razrabotka-funktsionalnoy-modeli-opisyvayuschey-vliyanie-signalnyh-belkov-na-protsess-osteointegratsii
2. Gudar'yan A.A., Shirinkin S.V. Sovremennye podhody v kompleksnom lechenii vospalitel'no- destruktivnyh oslozhneniy dental'noy implantacii. Sciences of Europe. 2019;36-2:36. [A.A. Gudaryan, S.V. Shirinkin. Modern approaches in the complex treatment of inflammatory and destructive complications of dental implantation. Sciences of Europe. 2019;36-2:36. (In Russ.)]. https://cyberleninka.ru/article/n/sovremennye-podhody-v-kompleksnom-lechenii-vospalitelno-destruktivnyh-oslozhneniy-dentalnoy-implantatsii
3. Gus'kov A.V., Abdurahmanova M.A., Nikiforov A.A., Oleynikov A.A., Kokunova A.S. Diagnosticheskaya znachimost' provospalitel'nyh citokinov pri planirovanii dental'noy implantacii u pacientov s obschesomaticheskimi patologiyami. Ros. med. -biol. vestn. im. akad. I.P. Pavlova. 2023;3. [A.V. Guskov, M.A. Abdurakhmanova, A.A. Nikiforov, A.A. Oleinikov, A.S. Kokunova. Diagnostical significance of provisional cytokines in planning dental implantation in patients with general pathologies. Ros. med. -biol. vestn. named after Acad. I.P. Pavlov. 2023;3. (In Russ.)]. https://cyberleninka.ru/article/n/diagnosticheskaya-znachimost-provospalitelnyh-tsitokinov-pri-planirovanii-dentalnoy-implantatsii-u-patsientov-sR
4. Don E.S., Tarasov A.V., Epshteyn O.I., Tarasov S.A. Biomarkery v medicine: poisk, vybor, izuchenie i validaciya. Klinicheskaya laboratornaya diagnostika. 2017;1. [E.S. Don, A.V. Tarasov, O.I. Epstein, S.A. Tarasov. Biomarkers in medicine: search, selection, study and validation. Clinical Laboratory Diagnostics. 2017;1. (In Russ.)]. https://cyberleninka.ru/article/n/biomarkery-v-meditsine-poisk-vybor-izuchenie-i-validatsiya.
5. Zhidovinov A.V., Glodenko D.A. Dental'naya implantaciya kak optimal'nyy sposob fiksacii s'emnyh protezov. Prikaspiyskiy vestnik mediciny i farmacii. 2021;2. [A.V. Zhidovinov, D.A. Glodenko. Dental implantation as optimal spouse of fixation of adjustable protests. Caspian Bulletin of Medicine and Pharmacy. 2021;2. (In Russ.)]. https://cyberleninka.ru/article/n/dentalnaya-implantatsiya-kak-optimalnyy-sposob-fiksatsii-semnyh-protezov
6. Zholudev S.E., Nersesyan P.M. Sovremennye znaniya i klinicheskie perspektivy ispol'zovaniya dlya pozicionirovaniya dental'nyh implantatov hirurgicheskih shablonov. Obzor literatury. Problemy stomatologii. 2017;4. [S.E. Zholudev, P.M. Nersesyan. Modern knowledge and clinical perspectives of using surgical templates for positioning of dental implants. Literature review. Actual Problems in Dentistry. 2017;4. (In Russ.)]. https://cyberleninka.ru/article/n/sovremennye-znaniya-i-klinicheskie-perspektivy-ispolzovaniya-dlya-pozitsionirovaniya-dentalnyh-implantatov-hirurgicheskih-shablonov
7. Zagorskiy V.A. Dental'naya implantaciya. Materialy i komponenty. Simvol nauki. 2016;9-2. [V.A. Zagorskii. Dental Implantation. Materials and components. Symbol of science. 2016;9-2. (In Russ.)]. https://cyberleninka.ru/article/n/dentalnaya-implantatsiya-materialy-i-komponenty
8. Ivanov P.V., Makarova N.I., Bulkina N. V., Zyul'kina L.A. Sovremennye predstavleniya ob osteointegracii dental'nyh implantatov (obzor literatury). Izvestiya vuzov. Povolzhskiy region. Medicinskie nauki. 2018;4:48. [P.V. Ivanov, N.I. Makarova, N.V. Bulkina, L.A. Zyulkina. Modern ideas about osteointegration of dental implants (literature review). News of universities. Volga region. Medical sciences. 2018;4:48. (In Russ.)]. https://cyberleninka.ru/article/n/sovremennye-predstavleniya-ob-osteointegratsii-dentalnyh-implantatov-obzor-literatury
9. Kiselevskiy M.V., Anisimova N.Yu., Martynenko N.S., Sitdikova S.M., Dobatkin S.V., Karaulov A.V., Estrin Yu.Z. Osteoimmunologiya i biosovmestmost' kostnyh implantatov. Immunologiya. 2018;5-6. [M.V. Kiselevsky, N.Yu. Anisimova, N.S. Martynenko, S.M. Sitdikova, S.V. Dobatkin, A.V. Karaulov, Yu.Z. Estrin. Osteoimmunology and biocompatibility of bone implants. Immunology. 2018;5-6. (In Russ.)]. https://cyberleninka.ru/article/n/osteoimmunologiya-i-biosovmestmost-kostnyh-implantatov
10. Kushnareva A.A., Sargsyan A.R. Implantaciya zubov kak al'ternativa mostovidnym i s'emnym protezam. Zdorov'e i obrazovanie v XXI veke. 2014;4. [A.A. Kushnareva, A.R. Sargsyan. Implantation of teeth as an alternative to bridges and removable prostheses. Health and Education in the XXI century. 2014;4. (In Russ.)]. https://cyberleninka.ru/article/n/implantatsiya-zubov-kak-alternativa-mostovidnym-i-semnym-protezam
11. Larichkin A.Yu., Fedorova N.V., Toder M.S., Shevela A.A. Razlichnye podhody k ocenke rabotosposobnosti implantatov v stomatologii: materialy, modelirovanie, sovremennye tendencii. Rossiyskiy zhurnal biomehaniki. 2019;1. [A.Yu. Larichkin, N.V. Fedorova, M.S. Toder, A.A. Shevela. Various approaches to assessing the performance of implants in dentistry: materials, modeling, current trends. Russian Journal of Biomechanics. 2019;1. (In Russ.)]. https://cyberleninka.ru/article/n/razlichnye-podhody-k-otsenke-rabotosposobnosti-implantatov-v-stomatologii-materialy-modelirovanie-sovremennye-tendentsii
12. Mahmudov T.G. Uroven' markerov osteoblastov i osteoklastov u pacientov s dental'nymi implantatami. Klinicheskaya stomatologiya. 2020;2(94):73-77. [T.G. Makhmudov. Level of markers of osteoblasts and osteoclasts in patients with dental implants. Clinical Dentistry. 2020;2(94):73-77. (In Russ.)]. DOI:https://doi.org/10.37988/1811-153X_2020_2_73.
13. Melkonyan K.I., Biryukova A.O., Ulitina N.N., Rusinova T.V., Yuckevich Ya.A., Litvinova M.G., Bykov I.M., Kartashevskaya M.I. Komponenty vnekletochnogo matriksa v vosstanovlenii povrezhdennyh tkaney: biohimicheskie vzaimodeystviya i protektivnyy effekt. Krymskiy zhurnal eksperimental'noy i klinicheskoy mediciny. 2019;4. [K.I. Melkonyan, A.O. Biryukova, N.N. Ulitina, T.V. Rusinova, Ya.A. Yutskevich, M.G. Litvinova, I.M. Bykov, M.I. Kartashevskaya. Components of the extracellular matrix in the repair of damaged tissues: biochemical interactions and protective effect. Crimean Journal of Experimental and Clinical Medicine. 2019;4. (In Russ.)]. https://cyberleninka.ru/article/n/komponenty-vnekletochnogo-matriksa-v-vosstanovlenii-povrezhdennyh-tkaney-biohimicheskie-vzaimodeystviya-i-protektivnyy-effekt
14. Naumovich S.A., Golovko A.I. Analiz faktorov, vliyayuschih na process osteointegracii dental'nyh implantatov pri planirovanii ortopedicheskogo lecheniya. Sovremennaya stomatologiya. 2019;3:76. [S.A. Naumovich, A.I. Golovko. Analysis of factors implicing on the process of osteointegration of dental implants in planning orthopedic treatment. Modern Dentistry. 2019;3:76. (In Russ.)]. https://cyberleninka.ru/article/n/analiz-faktorov-vliyayuschih-na-protsess-osteointegratsii-dentalnyh-implantatov-pri-planirovanii-ortopedicheskogo-lecheniya
15. Ostapovich A.A., Ivashenko S.V., Guzov S.A., Bezzubik S.D., Klimenko V.V., Gamzeleva T.V. Morfologicheskaya harakteristika osteointegracii dental'nyh implantatov. Sovremennaya stomatologiya. 2020;4:81. [A.A. Ostapovich, S.V. Ivashenko, S.A. Guzov, S.D. Bezzubik, V.V. Klimenko, T.V. Gamzeleva. Morphological characteristics of osteointegration of dental implants. Modern Dentistry. 2020;4:81. (In Russ.)]. https://cyberleninka.ru/article/n/morfologicheskaya-harakteristika-osteointegratsii-dentalnyh-implantatov
16. Panahov N.A. Oglu, Mahmudov T.G. Oglu. Urovni cirkuliruyuschih citokinov v rannie sroki posleimplantacionnogo perioda. Kazanskiy med.zh. 2017;6. [N.A. Panahov Oglu, T.G. Mahmudov Oglu. Levels of circulating cytokines in the early postimplantation period. Kazan Med.Zh. 2017;6. (In Russ.)]. https://cyberleninka.ru/article/n/urovni-tsirkuliruyuschih-tsitokinov-v-rannie-sroki-posleimplantatsionnogo-perioda
17. Rodriges H., Barallat L., Soriano S. i dr. Ocenka kriticheskoy podderzhki periapikal'noy kosti pri protezirovanii nizhney chelyusti s ispol'zovaniem dvuh implantatov. Pyatiletnee retrospektivnoe issledovanie. Postanovlenie o protezirovanii. 2018;62(3):331-336. [J. Rodriguez, L. Barallat, S. Soriano et al. Evaluation of critical periapical bone support in mandibular prosthetics using two implants. A five-year retrospective study. J Prosthodontics Resid. 2018;62(3):331-336. (In Russ.)]. doi:https://doi.org/10.1016/j.jpor.2018.02.010
18. Semenov E.I., Lepskiy V.V., Verbickaya T.G., Shnayder S.A. Vliyanie geneticheskogo faktora na dolgosrochnost' funkcionirovaniya dental'nyh implantatov. Vestnik stomatologii. 2017;2:99. [E.I. Semenov, V.V. Lepsky, T.G. Verbitskaya, S.A. Schneider. Influence of the genetic factor on the long-term functioning of dental implants. Vestnik Stomatologii. 2017;2:99. (In Russ.)]. https://cyberleninka.ru/article/n/vliyanie-geneticheskogo-faktora-na-dolgosrochnost-funktsionirovaniya-dentalnyh-implantatov
19. Simbircev A.S., Totolyan A.A. Citokiny v laboratornoy diagnostike // Infekcionnye bolezni: Novosti. Mneniya. Obuchenie. 2015;2:11. [A.S. Simbirtsev, A.A. Totolyan. Cytokines in laboratory diagnostics. Infectious Diseases: News. Opinions. Training. 2015;2:11. (In Russ.)]. https://cyberleninka.ru/article/n/tsitokiny-v-laboratornoy-diagnostike
20. Smirnov A.V., Rumyancev A.Sh. Stroenie i funkcii kostnoy tkani v norme i pri patologii. Soobschenie i. Nefrologiya. 2014;6. [A.V. Smirnov, A.Sh. Rumyantsev. Structure and functions of bone tissue in norm and pathology. Message i. Nephrology. 2014;6. (In Russ.)]. https://cyberleninka.ru/article/n/stroenie-i-funktsii-kostnoy-tkani-v-norme-i-pri-patologii-soobschenie-i
21. Tal'dzhi G., Kuper L. F. Molekulyarnaya ocenka osteointegracii in vitro: obzor sovremennoy literatury. Chelyustno-licevye implantaty. 2014;29(2):e171-e199. [G. Talji, L.F. Cooper. Molecular assessment of in vitro osseointegration: a review of the current literature. Int J Maxillofacial Implants. 2014;29(2):e171-e199. (In Russ.)]. doi:https://doi.org/10.11607/jomi.te55. PMID: 24683582.
22. Tamarova E.R., Shvec K.Yu., Mavzyutov A.R., Baymiev Al.H., Bulgakova A.I. Sozdanie molekulyarno-geneticheskoy test-sistemy dlya ranney diagnostiki i ocenki effektivnosti lecheniya vospalitel'nyh zabolevaniy parodonta. Klinicheskaya laboratornaya diagnostika. 2020;1. [E.R. Tamarova, K.Yu. Shvets, A.R. Mavzyutov, Al.H. Baimiev, A.I. Bulgakova. Creation of Molecular Genetic Test System for early diagnosis and evaluation of the effectiveness of treatment of inflammatory diseases of the mouth. Clinical Laboratory Diagnostics. 2020;1. (In Russ.)]. https://cyberleninka.ru/article/n/sozdanie-molekulyarno-geneticheskoy-test-sistemy-dlya-ranney-diagnostiki-i-otsenki-effektivnosti-lecheniya-vospalitelnyh
23. Tuneva N.A., Bogacheva N.V., Tuneva Yu.O. Problemy dental'noy implantacii. Vyatskiy medicinskiy vestnik. 2019;2:62. [N.A. Tuneva, N.V. Bogacheva, Yu.O. Tuneva. Problems of dental implantation. Vyatka Medical Bulletin. 2019;2:62. (In Russ.)]. https://cyberleninka.ru/article/n/problemy-dentalnoy-implantatsii
24. Shirinskiy V.S., Shirinskiy I.V. Osteoimmunologiya: mezhdisciplinarnyy podhod k izucheniyu vzaimodeystviya kletok immunnoy sistemy i kostnoy tkani. Medicinskaya immunologiya. 2022;5. [V.S. Shirinsky, I.V. Shirinsky. Osteoimmunology: megadisciplinary approach to the study of immune system and bone Tissue Cell Interaction. Medical Immunology. 2022;5. (In Russ.)]. https://cyberleninka.ru/article/n/osteoimmunologiya-mezhdistsiplinarnyy-podhod-k-izucheniyu-vzaimodeystviya-kletok-immunnoy-sistemy-i-kostnoy-tkani
