Stoma (dental surgeon)
Novokuznetsk, Kemerovo, Russian Federation
Regional Society of Maxillofacial Surgeons (teacher)
Novokuznetsk, Kemerovo, Russian Federation
GRNTI 76.29 Клиническая медицина
OKSO 31.05.03 Стоматология
The subject of the study is the formation of a biofilm in the area of ceramic and titanium implants. Objectives. A systematic analysis of modern domestic and foreign literature sources to determine the main features and differences in the formation of a biofilm in the field of ceramic and titanium implants. Methodology. The study was based on the search and study of original articles on dental implantation in databases: Russian State Library, eLibrary, PubMed, The Cochrane Library, Google Scholar. The main selection of materials was carried out by keywords. Results. Rehabilitation of edentulous spaces in patients with osseointegrated dental implants is a scientifically recognized and well-documented treatment method. Bacterial adhesion on dental implants can cause inflammatory conditions such as mucositis and peri-implantitis. Peri-implantitis can lead to bone resorption and eventual loss of the implant. It has been established that zirconium oxide has a lower bacterial capacity for adhesion and inflammatory infiltration compared to titanium, and due to its hygienic properties, it has significant advantages in maintaining the level of soft tissues of the aesthetic zone and maintaining the level of the alveolar bone. Numerous studies show that the clinical use of zirconium oxide implants is practically not accompanied by manifestations of peri-implantitis, and gum epithelial tissues are able to firmly and reliably attach to their surface. Zirconia is bioinert to other materials found in the oral cavity and is particularly suitable for patients who are allergic or intolerant to metals. The latest techniques and materials, which include zirconium dioxide, have important advantages, and its use as a material for dental implants significantly increases the clinical effectiveness of treatment. Conclusions. A review of the literature on the formation of a biofilm in the area of dental implants showed that zirconium oxide has a lower bacterial ability for adhesion and inflammatory infiltration compared to titanium, and due to hygienic properties has significant advantages in maintaining the level of soft tissues of the aesthetic zone and maintaining the level of the alveolar bone.
biofilm, microbial adhesion, dental implantation, zirconium dioxide, titanium, ceramic implants
1. Babushkina I.V., Mamonova I.A., Ul'yanov V.Yu., Shpinyak S.P. Antibiotikorezistentnost' gramotricatel'nyh vozbuditeley implantat-associirovannoy infekcii v sostave predformirovannoy bioplenki. Problemy medicinskoy mikologii. 2021;23(2):52. [I.V. Babushkina, I.A. Mamonova, V.Yu. Ulyanov, S.P. Spinyak Antibiotic resistance of gram-negative pathogens of implant-associated infection in preformed biofilm. Problems of medical mycology. 2021;23(2):52. (In Russ.)]. https://www.elibrary.ru/item.asp?id=46212865
2. Kirgueva D.V., Makoeva A.E. Gal'vanizm v polosti rta kak problema parodontologii. Fundamental science and technology. Sbornik nauchnyh statey po materialam IX Mezhdunarodnoy nauchno-prakticheskoy konferencii. Ufa. 2022:100-104. [D.V. Kirgueva, A.E. Makoeva Galvanism in the oral cavity as a problem of periodontology. Fundamental science and technology. Collection of scientific articles based on the materials of the IX International Scientific and Practical Conference. Ufa. 2022:100-104. (In Russ.)]. https://elibrary.ru/item.asp?id=49244490
3. Litvinova A.K. Sovremennye aspekty primeneniya dioksida cirkoniya v ortopedicheskoy stomatologii. Molodezhnyy innovacionnyy vestnik. 2021;10(1):400-402. [A.K. Litvinova Modern aspects of the use of zirconium dioxide in orthopedic dentistry. Youth innovation bulletin. 2021;10(1):400-402. (In Russ.)]. https://elibrary.ru/item.asp?id=47248531
4. Tebenova G.M., Askarova Sh.N., Safarov T.S. Puti resheniya diagnostiki neperenosimosti k metallicheskim vklyucheniyam v polosti rta. Vestnik Kazahskogo Nacional'nogo medicinskogo universiteta. 2018;1:541-544. [G.M. Tebenova, Sh.N. Askarova, T.S. Safarov. Ways to solve the diagnosis of intolerance to metal inclusions in the oral cavity. Bulletin of the Kazakh National Medical University. 2018;1:541-544. (In Russ.)]. https://elibrary.ru/item.asp?id=34989947
5. Titov P.L., Moyseychik P.N. Immunnyy status pacientov s zhalobami na neblagopriyatnoe deystvie dental'nyh splavov. Novye metody profilaktiki, diagnostiki i lecheniya v stomatologii. Minsk. 2017:433-439. [P.L. Titov, P.N. Moiseichik. The immune status of patients with complaints about the adverse effects of dental alloys. Sat. New methods of prevention, diagnosis and treatment in dentistry. Minsk. 2017:433-439. (In Russ.)]. https://elibrary.ru/item.asp?id=32416307
6. Cholokova G.S., Yuldashev I.M., Tynalieva D.M., Abykeeva R.S. Profilaktika stomatologicheskih zabolevaniy - prioritetnoe napravlenie stomatologii. Sovremennye tendencii razvitiya nauki i tehnologiy. 2017;2-4:94-104. [G.S. Cholokova, I.M. Yuldashev, D.M. Tynalieva, R.S. Abykeeva. Prevention of dental diseases is a priority in dentistry. The current state of development of science and technology. 2017;2-4:94-104. (In Russ.)]. https://elibrary.ru/item.asp?id=28784153
7. Habibullina A.R., Timofeeva A.V. Mikrobiom dental'noy blyashki cheloveka. Sovremennye problemy nauki i obrazovaniya. 2017;3:155. [A.R. Khabibullina, A.V. Timofeeva. Microbiome of human dental plaque. Modern problems of science and education. 2017;3:155. (In Russ.)]. https://www.elibrary.ru/item.asp?id=29452422
8. Shumakov F.G. Eksperimental'no-klinicheskoe sravnenie keramicheskih i titanovyh dental'nyh implantatov : avtoref. dis. … kand. med. nauk. Moskva, 2018:24. [F.G. Shumakov. Experimental and clinical comparison of ceramic and titanium dental implants : abstract dis. … cand. med. sciences. Moscow, 2018:24. (In Russ.)]. https://www.dissercat.com/content/eksperimentalno-klinicheskoe-sravnenie-keramicheskikh-i-titanovykh-dentalnykh-implantatov
9. Yakovlev M.V., Shulyatnikova O.A., Godovalov A.P., Rogozhnikov G.I., Batog K.A. Analiz vyrazhennosti mikrobnoy adgezii na poverhnosti titanovogo splava dlya dental'nyh implantov. Rossiyskiy vestnik dental'noy implantologii. 2020;3-4(49-50):39-42. [M.V. Yakovlev, O.A. Shulyatnikova, A.P. Godovalov, G.I. Rogozhnikov, K.A. Batog Analysis of the severity of microbial adhesion on the surface of titanium alloy for dental implants. Russian Bulletin of Dental Implantology. 2020;3-4(49-50):39-42. (In Russ.)]. https://www.elibrary.ru/item.asp?id=46305980
10. Acosta S., Ibañez-Fonseca A., Aparicio C., Rodríguez-Cabello J.C. Antibiofilm coatings based on protein-engineered polymers and antimicrobial peptides for preventing implant-associated infections // Biomater Sci. - 2020;8(10):2866-2877. doi:https://doi.org/10.1039/d0bm00155d.
11. Balmer M., Spies B.C., Kohal R.J., Hämmerle C.H., Vach K., Jung R.E. Zirconia implants restored with single crowns or fixed dental prostheses: 5-year results of a prospective cohort investigation // Clin Oral Implants Res. - 2020;31(5):452-462. doi:https://doi.org/10.1111/clr.13581.
12. Berglundh T., Armitage G., Araujo M.G., Avila-Ortiz G., Blanco J., Camargo P.M., Chen S., Cochran D., Derks J., Figuero E., Hämmerle C.H.F., Heitz-Mayfield LJA, Huynh-Ba G, Iacono V., Koo K.T., Lambert F., McCauley L., Quirynen M., Renvert S., Salvi G.E., Schwarz F., Tarnow D., Tomasi C., Wang H.L., Zitzmann N. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions // J Periodontol. - 2018;89(1):S313-S318. doi:https://doi.org/10.1002/JPER.17-0739.
13. Bormann K.H., Gellrich N.C., Kniha H., Schild S., Weingart D., Gahlert M. A prospective clinical study to evaluate the performance of zirconium dioxide dental implants in single-tooth edentulous area: 3-year follow-up // BMC Oral Health. - 2018;18(1):181. doi:https://doi.org/10.1186/s12903-018-0636-x.
14. Buser D., Sennerby L., De Bruyn H. Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions // Periodontol 2000. -2017;73(1):7-21. doi:https://doi.org/10.1111/prd.12185.
15. Carreño Carreño J., Aguilar-Salvatierra A., Gómez-Moreno G., García Carreño E.M., Menéndez López-Mateos M.L., Perrotti V., Piattelli A., Calvo-Guirado J.L., Menéndez-Núñez M. Update of Surgical Techniques for Maxillary Sinus Augmentation: A Systematic Literature Review // Implant Dent. - 2016;25(6):839-844. doi:https://doi.org/10.1097/ID.0000000000000467.
16. Chappuis V., Cavusoglu Y., Gruber R., Kuchler U., Buser D., Bosshardt D.D. Osseointegration of Zirconia in the Presence of Multinucleated Giant Cells // Clin Implant Dent Relat Res. - 2016;18(4):686-698. doi:https://doi.org/10.1111/cid.12375.
17. Chen J.H., Lin Y.C., Kung J.C., Yan D.Y., Chen I.H., Jheng Y.S., Lai C.H., Wu Y.M., Lee K.T. Efficacy of Er:YAG laser for the peri-implantitis treatment and microbiological changes: a randomized controlled trial // Lasers Med Sci. - 2022;37(9):3517-3525. doi:https://doi.org/10.1007/s10103-022-03627-8.
18. Cionca N., Hashim D., Mombelli A. Zirconia dental implants: where are we now, and where are we heading? // Periodontol 2000. - 2017;73(1):241-258. doi:https://doi.org/10.1111/prd.12180.
19. Cucchi A., Molè F., Rinaldi L., Marchetti C., Corinaldesi G. The Efficacy of an Anatase-Coated Collar Surface in Inhibiting the Bacterial Colonization of Oral Implants: A Pilot Prospective Study in Humans // Int J Oral Maxillofac Implants. - 2018;33(2):395-404. doi:https://doi.org/10.11607/jomi.5880.
20. Elangovan G., Mello-Neto J.M., Tadakamadla S.K., Reher P., Figueredo C.M.S. A systematic review on neutrophils interactions with titanium and zirconia surfaces: Evidence from in vitro studies // Clin Exp Dent Res. - 2022;8(4):950-958. doi:https://doi.org/10.1002/cre2.582.
21. Farawati F.A., Nakaparksin P. What is the Optimal Material for Implant Prosthesis? // Dent. Clin. N. Am. - 2019;63:515-530. doihttps://doi.org/10.1016/j.cden.2019.02.002
22. Grenade C., De Pauw-Gillet M.C., Pirard C., Bertrand V., Charlier C., Vanheusden A., Mainjot A. Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials with Human Gingival Keratinocytes (HGKs) // Dent Mater. - 2017;33(3):333-343. doi:https://doi.org/10.1016/j.dental.2017.01.001.
23. Grenade C., De Pauw-Gillet M.C., Pirard C., Bertrand V., Charlier C., Vanheusden A., Mainjot A. Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials with Human Gingival Keratinocytes (HGKs) // Dent Mater. - 2017;33(3):333-343. doi:https://doi.org/10.1016/j.dental.2017.01.001.
24. Haro Adánez M., Nishihara H., Att W. A systematic review and meta-analysis on the clinical outcome of zirconia implant-restoration complex // J Prosthodont Res. - 2018;62(4):397-406. doi:https://doi.org/10.1016/j.jpor.2018.04.007.
25. Jank S., Hochgatterer G. Success Rate of Two-Piece Zirconia Implants: A Retrospective Statistical Analysis // Implant Dent. - 2016;25(2):193-198. doi:https://doi.org/10.1097/ID.0000000000000365.
26. Kim G.O., Choi Y.S., Bae C.H., Song S.Y., Kim Y.D. Effect of titanium dioxide nanoparticles (TiO2 NPs) on the expression of mucin genes in human airway epithelial cells // Inhal Toxicol. - 2017;29(1):1-9. doi:https://doi.org/10.1080/08958378.2016.1267282.
27. Kim K.T., Eo M.Y., Nguyen T.T.H., Kim S.M. General review of titanium toxicity // Int J Implant Dent. - 2019;5(1):10. doi:https://doi.org/10.1186/s40729-019-0162-x.
28. Kohal R.J., Spies B.C., Bauer A., Butz F. One-piece zirconia oral implants for single-tooth replacement: Three-year results from a long-term prospective cohort study // J Clin Periodontol. - 2018;45(1):114-124. doi:https://doi.org/10.1111/jcpe.12815.
29. Kohal R.J., Spies B.C., Vach K., Balmer M., Pieralli S. A Prospective Clinical Cohort Investigation on Zirconia Implants: 5-Year Results // J Clin Med. - 2020;9(8):2585. doi:https://doi.org/10.3390/jcm9082585.
30. Kumar Y., Jain V., Chauhan S.S., Bharate V., Koli D., Kumar M. Influence of different forms and materials (zirconia or titanium) of abutments in peri-implant soft-tissue healing using matrix metalloproteinase-8: A randomized pilot study // J Prosthet Dent. - 2017;118(4):475-480. doi:https://doi.org/10.1016/j.prosdent.2016.11.017.
31. Lai H.C. Prevention and management of hardware and biological complications in implant dentistry // Zhonghua Kou Qiang Yi Xue Za Zhi. - 2020;55(11):814-818. Chinese. doi:https://doi.org/10.3760/cma.j.cn112144-20200615-00347.
32. Lockhart J.N., Spoonmore T.J., McCurdy M.W., Rogers B.R., Guelcher S.A., Harth E. Poly(glycidol) Coating on Ultrahigh Molecular Weight Polyethylene for Reduced Biofilm Growth // ACS Appl Mater Interfaces. - 2018;10(4):4050-4056. doi:https://doi.org/10.1021/acsami.7b15981.
33. Luengo F., Solonko M., Sanz-Esporrín J., Sanz-Sánchez I., Herrera D., Sanz M. Clinical, Microbiological, and Biochemical Impact of the Surgical Treatment of Peri-Implantitis-A Prospective Case Series // Clin Med. - 2022;11(16):4699. doi:https://doi.org/10.3390/jcm11164699.
34. Matos A.O., Ricomini-Filho A.P., Beline T., Ogawa E.S., Costa-Oliveira B.E., de Almeida A.B., Nociti Junior F.H., Rangel E.C., da Cruz N.C., Sukotjo C., Mathew M.T., Barão V.A.R. Three-species biofilm model onto plasma-treated titanium implant surface // Colloids Surf B Biointerfaces. - 2017;152:354-366. doi:https://doi.org/10.1016/j.colsurfb.2017.01.035.
35. McKay T.B., Hutcheon A.E.K, Guo X., Zieske J.D., Karamichos D. Modeling the cornea in 3-dimensions: Current and future perspectives // Exp Eye Res. - 2020;197:108127. doi:https://doi.org/10.1016/j.exer.2020.108127.
36. Meng F., Yin Z., Ren X., Geng Z., Su J. Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration. // Pharmaceutics. - 2022;14(5):1069. doi:https://doi.org/10.3390/pharmaceutics14051069.
37. Nishihara H., Haro Adanez M., Att W. Current status of zirconia implants in dentistry: preclinical tests // J Prosthodont Res. - 2019;63(1):1-14. doi:https://doi.org/10.1016/j.jpor.2018.07.006.
38. Osman M.A., Kushnerev E., Alamoush R.A., Seymour K.G., Yates J.M. Two Gingival Cell Lines Response to Different Dental Implant Abutment Materials: An In Vitro Study // Dent J (Basel). - 2022;10(10):192. doi:https://doi.org/10.3390/dj10100192.
39. Ozer F., Anadioti E., Mack Y.Y., Sen D., DiRienzo J., Blatz M.B. Influence of Surface Modifications on Bacterial Adherence to Implant Abutment Materials // Int J Periodontics Restorative Dent. - 2022;42(5):657-663. doi:https://doi.org/10.11607/prd.5961.
40. Petrini M., Giuliani A., Di Campli E., Di Lodovico S., Iezzi G., Piattelli A., D'Ercole S. The Bacterial Anti-Adhesive Activity of Double-Etched Titanium (DAE) as a Dental Implant Surface // Int J Mol Sci. - 2020;21(21):8315. doi:https://doi.org/10.3390/ijms21218315.
41. Pieralli S., Kohal R.J., Jung R.E., Vach K., Spies B.C. Clinical Outcomes of Zirconia Dental Implants // J Dent Res. - 2017;96(1):38-46. doi:https://doi.org/10.1177/0022034516664043.
42. Pieralli S., Kohal R.J., Lopez Hernandez E., Doerken S., Spies B.C. Osseointegration of zirconia dental implants in animal investigations: A systematic review and meta-analysis // Dental Materials. - 2018;34(2):171-182. doi:https://doi.org/10.1016/j.dental.2017.10.008.
43. Polonskiy V.I., Asanova A.A. Assessment of titanium dioxide nanoparticle effects on living organisms // Reserch Gate. - 2018. doi:https://doi.org/10.25750/1995-4301-2018-3-005-011.
44. Roehling S., Astasov-Frauenhoffer M., Hauser-Gerspach I., Braissant O., Woelfler H., Waltimo T. In vitro biofilm formation on titanium and zirconia implant surfaces // J Periodontol. - 2017;88(3):298-307. doi:https://doi.org/10.1902/jop.2016.160245.
45. Roehling S., Schlegel K.A., Woelfler H., Gahlert M. Performance and outcome of zirconia dental implants in clinical studies: A meta-analysis // Clin Oral Implants Res. - 2018;29(16):135-153. doi:https://doi.org/10.1111/clr.13352.
46. Safioti L.M., Kotsakis G.A., Pozhitkov A.E., Chung W.O., Daubert D.M. Increased levels of dissolved titanium are associated with peri-implantitis - a cross-sectional study // J Periodontol. - 2017;88:436-442. doi:https://doi.org/10.1038/sj.bdj.2017.669
47. Scheeren Brum R., Apaza-Bedoya K., Labes L.G., Volpato C.Â.M., Pimenta A.L., Benfatti C.A.M. Early Biofilm Formation on Rough and Smooth Titanium Specimens: a Systematic Review of Clinical Studies // J Oral Maxillofac Res. - 2021;12(4):e1. doi:https://doi.org/10.5037/jomr.2021.12401.
48. Siddiqi A., Milne T., Cullinan M.P., Seymour G.J. Analysis of P. gingivalis, T. forsythia and S. aureus levels in edentulous mouths prior to and 6 months after placement of one-piece zirconia and titanium implants // Clin Oral Implants Res. - 2016;27(3):288-294. doi:https://doi.org/10.1111/clr.12536.
49. Sivaraman K., Chopra A., Narayan A.I., Balakrishnan D. Is zirconia a viable alternative to titanium for oral implant? A critical review // J Prosthodont Res. - 2018;62(2):121-133. doi:https://doi.org/10.1016/j.jpor.2017.07.003.
50. Thoma D.S., Gamper F.B., Sapata V.M., Voce G., Hammerle C.H.F., Sailer I. Spectrophotometric analysis of fluorescent zirconia abutments compared to “conventional” zirconia abutments: A within subject controlled clinical trial // Clin Implant Dent Relat Res. - 2017;19(4):760-766. doi:https://doi.org/10.1111/cid.12488.
51. Yanagisawa N., Ikeda T., Takatsu M., Urata K., Nishio K., Tanaka H., Kawato T, Iinuma T. Human Gingival Fibroblast Attachment to Smooth Titanium Disks with Different Surface Roughnesses // Biomimetics (Basel). - 2022;7(4):164. doi:https://doi.org/10.3390/biomimetics7040164.