Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Kazan, Russian Federation
Bashkir State University (Scientific Laboratory for the Study of Social and Economic Problems, Head of the Scientific Laboratory)
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Kazan', Kazan, Russian Federation
The work presents the results of assessing the spread of pathology of hard tissues of teeth and periodontal in patients with chronic inflammatory bowel diseases (IBD). Objective. Assessment of the intensity and spread of pathology of dental hard tissues and inflammatory periodontal diseases in patients with Crohn's disease (CD) and chronic ulcerative colitis (CUC). Materials and methods. A comprehensive clinical and dental examination of 70 patients with CD and CUC was carried out. The complex of dental examination included the analysis of complaints, anamnesis, assessment of the condition of hard tissues of teeth, periodontal tissues. Assessment of the intensity level of nociceptive pain was carried out using a visual analog scale (VAS). Results and discussion. As a result of the clinical examination, a high prevalence of caries (K02) was revealed in CD and CUC, respectively, in 97.2% and 91.4% of cases, high and very high intensity of the carious process according to the CP index ≥ 10. With CD, the symptom of hyperesthesia, increased erasure of mixed teeth and wedge-shaped defects were most often observed in 100, 77.14 and 60.0% of cases, in 68.57% chronic periodontitis prevails (K05.3), with CD, the symptom of hyperesthesia (K03.80) and increased tooth erasure (K03.0) were 1.2 times less common) (p < 0.05), chronic gingivitis prevails in 62.85% (K05.10). The level of intensity of the pain symptom for patients with CD and CUC corresponds to the VAS scale from moderate to significant (p < 0.001). Results. As a result of a comprehensive dental examination of patients with CD and CUC, a high prevalence and intensity of caries and non-carious dental hard tissue lesions, inflammatory periodontal diseases, the level of dental care in persons with CD and CUC is insufficient. Conclusion. The connection of dental status with clinical manifestations of chronic inflammatory bowel diseases is beyond doubt. The ambiguity of the etiology and pathogenesis of CD and CUC as well as the significant similarity of their clinical manifestations, dictate the need for an integrated approach to the development of methods for diagnosing pathology of hard tissues of teeth and periodontal and assessing their clinical features.
caries, hypoplasia, wedge-shaped defect, erasability, periodontitis, hyperesthesia, nociceptive pain, VAS scale, Crohn's disease, chronic ulcerative colitis
1. Bakulin I.G., Skalinskaya M.I., Skazyvaeva E.V. «Trudnye» voprosy pri vedenii pacientov s vospalitel'nymi zabolevaniyami kishechnika. Mediko-social'naya ekspertiza i reabilitaciya. 2018;21(1-2):94-100. [I.G. Bakulin, M.I. Skalinskaya, E.V. Skazyvaeva. “Difficult” issues of the management of inflammatory bowel diseases patients. Medico-social expertise and rehabilitation. 2018;21(1-2):94-100. (In Russ.)]. http://doi.org/10.18821/1560-9537-2018-21-1-94-100
2. Belousova E.A., Abdulganieva D.I., Alekseeva O.P. Social'no-demograficheskaya harakteristika, osobennosti techeniya i varianty lecheniya vospalitel'nyh zabolevaniy kishechnika v Rossii. Rezul'taty dvuh mnogocentrovyh issledovaniy. Al'manah klinicheskoy mediciny. 2018;46(5):445-463. [E.A. Belousova, D.I. Abdulganieva, O.P. Alexeeva et al. Social and demographic characteristics, features of disease course and treatment options of inflammatory bowel disease in Russia: results of two multicenter studies. Almanac of Clinical Medicine. 2018;46(5):445-463. (In Russ.)]. https://doi.org/10.18786/2072-0505-2018-46-5-445-463
3. Bikbavova G.R., Livzan M.A., Novikov D.G., Bambul'skaya E.A. Precizionnaya medicina i vospalitel'nye zabolevaniya kishechnika: koncepciya, strategii, buduschee. Eksperimental'naya i klinicheskaya gastroenterologiya. 2021;190(6):121-129. [G.R. Bikbavova, M.A. Livzan, D.G. Novikov, E.A. Bambulskaya. Precision medicine and infl ammatory bowel diseases: concept, strategies, future. Experimental and Clinical Gastroenterology. 2021;190(6):121-129. (In Russ.)]. http://dx.doi.org/10.31146/1682-8658-ecg-190-6-121-129
4. Bodryagina E.S., Abdulganieva D.I., Schdincova A.H. Kliniko-epidemiologicheskie pokazateli vospalitel'nyh zabolevaniy kishechnika po Respublike Tatarstan. Lechaschiy vrach. 2013;7:21-26. [E.S. Bodryagina, D.I. Abdulganieva, A.H. Odintsovo. The Clinico-epidemiological indices of intestine inflammatory diseases in the republic of Tatarstan. Attending doctor. 2013;7:21-26. (In Russ.)]. https://elibrary.ru/item.asp?id=22474147
5. Klyaritskaya I.L., Stilidi E.I., Maksimova E.V., Shahbazidi G. Vnekishechnye proyavleniya vospalitel'nyh zabolevaniy kishechnika. Krymskiy Terapevticheskiy Zhurnal. 2017;1(32):47-51. [I.L. Kliaritskaia, E.I. Stilidi, E.V. Maksimova, G. Shakhbazidi. Extraintestinal manifestations of inflammatory bowel disease. Crimean journal of internal diseases. 2017;1(32):47-51. (In Russ.)]. https://elibrary.ru/item.asp?id=28367558
6. Dolgushina A.I., Husainova G.M., Vasilenko A.G., Kononec V.A. Rasprostranennost' vospalitel'nyh zabolevaniy kishechnika v Chelyabinskoy oblasti. Al'manah klinicheskoy mediciny. 2019;47(6):511-517. [A.I. Dolgushina, G.M. Khusainova, A.G. Vasilenko, V.A. Kononets. Prevalence of inflammatory bowel disease in the Chelyabinsk Region. Almanac of Clinical Medicine. 2019;47(6):511-517. (In Russ.)]. https://doi.org/10.18786/2072-0505-2019-47-066
7. Ivashkin V.T., Shelygin Yu.A., Halif I.L., Belousova E.A., Shifrin O.S., Abdulganieva D.I. i dr. Klinicheskie rekomendacii Rossiyskoy gastroentero-logicheskoy associacii i associacii koloproktologov Rossii po diagnostike i lecheniyu bolezni Krona. Koloproktologiya. 2017;2(60):7-29. [V.T. Ivashkin, Yu.A. She-lygin, I.L. Khalif, E.A. Belousova, O.S. Shifrin, D.I. Abdulganieva et al. Clinical recommendations of the Russian Gastroenterological Association and the Association of Coloproctologists of Russia for the diagno-sis and treatment of Crohn’s disease. Coloproctology. 2017;2(60):7-29. (In Russ.)]. https://elibrary.ru/item.asp?id=29145096
8. Kagramanova A.V., Mihaylova S.F. Knyaze O.V. i dr. Vnekishechnye proyavleniya vospalitel'nyh zabolevaniy kishechnika. Terapiya. 2017;4(14):107-118. [A.V. Kagramanova, S.F. Mikhailova, O.V. Knyazev et al. Extraintestinal manifestations of inflammatory bowel diseases. Therapy. 2017;4(14):107-118. (In Russ.)]. https://elibrary.ru/item.asp?id=29771052
9. Klinicheskie rekomendacii po diagnostike i lecheniyu bolezni Krona u vzroslyh (proekt). Koloproktologiya. 2020;19(2):8-38. [Crohn's disease. Clinical recommendations (preliminary version). Coloproctology. 2020;19(2):8-38. (In Russ.)]. https://doi.org/10.33878/2073-7556-2020-19-2-8-38
10. Kolomiec S.V., Udal'cova K.A., Shinkevich V.I. Debyut bolezni Krona v polosti rta. Klinicheskiy sluchay. Stomatologiya. 2017;96(5):28-30. [S.V. Kolomiets, K.A. Udaltsova, V.I. Shinkevich. Crohn's disease debut in the oral cavity. Case report Dentistry. 2017;96(5):28-30. (In Russ.)]. https://doi.org/10.17116/stomat201796528-30
11. Mahov V.M., Balahonov A.A., Isaykina M.A., Doronina Yu.A. Faktor vospaleniya v klinicheskoy kartine i terapii sindroma razdrazhennogo kishechnika. Medicinskiy Sovet. 2018;(14):67-72. [V.M. Makhov, A.A. Balakhonov, M.A. Isaikina, Yu.A. Doronina. Inflammatory factor in the clinical picture and therapy of irritable bowel syndrome. Medical Council. 2018;(14):67-72. (In Russ.)]. https://doi.org/10.21518/2079-701X-2018-14-67-72
12. Mezhdunarodnaya klassifikaciya orofacial'noy boli, 1-e izdanie (ICOP). Adaptirovannaya russkoyazychnaya versiya. Al'manah klinicheskoy mediciny. 2022;50:1-82. [International Classification of Orofacial Pain, 1st edition (ICOP). Adapted Russian-language version. Almanac of Clinical Medicine. 2022;50:1-82. (In Russ.)]. http://dx.doi.org/10.18786/2072-0505-2022-50-005
13. Nazirbekova M.M., Abasova A.S. Struktura zabolevaemosti vospalitel'nymi zabolevaniyami kishechnika v Dagestane za poslednie 5 let. Kardiovaskulyarnaya terapiya i profilaktika. 2021;20(1S):61. [M.M. Nazirbekova, A.S. Abasova. The structure of the incidence of inflammatory bowel diseases in Dagestan over the past 5 years. Cardiovascular therapy and prevention. 2021;20(1S):61. (In Russ.)]. https://doi.org/10.15829/1728-8800-2021-1S
14. Tytyuk S.Yu., Iordanishvili A.K., Romanenko I.G. Osobennosti morfologicheskogo stroeniya i himicheskogo sostava tverdyh tkaney zubov pri bolezni Krona i hronicheskom nespecificheskom yazvennom kolite. Vestnik medicinskogo instituta «REAVIZ»: Reabilitaciya, Vrach I Zdorov'e. 2019;1(37):88-92. [S.Yu. Tytyuk, A.K. Iordanishvili, I.G. Romanenko. Morphological structure and chemical composition of hard dental tissues in patients with crohn's disease and chronic ulcerative colitis. Bulletin of the medical Institute "REAVIZ": Rehabilitation, Doctor And Health. 2019;1(37):88-92. (In Russ.)]. https://elibrary.ru/item.asp?id=37634606
15. Robakidze N.S., Schukina O.B. Patogeneticheskie aspekty porazheniya polosti rta pri vospalitel'nyh zabolevaniyah kishechnika. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. 2019;29(4):15-21. [N.S. Robakidze, O.B. Shchukina. Pathogenetic Aspects of Oral Cavity Lesions in Inflammatory Gastrointestinal Tract Diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(4):15-21. (In Russ.)]. https://doi.org/10.22416/1382-4376-2019-29-4-15-21
16. Robakidze N.S., Pihur O.L. Sostoyanie tverdyh tkaney zubov pacientov s vospalitel'nymi zabolevaniyami kishechnika v raznyh vozrastnyh gruppah. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Medicina. Farmaciya. 2015;16(213):266-271. [N.S. Robakidze, O.L. Pikhur. Condition of hard tooth tissues of patients with inflammatory intestinal diseases in different age groups. Scientific bulletin of Belgorod state university. Series: medicine. Pharmacy. 2015;16(213):266-271. (In Russ.)]. https://elibrary.ru/item.asp?id=24910369
17. Shipicyna M.S., Tytyuk S.Yu., Iordanishvili A.K. Stomatologicheskaya zabolevaemost' pri bolezni Krona i hronicheskom nespecificheskom yazvennom kolite. Medicina: teoriya i praktika. 2018;3(1):121. [M.S. Shipitsyna, S.Yu. Tytyuk, A.K. Iordanishvili. Dental morbidity in Crohn's disease and chronic ulcerative colitis. Medicine: theory and practice. 2018;3(1):121. (In Russ.)]. https://elibrary.ru/item.asp?id=35173994
18. Truhan L.Yu., Truhan D.I. Ctomatologicheskie problemy gastroenterologicheskih pacientov i vozmozhnye puti ih resheniya. Medicinskiy Sovet. 2016;(19):134-137. [L.Yu. Trukhan, D.I. Trukhan. Stomatoligical problems of gastroenterological patients and their possible solutions. Medical Council. 2016;(19):134-137. (In Russ.)]. https://doi.org/10.21518/2079-701X-2016-19-134-137
19. Tytyuk S.Yu., Iordanishvili A.K. Harakteristika tverdyh tkaney zubov pri hronicheskih vospalitel'nyh zabolevaniyah kishechnika u vzroslyh. Krymskiy terapevticheskiy zhurnal. 2019;1:67-71. [S.Yu. Tytyk, A.K. Iordanishvili. Characteristics of hard dental tissues in chronic inflammatory bowel diseases in adults. Crimean Journal Of Internal Diseases. 2019;1:67-71. (In Russ.)]. https://elibrary.ru/item.asp?id=37254905
20. Neganova O.A., Styazhkina S.N., Nikolaeva V.N., Muradova D.M. Yazvennyy kolit i bolezn' krona: retrospektivnaya ocenka zabolevaemosti za 2016-2018 gody. Zdorov'e i obrazovanie v XXI veke. 2019;21(6):40-43. [O.A. Neganova, S.N. Styazhkina, V.N. Nikolaeva, D.M. Muradova. Ulcerative colitis and crohn's disease: a retrospective assessment of morbidity for 2016-2018. The Journal of scientific articles “Health and Education Millennium”. 2019;21(6):40-43. (In Russ.)]. http://dx.doi.org/10.26787/nydha-2226-7425-2019-21-6-40-43
21. Jajam M., Bozzolo P., Niklander S. Oral manifestations of gastrointestinal disorders // J Clin Exp Dent. - 2017;9(10):1242-1248. https://dx.doi.org/10.4317/jced.54008
22. Li X., Song P., Li J., Tao Y., Li G., Li X. The Disease Burden and Clinical Characteristics of Inflammatory Bowel Disease in the Chinese Population: A Systematic Review and Meta-Analysis // Int J Environ Res Public Health. - 2017;14(3):E238. https://doi.org/10.3390/ijerph14030238
23. Longo S., Chieppa M., Cossa L.G., Spinelli C.C., Greco M., Maffia M., Giudetti A.M. New Insights into Inflammatory Bowel Diseases from Proteomic and Lipidomic Studies // Proteomes. 2020;8(3):18. https://dx.doi.org/10.3390/proteomes8030018.
24. Ng S.C., Shi H.Y., Hamidi N. et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies // Lancet. - 2018;390(10114):2769-2778. https://doi.org/10.1016/s0140-6736(17)32448-0
25. Selvaratnam S., Gullino S., Shim L., Lee E., Lee A., Paramsothy S., Leong R.W. Epidemiology of inflammatory bowel disease in South America: A systematic review // World J Gastroenterol. - 2019;25(47):6866-6875. https://dx.doi.org/10.3748/wjg.v25.i47.6866
26. Yangyang R.Y., Rodriguez J.R. Clinical presentation of Crohn’s, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes // Seminars in pediatric surgery. - 2017;26:349-355. https://doi.org/10.1053/j.sempedsurg.2017.10.003
