Ufa, Ufa, Russian Federation
Ufa, Kazan, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Kazan, Russian Federation
Bashkir State University (Scientific Laboratory for the Study of Social and Economic Problems, Head of the Scientific Laboratory)
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Nizhniy Novgorod, Nizhny Novgorod, Russian Federation
Kazan', Kazan, Russian Federation
This work presents a comparative analysis of the effectiveness of local treatment of re-current aphtae in patients with clinical manifestations of hypersecretory diseases of the gastro-intestinal tract (GIT). Object. Evaluation of the effectiveness of the impact of a diode laser and applications of powdered platelet of autologous plasma relative to generally accepted methods of local treatment of recurrent oral aphtae. Materials and methods. 58 patients with clinical manifestations of K12.00 have been treated. Recurrent oral aphthae were at the age of 25 to 45 years. Depending on the method of local treatment, clinical subgroups – Ia and IIa (15 patients each) received the proposed complex of local treatment, Ib and IIb (14 patients each) treatment according to well-known methods. The effec-tiveness of local treatment was assessed by reducing the degree of inflammation, the intensity of the level of nociceptive pain and increasing the rate of epithelialization of aphtae. Results and discussion. The effectiveness of local treatment was assessed by reducing inflammation, pain and increasing the rate of epithelialization of aphtae. A more rapid reduction in pain and a decrease in the size of aft was observed in the Ia and IIa clinical subgroups during 3.0 ± 0.2 and 3.1 ± 0.2 days, complete epithelialization of aphtae and leveling of all complaints by 4.9 ± 0.4 and 4.7 ± 0.4 days, increased the remission period to 12 months. In patients Ib and IIb, pain reduction and reduction in aphtae size were observed by 3.5 ± 0.2 and 4.9 days, complete epithelialization and leveling of all complaints by 7.9 ± 0.2 and 7.5 ± 0.3 days, aft recurrence was observed by 6 and 12 months of dynamic observation. Conclusions. The in-clusion a diode laser in the local treatment regimen, applications of powdered autologous platelet plasma and maintenance therapy with a course frequency of 2 times a year is a highly effective method and helps to relieve nociceptive pain, inflammation, accelerate epithelializa-tion and regeneration of the mucous membrane and reduce relapses. Summary. The use a di-ode laser and applications of powdered autologous platelet plasma in combination with maintenance therapy is an effective method of local treatment of recurrent aphtae in patients against the background of basic and classical hypersecretory gastrointestinal diseases.
recurrent oral aphthae, hypersecretory gastrointestinal diseases, nociceptive pain, diode laser, maintenance therapy
1. Azimbaev N.M. Diagnostika i metody lecheniya hronicheskogo recidiviruyuschego aftoznogo stomatita polosti rta (obzor literatury). Nauka, obrazovanie i kul'tura. 2018;8(32):43-53. [N.M. Azimbaev. Diagnosis and treatment methods of chronic recurrent aphthous stomatitis of the oral cavity (review of literature). Science, education and culture. 2018;8(32):43-53. (In Russ.)]. https://elibrary.ru/item.asp?id=36366251
2. Blashkova S.L., Fazylova Yu.V., Ushakova M.A. Sovremennye aspekty mestnoy patogeneticheskoy terapii hronicheskogo recidiviruyuschego stomatita. Parodontolo-giya. 2018;4(89):77-80. [S.L. Blashkova, Yu.V. Fazylova, M.A. Ushakova. Modern aspects of local pathogenetic therapy of chronic recurrent stomatitis. Parodontologiya. 2018;24(4):77-80. (In Russ.)]. https://doi.org/10.25636/PMP.1.2018.4.14
3. Borisova E.G., Nikitina E.A. Metodika diagnostiki i lecheniya hronicheskogo recidiviruyuschego aftoznogo stomatita s ispol'zovaniem nizkointensivnogo svetodiodnogo izlucheniya. Vestnik Biomedicina i sociologiya. 2018;3;4:29-32. [E.G. Borisova, E.A. Nikitina. Methods of diagnosis and treatment of chronic recurrent aphthous stomatitis using low-intensity led radiation. Bulletin Biomedicine and sociology. 2018;3;4:29-32. (In Russ.)]. https://elibrary.ru/item.asp?id=36703431
4. Eshiev A.M., Azimbaev N.M., Abdykayymov A.T. Rezul'taty svetolecheniya v kompleksnoy terapii stomatitov. Mezhdunarodnyy zhurnal prikladnyh i fundamen-tal'nyh issledovaniy. 2019;3:23-27. [A.M. Eshiev, N.M. Azimbaev, A.T. Abdykayymov. Results of lightning in complex therapy ofstomatitis. International journal of applied and fun-damental research. 2019;3:23-27. (In Russ.)]. https://elibrary.ru/item.asp?id=37318710
5. Zhurbenko V.A., Lyaskina M.A. Izmeneniya slizistoy obolochki polosti rta pri zabolevaniyah zheludochno-kishechnogo trakta. Evraziyskoe Nauchnoe Ob'edinenie. 2019;12-2(58):132-136. [V.A. Zhurbenko, M.A. Lyaskina. Changes of the oral mucosa in diseases of the gastrointestinal tract. Eurasian Scientific Association. 2019;12-2(58):132-136. (In Russ.)]. https://elibrary.ru/item.asp?id=41827964
6. Iskakova M.K., Zarkumova A.E., Nurmuhambetova G.K. Udel'nyy ves zaboleva-niy slizistoy obolochki polosti rta sredi chasto vstrechayuschihsya stomatologicheskih zabolevaniy. Vestnik Kazahskogo nacional'nogo medicinskogo universiteta. 2018;1:188-192. [M.K. Iskakova, A.E. Zarkumova, G.K. Nurmukhambetova. Structure of morbidity of the multiple structure of the mouth of the mut. Bulletin of the Kazakh National Medical University. 2018;1:188-192. (In Russ.)]. https://elibrary.ru/item.asp?id=34989841
7. Galimova I.A. Kliniko-mikrobiologicheskoe obosnovanie kompleksa lechebnyh meropriyatiy u pacientov s recidiviruyuschimi aftami polosti rta : dis. … kand. med. Bashkirskiy gosudarstvennyy medicinskiy universitet. Ufa, 2019:185. [I.A. Galimova. Clinical and microbiological justification of the complex of therapeutic measures in patients with recurrent aphthae of the oral cavity : dis. ... Cand. Med. Sciences. Bashkir State Medical University. Ufa, 2019:185. (In Russ.)]. https://bashgmu.ru/upload/01.02.22%20%D0%93%D0%B0%D0%BB%D0%B8%D0%BC%D0%BE%D0%B2%D0%B0%20%D0%98%20%D0%90%20%D0%B0%D0%B2%D1%82%D0%BE%D1%80%D0%B5%D1%84%20(1).pdf
8. Starikova I.V., Radyshevskaya T.N., Pyslar' T.V., Dibceva T.S. Kompleksnoe lechenie hronicheskogo recidiviruyuschego aftoznogo stomatita. Nauchnyy al'manah. 2017;4-3(30):268-271. [I.V. Starikova, T.N. Radyshevskaya, T.V. Pyslar, T.S. Dibtseva. Complex treatment of chronic recurrent aphthous stomatitis. Scientific Almanac. 2017;4-3(30):268-271. (In Russ.)]. https://doi.org/10.17117/na.2017.04.03.268
9. Kravchuk I.V., Bobkova I.L., Zinovenko O.G. Kompleksnoe lechenie hronicheskogo recidiviruyuschego aftoznogo stomatita s primeneniem nizkointensivnogo lazernogo izlucheniya. Stomatologiya. Estetika. Innovacii. 2021;5;3:269-276. [I.V. Kravchuk, I.L. Bobkova, O.G. Zinovenko. Complex treatment of chronic recurrent aphthous stomatitis with the use of low-intensity laser radiation. Dentistry. Aesthetics. Innovations. 2021;5;3:269-276. (In Russ.)]. https://doi.org/10.34883/PI.2021.5.3.002
10. Mezhdunarodnaya klassifikaciya orofacial'noy boli, 1-e izdanie (ICOP). Adaptirovannaya russkoyazychnaya versiya. Al'manah klinicheskoy mediciny. 2022;50:1-82. [International Classification of Orofacial Pain, 1st edition (ICOP). Adapted Russian-language version. Almanac of Clinical Medicine. 2022;50:1-82. (In Russ.)]. http://dx.doi.org/10.18786/2072-0505-2022-50-005
11. Nikitina E.A., Borisova E.G. Tradicionnye metodiki terapii hronicheskogo recidiviruyuschego aftoznogo stomatita (obzor literatury). Problemy stomatologii. 2021;1(17):26-31. [E. Nikitina, E. Borisova. Traditional methods of chronic recurrent afthous stomatitis therapy. Actual problems in dentistry. 2021;1(17):26-31. (In Russ.)]. https://doi.org/10.18481/2077-7566-20-17-1-26-31
12. Ahmerov R.R., Korotkova O.I. Sposob lecheniya vospalitel'nyh zabolevaniy slizistyh obolochek s pomosch'yu poroshkoobraznoy formy trombocitarnoy autologich-noy plazmy. Patent № 2667653 C1 Rossiyskaya Federaciya, MPK G01N 33/48. № 2017132731. zayavl. 20.09.2017. opubl. 21.09.2018. [R.R. Akhmerov, O.I. Korotkova. Method of treatment of inflammatory diseases of mucous membranes using a powdered form of platelet-derived autologous plasma. Patent No 2667653 C1 of the Russian Federation, IPC G01N 33/48. № 2017132731. applied. 20.09.2017. publ. 21.09.2018. (In Russ.)]. https://elibrary.ru/item.asp?id=37360084
13. Usmanova I.N., Gerasimova L.P., Galimova I.A. i dr. Sposob lecheniya recidi-viruyuschih aft polosti rta s primeneniem diodnogo lazera i applikaciy poroshkoob-raznoy formy trombocitarnoy autologichnoy plazmy. Patent № 2707654 C1 Rossiy-skaya Federaciya, MPK A61N 5/067, A61K 31/155, A61K 35/16. № 2019110663. zayavl. 09.04.2019. opubl. 28.11.2019. [I.N. Usmanova, L.P. Gerasimova, I.A. Galimova et al. Pa-tent No. 2707654 C1 Russian Federation, MPK A61N 5/067, A61K 31/155, A61K 35/16. Method for treatment of recurrent oral AFTs using diode laser and applications of powdered form of platelet-derived autologous plasma. No. 2019110663. application. 09.04.2019. publ. 28.11.2019. (In Russ.)]. https://elibrary.ru/item.asp?id=41459070
14. Kosyuga S.Yu., Varvanina S.E., Klenina V.Yu., Voinova S.O. Povyshenie effek-tivnosti lecheniya recidiviruyuschego aftoznogo stomatita srednetyazheloy stepeni tya-zhesti, associirovannogo s Nelicobacter pylori. Sovremennye problemy nauki i obrazo-vaniya. 2018;6:145. [S.Yu. Kosyuga, S.E. Varvanina, V.Y. Klenina, S.O. Voinova. Improving the efficiency of treatment of recurrent aphthous stomatitis of moderate severity, association with helicobacter pylori. Modern problems of science and education. 2018;6:145. (In Russ.)]. https://elibrary.ru/item.asp?id=36871062
15. Kosyuga S.Yu., Varvanina S.E., Klenina V.Yu., Voinova S.O. Povyshenie effek-tivnosti lecheniya recidiviruyuschego aftoznogo stomatita srednetyazheloy stepeni tya-zhesti, associirovannogo s Nelicobacter pylori. Sovremennye problemy nauki i obrazovaniya. 2018;6:145. [S.Yu. Kosyuga, S.E. Varvanina, V.Y. Klenina, S.O. Voinova. Mproving the efficiency of treatment of recurrent aphthous stomatitis of moderate severity, association with helicobacter pylori. Modern problems of science and education. 2018;6:145. (In Russ.)]. https://elibrary.ru/item.asp?id=36871062
16. Popova A.N., Kraynov S.V. Lazeroterapiya pri lechenii zabolevaniy slizistoy obolochki polosti rta. Colloquim-Journal. 2018;11-2(22):57-58. [A.N. Popova, S.V. Krajnov. Photoradiotherapy in patients with oral mucosa diseases. Colloquim-Journal. 2018;11-2(22):57-58. (In Russ.)]. https://elibrary.ru/item.asp?id=36429870
17. Rabinovich O.F., Abramova E.S., Umarova K.V., Rabinovich I.M. Aspekty etio-logii i patogeneza recidiviruyuschego aftoznogo stomatita. Klinicheskaya stomatologiya. 2015;4(76):8-13. [O.F. Rabinovich, E.S. Abramova, K.V. Umarova, I.m. Rabinovich. Aetiology and pathogenesis of recurrent ulcerative stomatitis. Clinical Dentistry (Russia). 2015;4(76):8-13. (In Russ.)]. https://elibrary.ru/item.asp?id=25136352
18. Redinova T.L., Timofeeva V.N., Dmitrakova N.R. i dr. Recidiviruyuschiy aftoz-nyy stomatit: chastota, fonovye zabolevaniya, immunnye rasstroystva. Zdorov'e, demografiya, ekologiya finno-ugorskih narodov. 2019;2:41-43. [T.L. Redinova, V.N. Timofeeva, N.R. Dmitrakova et. al. Recurrent aphthous stomatitis: incidence, background diseases, immune disorders. Health, demography, ecology of finno-ugric peoples. 2019;2:41-43. (In Russ.)]. https://elibrary.ru/item.asp?id=38502271
19. Robakidze N.S. Sovremennye predstavleniya o patogeneze sochetannyh zaboleva-niy polosti rta i zheludochno-kishechnogo trakta. Institut stomatologii. 2020;4(89):64-65. [N.S. Robakidze. Modern concepts of the pathogenesis of combined dis-eases of the oral cavity and gastrointestinal tract. The dental institute. 2020;4(89):64-65. (In Russ.)]. https://elibrary.ru/item.asp?id=44287052
20. Starikova I.V., Dibceva T.S., Radyshevskaya T.N. Analiz obraschaemosti pacien-tov s zabolevaniyami slizistoy obolochki polosti rta. Aktual'nye nauchnye issledova-niya v sovremennom mire. 2018;2-3(34):82-85. [I.V. Starikova, T.S. Dibtseva, T.N. Radyshevskaya. Analysis of the treatment rate of patients with oral mucosa diseases. Actual scientific research in the modern world. 2018;2-3(34):82-85. (In Russ.)]. https://elibrary.ru/item.asp?id=32530597
21. Mishutina O.L., Volchenkova G.V., Kovaleva N.S. i dr. Fotodinamicheskaya tera-piya v stomatologii (obzor literatury). Smolenskiy medicinskiy al'manah. 2019;3:102-111. [O.L. Mishutina, G.V. Volchenkova, N.S. Kovaleva et al. Photodynamic therapy in dentistry (literature review). Smolensk Medical Almanac. 2019;3:102-111. (In Russ.)]. https://elibrary.ru/item.asp?id=41213547
22. Habibova N.N. Dinamicheskaya ocenka stomatologicheskogo statusa pacientov s recidiviruyuschim aftoznym stomatitom. Medicinskie novosti. 2019;11(302):65-67. [N.n. Khabibova. Dynamic evaluation of the dental status of patients with retaining ahtosic stomatis. Medical News. 2019;11(302):65-67. (In Russ.)]. https://elibrary.ru/item.asp?id=41440819
23. Hapsirokova Z.Z., Ponomarev A.A. Sravnitel'naya ocenka effektivnosti raz-lichnyh metodik lecheniya hronicheskogo recidiviruyuschego aftoznogo stomatita. Kli-nicheskaya stomatologiya. 2022;25(3):120-125. [Z.Z. Khapsirokova, A.A. Ponomarev. Com-parative evaluation of the efficiency of different treatment methods of the chronic recurrent aphthous stomatitis. Clinical dentistry (Russia). 2022;25(3):120-125. (In Russ.)]. https://doi.org/10.37988/1811-153X_2022_3_120
24. Liu C., Zhou Z., Liu G. et al. Efficacy and safety of dexamethasone ointment on recurrent aphthous ulceration // The American Journal of Medicine. - 2012;125;3:292-301. https://doi.org/10.1016/j.amjmed.2011.09.011
