PREDICTIVE FACTORS AND MECHANISMS OF THEIR IMPLEMENTATION IN THE DEVELOPMENT OF PRECANCEROUS AND ONCOLOGICAL DISEASES OF THE ORAL MUCOSA
Abstract and keywords
Abstract (English):
The problem of oncological and precancerous diseases of the oral mucosa is urgent, because the prevalence of these diseases is high, as well as malignant neoplasms of this localization are among the most aggressive and difficult to treat human neoplasms, characterized by a high percentage of mortality. These facts determine the increased importance of primary prevention of precancerous and cancerous diseases, the purpose of which is to identify and eliminate predictive factors of the development of these pathologies. Objective of the study is to conduct a systematic analysis of modern Russian and foreign literary sources in the aspect of predictive factors of the occurrence of precancerous and cancerous diseases of the red border of the lips and oral mucosa and their main mechanisms. Methodology. The research is based on the search and analysis of modern Russian and foreign original sources on the topic in the databases eLibrary, Pubmed, Crossref. Results. The development of precancerous and oncological diseases is a complex multifactorial process that proceeds under the influence of a number of prognostic factors that have both isolated and synergistic effects on the human body at the local or general level. Conclusion. We have analyzed the scientific literature, which indicates a significant contribution of a wide range of modifiable and unmodifiable factors in the development of precancerous and oncological processes. Identification and correction of probable risk factors for the occurrence of precancerous and oncological diseases of the oral mucosa can help prevent the development of these diseases.

Keywords:
precancerous diseases of the oral mucosa, oncological diseases of the oral mucosa, predictors of the development of oncological and precancerous diseases of the oral mucosa, genetic risk factors for cancer, human oral microbiome
References

1. Gordienko V.P. Zabolevaemost' i smertnost' bol'nyh zlokachestvennymi novoobrazovaniyami polosti rta. Byulleten' fiziologii i patologii dyhaniya. 2017;64:43-49. [V.P. Gordiyenko. Morbidity and mortality in patients with malignant neoplasms of the oral cavity. Bulletin of physiology and pathology of respiration. 2017;64:43-49. (In Russ.)]. https://doi.org/10.12737/article_59360a7dea5566.29299729

2. Zykova E.A. Onkologicheskaya nastorozhennost' pri zabolevaniyah slizistoy obolochki polosti rta. Zdravoohranenie Yugry: opyt i innovacii. 2016;3:49-55. [E.A. Zykova. Oncological alertness in diseases of the oral mucosa. Ugra healthcare: experience and innovations, 2016;3:49-55. (In Russ.)]. https://cyberleninka.ru/article/n/onkologicheskaya-nastorozhennost-pri-zabolevaniyah-slizistoy-obolochki-polosti-rta

3. Karpin A.D., Starinskiy V.V., Petrova G.V. Zlokachestvennye novoobrazovaniya v Rossii v 2018 godu (zabolevaemost' i smertnost'). Moskovskiy nauchno-issledovatel'skiy onkologicheskiy institut imeni P.A. Gercena, filial FGBU "NMIRC" Minzdrava Rossii. 2019:250. [A.D. Kaprin, V.V. Starinsky, G.V. Petrova. Malignant neoplasms in Russia in 2018 (morbidity and mortality). Moscow, PA Herzen Moscow state medical research Institute branch of the Federal state budgetary institution «NMIC of radiology» of the Ministry of health of Russia. 2019:205. (In Russ.)]. https://oncology-association.ru/wp-content/uploads/2020/09/2018.pdf

4. Romanenko I.G., Arakelyan K.A., Salischeva V.O. Sovremennye koncepcii profilaktiki i lecheniya oral'nogo mukozita pri onkoterapii. Vyatskiy medicinskiy vestnik. 2021;1(69):96-101. [I.G. Romanenko, K.A. Arakelyan, V.O. Salishcheva. Up-to-date concepts of prevention and treatment for oral mucositis in cancer therapy. Medical newsletter of Vyatka. 2021;1(69):96-101. (In Russ.)]. https://doi.org/10.24411/2220-7880-2021-10161

5. Mezhevikina G.S., Gluhova E.A. Sovremennye metody diagnostiki predrakovyh i rakovyh izmeneniy slizistoy obolochki rta. Nauka molodyh (Eruditio Juvenium). 2018;6(4):600-606. [G.S. Mezhevikina, E.A. Glukhova. Modern diagnostic methods precancerous and cancerous changes of the oral mucosa. Science of the young (Eruditio Juvenium). 2018;6(4):600-606. (In Russ.)]. https://doi.org/10.23888/HMJ201864600-606

6. Romanov I.S., Gel'fand I.M. i dr. Celesoobraznost' ispol'zovaniya indukcionnoy himioterapii v lechenii raka slizistoy obolochki polosti rta s rasprostranennost'yu processa sT2N0M0. Opuholi golovy i shei. 2017;7(2):37-44. [I.S. Romanov, I.M. Gelfand, D.B. et al. Feasibility of induction chemotherapy in the treatment of cT2N0M0 cancer of the oral mucosa. Head and neck tumors. 2017;7(2):37-44. (In Russ.)]. https://doi.org/10.17650/2222-1468-2017-7-2-37-44

7. Kaprin A.D., Aleksandrova L.M., Starinskiy V.V., Mamontov A.S. Tehnologii diagnostiki i skrininga v rannem vyyavlenii zlokachestvennyh novoobrazovaniy. Onkologiya. Zhurnal im. P.A. Gercena. 2018;7(1):34-40. [A.D. Kaprin, L.M. Alexandrova, V.V. Starinsky, A.S. Mamontov. Technologies for early diagnosis and screening in the early detection of malignant neoplasms. Moscow, P.A. Herzen journal of oncology. 2018;7(1):34-40. (In Russ.)]. https://doi.org/10.17116/onkolog20187134-40

8. Goryainova G.N. Litvinova E.S. Harakteristika faktorov riska i patomorfologii raka slizistoy obolochki polosti rta. Regional'nyy vestnik. 2020;10(49):30-31. [G.N. Goryainova, E.S. Litvinova. Characteristics of risk factors and pathomorphology of cancer of the oral mucosa. Regional Bulletin. 2020;10(49):30-31. (In Russ.)]. https://elibrary.ru/download/elibrary_43090485

9. Dzhuraeva Sh.F., Chistenko G.N., Terehova T.N., Ikonnikova A.V. Rak polosti rta: faktory riska i skrining. Mezhdunarodnye obzory: klinicheskaya praktika i zdorov'e. 2020;2:7-17. [S.F. Dzhuraeva, G. Chistenko, T. Terekhova, A. Ikonnikova. Oral cancer: risk factors and screening. International reviews: Clinical practice and health. 2020;2:7-17. (In Russ.)]. https://cyberleninka.ru/article/n/rak-polosti-rta-faktory-riska-i-skrining

10. Chang C.P., Siwakoti B., Sapkota A. et al. Tobacco smoking, chewing habits, alcohol drinking and the risk of head and neck cancer in Nepal // Int J Cancer. - 2020;147(3):866-875. https://doi.org/10.1002/ijc.32823

11. Bhatnagar A., Maziak W., Eissenberg T. et al. Water Pipe (Hookah) Smoking and Cardiovascular Disease Risk: A Scientific Statement From the American Heart Association // Circulation. - 2019;139(19):e917-e936. https://doi.org/10.1161/CIR.0000000000000671

12. Nakamura A., François O., Lepeule J. Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review // Int J Environ Res Public Health. - 2021;18(10):5083. https://doi.org/10.3390/ijerph18105083

13. Kostina I.N. i dr. Predrakovye zabolevaniya slizistoy obolochki polosti rta, krasnoy kaymy gub i kozhi lica. Uchebnoe posobie dlya vrachey-stomatologov-hirurgov, chelyustno-licevyh hirurgov i stomatologov-terapevtov. Ekaterinburg : Izdatel'skiy Dom «TIRAZh». 2019:84. [I.N. Kostina et al. Precancerous diseases of the oral mucosa, the red border of the lips and facial skin. A textbook for dental surgeons, maxillofacial surgeons and dental therapists. Yekaterinburg : «TIRAZH» Publishing House. 2019:84.(In Russ.)]. https://vestnik.astu.org/upload/21232f297a57a5a743894a0e4a801fc3/files/0aca07294b424f6b3818b8b94814fa3e.pdf

14. Galchenko V., Byval'ceva S., Galchenko L., Fedotova M. Kompleksnoe lechenie abrazivnogo prekanceroznogo heylita Manganotti na fone gerpeticheskoy infekcii s primeneniem preparata na osnove helatnogo kompleksa germaniy-organicheskogo soedineniya s guaninom. Parodontologiya. 2017;22(2):89-92. [V. Galchenko, S. Byvaltseva, L. Galchenko, M. Fedotova. Complex treatment for abrasiva preacancerosa Manganotti in patient with herpes infection using a chelate organic germanium guanine compound pharmaceutical treatment. Periodontology. 2017;22(2):89-92. (In Russ.)]. https://elibrary.ru/item.asp?id=29232392

15. Al-Bashaireh A.M., Haddad L.G., Weaver M., Kelly D.L., Chengguo X., Yoon S. The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review // J Environ Public Health. - 2018;2018:4184190. https://doi.org/10.1155/2018/4184190

16. Nikolenko V.N. Etiologicheskie faktory vozniknoveniya ploskokletochnogo raka slizistoy obolochki organov polosti rta. Voprosy onkologii. 2017;63(5):703-707. [V.N. Nikolenko, E.V. Kochurova, A.A. Mukhanov. Etiological factors of squamous cell cancer of the mucous membrane of the oral cavity. Problems in oncology. 2017;63(5):703-707. (In Russ.)]. https://doi.org/10.37469/0507-3758-2017-63-5-703-707

17. Makurina G.I., Makarchuk A.I. i dr. Verrukoznaya leykoplakiya krasnoy kaymy gub na fone ispol'zovaniya sistemy nagreva tabaka IQOS (klinicheskiy sluchay). Zaporozhskiy medicinskiy zhurnal. 2020;22;6(123):885-890. [G.I. Makurina, A.I. Makarchuk et al. Verrucous leukoplakia of the red border caused by the use of IQOS heated tobacco product (a case report) Zaporozhye medical journal. 2020;22;6(123):885-890. (In Russ.)]. https://doi.org/10.14739/2310-1210.2020.6.218477 2020ISSN 2306-4145

18. Makarova M.A. Kurenie i hronicheskaya obstruktivnaya bolezn' legkih. Astma i allergiya. 2016;4. [M.A. Makarova. Smoking and chronic obstructive pulmonary disease. Asthma and allergies. 2016;4. (In Russ.)]. https://cyberleninka.ru/article/n/kurenie-i-hronicheskaya-obstruktivnaya-bolezn-legkih

19. Hajat C., Stein E., Ramstrom L., Shantikumar S., Polosa R. The health impact of smokeless tobacco products: a systematic review // Harm Reduct J. - 2021;18(1):123. https://doi.org/10.1186/s12954-021-00557-6

20. Monika S., Dineshkumar T., Priyadharini S., Niveditha T., Sk P., Rajkumar K. Smokeless Tobacco Products (STPs) Harbour Bacterial Populations with Potential for Oral Carcinogenicity // Asian Pac J Cancer Prev. - 2020;21(3):815-824. https://doi.org/10.31557/APJCP.2020.21.3.815

21. Gupta S., Gupta R., Sinha D.N., Mehrotra R. Relationship between type of smokeless tobacco & risk of cancer: A systematic review // Indian J Med Res. - 2018;148(1):56-76. https://doi.org/10.4103/ijmr.IJMR_2023_17

22. Sajid M., Srivastava S., Kumar A., Kumar A., Singh H., Bharadwaj M. Bacteriome of Moist Smokeless Tobacco Products Consumed in India With Emphasis on the Predictive Functional Potential // Front Microbiol. - 2021;12:784841. https://doi.org/10.3389/fmicb.2021.784841

23. Parhomenko L.B. Rak organov golovy i shei i predraspolagayuschie k nemu faktory. Medicinskie novosti. 2018;9(288). [L.B. Parkhomenko. Head and neck cancer and preventing factors. Medical news. 2018;9(288). (In Russ.)]. https://cyberleninka.ru/article/n/rak-organov-golovy-i-shei-i-predraspolagayuschie-k-nemu-faktory

24. Kopylov D.O., Zolotova L.Yu., Anisimova I.V. i dr. Harakteristika kliniko-laboratornyh pokazateley sostoyaniya polosti rta i rotovoy zhidkosti molodyh lic, upotreblyayuschih zhevatel'nyy tabak snus. Problemy stomatologii. 2020;16(2):22-29. [D.O. Kopylov, L.Yu. Zolotova, I.V. Anisimova et al. Characteristics of clinical and laboratory indicators of the state of the oral cavity and oral fluid of young persons who use smokeless tobacco snus. Actual problems in dentistry. 2020;16(2):22-29. (In Russ.)]. https://doi.org/10.18481/2077-7566-20-16-2-22-29

25. Belyakova E.N. Faktory riska razvitiya zlokachestvennyh novoobrazovaniy golovy i shei. Epidemiologiya i Vakcinoprofilaktika. 2021;20(1):92-99. [E.N. Belyakova. Risk Factors for the Development of Malignant Tumors of the Head and Neck. Epidemiology and Vaccinal Prevention. 2021;20(1):92-99. (In Russ.)]. https://doi.org/10.31631/2073-3046-2021-20-1-92-99

26. Nieminen M.T., Salaspuro M. Local Acetaldehyde-An Essential Role in Alcohol-Related Upper Gastrointestinal Tract Carcinogenesis // Cancers (Basel). - 2018;10(1):11. https://doi.org/10.3390/cancers10010011

27. Hoes L., Dok R., Verstrepen K.J., Nuyts S. Ethanol-Induced Cell Damage Can Result in the Development of Oral Tumors // Cancers (Basel). - 2021;13(15):3846. https://doi.org/10.3390/cancers13153846

28. Stornetta A., Guidolin V., Balbo S. Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity // Cancers (Basel). - 2018;10(1):20. https://doi.org/10.3390/cancers10010020

29. Tagaino R., Washio J., Abiko Y., Tanda N., Sasaki K., Takahashi N. Metabolic property of acetaldehyde production from ethanol and glucose by oral Streptococcus and Neisseria // Sci Rep. - 2019;9(1):10446. https://doi.org/10.1038/s41598-019-46790-9

30. Rodriguez F.D., Coveñas R. Biochemical Mechanisms Associating Alcohol Use Disorders with Cancers // Cancers (Basel). - 2021;13(14):3548 https://doi.org/10.3390/cancers13143548

31. Saad M.A., Kuo S.Z., Rahimy E. et al. Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma // Mol Cancer. - 2015;14:181. https://doi.org/10.1186/s12943-015-0452-8

32. Liu Y., Chen H., Sun Z., Chen X. Molecular mechanisms of ethanol-associated oro-esophageal squamous cell carcinoma // Cancer Lett. - 2015;361(2):164-173. https://doi.org/10.1016/j.canlet.2015.03.006

33. Silva P., Latruffe N., Gaetano G. Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus // Molecules. - 2020;25(11):2569. https://doi.org/10.3390/molecules25112569

34. Katsanos K.H., Roda G., Brygo A., Delaporte E., Colombel J.F. Oral Cancer and Oral Precancerous Lesions in Inflammatory Bowel Diseases: A Systematic Review // J Crohns Colitis. - 2015;9(11):1043-1052. https://doi.org/10.1093/ecco-jcc/jjv122

35. Kirtaeva A.V., Gazhva. S.I., Trofimova I.N., Il'ina S.P. Vliyanie alkogolya na polost' rta. Zdravoohranenie Chuvashii. 2020;1. [A.V. Kirtaeva, S.I. Gazhva, I.N. Trofimova, S.P. Ilyina. The effect of alcohol on the oral cavity. Healthcare Of Chuvashia. 2020;1. (In Russ.)]. https://doi.org/10.25589/GIDUV.2020.63.67.007

36. Ding X., Zheng Y., Wang Z. et al. Expression and oncogenic properties of membranous Notch1 in oral leukoplakia and oral squamous cell carcinoma // Oncol Rep. - 2018;39(6):2584-2594. https://doi.org/10.3892/or.2018.6335

37. Yin J., Zeng X., Ai Z., Yu M., Wu Y., Li S. Construction and analysis of a lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in oral cancer // BMC Med Genomics. - 2020;13(1):84. https://doi.org/10.1186/s12920-020-00741-w

38. Irimie A.I., Braicu C., Sonea L. et al. A Looking-Glass of Non-coding RNAs in oral cancer // Int J Mol Sci. - 2017;18(12):2620. https://doi.org/10.3390/ijms18122620

39. Gilardi M., Wang Z., Proietto M. et al. Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas // Mol Cancer Ther. - 2020;19(9):1784-1796. https://doi.org/10.1158/1535-7163.MCT-19-0958

40. Shah P.A., Huang C., Li Q. et al. NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma // Cells. - 2020;9(12):2677. https://doi.org/10.3390/cells9122677

41. Haque M.M., Kowtal P., Sarin R. Identification and characterization of TP53 gene Allele Dropout in Li-Fraumeni syndrome and Oral cancer cohorts // Sci Rep. - 2018;8(1):11705. https://doi.org/10.1038/s41598-018-30238-7

42. Lu W., Wang Y., Gan M., Duan Q. Prognosis and predictive value of heat-shock proteins expression in oral cancer: A PRISMA-compliant meta-analysis // Medicine (Baltimore). - 2021;100(3):e24274. https://doi.org/10.1097/MD.0000000000024274

43. Usman S., Jamal A., Teh M.T., Waseem A. Major Molecular Signaling Pathways in Oral Cancer Associated With Therapeutic Resistance // Front Oral Health. - 2021;1:603160. https://doi.org/10.3389/froh.2020.603160

44. Fukusumi T., Califano J.A. The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma // J Dent Res. - 2018;97(6):645-653. https://doi.org/10.1177/0022034518760297

45. Wu-Chou Y.H., Hsieh C.H., Liao C.T., Lin Y.T., Fan W.L., Yang C.H. NOTCH1 mutations as prognostic marker in oral squamous cell carcinoma // Pathol Res Pract. - 2021;223:153474. https://doi.org/10.1016/j.prp.2021.153474

46. Starzyńska A., Adamska P., Sejda A. et al. Any Role of PIK3CA and PTEN Biomarkers in the Prognosis in Oral Squamous Cell Carcinoma? // Life (Basel). - 2020;10(12):325. https://doi.org/10.3390/life10120325

47. Alqahtani A., Ayesh H.S.K., Halawani H. PIK3CA Gene Mutations in Solid Malignancies: Association with Clinicopathological Parameters and Prognosis // Cancers (Basel). - 2019;12(1):93. https://doi.org/10.3390/cancers12010093

48. Du L., Chen X., Cao Y. et al. Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling // Oncogene. - 2016;35(35):4641-4652. https://doi.org/10.1038/onc.2016.1

49. Rock L.D., Rosin M.P., Zhang L., Chan B., Shariati B., Laronde D.M. Characterization of epithelial oral dysplasia in non-smokers: First steps towards precision medicine // Oral Oncol. - 2018;78:119-125. https://doi.org/10.1016/.

50. He X., Wang P., Li Y., Shen N., He X., Wang P., Li Y., Shen N. ATM rs189037 significantly increases the risk of cancer in non-smokers rather than smokers: an updated meta-analysis // Biosci Rep. - 2019;28;39(6):BSR20191298. https://doi.org/10.1042 / BSR20191298

51. Zhao Z.L., Xia L., Zhao C., Yao J. ATM rs189037 (G > A) polymorphism increased the risk of cancer: an updated meta-analysis // BMC Med Genet. - 2019;20(1):28. https://doi.org/10.1186/s12881-019-0760-8

52. Yan Z., Tong X., Ma Y., Liu S., Yang L., Yang X., Yang X., Bai M., Fan H. Association between ATM gene polymorphisms, lung cancer susceptibility and radiation-induced pneumonitis: a meta-analysis // BMC Pulm Med. - 2017;15;17(1):205. https://doi.org/10.1186/s12890-017-0555-7

53. Roi A., Roi C.I., Andreescu N.I. et al. Oral cancer histopathological subtypes in association with risk factors: a 5-year retrospective study // Rom J Morphol Embryol. - 2020;61(4):1213-1220. https://doi.org/10.47162/RJME.61.4.22

54. Wahab Khattak F., Salamah Alhwaiti Y., Ali A., Faisal M., Siddiqi M.H. Protein-Protein Interaction Analysis through Network Topology (Oral Cancer) // J Healthc Eng. - 2021;2021:6623904. https://doi.org/10.1155/2021/6623904

55. Singh A., Purohit B.M. ABO Blood Groups and Its Association with Oral Cancer, Oral Potentially Malignant Disorders and Oral Submucous Fibrosis- A Systematic Review and Meta-Analysis // Asian Pac J Cancer Prev. - 2021;22(6):1703-1712. https://doi.org/10.31557/APJCP.2021.22.6.1703

56. Bel'skaya L.V. Vozmozhnosti primeneniya slyuny dlya diagnostiki onkologicheskih zabolevaniy. Klinicheskaya laboratornaya diagnostika. 2019;64(6):333-336. [L.V. Bel’skaya. Possible applications of saliva for the diagnosis of cancer, Russuan clinical laboratory diagnostics. 2019;64(6):333-336. (In Russ.)]. https://doi.org/10.18821/0869-2084-2019-64-6-333-336

57. La Rosa G.R.M., Gattuso G., Pedullà E., Rapisarda E., Nicolosi D., Salmeri M. Association of oral dysbiosis with oral cancer development // Oncol Lett. - 2020;19(4):3045-3058. https://doi.org/10.3892/ol.2020.11441

58. Chen S.H., Hsiao S.Y., Chang K.Y., Chang J.Y. New Insights Into Oral Squamous Cell Carcinoma: From Clinical Aspects to Molecular Tumorigenesis // Int J Mol Sci. - 2021;22(5):2252. https://doi.org/10.3390/ijms22052252

59. Yang S.F., Huang H.D., Fan W.L., Jong Y.J., Chen M.K., Huang C.N., Chuang C.Y., Kuo Y.L., Chung W.H., Su S.C. Compositional and functional variations of oral microbiota associated with the mutational changes in oral cancer // Oral Oncol. - 2018;77:1-8. https://doi.org/10.1016/j.oraloncology.2017.12.005

60. Lee W.H., Chen H.M., Yang S.F., Liang C., Peng C.Y., Lin F.M., Tsai L.L., Wu B.C., Hsin C.H., Chuang C.Y., Yang T., Yang T.L., Ho S.Y., Chen W.L., Ueng K.C., Huang H.D., Huang C.N., Jong Y.J. Bacterial alterations in salivary microbiota and their association in oral cancer // Sci Rep. - 2017;28;7(1):16540. https://doi.org/10.1038/s41598-017-16418-x

61. Metsäniitty M., Hasnat S., Salo T., Salem A. Oral Microbiota-A New Frontier in the Pathogenesis and Management of Head and Neck Cancers // Cancers (Basel). - 2021;14(1):46. https://doi.org/10.3390/cancers14010046

62. Muzio L.L., Ballini A., Cantore S. et al. Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients // Biomed Res Int. - 2021;2021:7312611. https://doi.org/10.1155/2021/7312611

63. Sun J., Tang Q., Yu S. et al. Role of the oral microbiota in cancer evolution and progression // Cancer Med. - 2020;9(17):6306-6321. https://doi.org/10.1002/cam4.3206

64. Kazakova A.V. Ocenka stomatologicheskogo zdorov'ya u nikotinzavisimoy molodezhi 18-22 let s uchetom vliyaniya vidov kureniya na funkcional'nye pokazateli slyuny. Medicinskaya nauka i obrazovanie Urala. 2018;19;3(95):19-23. [A.V. Kazakova, O.A. Kuman. The dental health estimation in nicotine addicted young adults (19-22) in terms of smoking types influence on salivary functional indications. Medical science and education of Ural. 2018;19;3(95):19-23. (In Russ.)]. https://www.elibrary.ru/item.asp?id=35686794

65. Chattopadhyay I., Verma M., Panda M. Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer // Technol Cancer Res Treat. - 2019;18:1533033819867354. https://doi.org/10.1177/1533033819867354

66. Kazimov A.E., Mudunov A.M. i dr. Rol' parodontopatogenov v kancerogeneze ploskokletochnogo raka slizistoy obolochki polosti rta. Opuholi golovy i shei. 2020;4. [A.E. Kazimov, A.M. Mudunov et al. The role of periodontal pathogens in the carcinogenesis of squamous cell carcinoma of the oral mucosa. Tumors of the head and neck. 2020;4. (In Russ.)]. https://cyberleninka.ru/article/n/rol-parodontopatogenov-v-kantserogeneze-ploskokletochnogo-raka-slizistoy-obolochki-polosti-rta

67. Pevzner A.M., Cyganov M.M., Ibragimova M.K., Litvyakov N.V. Virus papillomy cheloveka i zlokachestvennye novoobrazovaniya golovy i shei (obzor literatury). Opuholi golovy i shei. 2019;2. [A.M. Pevzner, M.M. Tsyganov, M.K. Ibragimova, N.V. Litvyakov. Human papillomavirus in head and neck cancer (literature review). Tumors of the head and neck. 2019;2. (In Russ.)]. https://doi.org/10.17650/2222-1468-2019-9-2-43-52


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