Kazan, Kazan, Russian Federation
from 01.01.2018 to 01.01.1922
Kazan, Kazan, Russian Federation
Kazan, Kazan, Russian Federation
Subject. A literature was reviewed on the relevant subject dedicated to the prevention of dental diseases – the study of the modern market of toothpastes used as the basic oral care products. Methodology. The data of special literature were studied using scientific tracking library databases: Pub Med, Elibrary, Cochrane. Literature was analysed using 55 sources. Results. On the modern market, there is a wide range of toothpastes with various properties due to active ingredients they are composed of. Despite the wide and varied range of these oral care products, there is no officially recognized classification of this product. The children's toothpastes should meet the following requirements: be neutral, have cleansing and polishing properties, have a good smell, flavour and appearance, cooling and disinfecting effects, be harmless and have a therapeutic and prophylactic effect. In the special literature, there are many studies on the use of toothpastes in case of high caries severity. The modern direction of therapeutic and prophylactic pastes is the inclusion of various enzymes in their composition. These components are able to increase the cleansing effect of hygiene products due to the lysis of the organic matrix of soft and hard components of plaque, bacteriostatic or indirect bactericidal effects on the biocenosis of the mouth, including the products of microorganisms. Conclusions. On the modern market, there is a huge range of toothpastes with various active ingredients effecting the causes of oral diseases, but there is still no toothpaste which would be safe to accidentally swallow during long-term use, which is one of the main reasons for development of individual oral health programs for patients with aggravated somatic status, as well as for those who have neuropsychiatric disorders. Therefore, the question of the absolutely safe toothpastes as the basic oral care products remains open.
basic oral care products, toothpastes, prevention of dental diseases, individual oral health program, enzymes
1. Silagadze E.M., Salahov A.K., Baykeev R.F., Ksembaev S.S. Tehnologiya individual'nogo prognozirovaniya razvitiya kariesa zubov. Kazan'. 2019:130. [E.M. Silagadze, A.K. Salakhov, R.F. Baykeev, S.S. Ksembayev. Technology of individual forecasting of dental caries development. Kazan. 2019:130. (In Russ.)]. https://elibrary.ru/item.asp?id=38238438
2. Kuz'mina E.M., Vasina S.A., Urzov S.A. Diagnosticheskie kriterii nachal'nyh form kariesa zubov (obzor literatury). Dental Forum. 2015;1(56):35-41. [E.M. Kuzmina, S.A. Vasina, S.A. Urzov. Diagnostic criteria of initial forms of dental caries (literature review). Dental Forum. 2015;1(56):35-41. (In Russ.)]. https://elibrary.ru/item.asp?id=23062527
3. Suschenko A.V., Krasnikova O.P., Alferova E.A., Oleynik O.I., Solov'eva A.L. Koncepciya personificirovannogo profilakticheskogo podhoda k profilaktike stomatologicheskih zabolevaniy u detey. Zhurnal nauchnyh statey zdorov'e i obrazovanie v XXI veke. 2017;19(5):89-93. [A.V. Sushchenko, O.P. Krasnikova, E.A. Alferova, O.I. Oleynik, A.L. Solovyova. The concept of personalized prevention approach to the prevention of dental diseases in children. The journal of scientific articles health and education millennium. 2017;19(5):89-93. (In Russ.)]. https://elibrary.ru/item.asp?id=28278752
4. Ulitovskiy S.B., Antipova A.V. Izuchenie svoystv aktivnyh komponentov zubnyh past. Institut stomatologi. 2018;1(78):110-112. [S.B. Ulitovsky, A.V. Antipova. Studying the properties of active components of toothpastes. Institute of Dentists. 2018;1(78):110-112. (In Russ.)]. https://elibrary.ru/item.asp?id=34964806
5. Ulitovskiy S.B. Gigiena polosti rta v parodontologii. Moskva : Medicinskaya kniga. 2006. [S.B. Ulitovsky. Oral hygiene in periodontology. Moscow : Medical Book. 2006. (In Russ.)]. https://elibrary.ru/item.asp?id=19532906
6. Bulaeva A.M., Zolikova E.A., Ionrdanov E.V. Ocenka sootvetstviya zubnyh past gosudarstvennym standartam. Forcipe. 2020;3(S):930-931. [A.M. Bulaeva, E.A. Golikova, E.V. Iordanov. Assessment of compliance of toothpastes with state standards. Forcipe. 2020;3(S):930-931. (In Russ.)]. https://elibrary.ru/item.asp?id=43461439
7. Szhenova Tat'yana Mihaylovna. Sovremennye metody kontrolya kachestva zubnyh past i opolaskivateley lechebno-profilakticheskogo naznacheniya : avtoreferat dis. ... kandidata farmacevticheskih nauk: 14.04.02. [Mesto zaschity: Pervyy mosk. gos. med. un-t. im. I.M. Sechenova]. Moskva, 2018:24. [Sazhenova Tatiana Mikhailovna. Modern methods of quality control of toothpastes and rinses for therapeutic and prophylactic purposes : abstract of the dissertation of the Candidate of Pharmaceutical Sciences : 14.04.02. [Place of protection: First Moscow State Med. I.M. Sechenov Univ.]. Moscow, 2018:24. (In Russ.)]. https://elibrary.ru/item.asp?id=30492986
8. Faroponova E.A. Vozmozhnosti korrekcii metabolicheskih narusheniy v rotovoy zhidkosti s pomosch'yu gigienicheskih sredstv antioksidantnoy napravlennosti. Sovremennye problemy nauki i obrazovaniya. 2016;4:49. [E.A. Faroponova. Possibilities of correction of metabolic disorders in the oral fluid with the help of antioxidant hygiene products. Modern problems of science and education. 2016;4:49. (In Russ.)]. https://elibrary.ru/item.asp?id=30492986
9. Schepinova I.K., Saltykova E.N., Kuprina I.V. Effektivnost' vliyaniya zubnoy pasty «Parodontax» na mikroorganizmy zubnogo naleta. Organizm i sreda zhizni. 2018;4:101-105. [I.K. Shchepinova, E.N. Saltykova, I.V. Kuprina. The effectiveness of the influence of Parodontax toothpaste on plaque microorganisms. Organism and life environment. 2018;4:101-105. (In Russ.)]. https://elibrary.ru/item.asp?id=34981281
10. Malysheva A.V., Falaleeva E.A., Petrov S.B., Elikov A.V. Gromov Ya.P. Izmenenie biohimicheskoy struktury rotovoy zhidkosti pri ispol'zovanii pasty s glaukonitom. Aktual'nye voprosy stomatologii detskogo vozrasta : Sb.nauch.statey 3-ey Vserossiyskoy nauchno-prakticheskoy konferencii. Kazan'. 2020:107-110. [A.V. Malysheva, E.A. Falaleeva, S.B. Petrov, A.V. Elikov, Ya.P. Gromov. Changes in the biochemical structure of the oral fluid when using a paste with gluconate. Actual problem of pediatric dentistry : Collection of scientific articles of the 3rd All Russian scientific and practical conference. Kazan. 2020:107-110. (In Russ.)]. https://elibrary.ru/item.asp?id=42528761
11. Avdeeva M.V., Skvorcova K.M. Sravnitel'nyy analiz past dlya professional'noy chistki zubov. Byulleten' medicinskih internet-konferenciy. 2015;5(10):1244-1245. [M.V. Avdeeva, K.M. Skvortsova. Comparative analysis of pastes for professional dental cleaning. Bulletin of medical Internet conferences. 2015;5(10):1244-1245. (In Russ.)]. https://elibrary.ru/item.asp?id=24931653
12. Kiyun I.D. Sravnitel'noe issledovanie zubnyh past s umerennoy abrazivnost'yu. Molodoy uchenyy. 2015;6:274-277. [I.D. Kiyun. Comparative study of toothpastes with moderate abrasiveness. Young scientist. 2015;6:274-277. (In Russ.)]. https://elibrary.ru/item.asp?id=23172178
13. Gromova S.N., Smetanina O.A., Kuklina S.A., Elikov A.V., Petrov S.B. Vliyanie himicheskogo sostava zubnoy pasty na bufernye sistemy rotovoy polosti i pokazatel' sredy. Butlerovskie soobscheniya. 2020;61(1):104-110. [S.N. Gromova, O.A. Smetanina, S.A. Kuklina, A.V. Belikov, S.B. Petrov. The influence of the chemical composition of toothpaste on the buffer systems of the oral cavity and the environment indicator. Butlerov messages. 2020;61(1):104-110. (In Russ.)]. https://elibrary.ru/item.asp?id=42578927
14. Gazhva S.I., Shurova N.N., Kiptilova T.A., Eremeeva D.A. Ispol'zovanie zubnyh past dlya lecheniya giperestezii dentina (obzor). Sovremennye problemy nauki i obrazovaniya. 2012;3:51. [S.I. Gazhva, N.N. Shurova, T.A. Kiptilova, D.A. Eremeeva. Use toothpaste for treatment hyperesthesia dentin (review). Modern problems of science and education. 2012;3:51 (In Russ.)]. https://elibrary.ru/item.asp?id=17822291
15. Il'ina A.M., Nasybullina G.M., Ankudinova A.V. Gigiena polosti rta. Zubnye pasty. Aktual'nye voprosy sovremennoy medicinskoy nauki i zdravoohraneniya. 2019:645-651. [A.M. Ilyina, G.M. Nasybullina, A.V. Ankudinova. Oral hygiene. Toothpastes. Topical issues of modern medical science and healthcare. 2019:645-651. (In Russ.)]. https://elibrary.ru/item.asp?id=42424897
16. Dzarasova M.A., Neelova O.V. Osobennosti himicheskogo sostava nekotoryh zubnyh past, rekomenduemyh dlya profilaktiki kariesa zubov. Mezhdunarodnyy studencheskiy vestnik. 2016;3-3:450-451. [M.A. Dzarasova, O.V. Neelova. Features of the chemical composition of some toothpastes recommended for the prevention of dental caries. International Student Bulletin. 2016;3-3:450-451. (In Russ.)]. https://elibrary.ru/item.asp?id=26088812
17. Rotenfel'd S.A., Blinov A.V., Bordina D.A., Lopina N.P. Analiz himicheskogo sostava populyarnyh zubnyh past dlya otbelivaniya. Molodezh', nauka, medicina. 2019:213. [S.A. Rotenfeld, A.V. Blinov, D.A. Borodina, N.P. Lapina. Analysis of the chemical composition of popular toothpastes for whitening. Youth, science, medicine. 2019:213. (In Russ.)]. https://elibrary.ru/item.asp?id=38513748
18. Berezovikova P.P. Zaschischaet li zubnaya pasta nashi zuby? Yunyy uchenyy. 2020;S2-1;(32-1):4-6. [P.P. Berezovikova. Does toothpaste protect our teeth? Young Scientist. 2020;S2-1;(32-1):4-6. (In Russ.)]. https://elibrary.ru/item.asp?id=42519964
19. Ulitovskiy S.B., Antipova A.V. Issledovanie effektivnosti primeneniya otdel'nyh zubnyh past s razlichnymi aktivnymi komponentami. Uchenye zapiski SPBGMU Im. Akad. I.P. Pavlova. 2018;5(2):57-61. [S.B. Ulitovskiy, A.V. Antipova. Investigation of the effectiveness of the use of individual toothpastes with various active ingredients. Scientific notes of St. Petersburg State Medical University named after Acad. I.P. Pavlova. 2018;5(2):57-61. (In Russ.)]. https://doi.org/10.24884/1607-4181-2018-25-2-57-61
20. Fleysher G.M. Sovremennaya klassifikaciya lechebno-profilakticheskih zubnyh past. Stomatologiya detskogo vozrasta i profilaktika. 2005;1-2:39-41. [G.M. Fleisher. Modern classification of therapeutic and prophylactic toothpastes. Dentistry of childhood and prevention. 2005;1-2:39-41. (In Russ.)]. https://elibrary.ru/item.asp?id=9477888
21. Smetanin A.A., Ekimov E.V., Skripkina G.I. Ionoobmennye processy v emali zubov i sredstva dlya ee remineralizacii (obzor literatury). Stomatologiya detskogo vozrasta i profilaktika. 2020;1(73):77-80. [A.A. Smetanin, E.V. Ekimov, G.I. Skripkina. And Ion exchange processes in tooth enamel and means for its remineralization (literature review). Pediatric dentistry and prevention. 2020;1(73):77-80. (In Russ.)]. https://doi.org/10.33925/1683-3031-2020-20-1-77-80
22. Kadirova R.S., Muhamedov I.M. Biologiya polosti rta pri ispol'zovanii razlichnyh zubnyh past. Stomatologiya. 2018;4:67-70. [R.S. Kadirova, I.M. Mukhamedov. Biology of the oral cavity when using various toothpastes. Stomatologiya 2018;4:67-70. (In Russ.)]. https://doi.org/10.26739/2091-5845-2018-1-28
23. Sashina M.A. Ocenka effektivnosti primeneniya kompleksnoy zubnoy pasty s nanogidroksiapatitom i osvetlyayuschimi fermentami. Nacional'noe zdorov'e. 2018;4:84-90. [M.A. Sazhina. Evaluation of the effectiveness of the use of complex toothpaste with nanohydroxyapatite and clarifying enzymes. National Health. 2018;4:84-90. (In Russ.)]. https://elibrary.ru/item.asp?id=36824766
24. Sohova I.A., Doroshina V.Yu., Polyakova M.A., Margaryan E.G. Sravnitel'naya ocenka effektivnosti zubnyh past dlya snizheniya giperetezii pri vospalitel'nyh zabolevaniya parodonta. Stomatologiya. 2020;99(1):27-32. [I.A. Sokhova, V.Yu. Doroshina, M.A. Polyakova, E.G. Margaryan. Comparative evaluation of the effectiveness of toothpastes to reduce hyperesthesia in inflammatory periodontal diseases. Stomatologiya. 2020;99(1):27-32. (In Russ.)]. https://doi.org/10.17116/stomat20209901127
25. Saliasi I., Llodra J.K., Bravo M. et al. Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial // Int J Environ Res Public Health. - 2018;15(12):2660. https://doi.org/10.3390/ijerph15122660
26. Midda M.W. Cooksey. Clinical uses of an enzyme-containing dentifrice // J Clin Periodontol. - 1986;13(10):950-956. https://doi.org/10.1111/j.1600-051x.1986.tb01433.x
27. Sreenivasan P.K., Kakarla V.V.P., Sharda S. et al. The effects of a novel herbal toothpaste on salivary lactate dehydrogenase as a measure of cellular integrity // Clin Oral Invest. - 2021;25:3021-3030. https://doi.org/10.1007/s00784-020-03623-8.
28. Tadiconda A., Pentapati K.-C., Urala A.-S., Acharya S. Anti-plaque and anti-gingivitis effect of Papain, Bromelain, Miswak and Neem containing dentifrice: a rabdomized controller trial // J Clin Exp Dent. - 2017;9:1-6. https://doi.org/10.4317/jced.53593.
29. Adams S.E., Arnold D., Murphy B., Carroll P.,. Green A.K. et al. A randomized clinical study to determine the effect of a toothpaste containing enzymes and proteins on plaque oral microbiome ecology // Sci. Rep. - 2017;7. https://doi.org/10.1038/srep43344
30. Daily S., Seong J., Newcombe R. et al. A randomized clinical trial to determine the effect of a toothpaste containing enzymes and proteins on gum health over 3 month // Journal of Dentistry. - 2019;80:26-32. https://doi.org/10.1016/j.jdent.2018.12.002
31. Adams S.E., Arnold D., Murphy B., Carroll P. Green A.K., Smith A.M., Marsh P.D., Chen T., Marriott R.E. Brading. A randomised clinical study to determine the effect of a toothpaste containing enzymes and proteins on plaque oral microbiome ecology // Scientific reports. - 27;7:43344. https://doi.org/10.1038/srep43344 1-12.
32. Amizic I.P., Cigic L., Gavic L., Radic M., Lukenda D.B., Tonkic., Barisic I.G. Antimicrobial efficacy of probiotic - containing toothpastes: an invitro evaluation // Medicinski Glasnic. - 2017;1(14):139-144. https://doi.org/10.17392/870-16.
33. Avramova O.G., Zaborskaya A.R., Kulazhenko T.V., Goryacheva V.V., Skripkina G.I. Rol' ftoridnyh zubnyh past v profilaktike fissurnogo kariesa u detey. Stomatologiya. 2017;96(6-2):51-52. [O.G. Avramova, A.R. Zaborskaya, T.V. Kulazhenko, V.V. Goryacheva, G.I. Skripkina. The role of fluoride toothpastes in the prevention of fissure caries in children. Dentistry. 2017;96(6-2):51-52. (In Russ.)]. https://elibrary.ru/item.asp?id=35389757
34. Avraamova O.G., Zaborskaya A.R., Skripkina G.I., Zhorova T.N. Vliyanie zubnyh past na sostoyanie tverdyh tkaney postoyannyh zubov u detey. Stomatologiya detskogo vozrasta i profilaktika. 2014;13(2-49):53-56. [O.G. Avraamova, A.R. Zaborskaya, G.I. Skripkina, T.N. Zhorova. Toothpastes influence on a condition of teeth hard tissues at children. Pediatric dentistry and prophylaxis. 2014;13(2-49):53-56. (In Russ.)]. https://elibrary.ru/item.asp?id=22263933
35. Kupec T.V., Matelo S.K., Polyanskaya L.N., Zhugina L.F., Schur N.P. Sravnitel'naya ocenka effektivnosti razlichnyh detskih zubnyh past v profilaktike stomatologicheskih zabolevaniy u shkol'nikov mladshego vozrasta. Rossiyskiy vestnik perinatologii i pediatrii. 2021;57(4-1):46-151. [T.V. Kupets, S.K. Matelo, L.N. Polyanskaya, L.F. Zhugina, N.P. Shchur. Comparative evaluation of the effectiveness of various children's toothpastes in the prevention of dental diseases in younger schoolchildren. Russian Bulletin of Perinatology and Pediatrics. 2021;57(4-1):46-151. (In Russ.)]. https://elibrary.ru/item.asp?id=18814937
36. Matelo S.K., Kupec T.V., Akulovich A.V. Klinicheskiy podhod k vyboru zubnyh past na osnove antiseptikov i natural'nyh komponentov. Parodontologiya. 2007;3(44):69-72. [S.K. Matelo, T.V. Kupets, A.V. Akulovich. Clinical approach to the choice of toothpastes based on antiseptics and natural components. Periodontology. 2007;3(44):69-72. (In Russ.)]. https://elibrary.ru/item.asp?id=9924165
37. Makeeva I.M., Polyakova M.A., Hon Ya.A. Sravnitel'naya ocenka effektivnosti detskih lechebno-profilakticheskih zubnyh past, soderzhaschih ftorid i gidroksiapatit. DENTAL FORUM. 2013;4(50):39-42. [I.M. Makeeva, M.A. Polyakova, Ya.A. Khon. Comparative evaluation of the effectiveness of children's therapeutic and prophylactic toothpastes containing fluoride and hydroxyapatite. DENTAL FORUM. 2013;4(50):39-42. (In Russ.)]. https://doi.org/10.17116/stomat20189705134
38. Gerasimova L.P., Kabirova M.F., Usmanova I.N., Gadiullin A.M. Vliyanie lechebno-profilakticheskih zubnyh past na processy svobodnoradikal'nogo okisleniya v model'nyh sistemah i rotovoy zhidkosti u pacientov s hronicheskim gingivitom. Parodontologiya. 2016;21;2(79):53-56. [L.P. Gerasimova, M.F. Kabirova, I.N. Usmanova, A.M. Gadiullin. Influence therapeutic and prophylactic toothpaste on free radical oxidation processes in model systems and oral fluid of patients with chronic gingivitis. Parodontologiya. 2016;21;2(79):53-56. (In Russ.)]. https://doi.org/10.17116/stomat20209901127
39. Makeeva I.M., Polyakova M.A., Hon Ya.A. Sravnitel'naya ocenka effektivnosti detskih lechebno-profilakticheskih zubnyh past, soderzhaschih ftorid i gidroksiapatit. Dental Forum. 2013;4:39-42. [I.M. Makeeva, M.A. Polyakova, Ya.A. Khon. Comparative evaluation of the effectiveness of children's therapeutic and prophylactic toothpastes containing fluoride and hydroxyapatite. Dental Forum 2013;4:39-42. (In Russ.)]. https://doi.org/10.17116/stomat20189705134
40. Uspenskaya O.A., Trefilova O.V., Lenkovich E.N. Sravnitel'naya harakteristika effektivnosti zubnyh past, imeyuschih v svoem sostave kal'ciy i ftor. Endodontiya Today. 2019;17(4):8-11. [O.A. Uspenskaya, O.V. Trefilova, E.N. Levkovich. Comparative characteristics of the effectiveness of toothpastes containing calcium and fluoride. Endodontics Today. 2019;17(4):8-11. (In Russ.)]. https://doi.org/10.36377/1683-2981-2019-17-4-8-11
41. Zhil'cova E.S., Scherbakova T.A. Rol' zubnyh past v profilaktike kariesa zubov. Byulleten' medicinskih internet konferenciy. 2015;5(10):1237. [E.S. Zhiltsova, T.A. Shcherbakova. The role of toothpastes in the prevention of dental caries. Bulletin of medical Internet conferences. 2015;5(10):1237. (In Russ.)]. https://elibrary.ru/item.asp?id=24931649
42. Zykov A.G. Optimizaciya metodov profilaktiki osnovnyh stomatologicheskih zabolevaniy u detey mladshego shkol'nogo vozrasta i podrostkov. Problemy stomatologii. 2014;3:54-56. [A.G. Zykov. Optimization of methods for the prevention of major dental diseases in primary school children and adolescents. Actual problems in dentistry. 2014;3:54-56. (In Russ.)]. https://elibrary.ru/item.asp?id=21774954
43. Ekimov E.V., Smetanin A.A. Povyshenie effektivnosti profilakticheskih meropriyatiy kariesa zubov v detskom vozraste s ispol'zovaniem remineraliziruyuschey terapi. Stomatologiya detskogo vozrasta i profilaktika. 2018;3(66):18-22. [E.V. Ekimov, A.A. Smetanin. Improving the effectiveness of preventive measures of dental caries in childhood using remineralizing therapy. Pediatric Dentistry and Prevention. 2018;3(66):18-22. (In Russ.)]. https://doi.org/10.25636/PMP.3.2018.3.3
44. Bondarenko A.V., Yarceva A.V. Sravnitel'nyy analiz detskih zubnyh past. Zdorov'e i obrazovanie v XXI veke. 2009;11(2):108. [A.V. Bondarenko, A.V. Yartseva. Comparative analysis of children's toothpastes. Health and education in the XXI century. 2009;11(2):108. (In Russ.)]. https://elibrary.ru/item.asp?id=21686156
45. Sarap L.R., Podzorova E.A., Terent'eva N.V. Sravnitel'nye klinicheskie issledovaniya zubnyh past, soderzhaschih aminoftorid i ftorid natriya. Stomatologiya detskogo vozrasta i profilaktika. 2005;4(3-4):84-87. [L.R. Sarap, E.A. Podzorova, N.V. Terentyeva. Comparative clinical studies of toothpastes containing aminofluoride and sodium fluoride. Pediatric dentistry and prevention. 2005;4(3-4):84-87. (In Russ.)]. https://elibrary.ru/item.asp?id=9477928
46. Kuz'mina E.M., Lapatina A.V., Abdusalamova B.F., Lapteva L.I., Isaeva V.A. Effektivnost' zubnoy pasty s aminoftoridom dlya profilaktiki i lecheniya nachal'nogo kariesa zubov u detey. Dental forum. 2017;4:86-91. [E.M. Kuzmina, A.V. Lopatina, B.F. Abdusalamova, L.I. Lapteva, V.A. Isaeva. The effectiveness of toothpaste with aminofluoride for the prevention and treatment of initial dental caries in children. Dental forum. 2017;4:86-91. (In Russ.)]. https://elibrary.ru/item.asp?id=30504330
47. Gaysina E.F., Portnyagin A.V., Spicina T.P. Sovremennye razrabotki novyh zubnyh past s protivovospalitel'noy aktivnost'yu za period s 2017 po 2019 god. Problemy stomatologii. 2019;15(4):11-18. [E.F. Gaisina, A.V. Portnyagin, T.P. Spitsyna. Modern developments of new toothpastes with anti-inflammatory activity for the period from 2017 to 2019. Actual problems in dentistry. 2019;15(4):11-18. (In Russ.)]. https://doi.org/10.18481/2077-7566-2019-15-4-11-18
48. Eremin I.K., Proskuryakova A.S., Petrova A.P., Turusova E.V., Mahonova E.V. Protivovospalitel'nye pasty kak komponent kompleksnogo lecheniya zabolevaniy parodonta. Mezhdunarodnyy studencheskiy nauchnyy vestnik. 2018;4-1:140-142. [I.K. Eremin, A.S. Proskuryakova, A.P. Petrova, E.V. Turusova, E.V. Mazanova. Anti-inflammatory pastes as a component of complex treatment of periodontal diseases. International Student Scientific Bulletin. 2018;4-1:140-142. (In Russ.)]. https://elibrary.ru/item.asp?id=34930366
49. Varina N.R., Kurkin V.A., Avdeeva E.V., Zimenkina N.I., Bubnovich I.S. Obosnovanie sostava svoystv lechebno-profilakticheskoy zubnoy pasty na osnove antimikrobnoy i protivovospalitel'noy fitokompozicii. Sovremennye problemy farmakognozii. 2019:26-32. [N.R. Varina, V.A. Kurkin, E.V. Avdeeva, N.I. Zimenkina, I.S. Bubnovich. Substantiation of the composition of the properties of therapeutic and prophylactic toothpaste based on antimicrobial and anti-inflammatory phytocomposition. Modern problems of pharmacognosy. 2019:26-32. (In Russ.)]. https://elibrary.ru/item.asp?id=42939438
50. Kulazhenko T.V., Avraamova O.G., Vinnechenko Yu.A., Popovkina O.A., Ahmedova Z.R., Solov'eva T.A. Ocenka effektivnosti novyh otechestvennyh zubnyh past (lechebno-profilakticheskoy i gigienicheskoy). Stomatologiya. 2018;95(6-2 ):86. [T.V. Kulazhenko, O.G. Avraamova, Yu.A. Vinnichenko, O.A. Popovkina, Z.R. Akhmedova, T.A. Solovyova. Evaluation of the effectiveness of new domestic toothpastes (therapeutic, preventive and hygienic). Dentistry. 2018;95(6-2 ):86. (In Russ.)]. https://elibrary.ru/item.asp?id=28362687
51. Abdusalamova B.F., Borchalinskaya K.K., Benya V.N. Obosnovanie primeneniya lechebno-profilakticheskoy zubnoy pasty na osnove antioksidanta u pacientov s gingivitom. Dental Forum. 2018;3:49-54.[B.F. Abdusalamova, K.K. Borchalinskaya, V.N. Benya. Substantiation of the use of therapeutic and prophylactic toothpaste based on an antioxidant in patients with gingivitis. Dental Forum. 2018;3:49-54. (In Russ.)]. https://elibrary.ru/item.asp?id=35562290
52. Oksuzyan A.V., Bulatov R.R., Andreeva A.A. Osobennosti mineralizuyuschih svoystv slyuny pri ispol'zovanii zubnyh past na osnove fermentativnyh svoystv. Sovremennye problemy nauki i obrazovaniya. 2018;4:223. [A.V. Oksuzyan, R.R. Bulatov, A.A. Andreeva. Features of saliva mineralizing properties when using toothpastes based on enzymatic properties. Modern problems of science and education. 2018;4:223. (In Russ.)]. https://elibrary.ru/item.asp?id=36345052
53. Sälzer S., Rosema N., Hennequin-Hoenderdos N.L., Slot D.E., Timmer C., Dörfer C.E. et al. The effectiveness of a dentifrice without sodium lauryl sulphate on dental plaque and gingivitis - a randomized controlled clinical trial // Int J Dent Hyg. - 2017;15(3):203-210. https://doi.org/10.1111/idh.12201.
54. Green. A.K., Crichard S., Ling-Mountford N., Milward M., Hubber N., Platten S., Gupta A. K., Scott A., Barfoot R. The effect of SLS - free toothpaste containing enzymes and proteins on oral mucosa sloughing // J. Dent. - 2019;80:33-39. https://doi.org/10.1016/j.jdent.2018.11.005.
55. Saleev R.A., Abdrashitova A.B., Gaynullina D.K., Mustafin I.G. Sravnitel'nyy analiz mikrobioty rotovoy zhidkosti u pacientov s psihonevrologicheskimi rasstroystvami pri primenenii zubnoy pasty s fermentom «Bromelayn». Parodontologiya. 2020;25(1):16-21. [R.A. Saleev, A.B. Abdrashitova, D.K. Gainullina, I.G. Mustafin. Comparative analysis of microbiota of oral fluid in patients with psychoneurological disorders using toothpaste with the enzyme «Bromelain». Parodontologiya. 2020;25(1):16-21. (In Russ.)]. https://doi.org/10.33925/1683-3759-2020-25-1-16-21.