Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Subject. Inflammatory periodontal diseases are accompanied by violations of the body's reactivity to the introduction of the pathogen. At various stages of the immune response, Pro-inflammatory cytokines are produced, such as interleukins 1, 6 (IL-1, IL-6), tumor necrosis factor-alpha (TNF-α), and chemokines in particular IL-8. Cytokines serve as an organizing system that forms and regulates the entire complex of protective reactions of the body, provides activation of various types of cells, including white blood cells, dendritic, endothelial, epithelial cells, fibroblasts, macrophages, lymphocytes, and others. They cause endothelial activation, leading to increased permeability, increased expression of adhesive molecules, and increased procoagulant activity. The appearance of interleukins in the focus of inflammation causes the production of tissue factor, Willebrand factor, plasminogen activators, etc., which stimulate the reactions of vascular-platelet hemostasis, which activate the Pro-enzyme-enzyme cascade of blood clotting and fibrinolysis. The aim — to study the effect of cytokines on the hemostatic system in individuals with healthy periodontitis, chronic gingivitis, and chronic generalized periodontitis. Methodology. 60 cadets aged 18 to 25 years participated in the clinical study at the dental office of the medical unit No. 1 of the medical and sanitary unit of the Ministry of Internal Affairs of the Russian Federation (Ufa). The study group consisted of 45 people: 15 patients with intact periodontitis, 15 patients with moderate chronic gingivitis, and 15 patients with moderate chronic generalized periodontitis. Results. Correlations between IL-1β, IL-6, TNF-α, and IL-8 in gingival sulcus flushes, pockets, and hemostasis parameters were revealed. Conclusions. In inflammatory periodontal diseases, interleukins can inhibit fibrinolysis, leading to hypercoagulation. Increased thrombosis contributes to the progression of gingivitis to periodontitis.
gingivitis, periodontitis, cytokines, hemostasis, cadets
1. Barer G.M., Kocherzhinskiy V.V., Halitova E.S. Desnevaya zhidkost' - ob'ektivnyy kriteriy ocenki sostoyaniya tkaney parodonta. Stomatologiya. 1987;1:28-29. [G.M. Barer, V.V. Kocherzhinsky, E.S. Khalitova. Gingival fluid-an objective criterion for evaluating the state of periodontal tissues. Dentistry. 1987;1:28-29. (In Russ.)].
2. Belikov P.P. Processy fibrinoobrazovaniya i fibrinoliza v fiziologii i patologii parodonta (obzor). Stomatologiya. 1986;65;2:88-90. [P.P. Belikov. Processes of fibrin formation and fibrinolysis in the physiology and pathology of periodontal disease (review). Dentistry. 1986;65;2:88-90. (In Russ.)].
3. Baluda V.P., Barkagan Z.S., Gol'berg E. D. Laboratornye metody issledovaniya sistemy gemostaza. Tomsk. 1980:233. [V.P. Baluda, Z.S. Barkagan, E.D. Golberg. laboratory methods for studying the hemostasis system. Tomsk. 1980:233. (In Russ.)].
4. Kuznik B.I. Kletochnye i molekulyarnye mehanizmy regulyacii sistemy gemostaza v norme i patologii. Chita: Ekspress-izdatel'stvo. 2010:832. [B.I. Kuznik. Cellular and molecular mechanisms of regulation of the hemostatic system in normal and pathological conditions. Chita: Express publishing house. 2010:832. (In Russ.)].
5. Kuznik B.I., Cybikov N.N., Vitkovskiy Yu.A. Edinaya kletochno-gumoral'naya sistema zaschity organizma. Tromboz, gemostaz, reologiya. 2005;2(22):3-15. [B.I. Kuznik, N.N. Tsybikov, Yu.A. Vitkovsky. Unified cellular and humoral system of body protection. Thrombosis, hemostasis, rheology. 2005;2(22):3-15. (In Russ.)].
6. Koval'chuk L.V. i dr. Rol' citokinov v mehanizmah razvitiya hronicheskogo vospaleniya v tkanyah parodonta. Immunologiya. 2000;6:24-26. [L.V. Kovalchuk et al. The role of cytokines in the mechanisms of development of chronic inflammation in periodontal tissues. Immunology. 2000;6:24-26. (In Russ.)].
7. Kuznik B.I., Tsybikov N.N. Immune mechanisms regulating the haemostasis system // Hematology review. - 1992;3;2:3-20.
8. Schindler R. et al. Correlations and Interactions in the production of Interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear Sells: IL-6 suppresses IL-1 and TNF // Blood. - 1990;75:40-47.
9. Mamedov R.M., Sadygova N.N., Ibragimova L.K. Optimizaciya metodov profilaktiki i lecheniya vospalitel'nyh zabolevaniy parodonta. Problemy stomatologii. 2019;15;2:114-121. [R.M. Mamedov, N.N. Sadigova, L.K. Ibragimova. Optimization of methods of prevention and treatment of inflammatory periodontal diseases. Actual problems in dentistry. 2019;15;2:114-121. (In Russ.)]. https://elibrary.ru/item.asp?id=39165973
10. Mantovani A., Bussolino F., Introna M. Cytokine regulation of endotelial cell fuction: from molecular level to the bed side // Immunology todey. - 1997;18:231-239.
11. Bazarnyy V.V., Polushina L.G., Maksimova A.Yu., Svetlakova E.N., Mandra Yu.V. Patogeneticheskoe obosnovanie novyh podhodov k ocenke sostoyaniya tkaney polosti rta pri hronicheskom generalizovannom parodontite. Problemy stomatologii. 2018;14;4:14-18. [V.V. Bazarny, L.G. Polushina, A.Yu. Maksimova, E.N. Svetlakova, Yu.V. Mandra. Pathogenetic justification of new approaches to assessing the state of oral tissues in chronic generalized periodontitis. Actual problems in dentistry. 2018;14;4:14-18. (In Russ.)]. https://elibrary.ru/item.asp?id=36777701
12. Kuznecova N.S., Kabirova M.F., Gerasimova L.P., Haybullina R.R., Kogina E.N., Miftahova Z.K. Pokazateli gemodinamiki tkaney parodonta u lic molodogo vozrasta v sostoyanii psihoemocional'nogo napryazheniya. Problemy stomatologii. 2018;14;1:37-42. [N.S. Kuznetsova, M.F. Kabirova, L.P. Gerasimova, R.R. khaybullina, E.N. Kogina, Z.K. Miftakhova. Indicators of hemodynamics of periodontal tissues in young people in a state of psychoemotional stress. Actual problems in dentistry. 2018;14;1:37-42. (In Russ.)]. https://elibrary.ru/item.asp?id=32840687
13. Robustova T.G. Immunnyy status v polosti rta. Moskva. 1990:30. [T.G. Robustova. Immune status in the oral cavity. Moscow. 1990:30. (In Russ.)].
14. Simbircev A.S. Rol' citokinov v regulyacii fiziologicheskih funkciy immunnoy sistemy. Fiziologiya i patologiya immunnoy sistemy. 2004;10:3-9. [A.S. Simbirtsev. the Role of cytokines in the regulation of physiological functions of the immune system. Physiology and pathology of the immune system. 2004;10:3-9. (In Russ.)].
15. Samoylenko A.V., Maschenko I.S., Makarevich A.Yu. Disbalans v sisteme citokinov bol'nyh generalizovannym parodontitom i ego korrekciya citokinoterapiey. Sovremennaya stomatologiya. 2001;2:41-43. [A.V. Samoylenko, I.S. Mashchenko, A.Yu. Makarevich. Disbalance in the cytokine system of patients with generalized periodontitis and its correction by cytokine therapy. Modern dentistry. 2001;2:41-43. (In Russ.)].
16. Sehgal P.B., Wang L., Rayanade R. Interleukin-6-type cytokines // Annual of New York academy of sciences. - 1995;762:1-14.
17. Shmagel' K.V., Belyaeva O.V., Chereshnev V.A. Sovremennye vzglyady na immunologiyu parodonta. Stomatologiya. 2003;1:61-64. [K.V. Shmagel, O.V. Belyaeva, V.A. Chereshnev. Modern views on the immunology of periodontal. Dentistry. 2003;1:61-64. (In Russ.)].
