from 01.01.2002 to 01.01.2019
Barnaul, Barkaul, Russian Federation
from 01.01.2001 to 01.01.2019
Barnaul, Barkaul, Russian Federation
from 01.01.2015 to 01.01.2019
Barnaul, Barkaul, Russian Federation
UDK 61 Медицина. Охрана здоровья
GRNTI 76.29 Клиническая медицина
OKSO 31.07.01 Клиническая медицина
BBK 566 Стоматология
BISAC MED016020 Dentistry / Dental Hygiene
The preventive direction in dentistry is the leading one today. Individual oral hygiene plays a significant role in preventing the development of inflammatory periodontal diseases. The use of therapeutic and prophylactic toothpastes containing natural components with antibacterial properties is promising. Among plant extracts, grapefruit extract has the most pronounced antimicrobial activity. LysoTech and ProteLyse lysates, which have antimicrobial and immunomodulatory effects, have long been used in dentistry in the form of tablets for resorption in the complex treatment of various diseases. Their introduction into toothpastes is also considered a promising direction for the prevention and treatment of oral pathology. The aim of our study was to clinically evaluate the effectiveness of therapeutic and prophylactic toothpaste, which contains grapefruit extract and LysoTech and ProteLyse lysates, in patients with inflammatory diseases of periodontal tissues. A clinical and laboratory comparative study of two therapeutic and prophylactic toothpastes was conducted. The composition of the samples was identical, except for two components: grapefruit extract and LysoTech and ProteLyse lysates. The study involved 60 volunteers who were divided into two groups depending on the toothpastes used. The purifying and anti-inflammatory effects of the samples were evaluated for one month. An in vitro laboratory study was also conducted to identify the antimicrobial properties of toothpastes. During the work, high clinical results were noted in a group of volunteers using toothpaste with grapefruit seed extract and bacterial lysates, which are expressed in a decrease in PMA and SBI indices, and an improvement in oral hygiene. According to a laboratory study, the toothpaste containing grapefruit extract and LysoTech and ProteLyse lysates has a more pronounced antimicrobial and antifungal effect, which indicates a high preventive and therapeutic potential of the test sample.
periodontal inflammatory diseases, prevention, toothpaste, grapefruit extract, LysoTech and ProteLyse lysates, dentistry
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