employee
Moskva, Moscow, Russian Federation
employee
Omsk, Omsk, Russian Federation
employee
Omsk, Omsk, Russian Federation
Omsk, Omsk, Russian Federation
Background. Preventive measures that are implemented through the introduction of regional prevention programs have a massive focus and do not lead to a decrease in dental morbidity, because they are based on routine preventive measures without taking into account the individual characteristics of metabolic processes in the patient's oral cavity. All this confirms the need to abandon the mass approach when carrying out preventive measures, and requires the search for modern methods for predicting dental caries, based on predictive diagnostics of the risk of caries, which should be a key element of clinical examination of the pediatric population by a dentist. Purpose of the study: on the basis of a comprehensive clinical and laboratory approach with the use of mathematical analysis of the obtained data on homeostasis of the oral cavity, to establish predictors of the development of the carious process in children in order to determine the possibility of predicting dental caries during the period of mixed bite. Methodology. To achieve this goal, a comprehensive clinical and laboratory examination of metabolic processes in the oral cavity was carried out in 60 caries-resistant children during the period of mixed bite: from 7 to 12 years. Statistical analysis was performed using the STATISTICA 8.0 software. Results. According to the results of the study, strong relationships were revealed between individual clinical and laboratory indicators-predictors, an optimal set of predictors was established for constructing classification models for patients with different types of MCS, which is a prerequisite for the possibility of predicting the risk of caries development in children during the mixed bite period. Conclusions. An optimal set of predictors has been established for constructing classification models for patients with different types of ISS for creating computer programs aimed at preclinical diagnostics of the subclinical course of the carious process with access to prediction, which will allow planning individual primary preventive measures in children during the period of active formation of hard dental tissues.
clinical and laboratory research, caries predictors, caries-resistant children, changeable bite, computer programs, preclinical diagnostics
1. Belskaya, L. V., Golovanova, O. A., Shukailo, E. S. (2010). Kristallizatsiya biologicheskikh zhidkostey - perspektivy ispol'zovaniya pri diagnostike [Crystallization of biological liquids: - prospects for use in diagnosis]. Butlerovskiye soobshcheniya [Butlerov messages], 15 (23), 52-56. (In Russ.)
2. Borovikov, V. A. (2001). STATISTICA: iskusstvo analiza dannykh na komp'yutere dlya professionalov [STATISTICA: the art of computer data analysis for professionals]. St. Petersburg, 635. (In Russ.)
3. Voloshina, I. M., Skripkina, G. I., Makarov, S. E., Pitaeva, A. N., Solonenko, A. P. (2015). Mineralizuyushchiy potentsial rotovoy zhidkosti : svidetel'stvo o gosudarstvennoy Registratsii programmy dlya EVM Rossiyskaya Federatsiya [Mineralizing potential of oral fluid. Certificate of state registration of a computer program Russian Federation]. 20155612583, 24.02.15. (In Russ.)
4. Ekimov, E. V. (2017). Kliniko-laboratornyye osobennosti techeniya i konservativnogo lecheniya nachal'nogo kariyesa zubov u detey pri razlichnoy aktivnosti karioznogo protsessa :diss. … kand. med. nauk [Clinical and laboratory features of the course and conservative treatment of initial dental caries in children with various activity of the carious process : diss. ... cand. med sciences]. Perm, 197. (In Russ.)
5. Zyryanov, B. N., Ongoev, P. A., Ongoev, A. P. (2001). Mikrotvordost' zubnykh tkaney v patogeneze kariyesa zubov u naseleniya Kraynego Severa Zapadnoy Sibiri [Microhardness of dental tissues in the pathogenesis of dental caries in the population of the Far North of Western Siberia]. Novoye v stomatologii [New in dentistry], 10, 94-95. (In Russ.)
6. Yuldashkhonova, A. S., Abdullaev, J. R., Khudanov, B. O., Khasanov, D. M. (2012). Otsenka effektivnosti profilaktiki kariyesa zubov u detey, osnovannaya na metodakh ikh prognozirovaniya [Evaluation of the effectiveness of the prevention of dental caries in children, based on methods for their prediction]. Vrach-aspirant [Graduate student], 51 (2.1), 164-169. (In Russ.)
7. Kuzmina, I. N. (2013). Profilaktika kariyesa zubov v razlichnykh vozrastnykh gruppakh naseleniya (monitoring, taktika, metody, programmy) : avtoref. dis. … d-ra med. nauk [Prevention of dental caries in different age groups of the population (monitoring, tactics, methods, programs) : author. dis. ... dr. med. sciences]. Moscow : Moscow State University of Medicine and Dentistry, 54. (In Russ.)
8. Kuzmina, I. N., Smirnova, T. A., Vasina, C. A. (2011). Dinamika pokazateley intensivnosti kariyesa zubov u 6-letnikh detey Rossii za period s 1998 po 2008 g. [The dynamics of the intensity of dental caries in 6-year-old children of Russia for the period from 1998 to 2008]. VIII Vserossiyskaya nauchno-prakticheskaya konferentsiya «Obrazovaniye, nauka i praktika v stomatologii» [VIII of the All-Russian Scientific and Practical Conference "Education, Science and Practice in Dentistry"], Moscow, 82-83. (In Russ.)
9. Ed. Kuzmina, E. M. (1999). Stomatologicheskaya zabolevayemost' naseleniya Rossii [Dental morbidity of the population of Russia]. Moscow : Informelektro, 263. (In Russ.)
10. Ed. Kuzmina, E. M. (2009). Stomatologicheskaya zabolevayemost' naseleniya Rossii. Sostoyaniye tverdykh tkaney zubov. Rasprostranennost' zubochelyustnykh anomaliy. Potrebnost' v protezirovanii [Dental morbidity of the population of Russia. The state of hard tooth tissue. The prevalence of dental anomalies. The need for prosthetics]. Moscow : MSUMD. (In Russ.)
11. Kuzmina, E. M., Yanushevich, O. O., Kuzmina, I. N. (2019). Stomatologicheskaya zabolevayemost' naseleniya Rossii [Dental morbidity of the population of Russia]. Moscow : MSUMD. (In Russ.)
12. Kuzmina, E. M., Yanushevich, O. O., Kuzmina, I. N., Lapatina, A. V. (2020). Tendentsii rasprostranennosti i intensivnosti kariyesa zubov sredi naseleniya Rossii za 20-letniy period [Trends in the prevalence and intensity of dental caries among the population of Russia over a 20-year period]. DENTAL FORUM [DENTAL FORUM], 3 (78), 2-8. (In Russ.)
13. Leontyev, V. K., Konarev, A. V. (2017). O kachestve okazaniya stomatologicheskoy pomoshchi [On the quality of dental care]. Stomatologiya dlya vsekh [Dentistry for everyone], 1, 6-10. (In Russ.)
14. Leontyev, V. K. (1978). Kariyes i protsessy mineralizatsii. (Razrabotka metodicheskikh podkhodov, molekulyarnyye mekhanizmy, patogeneticheskoye obosnovaniye printsipov profilaktiki i lecheniya) : diss. … d-ra med. nauk [Caries and mineralization processes. (Development of methodological approaches, molecular mechanisms, pathogenetic substantiation of the principles of prevention and treatment) : diss. … d-ra med. sciences]. Moscow, 541. (In Russ.)
15. Leontyev, V. K., Pitaeva, A. N., Skripkina, G. I., Adkina, G. V. (2017). Vliyaniye sostava i svoystv rotovoy zhidkosti na energeticheskoye vzaimodeystviye v sisteme emal'-slyuna [Influence of the composition and properties of the oral fluid on the energy interaction in the enamel-saliva system]. Materialy XXIV Mezhdunarodnogo yubileynogo simpoziuma "Innovatsionnyye tekhnologii v stomatologii", posvyashchennogo 60-letiyu stomatologicheskogo fakul'teta Omskogo Gosudarstvennogo Meditsinskogo Universiteta [Materials of the XXIV International Jubilee Symposium "Innovative Technologies in Dentistry" dedicated to the 60th anniversary of the Faculty of Dentistry of Omsk State Medical University], 240-243. (In Russ.)
16. Leus, P. A. (1997). Kliniko-eksperimental'noye issledovaniye patologii, patogeneticheskoy konservativnoy terapii i profilaktiki kariyesa zubov : avtoref. … d-ra med nauk [Clinical and experimental study of pathology, pathogenetic conservative therapy and prevention of dental caries : author. ... doctor of medical sciences]. Minsk, 30. (In Russ.)
17. Lukashevich, I. K., Vardugina, O. K., Gorbunova, I. L. (2018). Obosnovaniye vybora sredstv profilaktiki kariyesa u beremennykh s uchetom chastoty polimorfizma gena kallekreina-4 [Substantiation of the choice of means for the prevention of caries in pregnant women, taking into account the frequency of polymorphism of the kallecrein-4 gene]. Sovremennaya stomatologiya [Modern dentistry], 2 (39), 39-40. (In Russ.)
18. Naronova, N. A., Molvinskikh, V. S., Belokonova, N. A., Olshvang, O. Yu. (2019). Effektivnost' remineralizuyushchey terapii u detey [The effectiveness of conservative therapy in children]. Problemy stomatologii [Actual problems in dentistry], 15 (3), 47-54. (In Russ.)
19. Okushko, V. R. (2012). Problema kariyesa v koordinatakh biologii cheloveka i ekonomiki [Problem of caries in the coordinates of human biology and economics]. Klinicheskaya stomatologiya [Clinical Dentistry], 3 (63), 30-36. (In Russ.)
20. Eds. Pitaeva, A. N., Korshunov, A. P., Suntsov, G. G. (2001). Fiziko-khimicheskiye metody issledovaniya smeshannoy slyuny v klinicheskoy i eksperimental'noy stomatologii : uchebnoye posobiye [Physicochemical methods for the study of mixed saliva in clinical and experimental dentistry: a training manual]. Omsk : Omsk State Medical Academy, 71. (In Russ.)
21. (2003). Prikaz ot 30 dekabrya 2003 g. N 620 «Ob utverzhdenii protokolov vedeniya detey, stradayushchikh stomatologicheskimi zabolevaniyami». «O strategii snizheniya zabolevayemosti kariyesom zubov v Rossii v usloviyakh defitsita gosudarstvennogo finansirovaniya stomatologii» [Order of December 30, 2003 N 620 On the approval of the protocols "management of children suffering from dental diseases On the strategy of reducing the incidence of dental caries in Russia in the context of a shortage of state funding for dentistry]. (In Russ.)
22. Puzikova, O. Yu. (1999). Prognozirovaniye razvitiya kariyesa zubov s uchetom integrirovannykh pokazateley i matematicheskogo modelirovaniya : diss. … kand. med. nauk [Predicting the development of dental caries taking into account integrated indicators and mathematical modeling : diss. ... cand. med. sciences]. Omsk, 183. (In Russ.)
23. Razmakhnina, E. M. (2018). Klinicheskiye i molekulyarno-geneticheskiye osobennosti prognozirovaniya i otsenki effektivnosti profilaktiki kariyesa : avtoref. … kand. med. nauk [Clinical and molecular genetic features of predicting and evaluating the effectiveness of caries prevention : author. ... cand. med. sciences]. Ekaterinburg, 23. (In Russ.)
24. Rebrova, O. Yu. (2002). Statisticheskiy analiz meditsinskikh dannykh. Primeneniye paketa prikladnykh programm STATISTICA [Statistical analysis of medical data. Application of the STATISTICA application package]. Moscow : MediaSfera, 305. (In Russ.)
25. Silagadze, E. M., Salahov, A. K., Ksembaev, S. S., Bykeev, R. F. (2020). Faktory, vliyayushchiye na sostoyaniye stomatologicheskogo statusa naseleniya Rossii [Factors affecting the dental status of the Russian population]. Problemy stomatologii [Actual problems in dentistry], 16 (1), 47-57. (In Russ.)
26. Skripkina, G. I. (2014). Diagnostika urovnya zdorov'ya polosti rta i prognozirovaniye kariyesa zubov u detey [Diagnosis of the level of oral health and prediction of dental caries in children]. Omsk, 180. (In Russ.)
27. Skripkina, G. I. (2012). Donozologicheskaya diagnostika i prognozirovaniye karioznogo protsessa u detey (kliniko-laboratornoye issledovaniye, matematicheskoye modelirovaniye) : disc. … d-ra med. nauk [Donosological diagnosis and prediction of the carious process in children (clinical and laboratory research, mathematical modeling) : diss. … d-ra med. sciences]. Omsk, 443. (In Russ.)
28. Skripkina, G. I., Garifullina, A. Zh., Leus, P. A. (2017). Yevropeyskiye indikatory stomatologicheskogo zdorov'ya detey shkol'nogo vozrasta g. Omska [European indicators of dental health for schoolchildren in Omsk]. Materialy XXIV Mezhdunarodnogo yubileynogo simpoziuma "Innovatsionnyye tekhnologii v stomatologii", posvyashchennogo 60-letiyu stomatologicheskogo fakul'teta omskogo gosudarstvennogo meditsinskogo universiteta [Materials of the XXIV International Jubilee Symposium "Innovative Technologies in Dentistry" dedicated to the 60th anniversary of the Faculty of Dentistry of Omsk State Medical University], 449-451. (In Russ.)
29. Skripkina, G. I., Ekimov, E. V., Mityaeva, T. S. (2019). Sistemnyy podkhod k probleme prognozirovaniya kariyesa zubov [System approach to the problem of forecasting the caries of teeth]. Stomatologiya detskogo vozrasta, profilaktika i ortodontiya [Pediatric dentistry, prevention and orthodontics], 3 (15), 121-126. (In Russ.)
30. Skripkina, G. I., Ekimov, E. V., Nikitin, Yu. B., Korunov, A. P., Bernetsyan, T. L. (2020). Kolichestvennaya otsenka urovnya mineralizuyushchego potentsiala rotovoy zhidkosti u detey [Quantitative assessment of the level of mineralizing potential of oral fluid in children]. Problemy stomatologii [Actual problems in dentistry], 16 (1), 127-132. (In Russ.)
31. Skipkina, G. I., Pitaeva, A. N., Romanova, Yu. G., Golochalova, N. V. (2014). Kariyesogennost' zubnogo naleta i problema prognozirovaniya kariyesa zubov v detskom vozraste [Cariogenicity of dental plaque and the problem of predicting dental caries in childhood]. Stomatologiya detskogo vozrasta i profilaktika [Pediatric dentistry and prevention], 13, 2 (49), 9-11. (In Russ.)
32. Skipkina, G. I., Pitaeva, A. N., Voloshina, I. M., Suntsov, V. G. (2011). Sposob opredeleniya PH zubnogo naleta : patent 2424524 C1 Rossiyskoy Federatsii na izobreteniye [Method for determining the PH of plaque : invention patent RU 2424524 C1]. (In Russ.)
33. Skripkina, G. I., Khvostova, K. S., Weitz, S. V. (2010). Primeneniye elektrometrii tvordykh tkaney zubov u detey [The application of teeth hard tissue electrometry at children's]. Stomatologiya detskogo vozrasta i profilaktika [Pediatric dentistry and prophylaxis], 2 (33), 23-25. (In Russ.)
34. Ed. Trushevskaya, A. G. (1989). Stomatologicheskoye obsledovaniye: ssnovnyye metody [Dental examination : Basic methods]. 3, Geneva, 58. (In Russ.)
35. Shirobokova, V. G. (1974). Kliniko-biokhimicheskaya kharakteristika osadka smeshannoy slyuny v zdorovoy polosti rta i pri kariyese zubov : diss. … kand. med. nauk [Clinical and biochemical characteristics of sediment of mixed saliva in a healthy oral cavity and with dental caries : diss. … cand. med. sciences]. Omsk, 180. (In Russ.)
36. Yatsenko, A. K., Pervov, Yu. Yu., Trankovskaya, L. V. (2018). Nauchnoye obosnovaniye i optimizatsiya sistemy okazaniya profilakticheskoy i stomatologicheskoy pomoshchi detskomu naseleniyu v usloviyakh dal'nevostochnogo regiona [Scientific substantiation and optimization of the system for the provision of preventive and dental care to the children's population in the conditions of the Far Eastern region]. Problemy stomatologii [Actual problems in dentistry], 14, 3, 97-101. (In Russ.)
37. Bratthall, D., Hansel Petersson, G. (2005). Cariogramma multifactorial risk assessment model for a multifactorial disease. Com. Dent. Oral. Epidemiol, 33 (4), 256-264.
38. Kallestal, C., Wang, N. J., Petersen, P. E., Arnadottir, I. B. (1999). Caries-Preventive method used for children and adolescents in Denmark, Iceland, Norway, and Sweden. Com. Dent. Oral Epidemiol, 27, 2, 144-151.
39. Lulic-Dukis, O. et al. (2001). Factors predisposing to early childhood caries (ECC) in children of preschool age the city Zagreb, Croatia. Col. Anthropol, 25, 1, 297-302.
