MODERN ASPECTS OF ETIOPATHOGENESIS, CLINICS AND TREATMENT OF PATHOLOGY MUCOUS MEMBRANE OF MOUTH IN PATIONS WITH GASTROINTESTINAL TRACT DISEASES
Abstract and keywords
Abstract (English):
Subject. Despite the many pathogenetic links in the lesions of the gastrointestinal tract and oral mucosa, unresolved issues related to their etiopathogenesis, diagnosis and high-quality therapeutic and preventive measures. Among the various pathological processes manifesting on the oral mucosa, recurrent aphthous stomatitis is a chronic disease characterized by the appearance of secondary pathomorphological elements (aphthae) in response to the development of acute proliferative inflammation. The goal is the analysis and systematization of literature data on the problem of damage to the oral mucosa in acid-dependent diseases of the gastrointestinal tract. Methodology. Recurrent aphthae of the oral cavity belong to the chronic pathology of the oral mucosa, are characterized by a prolonged course and periodic relapses, which are most often associated with the state of somatic status, including the presence of acid-dependent diseases of the gastrointestinal tract. Results. The main pathomorphological element inherent in this pathology is aphtha. Its localization is the mucous membrane of the vestibule of the oral cavity, cheeks, and lateral surface of the tongue, visually oval or round, covered with a dirty white fibrinous coating. Treatment of recurrent aphthae of the oral cavity includes a complex consisting of general systemic therapy of the underlying disease. Local treatment includes the use of antihistamines, immunocorrection, drugs that increase nonspecific hypersensitivity, normalization of cellular metabolism and stimulate nonspecific defense mechanisms, vitamin therapy and physiotherapy methods. Conclusions. This treatment should ultimately be aimed at eliminating not only pain, but also at increasing local immunity factors, combating pathogenic microflora and promoting the epithelization of pathological processes on the oral mucosa. Of great importance in the treatment and prevention of recurrent aphthae is a comprehensive examination of the patient in order to identify risk factors.

Keywords:
oral mucosa, recurrent aphthosis, gastrointestinal tract diseases, risk factors, quality of life
References

1. Anisimova, I. V., Nagaeva, M. O. (2017). Analiz struktury zabolevaniy slizistoy obolochki rta i krasnoy kaymy gub po obrashcheniyam patsiyentov v GKSP № 1 g. Omsk [Analysis of the structure of diseases of the oral mucosa and the red border of the lips according to patients' appeals to GKSP №1 g. Omsk]. Materialy simpoziuma «Innovatsionnyye tekhnologii v stomatologii» [Materials of the Symposium "Innovative Technologies in Dentistry"], Omsk, 51-54. (In Russ.)

2. Blashkova, S. L., Fazylova, Yu. V., Ushakova, M. A. (2018). Sovremennyye aspekty mestnoy patogeneticheskoy terapii khronicheskogo retsidiviruyushchego stomatita [Current aspects of local pathogenetic therapy of chronic recurrent stomatitis]. Parodontologiya [Periodontology], 24 (4), 77-80. (In Russ.)

3. Bondarenko, O. V., Tokmakova, S. I., Shestun, K. B., Kiseleva, K. A. (2014). Sostoyaniye mikrobiotsenoza u patsiyentov pri razlichnykh zabolevaniyakh slizistoy obolochki rta [The state of microbiocenosis in patients with various diseases of the oral mucosa]. Problemy stomatologii [Actual Problems in dentistry], 5, 12-14 (In Russ.)

4. Volkov, E. A., Butova, V. G., Pozdnyakova, T. I., Dzugaeva, I. I. (2014). Klinicheskiye rekomendatsii (protokol lecheniya) khronicheskiy retsidiviruyushchiy aftoznyy stomatit [Clinical recommendation (treatment protocol) chronic recurrent aphthous stomatitis]. Rossiyskiy stomatologicheskiy zhurnal [Russian Dental Journal], 5, 35-49. (In Russ.)

5. Gazhva, S. I., Igolkina, N. A. (2013). Vzaimosvyaz' zabolevaniy vnutrennikh organov i sostoyaniya polosti rta [The relationship of diseases of the internal organs and the state of the oral cavity]. Terapevticheskiy arkhiv [Therapeutic Archive], 85, 10, 116-118. (In Russ.)

6. Gazhva, S. I., Kasumov, N. S. (2016). Vzaimosvyaz' strukturnykh izmeneniy polosti rta s diffuznymi porazheniyami pecheni [The relationship of structural changes in the oral cavity with diffuse lesions of the liver]. Pul's [Pulse], 18 (2), 99-101. (In Russ.)

7. Gazhva, S. I., Leskov, A. S., Shkarednaya, O. V. et al (2012). Otsenka stomatologicheskikh i obshchesomaticheskikh pokazateley kachestva zhizni u patsiyentov s gastroduodenal'noy patologiyey [Assessment of dental and somatic indicators of quality of life in patients with gastroduodenal pathology]. Obozreniye [Review], 1 (75), 25-32. (In Russ.)

8. Devlikanova, L. I., Shashmurina, V. R. (2014). Osobennosti parodontologicheskogo statusa i nuzhdayemost' v lechenii patsiyentov s soputstvuyushchey patologiyey zheludochno-kishechnogo trakta [Features of periodontal status and the need for treatment of patients with concomitant gastrointestinal tract pathology]. Uchenyye zapiski Orlovskogo gosuniversiteta [Scientific notes of Oryol State University], 1, 7, 41-42. (In Russ.)

9. Gazhva, S. I., Shkarednaya, O. V., Pyatova, Ye. D. (2013). Kompleksnyy podkhod k lecheniyu zabolevaniy slizistoy obolochki polosti rta u patsiyentov s khronicheskimi gastritami [An integrated approach to the treatment of diseases of the oral mucosa in patients with chronic gastritis]. Stomatologiya [Dentistry], 92, 6, 16-19. (In Russ.)

10. Prokhonchukov, A. A., Zhizhina, N. A., Grigoryants, L. A., Stebelkova, M. L. et al. (2008). Lecheniye zabolevaniy parodonta i slizistoy obolochki rta s primeneniyem lazernogo i magnito-lazernogo izlucheniy [Treatment of periodontal diseases and oral mucosa using laser and magneto-laser radiation]. Parodontologiya [Periodontology], 4, 36-38. (In Russ.)

11. Mikhalchenko, V. F., Temkin, E. S., Chizhikova, T. S., Petrukhin, A. G. et al. (2004). Primeneniye preparata «Kholisal» v kompleksnom lechenii zabolevaniy slizistoy obolochki polosti rta i parodonta [Use of the Cholisal preparation in the complex treatment of diseases of the oral mucosa and periodontium]. Vestnik Volgogradskogo gosudarstvennogo meditsinskogo universiteta [Bulletin of the Volgograd State Medical University], 12, 78-80. (In Russ.)

12. Orekhova, L. Yu., Atrushkevich, V. G., Mikhalchenko, D. V., Gorbacheva, I. A. et al. (2017). Stomatologicheskoye zdorov'ye i polimorbidnost': analiz sovremennykh podkhodov k lecheniyu stomatologicheskikh zabolevaniy [Dental health and polymorbidity: analysis of modern approaches to the treatment of dental diseases]. Parodontologiya [Periodontology], 22, 3, 15-17. (In Russ.)

13. Korchazhkina, N. B., Markina, L. A., Schukin, A. I. Et al. (2012). Primeneniye fotoforeza kolegelya u bol'nykh khronicheskim aftoznym stomatitom [The use of collegel photophoresis in patients with chronic aphthous stomatitis]. Fizioterapevt [Physiotherapist], 8, 28-33. (In Russ.)

14. Rabinovich, O. F. et al. (2015). Aspekty etiologii i patogeneza retsidiviruyushchego aftoznogo stomatita [Aspects of the etiology and pathogenesis of recurrent aphthous stomatitis]. Klinicheskaya stomatologiya [Clinical Dentistry], 4, 8-13. (In Russ.)

15. Rabinovich, O. F. et al. (2014). Lecheniye bol'nykh s retsidiviruyushchim aftoznym stomatitom, oslozhnennym disbakteriozom polosti rta [Treatment of patients with recurrent aphthous stomatitis complicated by oral dysbiosis]. Klinicheskaya stomatologiya [Clinical Dentistry], 3, 18-20. (In Russ.)

16. Robakidze, N. S., Schukina, O. B. (2019). Patogeneticheskiye aspekty porazheniya polosti rta pri vospalitel'nykh zabolevaniyakh kishechnika [Pathogenetic aspects of the defeat of the oral cavity in inflammatory bowel diseases]. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii [Russian Journal of Gastroenterology, Hepatology, Coloproctology], 29 (4), 15-21. (In Russ.)

17. Ed. Karakov, K. G. (2014). Retsidiviruyushchiye i rubtsuyushchiyesya afty pri zabolevaniyakh zheludochnokishechnogo trakta : uchebnoye posobiye [Recurrent and scarring aphthae in diseases of the gastrointestinal tract : textbook]. Stavropol : StGMU, 112. (In Russ.)

18. Karakov, K. G., Khachaturian, E. E., Vlasova, T. N., Oganyan, A. V., Vanchenko, N. B., Uzdenova, L. Kh., Khachaturian, A. E. (2018). Resheniye problemy lecheniya neytropenicheskikh aft slizistoy obolochki polosti rta [Solution of the problem of treatment of neuropenical aft mercular shell of the oral cavity]. Problemy stomatologii [Actual Problems in dentistry], 14, 4, 19-23. (In Russ.).

19. Bulkina, N. V., Tokmakova, E. V., Meleshina, O. V., Lomakina, D. O. (2012). Sovremennyye aspekty patogeneza i kompleksnoy terapii khronicheskogo retsidiviruyushchego aftoznogo stomatita [Modern aspects of pathogenesis and complex therapy of chronic recurrent aphthous stomatitis]. Fundamental'nyye issledovaniya [Fundamental research], 4-1, 30-33. (In Russ.)

20. Kosyuga, S. Yu., Klenina, V. Yu. (2014). Sovremennyye aspekty etiopatogeneza retsidiviruyushchego aftoznogo stomatita [Current aspects of the etiopathogenesis of recurrent aphthous stomatitis]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 6. (In Russ.)

21. Zhitkova, L. A., Kamluk, E. B., Monina, E. V. et al. (2018). Sovremennyye aspekty etiologii, patogeneza, kliniki, diagnostiki i lecheniya khronicheskogo aftoznogo stomatita [Modern aspects of the etiology, pathogenesis, clinic, diagnosis and treatment of chronic aphthous stomatitis]. Zdravookhraneniye Dal'nego Vostoka [Healthcare of the Far East], 1 (75), 44-46. (In Russ.)

22. Poluektova, E. A., Lyashenko, O. S., Shifrin. O. S., Sheptulin, A. A., Ivashkin, V. T. (2014). Sovremennyye metody izucheniya mikroflory zheludochno-kishechnogo trakta [Modern methods of studying the microflora of the gastrointestinal tract]. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii [Russian Journal of Gastroenterology, Hepatology, Coloproctology], 2, 85-91. (In Russ.)

23. Silantyeva, E. H., Berezina, H. V., Krivonos, S. M. (2013). Kompleksnoye lecheniye khronicheskogo retsidiviruyushchego stomatita s ispol'zovaniyem preparatov lineyki «Asepta» [Complex treatment of chronic recurrent stomatitis using Asepta drugs]. Prakticheskaya meditsina [Practical Medicine], 4 (72), 52-53. (In Russ.)

24. Starikova, I. V., Radyshevskaya, T. N., Pyslar, T. V., Dibtseva, T. S. (2017). Kompleksnoye lecheniye khronicheskogo retsidiviruyushchego aftoznogo stomatita [Complex treatment of chronic recurrent aphthous stomatitis]. Nauchnyy al'manakh [Scientific almanac], 4-3 (30), 268-271. (In Russ.)

25. Tokmakova, S., Starokozheva, L.Yu. (2008). Sposoby otsenki effektivnosti krioobezbolivaniya aft pri lechenii khronicheskogo retsidiviruyushchego aftoznogo stomatita [Methods for assessing the effectiveness of cryo-analgesia of aphthae in the treatment of chronic recurrent aphthous stomatitis]. Cathedra [Cathedra], 2, 14-19. (In Russ.)

26. Chernysheva, H. D. (2011). Rol' gamma-interferona v immunopatogeneze khronicheskogo retsidiviruyushchego stomatita [The role of gamma-interferon in the immunopathogenesis of chronic recurrent stomatitis]. Parodontologiya [Periodontology], 3 (60), 10-11. (In Russ.)

27. Shumsky, A. V. (2000). Imudon v lechenii infektsionno-vospalitel'nykh zabolevaniy slizistoy obolochki polosti rta [Imudon in the treatment of infectious and inflammatory diseases of the oral mucosa]. Stomatologiya [Dentistry], 6, 40-42. (In Russ.)

28. Rabinovich, S. A., Prikuls, V. F., Shlykova, E. I. (2013). Effektivnost' primeneniya krioterapii pri kompleksnom stomatologicheskom lechenii [The effectiveness of cryotherapy in complex dental treatment]. Stomatologiya [Dentistry], 4, 78-81. (In Russ.)

29. Solomon, L. W., Neiders, M., Zwick, M. G. (2007). Autoimmunity to delta Np63alpha in chronic ulcerative stomatitis. J. Dent. Res, 9, 826-831.

30. Ramose-Silva, M., Ferreira, A. F., Bibas, R. et al. (2006). Clinical evaluation of fluid extract of Chamomilla recutita for oral aphthae. J.Drugs Dermatol, 7, 612-617.

31. Solomon, L. W., Aguirre, A., Neiders, M. et al. (2003). Chronic ulcerative stomatitis: clinical, histopathologic and immunopathologic findings. Oral Surg. Oral Med. Oral Pathol Oral Radiol. Endod, 6, 718-726.

32. Cullough, M. G., Abdel-Hafeth, S., Scully, C. (2007). Recurrent aphthous stomatitis revisited; clinical features, associations, and new association with infant feeding practices. J. Oral. Pathol. Med, 36, 10, 615-620.

33. Richter, J., Grimmova, M., Stiborova, I. et al. (2003). Detection of Helicobacter pylori in the saliva of patients with recurrent aphthous stomatitis. Cas. Lek. Cesk, 11, 665-669.

34. Lewkowicz, N., Lewkowicz, P., Kurnatowska, A. et al. (2003). Innate immune system is implicated in recurrent apthous ulcer pathogenesis. J. Oral. Pathol. Med, 8, 475-481.

35. Kato, Y., Takoda, N., Ivasaki, K., Sugimoto, M. (2004). Use of solcoseril in aphthous stomatitis. Clin Dentist, 11, 17.

36. Koybasi, S., Parlak, A. H., Serin, E. et al. (2006). TRecurrent aphthous stomatitis: investigation of possible etiologic factors. Am J Otolaryngol, 27, 4, 229-232.

37. Scully, C., Porter, S. (2007). Oral mucosal disease: recurrent aphthous stomatitis. Br. J. Oral. Maxillofac. Surg, 10, 72-75.

38. Toche, P. P., Salinas, L. J., Guzman, M. et al. (2007). Recurrent oral ulcer: clinical characteristic and differential diagnosis. Rev. Chilena Infectol, 3, 215-219.

39. Scully, C., Porter, S. (2008). Oral mucosal disease: recurrent aphthous stomatitis. Br. Oral. Maxillofac. Surg, 46, 198-206.


Login or Create
* Forgot password?