DIAGNOSTIC SIGNIFICANCE OF SOME REPRESENTATIVES OF NORMAL MICROBIOME OF THE ORAL CAVITY IN THE DEVELOPMENT OF RECOVERABLE ACTS OF THE ORAL CAVITY IN PATIENTS WITH ACID-DEPENDENT GASTROINTESTINAL DISEASES
Abstract and keywords
Abstract (English):
Subject. The results of a comprehensive microbiological study of the state of the normobioma of the oral cavity in individuals with recurrent aphthae of the oral cavity against the background of acid-dependent diseases of the gastrointestinal tract are considered. The goal is to determine the diagnostic significance of individual representatives of the oral normobioma in patients with recurrent aphthae of the oral cavity against the background of acid-dependent diseases of the gastrointestinal tract. Methodology. The study involved 83 patients who were divided into two main and control groups depending on the clinical manifestations of recurrent aphthae of the oral cavity on the background of hypersecretory syndrome. Results. The results of the study showed that in patients of the first and second main groups, in which the manifestations of recurrent aphthae in the oral cavity were accompanied by diseases of the gastrointestinal tract with hypersecretory syndrome, the frequency of allocation of staphylococcal flora was 1.3—1.5 times higher compared to control (p≤0.05), an increase in the proportion of S. aureus — 2.5 times. The detection frequency of S. epidermidis in the control and both clinical groups was 28.0, 27.6 and 31.0 % of cases, respectively, the proportion of hemolytic forms in the control group was 4.0 %, in the first 10.3 % (an increase of 2 5 times), in the second — 17.2 % (4.3 times). The observed changes in the species composition may indicate dysbiosis in the oral cavity, caused not only by the presence of recurrent aphthae, but also by acid-dependent diseases of the gastrointestinal tract. Conclusions. In recurrent aphthae of the oral cavity in patients with acid-dependent diseases of the gastrointestinal tract in the microbiome of the oral cavity against the background of reduced titers of lactobacilli, an increase in representatives of Staphylococcus spp., Enterococcus spp is most often observed. and Candida spp. (1.2 times average), Enterococcus spp. (1.4 times), Staphylococcus spp. and Enterobacteriaceae spp. (1.2 times), Actinobacillus spp. (1.1 times).

Keywords:
recurrent aphthae of the oral cavity, microbiome of the oral cavity, acid-dependent gastrointestinal diseases, chronic gastroduodenitis, chronic pancreatitis
References

1. Bondarenko, O. V., Tokmakova, S. I., Shestun, K. B., Kiseleva, K. A. (2014). Sostoyaniye mikrobiotsenoza u patsiyentov pri razlichnykh zabolevaniyakh slizistoy obolochki rta [The state of microbiocenosis in patients with various diseases of the oral mucosa]. Problemy stomatologii [Actual problems in dentistry], 5, 12–14. (In Russ.)

2. Vagner, V. D., Gurevich, K. G., Peshkov, M. V., Arharova, O. N. (2013). Znacheniye stomatologicheskogo zdorov'ya dlya kachestva zhizni patsiyenta [The value of oral health on the quality of life of the patient]. Problemy stomatologii [Actual problems in dentistry], 2, 21–25. (In Russ.)

3. Denisova, T. P., Shul'dyakov, V. A., Tyul'tyaeva, L. A., Chernenkov, YU. V., Alipova, L. N., Sadzhaya, L. A. (2011). Monitoring rasprostranennosti zabolevaniy vnutrennikh organov na primere patologii pishchevaritel'noy sistemy [Monitoring of internal diseases dissemination (digestive disorders)]. Saratovskiy nauchno-meditsinskiy zhurnal [Saratov scientific medical journal], 7, 4, 772–776. (In Russ.)

4. Livzan, M. A., Makejkina, M. A., Anisimova, I. V., Nedoseko, V. B., Lomiashvili, L. M. (2016). Diagnostika i lecheniye nekroticheski-yazvennogo stomatita, assotsiirovannogo s yazvennym kolitom (klinicheskiy sluchay) [Diagnosis and treatment of necrotic-ulcerative stomatitis, associated with ulcerative colitis (case report)]. Problemy stomatologii [Actual problems in dentistry], 12, 5, 23–28. (In Russ.)

5. Drobot'ko, L. N., Strahova, S. YU. (2006). Khronicheskiy retsidiviruyushchiy aftoznyy stomatit [Chronic recurrent aphthous stomatitis]. Rossiyskiy Meditsinskiy Zhurnal [Russian Medical Journal], 29, 2096–2098. (In Russ.)

6. Eds. Borovsky, E. V., Mashkillaysona, A. L. (2001). Zabolevaniya slizistoy obolochki polosti rta i gub [Diseases of the oral mucosa and lips]. Moscow : MEDpress, 320. (In Russ.)

7. Kabirova, M. F., Gerasimova, L. P., Usmanova, I. N., Karimova, S. R. (2015). Stomatologicheskiy status lits molodogo vozrasta s khronicheskim gastroduodenitom [Dental status of young adults with chronic gastroduodenitis]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 5, 301. (In Russ.)

8. Klimova, T. N., Kramar, V. O., Kramar, O. G., Dobrenkov, D. S. (2013). Stomatologicheskiy status pri narusheniyakh mikroekosistemy polosti rta [Dental status in impaired microecosystem of the oral cavity]. Vestnik VolgGMU [Bulletin of Volgograd State Medical University], 4 (48), 75–77. (In Russ.)

9. Labis, V. V., Bazikyan, E. A., Kozlov, I. G. (2013). Bakterial'nyy faktor kak uchastnik infektsionnogo vospalitel'nogo protsessa v polosti rta [Bacterial factor as a participant in the infectious inflammatory process in the oral cavity]. Rossiyskiy stomatologicheskiy zhurnal [Russian Medical Journal], 4, 19–21. (In Russ.)

10. Lunitsyna, Yu. V., Tokmakova, S. I. (2012). Kandidoz slizistoy obolochki polosti rta - aktual'naya problema stomatologii XXI veka [Oral candidosis is an urgent problem of dentistry of the xxi century]. Problemy stomatologii [Actual problems in dentistry], 1, 30–33. (In Russ.)

11. Mamedov, R. M., Alizade, A. R., Ibragimova, L. K., Gamzaev, B. M. (2013). Sostoyaniye stomatologicheskogo statusa vzroslogo naseleniya v zavisimosti ot nalichiya zabolevaniy slizistoy obolochki polosti rta [Condition of dental adult status in relation to oral mucosa diseases]. Problemy stomatologii [Actual problems in dentistry], 6, 18–21. (In Russ.)

12. Orlova, E. S., Bragin, A. V. (2016). Kompleksnyy podkhod k lecheniyu vospalitel'nykh zabolevaniy parodonta u patsiyentov s helicobacter pylori-assotsiirovannoy gastroduodenal'noy patologiyey [An integrated approach to the treatment of inflammatory periodontal diseases in patients with helicobacter pylori-associated gastroduodenal pathology]. Problemy stomatologii [Actual problems in dentistry], 12, 2, 36–42. (In Russ.)

13. Galimova, I. A., Usmanova, I. N., Al-Kofish, M. A. M., Khusnarizanova, R. F., Safiullina, R. A., Sharafutdinova, L. M. (2018). Otsenka sostoyaniya mikroekologii polosti rta u lits molodogo vozrasta [Assessment of microecology of the oral cavity at persons of young age]. Ural'skiy meditsinskiy zhurnal [Ural Medical Journal], 7 (162), 22–25. (In Russ.)

14. Galimova, I. A., Usmanova, I. N., Gerasimova, L. P., Petrova, K. A., Ermolaeva, A. V., Eshtukova, Yu. V. (2019). Otsenka sostoyaniya slizistoy obolochki rta u lits s patologiyey zheludochno-kishechnogo trakta [Assessment of the condition of the oral mucosa in patients with pathology of the gastrointestinal tract]. Ural'skiy meditsinskiy zhurnal [Ural Medical Journal], 9 (177), 15–19. (In Russ.)

15. Gerasimova, L. P., Daurova, F. Yu., Usmanova, I. N., Kabirova, M. F., Vayts, S. V., Makeeva, M. K. (2017). Porazheniya slizistoy obolochki rta pri zabolevaniyakh zheludochno-kishechnogo trakta : uchebnoye posobiye [Lesions of the oral mucosa in diseases of the gastrointestinal tract]. Moscow. (In Russ.)

16. Rabinovich, O. F., Rabinovich, I. M., Panfilova, E. L., Vakhrushina, E. V. (2010). Retsidiviruyushchiy aftoznyy stomatit – etiologiya, patogenez (chast' I) [Recurrent aphthous stomatitis – aetiology and pathogenesis (part I)]. Stomatologiya [Dentistry], 1, 71–74. (In Russ.)

17. Karakov, K. G., Khachaturian, E. E., Vlasova, T. N., Oganyan, A. V., Vanchenko, N. B., Uzdenova, L. Kh., Khachaturian, A. E. (2018). Resheniye problemy lecheniya neytropenicheskikh aft slizistoy obolochki polosti rta [Solution of the problem of treatment of neuropenical aft mercular shell of the oral cavity]. Problemy stomatologii [Actual problems in dentistry], 14, 4, 19–23. (In Russ.)

18. Ron, G. I., Balyan, L. N. (2018). Ekologicheskaya sistema i immunitet polosti rta [Ecological system and immunity of an oral cavity]. Problemy stomatologii [Actual problems in dentistry], 2, 8–12. (In Russ.)

19. Tokmakova, S. I., Bondarenko, O. V., Sysoeva, O. V., Shestun, K. B. (2013). Korrektsiya trevozhnykh rasstroystv v kompleksnom lechenii zabolevaniy slizistoy obolochki rta [Correction of anxiety disorders in the complex treatment of oral mucous diseases]. Problemy stomatologii [Actual problems in dentistry], 1, 20–22. (In Russ.)

20. Uspenskaya, O. A., Lukinykh, L. M., Shevchenko, E. A., Tiunova, N.V. (2015). Khronicheskiy retsidiviruyushchiy aftoznyy stomatit : uchebnoye posobiye [Chronic Recurrent Aphthous Stomatitis: A Tutorial]. Nizhny Novgorod. (In Russ.)

21. Socransky, S. S., Haffajee, A. D. (2005). Periodontal microbial ecology. Periodontol. 2000, 38, 135–187.

22. Teles, F. R., Teles, R. P. (2012). Early microbial succession in redeveloping dental biofilms in periodontal health and disease. J Periodont Res, 47, 95–104.

23. Usmanova, I. N., Gerasimova, L. P., Tuigunov, M. M., Galimova, I. A., Khusnarizanova, R. F., Usmanov, I. R. (2018). Associative and initiative connections of the pathogenic and opportunistic microflora in the development of inflammatory diseases of the oral mucosa in young people. Journal of Pharmaceutical Sciences and Research, 10, 2, 243–254.

24. Aliaga, L., Cobo, F., Mediavilla, J. D. et al. (2003). Localized mucosal leishmaniasis due to Leishmania (Leishmania) infantum: clinical and microbiologic findings in 31 patients. Medicine (Baltimore), 3, 147–158.

25. Patil, C. S., Kirkwood, K. L. (2007). MAPK signaling in oral-related diseases. J Dent. Res, 9, 812–825.

26. Scully, C., Porter, S. (2008). Oral mucosal disease: recurrent aphthous stomatitis. Br. J. Oral Maxillofac. Surg, 46, 198–206.

27. Serra-Guillen, C., Requena, C., Alfaro, A. et al. (2007). Oral involvement in lymphomatoidpapulosis. ActasDermosifiliogr, 4, 265–267.

28. Slomiany, B. L., Piotrowski, J., Slomiany, A. (1999). Role of endothelin-1 and interleukin-4 in buccal mucosal ulcer healing: effect of chronic alcohol ingestion. Biochem. Biophys. Res. Commun, 2, 373–377.

29. Storck, C. (2000). Aphthae of the oral cavity: differential diagnostic considerations concerning a case report. Schweiz. Med. Wochenschr, 125, 127S–130S.

30. Thomas, S., Kolumam, G. A., Murali-Krishna, K. (2007). Antigen presentation by nonhemopoietic cells amplifies clonal expansion of effector CD8 T cells in a pathogen-specific manner. J Immunol, 9, 5802–5811.