employee
Ufa, Ufa, Russian Federation
employee
Ufa, Ufa, Russian Federation
Subject. The problem of complex treatment of candida-associated periodontitis is considered. The authors propose a two-component probiotic, which, due to antagonistic activity regarding periodontal pathogenic infection and fungi of the genus Candida, leads to the relief of the inflammatory process, positive dynamics and stabilization of immunological parameters. The aim ― to evaluate the dynamics of clinical and immunological parameters in the complex treatment of candida-associated periodontitis with an average degree of quantitative seeding of periodontal pockets using a two-component probiotic. Methodology. A clinical and laboratory examination of three groups (I, II, III) of patients with Candida-associated periodontitis with an average degree of quantitative contamination of periodontal pockets (> 3 <6 CFU / ml) was carried out. Patients I groups were prescribed the well-known complex treatment including an antimycotic drug, patients II groups included a two-component probiotic locally in the treatment complex, and patients III groups locally and per os. The state of the oral mucosa was assessed, PMA, PI, OHI - S were determined, and indicators of cellular and humoral immunity were examined. Results. The study made it possible to establish that the inclusion of a two-component probiotic in the complex of treatment of candida-associated periodontitis with an average degree of quantitative contamination of periodontal pockets with fungi of the genus Candida contributes to the relief of the inflammatory process, an increase in phagocytosis, the metabolic activity of neutrophils, the concentration of immunoglobulins A, lysozyme levels, and a decrease in the concentration of immunoglobulins. G, positive dynamics of other indicators of immunity and their stabilization. Conclusions. The inclusion of a two-component probiotic from two strains in the complex treatment of chronic hepatitis C associated with fungi of the genus Candida contributes to the rapid relief of the inflammatory process in periodontal tissues, positive dynamics and stabilization of cellular and humoral immunity parameters.
chronic generalized periodontitis, candida-associated periodontitis, degree of dissemination of periodontal pockets, two-component probiotic, serum immunoglobulins, oral liquid immunoglobulins, neutrophil phagocytic activity
1. Orekhova, L. YU. (1997). Immunologicheskie mekhanizmy v patogeneze vospali-tel'nyh zabolevanij parodonta : avtoref. dis. .. .d-ra med. nauk [Immunological mechanisms in the pathogenesis of inflammatory periodontal diseases: author. dis. ... d-ra med. of science]. St. Peterburg, 34. (In Russ.)
2. Waltimo, T. M., Siren, E. K., Orstavik, D. et al. (1999). Susceptibility of oral Candida species to calcium hydroxide in vitro. Int. Endod J, 32, 2, 94-98.
3. Cepov, L. M. (2006). Zabolevanija parodonta: vzgljad na problem [Periodontal diseases: look at an issue]. Moscow : MEDpress-inform, 192. (In Russ.)
4. Muller, H. P. (2004). Parodontologie. New York: Stuttgart, 256.
5. Vol’f, G. F., Rateytskhak, J. M., Raytetskhak, K.,. Barer, G. M. ed. (2008). Parodontologija [Parodontology]. Moscow : MEDpress-inform, 548. (In Russ.)
6. Grudjanov, A. I. (2009). Zabolevanija parodonta [Periodontal diseases]. Moscow : Med. inform. agenstvo, 336. (In Russ.)
7. Chepurkova, O. A., Chesnokova, M. G., Nedoseko, V. B., Komleva, A. S. (2009). Rasprostranennost' gribkovoy flory i osobennosti mikrobiotsenoza u lits s intaktnym parodontom i s khronicheskimi vospalitel'nymi zabolevaniyami parodonta [Prevalence of fungal flora and features of microbiocenosis in individuals with intact parodontium and chronic inflammatory periodontal diseases]. Parodontologiya [ Periodontics], 1 (50), 60-65. (In Russ.)
8. Komleva, A. S., Chepurkova, O. A., Chesnokova, M. G., Nedoseko, V. B. (2010). Kliniko-mikrobiologicheskiye osobennosti vospalitel'nykh i vospalitel'no-destruktivnykh zabolevaniy parodonta, assotsiirovannykh s kandidoznoy infektsiyey [Clinical and microbiological features of inflammatory and inflammatory-destructive periodontal diseases associated with candidal infection]. Vestnik Ural'skoy meditsinskoy akademicheskoy nauki [Bulletin of the Ural Medical Academic Science], 2 (30), 70-73. (In Russ.)
9. Gileva, O. S., Bondarenko, E. A., Gibadullina, N. V. et al. (2011). Novye podhody k lecheniyu vospalitel'nyh zabolevanij parodonta [New approaches to the treatment of inflammatory periodontal diseases]. Ural'skij medicinskij zhurnal [Ural Medical Journal], 5 (83), 22-27. (In Russ.)
10. Leonova, L. E., Kovtun, A. A., Pavlova, G. A. (2013). Ocenka effektivnosti kompleksnogo lecheniya bol'nyh parodontitom na osnovanii kliniko-rentgenologicheskih i biohimicheskih pokazatelej [Evaluation of the effectiveness of complex treatment of patients with periodontitis on the basis of clinical, radiological and biochemical parameters]. Permskoj medicinskij zhurnal [Perm Medical Journal], 30, 2, 103-108. (In Russ.)
11. Bejbulatov, G. D, Ostrovskaya, L. YU., Lepilin A. V. (2014). Faktory, vliyayushchiye na razvitye kandidat-assotsiirovannogo parodontita [Faktors affecting the development of candida - associated periodontitis]. Rossiyskiy stomatologicheskiy zhurnal [Russian Dental Journal], 4, 36-38. (In Russ.)
12. Dmitrieva, L. A. (2014). Parodontologija : nacional'noe rukovodstvo [Periodontology : The National guidebook]. Moscow : GjeOTAR-Media, 704. (In Russ.)
13. SHipskij, A. V. (2014). Kompleksnoe lechenie i reabilitaciya pacientov s generalizovannym parodontitom tyazheloj stepeni tyazhesti [Complex treatment and rehabilitation of patients with severe generalized periodontitis]. Parodontologiya [Periodontology], 1 (70), 35-42. (In Russ.)
14. Zhura, V. V., Rudova, Yu. V. (2016). Bioethical aspects of medical discourse. Bioehtika [Bioehtics], 1 (17), 42-46. (In Russ.)
15. Fagiolo, U. et al. (1993). Humoral and cellular immune response to influenza virus vaccination in aged humans. Aging (Milano), 5, 451-458.
16. Vincent, J.-L., Annasie, E., Bruining, H. et al. (1998). Epidemiology, diagnosis and treatment of systemic candida infection in surgical patients under intensive care. Intensive Care Med, 24, 206-216.
17. Williams, A., Yanagisawa, M. (2007). Oral Microbiology and immunology. 22, 285-288.
18. Cepov, L. M., Nikolaev, A. I., Nesterova, M. M., Nakonechnyj, D. A. (2014). Problema etiologii vospalitel'nykh generalizovannykh zabolevaniy parodonta [The problem of the etiology of inflammatory generalized periodontal diseases]. Sovremennaya stomatologiya - ehffektivnost' profilaktiki i lecheniya. Nanotekhnologii v stomatologii : materialy konferencii, posvyashchennoj 60-letiyu TGMA [Modern dentistry - the effectiveness of prevention and treatment. Nanotechnology in dentistry: materials of the conference dedicated to the 60th anniversary of the Tbilisi State Medical Academy], Tver', 310-319. (In Russ.)
19. Bykova, N. I., Odolskiy, A. V., Grigoryan, V. A. (2016). Pokazateli kletochnogo i gumoral’nogo immuniteta pri eksperimental’nom vospalenii tkanej parodonta [Indicators of cellular and humoral immunity in experimental inflammation of periodontal tissues]. Kubanskij nauchnyj meditsinskij vestnik.[Kuban Scientific Medical Bulletin], 6 (161), 20-26. (In Russ.)
20. Zabolotny, T. D., Bandrivky, YU. L., Dyryk, V. T. (2016). Sostoyanie mestnogo i sistemnogo immuniteta u bol'nyh s raznym techeniem generalizovannogo parodontita [Local and systemic immunity in patients with different of generalized periodontitis]. Stomatologiya [The Dentistry]. 6, 95, 23-25. (In Russ.)
21. Krajnov, S. V., Popova, A. N., Alekhanova, I. F., Vasenev, E. E. (2018). Immunomodulyaciya v gerontoparodontologii: vliyanie na gumoral'nyj immunitet [Immunomodulation in gerontoparodontology: effect on humoral immunity]. Problemy stomatologii [Problems of Dentistry], 14, 3, 22-28. (In Russ.)
22. Slots, J., Rams, T. E. (1990). Antibiotics in periodontal therapy: advantages and disadvantages. J.- Clin. Periodontol, 17, 479-493.
23. Tokmakova, S. I., Bondarenko, O. V., Chudova, L. V. (2013). Lechenie kandida-associirovannogo parodontita s ispol'zovaniem sovremennyh ul'trazvukovyh tekhnologiy [Treatment of candida- associated periodontitis with the use of modern ultrasound technogogies]. Problemy stomatologii.[Problems of dentistry], 5. 21-22. (In Russ.)
24. Parve, Z. S. et al. (2006). Probiotics and their fermented food products are beneficial for health. Appl. Microbiol, 100 (6), 1171-1185.
25. Mihajlova, N. A., Kuznecova, T. N., Kunyagina, O. V. Shtamm bakteriy Bacillus subtilis, nesushchiy svoystvo antibiotikorezistentnosti, ispol'zuyemyy dlya polucheniya preparata Baktisporin : patent 2067616 Rossiyskaya Federatsiya [The bacterial strain Bacillus subtilis, bearing the property of antibiotic resistance, used to obtain the drug Backspin: patent 2067616 Russian Federation]. 1/22, 12. (In Russ.)
