Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Nagariya, Israel
Moskva, Moscow, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Subject. On the basis of a comprehensive dental examination, the clinical condition of the oral mucosa was assessed. With the use of laboratory research methods, the parameters of the microta state from the surface of erosion, the state of local immunity of the oral fluid, as well as anamnesis data with the assessment of somatic status, clinical blood analysis, ultrasound examination of the state of internal organs, the tactics of the complex of phased local and General therapy were studied. In clinical conditions, the analysis of minimizing pain, the nature of the epithelialization of erosive elements and regeneration of the oral mucosa. Using the analysis of laboratory methods, the pronounced antibacterial effect, increase of local immunity factors of the oral cavity, a qualitative decrease in chronic inflammation in the oral mucosa and in the body as a whole, as well as a decrease in the depressive state of the patient were evaluated. Proven and proved the efficiency of application of this complex treatment in the early and late periods. The purpose ― is to draw the attention of practicing dentists and related specialists to the need for an effective phased scheme of diagnostic and therapeutic and preventive measures in patients with lichen planus. Material and methods. The article is based on the description of clinical observation of a patient with erosive-ulcerative form of lichen planus. Results. The use of the proposed complex of step-by-step local injection methods on the oral mucosa and General measures by dermatologists, therapists, gastroenterologists in the erosive and ulcerative form of lichen planus contributes to a better acceleration of the epithelialization process, regeneration, reducing the signs of chronic inflammation, qualitative improvement of the somatic status and quality of life of patients. Summary. The inclusion in the scheme of the complex of local and General therapeutic and preventive measures of erosive-ulcerative form of lichen planus by injection of autologous plasma (AP) and human placenta hydrolysate (HRH) is a more effective method of therapy in these patients.
chronic inflammation, oral mucosa, lichen planus, autologous plasma, human placenta hydrolysate (HRH), injection methods, quality of life
1. Anisimova, I. V., Zolotova, L. Yu., Lomiashvili, L. M., Simonyan, L. A. (2018). Kharakteristika dannykh anketirovaniya, mikrokristallizatsii i laboratornykh pokazateley rotovoy zhidkosti u patsiyentov s krasnym ploskim lishayem [Characteristics of survey data, microcrystallization and laboratory parameters of oral fluid in patients with lichen planus]. Problemy stomatologii [Problems of dentistry], 1 (14), 5-10. (In Russ.)
2. Arutyunov, S. D., Akinfieva, V. B., Perlamutrov, Yu. N. (2007). Sovremennyye aspekty lecheniya erozivno-yazvennoy formy ploskogo lishaya slizistoy obolochki rta [Modern aspects of the treatment of erosive and ulcerative forms of lichen planus of the oral mucosa]. Rossiyskiy stomatologicheskiy zhurnal [Russian dental journal], 2, 17-20. (In Russ.)
3. Akhmerov, R. R., Korotkova, O. I., Ovechkina, M. V. et al. (2013). Primeneniye autoplazmy, soderzhashchey trombotsity, v dermatokosmetologii i stomatologii. Tekhnologiya PLASMOLIFTING™ [The use of autoplasma containing platelets, in dermatology and dentistry. Plasmolifting technology]. Plasticheskaya khirurgiya i kosmetologiya [Plastic surgery and cosmetology], 1, 94-104. (In Russ.)
4. Demyanenko, S. A. (2015). Stressindutsirovannyye reaktsii psikhoemotsional'nogo napryazheniya patsiyentov na stomatologicheskom priyeme [Stress-induced reaction of emotional stress of patients on dental reception]. Rossiyskiy stomatologicheskiy zhurnal [Russian dental journal], 19, 4, 23-26. (In Russ.)
5. Butov, Yu. S., Vasenova, V. Yu., Anisimova, T. V. (2009). Klinicheskaya dermatovenerologiya [Clinical dermatology]. Moscow : GEOTAR Media, 2, 928. (In Russ.)
6. Gazhva, S. I., Gulyaev, R. S., Gazhva, Yu. V. (2012). Kachestvo zhizni patsiyentov s zabolevaniyami polosti rta (obzor literatury) [Quality of life of patients with oral diseases (literature review)]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 4, 2-4. (In Russ.)
7. Grigoryan, A. A., Sirak, S. V., Sirak, A. G., Khanova, S. A. (2013). Razrabotka i klinicheskoye primeneniye novogo ranozazhivlyayushchego sredstva dlya lecheniya zabolevaniy slizistoy obolochki polosti rta u detey i podrostkov [Development and clinical application of a new wound healing agent for the treatment of oral mucosa diseases in children and adolescents]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 2, 41. (In Russ.)
8. Gromova, O. A., Torshin, I. Yu., Gilels, A. V., Dibrova, E. A., Grishina, T. R., Volkov, A. Yu., Limanova, O. A., Tomilova, I. K., Demidov, V. I. (2014). Preparaty platsenty cheloveka: fundamental'nyye i klinicheskiye issledovaniya [Preparations of human placenta: basic science and clinical research]. Vrach [Doctor], 4, 67-72. (In Russ.)
9. Ivanova, E. V., Rabinovich, I. M., Tupitsyn, H. H. (2003). Immunomorfologicheskaya kharakteristika ploskogo lishaya slizistoy obolochki rta [Immunomorphological characteristics of lichen planus of the oral mucosa]. Stomatologiya [Stomatology], 5, 23-27. (In Russ.)
10. Ivanova, E. V., Tupitsyn, H. H., Rabinovich, I. M., Rabinovich, O. F. (2007). Subpopulyatsii limfotsitov slizistoy obolochki rta, porazhennoy ploskim lishayem [lymphocyte Subpopulations of the oral mucosa affected by lichen planus]. Klinicheskaya immunologiya [Clinical immunology], 1, 31-33. (In Russ.)
11. Ivanova, I. N., Mansurov, R. A. (2003). Psikhosomaticheskoye sostoyaniye bol'nykh krasnym ploskim lishayem [Psychosomatic state of patients with lichen planus]. Vestn. dermatol. i venerol. [Vestn. dermatol. and venerol], 5, 28-31. (In Russ.)
12. Lukinykh, L. M., Tiunova, N. In. (2008). Perekisnoye okisleniye lipidov kak odno iz zven'yev patogeneza krasnogo ploskogo lishaya slizistoy obolochki polosti rta [Lipid Peroxidation as one of the links in the pathogenesis of lichen planus of the oral mucosa]. Nizhegorodskiy meditsinskiy zhurnal [Nizhny Novgorod medical journal], 2, 2, 105-107. (In Russ.)
13. Lukinykh, L. M., Tiunova, N. In. (2009). Optimizatsiya lecheniya krasnogo ploskogo lishaya slizistoy obolochki polosti rta [Optimization of treatment of lichen planus of the oral mucosa]. Maestro stomatologii [Maestro dentistry], 4, 79-81. (In Russ.)
14. Mikhalchenko, A. V., Medvedeva, E. A., Mikhalchenko, D. V. (2016). Osobennosti struktury zabolevaniy slizistoy polosti rta u zhiteley Volgograda i Volgogradskoy oblasti [Features of the structure of diseases of the oral mucosa in residents of Volgograd and Volgograd region]. Volgogradskiy nauchno-meditsinskiy zhurnal [Volgograd scientific medical journal], 1, 3-7. (In Russ.)
15. Molochkov, V. A., Molochkov, A. V., Pereverzeva, O. E. (2011). K sovershenstvovaniyu terapii krasnogo ploskogo lishaya [To improve therapy lichen planus]. Rossiyskiy zhurn. kozh. i ven. bol. [Russian Journ. skins'. and Wen. Bole], 2, 7-9. (In Russ.)
16. Molochkov, V. A., Prokofiev, A. A., Bobrov, M. A., Pereverzeva, O. E. (2011). Klinicheskiye osobennosti razlichnykh form krasnogo ploskogo lishaya [Clinical features of various forms of lichen planus]. Rossiyskiy zhurnal kozhnykh i venerologicheskikh bolezney [Russian journal of skin and venereal diseases], 1, 30-36. (In Russ.)
17. Orekhova, L. Yu., Kudryavtseva, T. V., Cheminava, N. R., Tachalov, V. V., Loboda, E. S. (2014). Problemy stomatologicheskogo zdorov'ya u lits molodogo vozrasta (obzor literatury) [Problems of dental health in young people (literature review)]. Parodontologiya [Periodontology], 19, 2, 3-5. (In Russ.)
18. Ron, G. I., Akmalova, G. M. (2014). Rol' virusnoy infektsii v razvitii krasnogo ploskogo lishaya slizistoy obolochki polosti rta [The Role of viral infection in the development of lichen planus of the oral mucosa]. Parodontologiya [Periodontics], 19, 1, 24-26. (In Russ.)
19. Sirak, S. V., Chebotarev, V. V., Sirak, A. G., Kirianova, E. M., Khan, S. A., Sirak, S. V., Kopylov, I. A., Sirak, A. G. (2013). Lecheniye krasnogo ploskogo lishaya slizistoy obolochki polosti rta (prakticheskiye rekomendatsii) [Treatment of lichen planus of the mucous membrane of the oral cavity (practical recommendations)]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 3, 177. (In Russ.)
20. Sluzhaev, I. F., Oskolskaya, G. I., Zavgorodnyaya, E. B. (2010). Krasnyy ploskiy lishay slizistoy obolochki polosti rta: klinika, lecheniye [Lichen planus of the mucous membrane of the oral cavity: clinical features, treatment]. Dal'nevostochnyy meditsinskiy zhurnal [Far Eastern medical journal], 2, 132-136. (In Russ.)].
21. Usmanova I.N., Gerasimova L.P., Kabirova M.F., Usmanov I.R., Tuygunov M.M. (2017). Sposob lecheniya khronicheskogo vospaleniya slizistoy obolochki rta s elementami giperkeratoza u lits molodogo vozrasta : patent 2637413 Rossiyskaya Federatsiya [Method for the treatment of chronic inflammation of the oral mucosa with elements of hyperkeratosis in young people: patent 2637413 Russian Federation]. 34. (In Russ.)
22. Tiunova, N. V., Yanova, N. A. (2009). Kliniko-epidemiologicheskaya otsenka predrakovykh zabolevaniy slizistoy obolochki polosti rta i krasnoy kaymy gub v krupnom promyshlennom gorode na primere Nizhnego Novgoroda [Clinical and epidemiological assessment of precancerous diseases of the oral mucosa and red border of the lips in a large industrial city on the example of Nizhny Novgorod]. Klinicheskaya stomatologiya [Clinical dentistry], 3, 32-34. (In Russ.)
23. Firsova, I. V., Vorobyov, A. A., Makedonova, Y. A., Zhuravleva, M. V., Makarova, E. A. (2015). Eksperimental'naya model' dlya issledovaniya vliyaniya metoda kombinirovannogo plazmoliftinga na slizistuyu obolochku polosti rta [Experimental model to study the effect of combined method of plasmolifting on the mucous membrane of the oral cavity]. Parodontologiya [Periodontics], 3 (76), 28-33. (In Russ.)
24. Firsova, I. V., Mikhalchenko, V. F., Mikhalchenko, D. V. (2013). Vrachebnaya taktika pri diagnostike predrakovykh zabolevaniy slizistoy obolochki polosti rta i krasnoy kaymy gub [Medical tactics in the diagnosis of precancerous diseases of the oral mucosa and the red border of the lips]. Vestnik Volgogradskogo gosudarstvennogo meditsinskogo universiteta [Bulletin of Volgograd state medical University], 1 (45), 3-6. (In Russ.)
25. Firsova, I. V., Porowski, S. V., Makedonova, Y. A., Piterskaa, N. V., Mikhalchenko, V. F. (2016). Effektivnost' PRP-terapii pri erozivno-yazvennoy forme u bol'nykh krasnym ploskim lishayem slizistoy polosti rta [The Effectiveness of PRP-therapy in erosive-ulcerative form of lichen planus of the oral mucosa]. Vestnik Volgogradskogo gosudarstvennogo meditsinskogo universiteta [Vestnik of Volgograd state medical University], 1 (57), 105-108. (In Russ.)
26. Khanova, S. A. (2015). Krasnyy ploskiy lishay slizistoy obolochki polosti rta: vozmozhnosti mestnogo lecheniya na fone obshchey terapii [Red lichen planus of the oral mucosa: possibilities of local treatment against the background of General therapy]. Parodontologiya [Periodontics], 20, 1 (74), 26-30. (In Russ.)
27. Chuikin, S. V., Akmalova, G. M., Chernysheva, N. D. (2014). Kharakteristika mikroflory polosti rta u bol'nykh s krasnym ploskim lishayem [Characteristics of oral microflora in patients with lichen planus]. Parodontologiya [Periodontics], 4 (73), 41-43. (In Russ.)
28. Yanushevich, O. O., Maksimovsky, Yu. M., Maksimovskaya, L. N., Orekhova, L. Yu. (2016). Terapevticheskaya stomatologiya [Therapeutic dentistry]. Moscow : GEOTAR-Media, 760. (In Russ.)
29. Goswami, S., Sarkar, R., Saha, P., Maity, A., Sarkar, T., Das, D., Chakraborty, P. D., Bandyopadhyay, S., Ghosh, C. K., Karmakar, S., Sen, T. (2017). Effect of human placental extract in the management of biofilm mediated drug resistance - A focus on wound management. Microb Pathog, 2017, 111, 307-315.
30. Marx, R. E. (2004). Platelet-rich plasma: evidence to support its use. Journal of Oral and Maxillofacial Surgery, 62, 489-496.
31. Peters, B. M., Jabra-Rizk, M. A., Scheper, M. A. et al. (2010). Microbial interactions and differential protein expression in Staphylococcus aureus - Candida albicans dual-species biofilms. FEMS Immunol Med Microbiol, 59, 3, 493-503.
32. Tar, I. (2009). The oral lichen planus: doubts and evidence. Fogorvosi Szemle, 102, 3, 103-109.
33. Torrente-Castells, E. (2010). Clinical features of oral lichen planus. A retrospective study of 65 cases. Medicina Oral, Patología Oral Y Cirugía Bucal, 15, 5, 685-690.
