Tyumen', Tyumen, Russian Federation
Tyumen', Tyumen, Russian Federation
Tyumen', Russian Federation
Subject: Inflammatory periodontal diseases are one of the most common dental diseases in the world. To ensure successful treatment and a stable period of remission, it is necessary to take into account the etiopathogenesis of the disease. One of the main roles in the development of inflammatory periodontal diseases is played by the immune response of the body to the action of periodontal-pathogenic micro-organisms. Objective ― to study the current literature indicates about the role of immunological processes in the development of inflammatory periodontal diseases, as well as the possibility of their correction Material and methodologies: Data from the scientific literature on the etiopathogenesis of inflammatory periodontal diseases was used in the study. To achieve this objective the databases of the Tyumen State Medical University Library, electronic libraries (eLibrary, Cyberleninka, PubMed, Googl.Scholar), official sites of scientific publications were used. Results: the review of the literature presents information on the immunological processes developing in inflammatory periodontal diseases. The role of cellular and humoral elements in pathogenesis, the role of pro and anti-inflammatory cytokines in the chronization of the inflammatory process is described. The possibilities of local immunological correction in the treatment of inflammatory periodontal diseases are considered. Conclusions: The concept of cytokine development of inflammatory periodontal diseases has been formed and substantiated in modern scientific literature. The evaluation of the cytokine profile of the oral and gingival fluid allows to establish the activity and severity of the disease. The established immunological and molecular genetic mechanisms of the development of inflammatory periodontal diseases associated with the influence of cytokines make it possible to adjust the complex treatment of inflammatory periodontal diseases, determine the direction of personalized therapy of patient, determine the effectiveness of the treatment and the prognosis of the disease.
gingivitis, periodontal disease, periodontal inflammatory diseases, periodontal- pathogenic micro-organisms, cellular immunity, humoral immunity, cytokines, interleukins, immunotropic drugs, treatment of inflammatory periodontal diseases
1. Miklyaev, S. V., Leonova, O. M., Sushchenko, A. V. (2018). Analiz rasprostranennosti khronicheskikh vospalitel'nykh zabolevaniy tkaney parodonta [Analysis of the prevalence of chronic inflammatory diseases of periodontal tissues]. Sovremennye problemy nauki i obrazovaniya [Modern problems of science and education], 2. (In Russ.)
2. Fuks, E. I., Kareva, YU. A., Galizina, O. A., Tabolina, E. S. (2013). Sovremennyye aspekty etiologii i patogeneza zabolevaniy parodonta [Modern aspects of the etiology and pathogenesis of periodontal disease]. Ros. med.-biol. vestn. im. akad. I. P. Pavlova [Ros. med.-biol. we know them. Acad. I. P. Pavlova], 3. URL: https://cyberleninka.ru/article/n/sovremennye-aspekty-etiologii-i-patogeneza-zabolevaniy-parodonta (In Russ.)
3. Kovalevskij, A. M., Kovalevskij, V. A. (2017). Etiologiya i patogenez vospalitel'nykh zabolevaniy parodonta (obzor literatury). CH. I [Etiology and pathogenesis of inflammatory periodontal diseases (literature review). Part I]. Institut stomatologii [Institute of Dentistry], 4 (77), 88-90. (In Russ.)
4. Suetenkov, D. E., Akulovich, A. V., Gricenko, E. A. (2012). Kachestvennaya i kolichestvennaya otsenka parodontopatogennoy mikroflory polosti rta pri pomoshchi Bana-testa [Qualitative and quantitative assessment of the periodontal pathogenic microflora of the oral cavity using the Bana test]. Parodontologiya [Parodontology], 2 (63), 66-70. (In Russ.)
5. Allais, G. (2006). Bioplenka polosti rta [Oral biofilm]. Novoe v stomatologii [New in dentistry], 4 (136), 4-14. (In Russ.)
6. Dunyazina, T. M., ed. Iordanishvili, A. K. (2008). Mikroorganizmy zubnoj blyashki [Microorganisms of dental plaque]. Moscow : Medpress-inform, 183. (In Russ.)
7. Zambon, J. J., Reynolds, H., Fisher, J. G. et al. (1988). Microbiological and immunological studies of adalt periodontitis in patients with noninsulin-dependent diabetes mellitus. J. Periodontol, 59, 1, 23-31.
8. Suchett-Kaye, G., Morrier, J. J., Barsotti, O. (2001). Clinical usefulness of microbiological diagnostic tools in the management of periodontal disease. Res. Microbiol, 152, 7, 631-639.
9. Ippolitov, E. V., Didenko, L. V., Carev, V. N. (2015). Osobennosti morfologii bioplenki parodonta pri vospalitel'nykh zabolevaniyakh desen (khronicheskiy kataral'nyy gingivit, khronicheskiy parodontit, kandida-assotsiirovannyy parodontit) po dannym elektronnoy mikroskopii [Features of the morphology of periodontal biofilm in inflammatory diseases of the gums (chronic catarrhal gingivitis, chronic periodontitis, candida-associated periodontitis) according to electron microscopy]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics], 12, 59-63. (In Russ.)
10. Shostenko, A. A. (2014). Osobennosti mikrobiotsenoza desnevykh tkaney i mestnogo immuniteta u bol'nykh s khronicheskim i obostrivshimsya techeniyem generalizovannogo kataral'nogo gingivita [Features of microbiocenosis of gingival tissues and local immunity in patients with chronic and exacerbated course of generalized catarrhal gingivitis]. Medicinskie perspektivy [Medical Perspectives], 19, 4, 141-145. (In Russ.)
11. Zorina, O. A., Kulakov, A. A., Boriskina, O. A., Rebrikov, D. V. (2011). Sootnosheniye patogennykh predstaviteley mikrobiotsenoza parodontal'nykh karmanov pri parodontite raznoy stepeni tyazhesti [Ratio of pathogenic microbiocenosis of periodontal pockets with periodontitis of varying severity]. Acta Naturae (russkoyazychnaya versiya) [ActaNaturae (Russian version)], 2. (In Russ.)
12. Bol'shedvorskaya, N. E., Kazankova, E. M. (2017). Etiopatogeneticheskiye osobennosti vospalitel'nykh zabolevaniy parodonta [Etiopathogenetic features of inflammatory periodontal diseases]. Bezopasnost' zdorov'ya cheloveka [Safety of human health], 3, 26-35. DOI:https://doi.org/10.17117/na.2016.04.03.294 (In Russ.)
13. Loktionov, A. L. et al. (2015). Immunnyye i oksidantnyye narusheniya v patogeneze vospalitel'nykh zabolevaniy parodonta [Immune and oxidative disorders in the pathogenesis of inflammatory periodontal diseases]. Immunologiya [Immunology], 36, 5, 24-26. (In Russ.)
14. Pintucci, J. P., Corno, S., Garotta, M. (2010). Biofilms and infections of the upper respiratory tract. Eur Rev Med Pharmacol Sci, 14, 683-690.
15. Kostrigina, E. D., Zyul'kina, L. A, Ivanov, P. V. (2017). Sovremennyy vzglyad na etiopatogenez parodontita (obzor literatury) [Modern view on the etiopathogenesis of periodontitis (literature review)]. Izvestiya vuzov. Region. Medicinskie nauki [News of universities. Region. Medical sciences], 3 (43). DOIhttps://doi.org/10.21685/2072-3032-2017-3-1 (In Russ.)
16. Usova, N. F. (2013). Vospalitel'nyye zabolevaniya parodonta: patogenez, printsipy kompleksnogo lecheniya [Inflammatory periodontal diseases: pathogenesis, principles of complex treatment]. Sibirskij medicinskij zhurnal [Siberian Medical Journal], 1, 141-144. (In Russ.)
17. Bazarnyj, V. V., Polushina, L. G., Vanevskaya, E. A. (2014). Immunologicheskiy analiz rotovoy zhidkosti kak potentsial'nyy diagnosticheskiy instrument [Immunological analysis of oral fluid as a potential diagnostic tool]. Rossijskij immunologicheskij zhurnal [Russian Journal of Immunology], 8, 3, 769-771. DOI:https://doi.org/10.22138/2500-0918-2018-15-4-563-569. (In Russ.)
18. Melekhov, S. V., Kolesnikova, N. V. (2013). Sostoyaniye mestnogo immuniteta i mikrobiotsenoza polosti rta u bol'nykh khronicheskim generalizovannym parodontitom [The state of local immunity and oral microbiocenosis in patients with chronic generalized periodontitis]. Parodontologiya [Periodontics], 18 (1), 3-9. (In Russ.)
19. Grudyanov, A. I. (2009). Zabolevaniya parodonta [Periodontal disease]. Moscow : Medical Information Agency. (In Russ.)
20. Avagimov, A. G., Bondarenko, M. A., Slavinskij, I. A. (2008). Funktsional'naya aktivnost' neytrofil'nykh leykotsitov pri vospalitel'nykh zabolevaniyakh parodonta [Functional activity of neutrophilic leukocytes in inflammatory periodontal diseases]. Kubanskij nauchnyj medicinskij vestnik [Kuban Scientific Medical Journal], 3-4. URL:https://cyberleninka.ru/article/n/funktsionalnaya-aktivnost-neytrofilnyh-leykotsitov-pri-vospalitelnyh-zabolevaniyah-parodonta. (In Russ.)
21. Vasil'eva, H. A., Bulgakova, A. I., Imel'baeva, E. A. (2011). Analiz tsitogramm u bol'nykh vospalitel'nymi zabolevaniyami parodonta [Analysis of cytograms in patients with inflammatory periodontal diseases]. Kazanskij med zhurnal [Kazan medical journal], 92, 1, 41-45. DOI:https://doi.org/10.18481/2077-7566-2018-14-3-11-16. (In Russ.)
22. Miroshnichenko, V. V. et al. (2018). Tsitomorfometricheskaya otsenka sostoyaniya tkaney parodonta pri lechenii patsiyentov s khronicheskim kataral'nym gingivitom [Cytomorphometric Assessment of Periodontal Tissues in Treatment of Patients with Chronic Catarrhal Gingivitis]. Problemy stomatologii [Problems of Dentistry], 14, 2, 42-47. (In Russ.)
23. Bykova, N. I., Odol'skij, A. V., Grigoryan, V. A. (2016). Pokazateli kletochnogo i gumoral'nogo immuniteta pri eksperimental'nom vospalenii tkaney parodonta [Indicators of cellular and humoral immunity in experimental inflammation of periodontal tissues]. Kubanskij nauchnyj medicinskij vestnik [Kuban Scientific Medical Herald], 6. DOI:https://doi.org/10.25207/1608-6228-2016-6-20-26. (In Russ.)
24. Zemskaya, E. A., Hazanova, V. V., Nikitina, T. V. (1980). Kliniko - immunologicheskiye pokazateli u bol'nykh posle kompleksnogo lecheniya parodontita [Kliniko - Clinical and immunological parameters in patients after complex treatment of periodontitis]. Stomatologiya [Dentistry], 3, 20-21. (In Russ.)
25. Cybikov, N. N., Domanova, E. T., Zobnin, V. V., Ignatov, M. YU., Maslo, E. YU., Isakova, N. V. (2012). Svoystva desnevoy zhidkosti pri ostrom gingivite i khronicheskom parodontite [Properties of gingival fluid in acute gingivitis and chronic periodontitis]. Rossijskij stomatologicheskij zhurnal [Russian dental journal], 1. Url: https://cyberleninka.ru/article/n/svoystva-desnevoy-zhidkosti-pri-ostrom-gingivite-i-hronicheskom-parodontite. (In Russ.)
26. Kuznecova, O. A., Gubanova, E. I., Shemonaev, V. I. (2013). Tsitokiny kak pokazatel' mestnogoimmunnogo statusa patsiyentov s khronicheskim parodontitom [Cytokines as an indicator of the local immune status of patients with chronic periodontitis]. Lekarstvennyj vestnik [Medicinal Bulletin], 7, 2 (50), 20-26. (In Russ.).
27. Shajmardanov, T. N., Gerasimova, L. P., Chemikosova, T. S., Kamilov, F. H. (2017). Otsenka urovnya provospalitel'nykh tsitokinov u patsiyentov s khronicheskim parodontitom v zavisimosti ot mineral'noy plotnosti kosti pered dental'noy implantatsiyey [Assessment of the level of pro-inflammatory cytokines in patients with chronic periodontitis, depending on bone mineral density before dental implantation]. Sovremennye problemy nauki i obrazovaniya [Modern Problems of Science and education], 1. URL: http://science-education.ru/ru/article/view?id=26144. (In Russ.)
28. Abadzhidi, M. A., Lukushkina, E. F., Mayanskaya, I. V. et al. (2002). Uroven' tsitokinov v sekrete rotovoy polosti u detey s bronkhial'noy astmoy [Cytokine level in oral secretion in children with bronchial asthma]. Citokiny i vospalenie [Cytokines and inflammation], 1, 3, 9-14. (In Russ.)
29. Ostrovskaya, L. YU., Zaharova, N. B., Mogila, A. P., Kathanova, L. S., Akulova, E. V., Popyhova, E. B. (2014). Izmeneniye balansa tsitokinov v desnevoy zhidkosti pri zabolevaniyakh parodonta i yego znacheniye dlya prognozirovaniya regeneratornykh narusheniy v tkanyakh parodonta [Changes in the balance of cytokines in the gingival fluid in periodontal diseases and its importance for predicting regenerative disorders in periodontal tissue]. Saratovskij nauchno-medicinskij zhurnal [Saratov Journal of Medical Scientific Research], 10 (3), 435-440. (In Russ.)
30. Oshnokov, A. K., Bragin, E. A., Barycheva, L. YU. (2016). Diagnosticheskoye i prognosticheskoye znacheniye opredeleniya tsitokinov v desnevoy zhidkosti pri khronicheskom parodontite [Diagnostic and prognostic value of cytokine detection in gingival fluid in chronic periodontitis]. Medicinskij vestnik severnogo Kavkaza [Medical Journal of the North Caucasus], 4. DOI:https://doi.org/10.14300/mnnc.2016.11131. (In Russ.)
31. Parahonskij, A. P., Perova, N. YU. (2015). Rol' tsitokinov v patogeneze parodontita [The role of cytokines in the pathogenesis of periodontitis]. Estestvenno-gumanitarnye issledovaniya [Natural and Humanitarian Studies], 7, 75-81. (In Russ.)
32. Koshy, B., Reesj, S., Farnelld, D., Weix, Q. (2014). Waddingtonr. Array analysis for t-cell associated cytokines in gingival crevicular fluid; identifying altered profiles associated with periodontal disease status. J Periodontal Res, 49 (2), 237-245. Doi:https://doi.org/10.1016/j.jdent.2019.04.009
33. Borzikova, N. S. (2015). Markery vospalitel'nykh protsessov pri boleznyakh parodonta [Markers of inflammatory processes in periodontal diseases]. MS [MS], 2. DOI:https://doi.org/10.21518/2079-701X-2015-2-78-79. (In Russ.)
34. Van Der Bijl', P. (2014). Vzaimosvyaz' zabolevaniy parodonta i serdechno-sosudistoy sistemy [The relationship between periodontal diseases and the cardiovascular system. Literature review]. Problemy stomatologii [Actual problems of stomatology], 6. (In Russ.)
35. Grigorovich, E. SH., Pomorgajlo, E., Homutova, E. YU., Stepanov, S. S. (2015). Klinicheskiye varianty khronicheskogo generalizovannogo parodontita, geneticheskiy polimorfizm i sistemnaya produktsiya vospalitel'nykh tsitokinov [Clinical variants of chronic generalized periodontitis, genetic polymorphism and systemic production of inflammatory cytokines]. Stomatologiya [Dentistry], 5, 11-17. (In Russ.).
36. Zhelnin, E. V. (2015). Rol' polimorfizmov genov IL-1b i TNFRSF11b v razvitii khronicheskogo periodontita [The role of the polymorphisms of the IL-1β and TNFRSF11b genes in the development of chronic periodontitis]. Aktual'nі problemi suchasnoї medicini : vіsnik ukraїns'koї medichnoї stomatologіchnoї akademії [Actual problems of modern medicine: the herald of the Ukrainian Dental Academy], 2 (50). (In Russ.)
37. Isamulaeva, A. Z. (2015). Analiz assotsiatsii variantnykh alleley gena IL-1b (511 s/t) na patogenez zabolevaniy parodonta u bol'nykh s yazvennoy bolezn'yu zheludka i dvenadtsatiperstnoy kishki [Analysis of the association of variant IL-1b gene alleles (511 s / t) on the pathogenesis of periodontal diseases in patients with gastric ulcer and duodenal ulce]. Sovremennye problemy nauki i obrazovaniya [Modern problems of science and education], 6. (In Russ.)
38. Rossomando, E., Kennedy, J., Hadjimichael, J. (1990). Tumor necrosis factor in a gingival cresticular fluid as a possible indicator of periodontal disease in humans. Arch.Oral Biol, 35, 6, 431-434.
39. Noh, K. et al. (2013). Assessment of IL 6, IL 8 and TNF α levels in the gingival tissue of patients with periodontitis. Experrimental and therapeutic medicine, 6, 847-851.
40. Ostrovskaya, L. YU., Mogila, A. P., Hanina, A. I., Bejbulatov, D., Kathanova, L. S., Rezanov, A. V. (2013). Ispol'zovaniye molekulyarnykh markerov v obsledovanii patsiyentov s patologiyey parodonta [Use of molecular markers in examining patients with periodontal pathology]. Vestnik SGTU [SSTU Bulletin], 1 (70). (In Russ.)
41. Parahonskij, A. P., Perova, N. YU. (2015). Rol' tsitokinov v patogeneze parodontita [The role of cytokines in the pathogenesis of periodontitis]. Estestvenno-gumanitarnye issledovaniya [Natural and Humanitarian Studies], 7, 75-81. (In Russ.)
42. Moiseeva, E. G. (2006). Analiz deystviya interleykina-4 na funktsional'nyye svoystva neytrofilov pri modelirovanii parodontita [Analysis of the effect of interleukin-4 on the functional properties of neutrophils in the simulation of periodontitis]. Vestnik zdorov'e i obrazovanie v XXI veke [Herald health and education in the XXI century], 11. Url: https://cyberleninka.ru/article/n/analiz-deystviya-interleykina-4-na-funktsionalnye-svoystva-neytrofilov-pri-modelirovanii-parodontita. (In Russ.)
43. Bazarnyj, V. V. et al. (2017). Znacheniye nekotorykh interleykinov v patogeneze parodontita [The value of some interleukins in the pathogenesis of periodontitis]. Vestnik Ural'skoj medicinskoj akademicheskoj nauki [Bulletin of the Ural Medical Academic Science], 14, 1, 35-39. DOI:https://doi.org/10.22138/2500-0918-2017-14-1-35-39. (In Russ.)
44. Krajnov, S. V., Mihal'chenko, V. F., Popova, A. N., Yakovlev, A. T., Linchenko, I. V. (2018). Vliyanie nfluence of immunomodulatory therapy on the cellular composition of the gingival fluid in elderly people with periodontitis [The effect of immunomodulating therapy on the cellular composition of the gingival fluid in elderly people suffering from periodontitis]. Problemy stomatologii [Problems dentistry], 1. DOI:https://doi.org/10.24411/2077-7566-2018-10004. (In Russ.)
45. Kravchenko, E. V., Kravchenko, D. S. (2012). Ronkoleykin v kompleksnom lechenii zabolevaniy parodonta [Roncoleukin in complex treatment of periodontal diseases]. Fundamental'nye issledovaniya [Basic research], 7-2, 355-358. (In Russ.)
46. Petrova, N. YU. (2005). Kliniko-immunologicheskaya effektivnost' muramildipeptida v kompleksnom lechenii bol'nykh khronicheskim generalizovannym parodontitom : avtoref. dis. … kand. med. nauk [Clinical and immunological efficacy of muramyldipeptide in the complex treatment of patients with chronic generalized periodontitis : avtoref. dis. … kand. med. nauk]. Rostov-on-Don, 30. (In Russ.)
47. Garazha, N. N., Majboroda, YU. N., Markina, T. V. (2011). Tsitoenzimokhimicheskaya otsenka primeneniya preparata «Galavit» v terapii khronicheskogo generalizovannogo parodontita [Cytoenzimochemical assessment of the use of the drug "Galavit" in the treatment of chronic generalized periodontitis]. Medicinskij vestnik Severnogo Kavkaza [Medical Journal of the North Caucasus], 4. (In Russ.)
48. Hohlova, E. A. (2012). Narusheniya adaptivnogo immuniteta pri khronicheskikh vospalitel'nykh zabolevaniyakh parodonta: sovremennyye podkhody k otsenke i posleduyushchey korrektsii : avtoref. dis. ... kand. med. nauk [Violations of adaptive immunity in chronic inflammatory periodontal diseases: modern approaches to the assessment and subsequent correction : avtoreferat dis. ... kand. med. science : 14.01.14]. Moscow, 25. (In Russ.)
