In order to increase the bone height in the distal portions of the maxilla during dental implantation the method of «closed» sinus lift is widely applied. Manipulation is considered to be a minimally invasive osteotomy but despite this fact, it is associated with a high complication rate that might lead to the loss of the dental implant.
The purpose of the project is to analyze the evaluation of the effectiveness of immunomodulators local application during the "closed" sinus lift manipulation that is based on local in uence of «Betaleukin» and «Roncoleukin» drugs in the area of unexpected perforation of the mucous membrane of the maxillary sinus during the formation of the bone bed and close contact surface of the implant with a damaged part. A clinical randomized trial was held which of 105 patients aged 30 to 57, divided into three groups: comparison group, n = 35 (implants placed by the closed sinus lift standard method); betaleukin group, n = 35 (in addition to the surgery performed local recombinant IL-1β immunotherapy was conducted); roncoleukin group, n = 35 (the surgery done was combined with the local ronkoleukine immunomodulation). Within 10-12 days after the surgery hydrogel «Koleteks-Beta» and a gel containing recombinant IL-2 for a local effect on the oral mucous membrane around the installed implant were applied. During the study, all patients had a number of clinical signs that allow assessing the dynamics of post-operative course of the integration process of implants. Radiological control in the postoperative period was conducted to evaluate the position of the implant in relation to the maxillary sinus; the dynamics of bone tissue around it was observed. It was found out that the local treatment by immunomodulators improves the performance dynamics of clinical postoperative period; it reduces the risk of graft rejection and increases the ef ciency of integration process.
closed sinus lift, dental implantation, an immunomodulator, betaleukin, roncoleukin
