Nizhny Novgorod, Nizhny Novgorod, Russian Federation
employee
Kineshma, Ivanovo, Russian Federation
student
Nizhny Novgorod, Nizhny Novgorod, Russian Federation
student
Nizhny Novgorod, Nizhny Novgorod, Russian Federation
employee
Kemerovo, Kemerovo, Russian Federation
UDC 616.31
An integrated analysis of the levels of homocysteine, ferritin, parathyroid hormone, and vitamin D in people with desquamative glossitis is a key task for identifying real modifiable risk factors. The aim of this study is to evaluate the levels of vitamin D, parathyroid hormone, homocysteine, and ferritin in patients with symptomatic migratory glossitis and to analyze the correlation with clinical signs of the disease. Methodology. The study was based on the results of a dental examination of 24 patients (5 men and 19 women aged 18 to 55 years) with a confirmed diagnosis of desquamative glossitis (benign migratory glossitis), who complained of burning and discomfort when eating and when exposed to irritants. All participants underwent a comprehensive dental examination, a consultation with a gastroenterologist, an abdominal ultrasound, and serum levels of homocysteine, vitamin D, ferritin, and intact parathyroid hormone were measured. Results. Patients with symptomatic migratory glossitis had biliary stasis and chronic gastritis. Clinical data were accompanied by a statistically significant decrease in vitamin D levels, a decrease in ferritin levels in women and an increase in ferritin levels in men, as well as hyperhomocysteinemia and a tendency towards an increase in parathyroid hormone. A link was established between the appearance of desquamated areas on the tongue and specific metabolic disorders. These results confirm the importance of assessing this laboratory complex for a pathogenetically based approach. Conclusions. Patients with symptomatic migratory glossitis have multifactorial nutritional deficiency, including a decrease in ferritin levels and vitamin D deficiency, a tendency towards increased parathyroid hormone levels, and hyperhomocysteinemia. The combination of these abnormalities indicates a disruption in the processes of epithelial regeneration, as well as in the mineral metabolism of calcium, phosphorus, and hematopoiesis.
symptomatic benign migratory glossitis, desquamative glossitis, polydeficiency conditions, vitamin D, homocysteine, parathyroid hormone, ferritin, laboratory diagnostics
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