Pavlov First Saint Petersburg State Medical University (Deputy Director for Scientific Work, Research Institute of Dentistry and Maxillofacial Surgery)
from 01.01.2013 until now
Saint Petersburg, St. Petersburg, Russian Federation
Moscow, Moscow, Russian Federation
Saint Petersburg, St. Petersburg, Russian Federation
Saint Peterburg, St. Petersburg, Russian Federation
Saint Peterburg, St. Petersburg, Russian Federation
Saint Peterburg, St. Petersburg, Russian Federation
UDC 616.31
Actuality. Effective oral hygiene products with an anti-plaque effect can significantly reduce the risk of developing diseases. New active ingredients of oral hygiene products, such as octacalcium phosphate, nanohydroxyapatite, aminophthroid, as well as various plant extracts and probiotics, are becoming increasingly popular due to their unique properties that help not only in the fight against plaque, but also in maintaining the health of hard and soft tissues of the mouth. Material and methods. To study the preventive effect of "PRESIDENT® Profi Biomineral" toothpaste, a clinical trial was conducted with the participation of 60 people (34 women, 26 men). The study participants used the preventive toothpaste "PRESIDENT® Profi Biomineral" every day, morning and evening, for 28 days. An objective assessment of the condition of the hard tissues of the mouth was carried out every week in order to determine the anti-caries, remineralizing and desensitizing effects, as well as an assessment of the buffer capacity of saliva. Results. Based on the results of a study of the preventive effect of oral hygiene products based on octacalcium phosphate in the examined patients who used PRESIDENT® Profi Biomineral toothpaste for individual oral hygiene, it was determined that the anti-caries effectiveness increased from 2.03 ± 0.90% to 16.24 ± 4.34% in one month of using PRESIDENT® Profi Biomineral paste. The remineralizing efficacy in one month of using PRESIDENT® Profi Biomineral toothpaste was 24.76 ± 3.92%. The desensitive efficiency increased from 7.11 ± 1.23% to 19.72 ± 5.24% and increased by 12.61%. Conclusion. It was revealed that the toothpaste "PRESIDENT® Profi Biomineral" based on octacalcium phosphate, when used in individual hygiene measures, has a significant preventive effect, which was established as a result of its clinical testing.
prevention of dental diseases, preventive toothpastes, individual oral hygiene, prevention of caries, hypersensitivity of teeth, remineralizing effect
1. Dionysopoulos D., Gerasimidou O., Beltes C. Dentin Hypersensitivity: Etiology, Diagnosis and Contemporary Therapeutic Approaches - A Review in Literature. Applied Sciences. 2023;13(21):11632. https://doi.org/10.3390/app132111632
2. Ulitovskiy S.B., Kalinina O.V., Leont'ev A.A., Alekseeva E.S. Realizaciya stomatologicheskih profilakticheskih programm v Rossiyskoy Federacii. Institut stomatologii. 2025;(1):18-19. [Ulitovskiy S.B., Kalinina O.V., Leontiev A.A., Alekseeva E.S. Implementation of dental preventive programs in the Russian Federation. The dental institute. 2025;(1):18-19. (In Russ.)]. https://instom.spb.ru/catalog/article/20416/
3. Altinsoy G.O., Ceyhan D. Effects of Five Different Toothpastes on Remineralization and Surface Roughness of Primary Tooth Enamel with Artificial Initial Caries. Applied Sciences. 2024;14(16):7232. https://doi.org/10.3390/app14167232
4. Ulitovskiy S.B., Kalinina O.V., Leont'ev A.A. Osobennosti podbora sredstv oral'noy gigieny studentami. Institut stomatologii. 2025;(2):13-15. [Ulitovskiy S.B., Kalinina O.V., Leontiev A.A. Features of selection of oral hygiene products by students. The dental institute. 2025;(2):13-15. (In Russ.)]. https://instom.spb.ru/catalog/article/20510/
5. Cocco F., Salerno C., Wierichs R., Wolf T., Arghittu A., Cagetti M. et al. Hydroxyapatite-Fluoride Toothpastes on Caries Activity: A Triple-Blind Randomized Clinical Trial. International Dental Journal. 2025;75(2):632-642. https://doi.org/10.1016/j.identj.2024.09.037
6. Iordanishvili A.K., Malyshev M.E., Petrov A.A. Izmeneniya v tkanyah parodonta, chuvstvitel'nosti zubov i mukozal'nogo immuniteta pri ispol'zovanii zubnoy pasty s gidroksiapatitom, papainom, termal'noy gryaz'yu, ekstraktami eleuterokokka i kalenduly. Medicinskiy alfavit. 2020;(3):35-38. [Iordanishvili A.K., Malyshev M.E., Petrov A.A. Changes in periodontal tissues, tooth sensitivity and mucosal immunity when using toothpaste with hydroxyapatite, papain, thermal mud, extracts of eleutherococcus and calendula. Medical alphabet. 2020;(3):35-38. (In Russ.)]. https://doi.org/10.33667/2078-5631-2020-3-35-38
7. Fernandes N.L., Silva V.C., Sousa E.B., Perlatti D’Alpino P.H., Bezerra de Oliveira A.F., Jong E.J. et al. Effectiveness of fluoride-containing toothpastes associated with different technologies to remineralize enamel after pH cycling: an in vitro study. BMC Oral Health. 2022;22(1):489. https://doi.org/10.1186/s12903-022-02429-2
8. Aleshina N.F., Piterskaya N.V., Starikova I.V. Individual'nyy podhod k obsledovaniyu pacientov i vyboru metodov lecheniya povyshennoy chuvstvitel'nosti zubov. Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta. 2020;17(3):60-64. [Aleshina N.F., Piterskaya N.V., Starikova I.V. Individual approach to the examination of patients and the choice of treatment methods tooth sensitivity. Journal of Volgograd State Medical University. 2020;17(3):60-64. (In Russ.)]. https://old.volgmed.ru/uploads/journals/articles/1602153323-vestnik-2020-3-3721.pdf
9. Avraamova O.G., Kuz'michevskaya M.V., Sorokin N.I., Lavrovskaya Ya.A. Analiz effektivnosti ispol'zovaniya remineralizuyuschego gelya «Asepta» dlya vosstanovleniya emali postoyannyh zubov v detskom vozraste. Klinicheskie nablyudeniya. Institut stomatologii. 2025;(1):79-81. [Avraamova O.G., Kuz'michevskaya M.V., Sorokin N.I., Lavrovskaya Ya.A. Analysis of the effectiveness of the use of remineralizing gel «Asepta» for the restoration of enamel of permanent teeth in childhood. Clinical observations. The dental institute. 2025;(1):79-81. (In Russ.)]. https://instom.spb.ru/catalog/article/20462/
10. Buschang P.H., Chastain D., Keylor C.L., Crosby D., Julien K.C. Incidence of white spot lesions among patients treated with clear aligners and traditional braces. The Angle orthodontist. 2019;89(3):359-364. https://doi.org/10.2319/073118-553.1
11. Ulitovskiy S.B., Orehova L.Yu., Kalinina O.V., Leont'ev A.A., Loboda E.S. Mirovoy opyt vnedreniya profilakticheskih programm v stomatologii. Parodontologiya. 2024;29(1):13-23. [Ulitovskiy S.B., Orekhova L.Y., Kalinina O.V., Leontev A.A., Loboda E.S. The world's experience of introducing prophylactic programs in dentistry. Parodontologiya. 2024;29(1):13-23. (In Russ.)]. https://doi.org/10.33925/1683-3759-2024-895
12. Ulitovskiy S.B., Sadovskiy V.V., Kalinina O.V., Leont'ev A.A., Rusakova E.Yu., Bukov D.O. Izuchenie ochischayuschego effekta spreya dlya profilaktiki kariesa, soderzhaschego Streptococus Thermophilus lizat i prebiotiki, kak promezhutochnogo sredstva gigieny rta. Problemy stomatologii. 2023;19(3):91–95. [Ulitovskiy S.B., Sadovski V.V., Kalinina O.V., Leontiev A.A., Rusakova E.Y., Bukov D.O. The study of the cleaning effect of the spray for the prevention of caries «DENTABALANCE®» synbiotic complex including lysate from streptococcus thermophilus and prebiotics as an intermediate means of oral hygiene. Actual problems in dentistry. 2023;19(3):91–95. (In Russ.)]. https://elibrary.ru/item.asp?id=54915950
13. Enax J., Fandrich P., Schulze zur Wiesche E., Epple M. The Remineralization of Enamel from Saliva: A Chemical Perspective. Dentistry journal. 2024;12(11):339. https://doi.org/10.3390/dj12110339
14. Podoprigora A.V., Chirkova N.V., Tokarev V.A., Vecherkina Zh.V., Morozov A.N., Lescheva E.A. Kompleksnyy podhod k lecheniyu giperestezii zubov u pacientov s recessiey desny. Mezhdunarodnyy nauchno-issledovatel'skiy zhurnal. 2024;(5):[8 s.]. [Podoprigora A.V., Chirkova N.V., Tokarev V.A., Vecherkina Z.V., Morozov A.N., Leshcheva Y.A. An integrated approach to the treatment of hyperesthesia teeth in patients with gum recession. International Research Journal. 2024;(5):8 p. (In Russ.)]. https://doi.org/10.60797/IRJ.2024.143.47
