Аннотация (русский):
Цель систематического обзора — поиск и анализ публикаций по перспективным направлениям применения жевательной резинки (ЖР) в стоматологии (включая гигиенический уход за полостью рта, диагностический потенциал и комплексное лечение заболеваний и состояний стоматологического профиля), а также в гастроэнтерологии и когнитивной психологии. Материалы и методы исследования. В обзоре представлены результаты анализа материалов оригинальных полнотекстовых статей, систематических обзоров и мета-анализа (c анализом процитированных ссылок) на русском и английском языках, отражающих лечебно-профилактические направления применения ЖР у пациентов c различными стоматологическими и системными заболеваниями; тезисы докладов аналитике не подлежали. Источники информации — электронные базы данных еLibrary, Cyberlenika, MEDLINE, PubMed, Scopus, Web of Science, Сochrane Library. Результаты исследования и их обсуждение. В соответствии с заданными требованиями на первом этапе было отобрано и проанализировано 481 публикаций; глубина поиска — до 35 лет. После скрининга материала, с учетом конкретизации ключевых слов, было отобрано 132 публикации, включая мета-анализы. Выводы. Отражены разные лечебно-профилактические направления применения ЖР у пациентов c различными стоматологическими и системными заболеваниями. Обобщенная позиция авторов публикаций — главным условием отнесения жевательной резинки к средствам гигиены полости рта является отсутствие в ней сахара и наличие ингредиентов, определяющих лечебно-профилактические эффекты, а именно очищающее, противокариозное, противовоспалительное, дезодорирующее действие, стимуляция слюноотделения; специфические эффекты (за счет введения в жевательные резинки лечебно-профилактических добавок); стимуляция кровообращения в тканях мукопародонтального комплекса; положительное влияние на когнитивную деятельность, на настроение индивидуума, на концентрацию внимания; снижение симптомов пищеводного рефлюкса.

Ключевые слова:
жевательная резинка, жевание, средства гигиены полости рта, ротовая жидкость, микрофлора полости рта, кариес зубов, заболевания пародонта и слизистой оболочки рта, ксеростомия, полипрагмазия, галитоз, системная патология, когнитивные функции, пищеварение

1. Блынская Е.В., Тишков С.В., Алексеев К.В., Буева В.В., Иванов А.А. Особенности технологии производства лекарственных жевательных резинок. Российский биотерапевтический журнал. 2020;19(3):21-28. [E.V. Blynskaya, S.V. Tishkov, K.V. Alekseev, V.V. Bueva, A.A. Ivanov. Features of the production technology of medicinal chewing gums. Russian Journal of Biotherapeutics. 2020;19(3):21-28. (In Russ.)]. https://doi.org/10.17650/1726-9784-2020-19-3-21-28

2. Гилева О.С., Либик Т.В., Гибадуллина Н.В., Сивак Е.Ю., Гавриленко М.С., Белева Н.С., Задорина И.И. Ключевые стоматологические проблемы периода пандемии COVID-19: мониторинг состояния стоматологического здоровья у пациентов с хроническими заболеваниями слизистой оболочки полости рта. Стоматология. 2021;100(6-2):8-15. [O.S. Gileva, T.V. Libik, N.V. Gibadullina, E.Yu. Sivak, M.S. Gavrilenko, N.S. Beleva, I.I. Zadorina. Key dental problems during the COVID-19 pandemic: monitoring the state of dental health in patients with chronic diseases of the oral mucosa. Dentistry. 2021;100(6-2):8-15. (In Russ.)]. DOIhttps://doi.org/10.17116/stomat20211000628.

3. Гилева О.С., Либик Т.В., Позднякова А.А., Гибадуллина Н.В., Сюткина Е.С., Коротин С.В. Заболевания слизистой оболочки полости рта: методы диагностики и лечения. Dental Forum. 2019;1(72):27-36. [O.S. Gileva, T.V. Libik, A.A. Pozdnyakova, N.V. Gibadullina, E.S. Syutkina, S.V. Korotin. Diseases of the oral mucosa: diagnostic and treatment methods. Dental Forum. 2019;1(72):27-36. (In Russ.)]. https://elibrary.ru/item.asp?id=37307583

4. Гилева О.С., Либик Т.В., Халилаева Е.В., Данилов К.В., Халявина И.Н., Гилева Е.С., Садилова В.А., Пленкина Ю.А., Хохрин Д.В. Стоматологическое здоровье в критериях качества жизни. Медицинский вестник Башкортостана. 2011;6(3):6-11. [O.S. Gileva, T.V. Libik, E.V. Khalilaeva, K.V. Danilov, I.N. Khalyavina, E.S. Gileva, V.A. Sadilova, Yu.A. Plenkina, D.V. Khokhrin. Dental health in terms of quality of life criteria. Medical Bulletin of Bashkortostan. 2011;6(3):6-11. (In Russ.)]. https://elibrary.ru/item.asp?id=17047841

5. Ризаев Ж.А., Бекжанова О.Е., Козиолова Н.А., Либик Т.В., Данилова М.А., Сивак Е.Ю., Сычёва М.А., Немова Е.М. Ключевые стоматологические проблемы пациента пожилого возраста: междисциплинарная образовательная платформа. Пермский медицинский журнал. 2023;40(3):60-77. [Zh.A. Rizaev, O.E. Bekzhanova, N.A. Koziolova, T.V. Libik, M.A. Danilova, E.Yu. Sivak, M.A. Sycheva, E.M. Nemova. Key dental problems of an elderly patient: an interdisciplinary educational platform. Perm Medical Journal. 2023;40(3):60-77. (In Russ.)]. DOIhttps://doi.org/10.17816/pmj40360-77.

6. Гилева О.С., Смирнова Е.Н., Позднякова А.А., Либик Т.В. Особенности диагностики и лечения ксеростомического синдрома при заболеваниях пародонта и слизистой оболочки полости рта у пациентов с сахарным диабетом 2-го типа. РМЖ. 2016;24(20):1340-1345. [O.S. Gileva, E.N. Smirnova, A.A. Pozdnyakova, T.V. Libik. Features of diagnostics and treatment of xerostomia syndrome in diseases of the periodontium and oral mucosa in patients with type 2 diabetes mellitus. RMJ. 2016;24(20):1340-1345. (In Russ.)]. https://elibrary.ru/item.asp?id=28124434

7. Гилева О.С., Фельдблюм И.В., Либик Т.В., Байдаров А.А., Сметанин Д Г., Чупракова Е.В., Сивак Е.Ю., Сюткина Е.С. Ключевые стоматологические проблемы периода пандемии COVID-19: междисциплинарная платформа. Стоматология детского возраста и профилактика. 2021;21(1):61-65. [O.S. Gileva, I.V. Feldblyum, T.V. Libik, A.A. Baidarov, D.G. Smetanin, E.V. Chuprakova, E.Yu. Sivak, E.S. Syutkina. Key dental issues during the COVID-19 pandemic: an interdisciplinary platform. Pediatric dentistry and prevention. 2021;21(1):61-65. (In Russ.)]. https://elibrary.ru/item.asp?id=45574240

8. Григорьев С.С., Кудинов П.Н., Бурлак А.В. Синдром сухого рта (обзор литературы). Уральский медицинский журнал. 2019;12(180):18-25. [S.S. Grigoriev, P.N. Kudinov, A.V. Burlak. Dry mouth syndrome (literature review). Ural Medical Journal. 2019;12(180):18-25. (In Russ.)]. DOIhttps://doi.org/10.25694/URMJ.2019.12.07.

9. Деркачева Е.И., Ронь Г.И. Клинические проявления в полости рта при ксеростомии различной этиологии. Уральский медицинский журнал. 2014;5(119):44-47. [E.I. Derkacheva, G.I. Ron. Clinical manifestations in the oral cavity in xerostomia of various etiologies. Ural Medical Journal. 2014;5(119):44-47. (In Russ.)]. https://elibrary.ru/item.asp?id=21982443

10. Кисельникова Л.П., Данилова И.Г. Жевательная резинка и ее роль в профилактике стоматологических заболеваний. Екатеринбург. 2009:44. [L.P. Kiselnikova, I.G. Danilova. Chewing gum and its role in the prevention of dental diseases. Ekaterinburg. 2009:44. (In Russ.)].

11. Кисельникова Л.П., Сахарова Э.Б., Гетте И.К., Данилова И.Г. Изучение противовоспалительного действия фторсодержащей жевательной резинки “Fluorette”. Пародонтология. 1998;3:40-42. [L.P. Kiselnikova, E.B. Sakharova, I.K. Gette, I.G. Danilova. Study of the anti-inflammatory effect of fluoride-containing chewing gum “Fluorette”. Periodontology. 1998;3:40-42. (In Russ.)]. http://elib.fesmu.ru/Article.aspx?id=17092&;ysclid=ly2yie02ax419609145

12. Леонтьев В.К., Кисельникова Л.П. Детская терапевтическая стоматология. Национальное руководство. 2-е изд., перераб. и доп. Москва : ГЭОТАР - Медиа. 2017:952. [V.K. Leontiev, L.P. Kiselnikova. Children's therapeutic dentistry. National guidelines. 2nd ed., revised and enlarged. Moscow: GEOTAR-Media. 2017:952. (In Russ.)]. https://www.rosmedlib.ru/book/ISBN9785970461730.html

13. Петрова Т.Г., Зверева Т.В., Бородина Н.Б., Покатова Е.Е. Стоматологический статус и показатели качества жизни у лиц пожилого и старческого возраста. Успехи геронтологии. 2017;30(3):390-393. [T.G. Petrova, T.V. Zvereva, N.B. Borodina, E.E. Pokatova. Dental status and quality of life indicators in elderly and senile individuals. Advances in Gerontology. 2017;30(3):390-393. (In Russ.)]. https://elibrary.ru/item.asp?id=29823540

14. Позднякова А.А., Гилева О.С., Либик Т.В., Сатюкова Л.Я. Особенности клинической симптоматологии заболеваний слизистой оболочки полости рта и влияние ксеростомического симптома на стоматологические показатели качества жизни. Современные проблемы науки и образования. 2013;2:77. [A.A. Pozdnyakova, O.S. Gileva, T.V. Libik, L.Ya. Satyukova. Peculiarities of clinical symptomatology of diseases of the oral mucosa and the influence of xerostomia symptom on dental indicators of quality of life. Modern problems of science and education. 2013;2:77. (In Russ.)]. https://elibrary.ru/item.asp?id=21285428

15. Попова Н.С. Уровень санитарно-гигиенических знаний среди беременных женщин. Dental Forum. 2012;3:84. [N.S. Popova. Level of sanitary and hygienic knowledge among pregnant women. Dental Forum. 2012;3:84. (In Russ.)]. https://elibrary.ru/item.asp?id=17735443

16. Ризаев Ж.А., Кушаков Б.Ж., Рустамова Д.А., Зейнитдинова З.А. Проявления коронавирусной инфекции SARS-COV-2 в полости рта. Журнал биомедицины и практики. 2022;7(2):102-107. [Zh.A. Rizaev, B.Zh. Kushakov, D.A. Rustamova, Z.A. Zeynitdinova. Manifestations of coronavirus infection SARS-COV-2 in the oral cavity. Journal of Biomedicine and Practice. 2022;7(2):102-107. (In Russ.)]. https://www.sammu.uz/ru/article/2035

17. Рязанова О.А. Жевательная резинка: классификация, виды. Пищевая промышленность. 2014;(1):68-71. [O.A. Ryazanova. Chewing gum: classification, types. Food industry. 2014;(1):68-71. (In Russ.)]. https://elibrary.ru/item.asp?id=21046629

18. Семенцова Е.А., Мандра Ю.В., Базарный В.В., Полушина Л.Г., Григорьев С.С., Еловикова Т.М., Светлакова Е.Н., Жегалина Н.М. Взаимосвязь клинических стоматологических возраст-ассоциированных синдромов и некоторых предикторов старения в полости рта. Пародонтология. 2022;27(1):74-79. [E.A. Semenova, Yu.V. Mandra, V.V. Bazarnyy, L.G. Polushina, S.S. Grigoriev, T.M. Elovikova, E.N. Svetlakova, N.M. Zhegalina. Relationship between clinical dental age-associated syndromes and some predictors of aging in the oral cavity. Periodontology. 2022;27(1):74-79. (In Russ.)]. https://elibrary.ru/item.asp?id=48074256

19. Соловьева А.М., Матело С.К., Купец Т.В. Лечебно-профилактические аспекты употребления жевательной резинки. Учебно-методическое пособие для стоматологических факультетов медицинских ВУЗов РФ. Мовква. 2003. [A.M. Solovieva, S.K. Matelo, T.V. Kupets. Therapeutic and preventive aspects of chewing gum use. Study guide for dental faculties of medical universities of the Russian Federation. Moscow. 2003. (In Russ.)]. https://rusneb.ru/catalog/010003_000061_2193d087a6906b13c5deccd3fcd735e6/?ysclid=ly2z1kw7w1919989956

20. Соловьёва Н.Л., Сокуренко М.С. Жевательная лекарственная резинка как перспективная система доставки лекарств (обзор). Разработка и регистрация лекарственных средств. 2017;2:90-95. [N.L. Solovieva, M.S. Sokurenko. Chewing medicinal gum as a promising drug delivery system (review). Development and registration of drugs. 2017;2:90-95. (In Russ.)]. https://elibrary.ru/item.asp?id=34994622

21. Тишков С.В., Блынская Е.В., Алексеев К.В., Буева В.В., Иванов А.А. Резинки жевательные лекарственные - перспективы, ассортимент, особенности разработки и применения. Фармацевтическое дело и технология лекарств. 2020;4:39-53. [S.V. Tishkov, E.V. Blynskaya, K.V. Alekseev, V.V. Bueva, A.A. Ivanov. Medicinal chewing gums - prospects, assortment, features of development and application. Pharmaceutical business and drug technology. 2020;4:39-53. )In Russ.)]. DOIhttps://doi.org/10.33920/med-13-2004-01.

22. Шаковец Н.В., Бекжанова О.Е., Каюмова В.Р. Патогенез дисфункции слюнных желез у пациентов с COVID-19. Медицинские новости. 2022;8(335):13-17. [N.V. Shakovets, O.E. Bekzhanova, V.R. Kayumova. Pathogenesis of salivary gland dysfunction in patients with COVID-19. Medical news. 2022;8(335):13-17. (In Russ.)]. https://elibrary.ru/item.asp?id=49560681

23. Aagaard A., Godiksen S., Teglers P.T., Schiodt M., Glenert U. Comparison between new saliva stimulants in patients with dry mouth: a placebo-controlled double-blind crossover study // J oral Pathol Med. – 1992;21:376-380. DOI:https://doi.org/10.1111/j.1600-0714.1992.tb01369.x

24. Abdul-Aziz A.I. Effect of chewing gum on pain following orthodontic elastomeric separators placement: a randomized controlled trial // Open Access Maced J Med Sci. – 2021;9:134-138. https://doi.org/10.3889/oamjms.2021.6782

25. Abelson D.C., Barton J., Mandel I.D. The effect of chewing sorbitol-sweetened gum on salivary fow and cemental plaque pH in subjects with low salivary flow // J Clin Dent. – 1990;2:3-5. https://pubmed.ncbi.nlm.nih.gov/2133392/

26. Al-Haboubi M., Zoitopoulos L., Beighton D., Gallagher J.E. The potential benefits of sugar-free chewing gum on the oral health and quality of life of older people living in the community: a randomized controlled trial // Community Dent Oral Epidemiol. – 2012;40:415-424. DOI:https://doi.org/10.1111/j.1600-0528.2012.00685.x

27. Allen A.P., Smith A.P. Chewing gum: cognitive performance, mood, well-being, and associated physiology // Biomed Res Int. – 2015;2015:654806. doi:https://doi.org/10.1155/2015/654806.

28. Allida S.M., Shehab S., Inglis S.C., Davidson P.M., Hayward C.S., Newton P.J. A RandomisEd ControLled TrIal of ChEwing Gum to RelieVE Thirst in Chronic Heart Failure (RELIEVE-CHF) // Hear Lung Circ. – 2021;30:516-524. DOI:https://doi.org/10.1016/j.hlc.2020.09.004

29. Aslani A., Rostami F. Medicated chewing gum, a novel drug delivery system // J Res Med Sci. – 2015;20(4):403-411. https://pubmed.ncbi.nlm.nih.gov/26109999/

30. Avidan B., Sonnenberg A., Schnell T.G., Sontag S.J. Walking and chewing reduce postprandial acid reflux // Aliment Pharmacol Ther. – 2001;15:151-155. DOI:https://doi.org/10.1046/j.1365-2036.2001.00902.x

31. Banakar M., Moayedi S., Shamsoddin E., Vahedi Z., Banakar M.H., Mousavi S.M., Rokaya D., Bagheri Lankarani K. Chewing Gums as a Drug Delivery Approach for Oral Health // Int J Dent. – 2022;2022:9430988. doi:https://doi.org/10.1155/2022/9430988.

32. Bang Y.J., Lee J.H., Kim C.S., Lee Y.Y., Min J.J. Anxiolytic effects of chewing gum during preoperative fasting and patient-centered outcome in female patients undergoing elective gynecologic surgery: randomized controlled study // Sci Rep. – 2022;12(1):4165. doi:https://doi.org/10.1038/s41598-022-07942-6.

33. Barabolak R., Hoerman K., Kroll B., Record D. Gum chewing profiles in the US population Community Dent // Oral Epidemiol. – 1991;19:125-126. DOI:https://doi.org/10.1111/j.1600-0528.1991.tb00126.x

34. Bartlett D.W., Evans D.F., Anggiansah A., Smith B.G.N. A study of the association between gastro-oesophageal reflux and palatal dental erosion // Br Dent J. – 1996;181:125-132. DOI:https://doi.org/10.1038/sj.bdj.4809187

35. Basam L.C., Singaraju G.S., Obili S. et al. Orthodontic pain control following arch wire placement; a comparison between pre-emptive tenoxicam and chewing gum: a randomized clinical trial // J Dent Anesth Pain Med. – 2022; 22:107-116. DOI:https://doi.org/10.17245/jdapm.2022.22.2.107

36. Bergius M., Berggren U., Kiliaridis S. Experience of pain during and orthodontic procedure // Eur J Oral Sci. – 2002;110:92-98. DOI:https://doi.org/10.1034/j.1600-0722.2002.11193.x

37. Björnström M., Axell T., Birkhed D. Comparison between saliva stimulants and saliva substitutes in patients with symptoms related to dry mouth // A multi-centre study Swed Dent J. – 1990;14:153-161. https://pubmed.ncbi.nlm.nih.gov/2147787/

38. Bossola M. Xerostomia in patients on chronic hemodialysis: an update // Semin Dial. – 2019;32:467-474. DOI:https://doi.org/10.1111/sdi.12821

39. Bots C.P., Brand H.S., Veerman E.C.I., Korevaar J.C., Valentijn-Benz M., Bezemer P.D. et al. Chewing gum and a saliva substitute alleviate thirst and xerostomia in patients on haemodialysis // Nephrol Dial Transplant. – 2005;20:578-584. DOI:https://doi.org/10.1093/ndt/gfh675

40. Bots C.P., Brand H.S., Veerman E.C.I., Valentijn-Benz M., Van A.B.M., Amerongen A.V.N. et al. The management of xerostomia in patients on haemodialysis: comparison of artifcial saliva and chewing gum // Palliat Med. – 2005;19:202-207. DOI:https://doi.org/10.1191/0269216305pm1009oa

41. Bulthuis M.S., Jan Jager D.H., Brand H.S. Relationship among perceived stress, xerostomia, and salivary fow rate in patients visiting a saliva clinic // Clin Oral Investig. – 2018;22:3121-3127. DOI:https://doi.org/10.1007/s00784-018-2393-2

42. Burton J.P., Chilcott C.N., Tagg J.R. The rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics // Oral Dis. – 2005;11(1):29-31. DOI:https://doi.org/10.1111/j.1601-0825.2005.01084.x

43. Celebi F. Mechanical vibration and chewing gum methods in orthodontic pain relief // Turk J Orthod. – 2022;35:133-138. DOI:https://doi.org/10.5152/TurkJOrthod.2022.21091

44. Cortelli J.R., Barbosa M.D., Westphal M.A. Halitosis: a review of associated factors and therapeutic approach Braz // Oral. Res. – 2008;22(1):44-54. DOI:https://doi.org/10.1590/s1806-83242008000500007

45. Da Silva Santos D.J., Capelli J.Jr. Chewing gum as a nonpharmacological alternative for orthodontic pain relief: a randomized clinical trial using an intention-to-treat analysis // Korean J Orthod. – 2021;51:346-354. DOI:https://doi.org/10.4041/kjod.2021.51.5.346

46. Davies A.N. A comparison of artifcial saliva and chewing gum in the management of xerostomia in patients with advanced cancer // Palliat Med. – 2000;14:197-203. DOI:https://doi.org/10.1191/026921600672294077

47. Dawes C., Macpherson L.M. Efects of nine diferent chewing-gums and lozenges on salivary fow rate and pH // Caries Res. – 1992;26:176-182. DOI:https://doi.org/10.1159/000261439

48. Dehghanmehr S., Sheikh A., Siyasari A., Karimkoshteh M.H., Sheikh G., Salarzaei M. et al. Investigating the impact of sugar free gum on the thirst and dry mouth of patients undergoing hemodialysis // Int J Pharm Sci Res. – 2018;9:2062-2066. https://www.researchgate.net/profile/Morteza-Salarzaee/publication/329687240_INVESTIGATING_THE_IMPACT_OF_SUGAR_FREE_GUM_ON_THE_THIRST_AND_DRY_MOUTH_OF_PATIENTS_UNDERGOING_HEMODIALYSIS/links/5c1566f0299bf139c75bc1e5/INVESTIGATING-THE-IMPACT-OF-SUGAR-FREE-GUM-ON-THE-THIRST-AND-DRY-MOUTH-OF-PATIENTS-UNDERGOING-HEMODIALYSIS.pdf

49. Dodds M.W.J., Haddou M.B., Day J.E.L. The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised subjects: a systematic review and meta-analysis // BMC Oral Health. – 2023;23(1):406. doi:https://doi.org/10.1186/s12903-023-03084-x.

50. Duruk N., Eser I. The null efect of chewing gum during hemodialysis on dry mouth // Clin Nurse Spec. – 2016;30:E12-23. DOIhttps://doi.org/10.1097/NUR.0000000000000234

51. Eds. Edgar W.M., O'Mullane D.M. Saliva and oral health. 2nd ed. London. 1996. https://books.google.ru/books/about/Saliva_Oral_Health.html?id=6qVpAAAAMAAJ&;redir_esc=y

52. Erovic Ademovski S., Lingström P., Renvert S. The effect of different mouth rinse products on intra-oral halitosis // Int. J. Dent. Hyg. – 2016;14:117-123. DOIhttps://doi.org/10.1111/idh.12148

53. Fan W.F., Zhang Q., Luo L.H., Niu J.Y., Gu Y. Study on the clinical significance and related factors of thirst and xerostomia in maintenance hemodialysis patients // Kidney Blood Press Res. – 2013;37:464-474. doi:https://doi.org/10.1159/000355717.

54. Fedorowicz Z., Aljufairi H., Nasser M., Outhouse T.L., Pedrazzi V. Mouthrinses for the treatment of halitosis // Cochrane Database Syst. Rev. – 2008;8(4):CD006701. doi:https://doi.org/10.1002/14651858.CD006701.pub2.

55. Fox P.C., Busch K.A., Baum B.J. Subjective reports of xerostomia and objective measures of salivary gland performance // J Am Dent Assoc. – 1987;115:581-584. doi:https://doi.org/10.1016/s0002-8177(87)54012-0.

56. Furness S., Worthington H.V., Bryan G., Birchenough S., McMillan R. Interventions for the management of dry mouth: topical therapies // Cochrane Database Syst Rev. – 2011;12:CD008934. doi:https://doi.org/10.1002/14651858.CD008934.pub2.

57. Garcia A.K.A., Fonseca L.F., Furuya R.K., Rabelo P.D., Rossetto E.G. Effect of chewing gum on thirst: an integrative review // Rev Bras Enferm. – 2019;72:484-493. doi:https://doi.org/10.1590/0034-7167-2018-0132.

58. Garcia A.K.A., Furuya R.K., Conchon M.F., Rossetto E.G., Dantas R.A.S, Fonseca LF. Menthol chewing gum on preoperative thirst management: randomized clinical trial // Rev Lat Am Enfermagem. – 2019;27:e3180. doi:https://doi.org/10.1590/1518-8345.3070.3180.

59. Gavish A., Halachmi M., Winocur E., Gazit E. Oral habits and their association with signs and symptoms of temporomandibular disorders in adolescent girls // J. Oral Rehabil. – 2000;27:22-32. doi:https://doi.org/10.1046/j.1365-2842.2000.00484.x.

60. Gileva O.S., Sazhina M.V., Scully C., Gileva E.S., Efimov A.V. Spectrum of oral manifestations of HIV/AIDS in the Perm region (Russia) and identification of self-induced ulceronecrotic lingual lesions // Medicina Oral. – 2004;9(3):212-215. PMID:15122122

61. Guggenheimer J., Moore P.A. Xerostomia: etiology, recognition and treatment // J Am Dent Assoc. – 2003;134:61-69. doi:https://doi.org/10.14219/jada.archive.2003.0018.

62. Gueimonde L., Vesterlund S., García-Pola M.J., Gueimonde M., Söderling E., Salminen S. Supplementation of xylitol-containing chewing gum with probiotics: a double blind, randomised pilot study focusing on saliva flow and saliva properties // Food Funct. – 2016;7:1601-1609. doi:https://doi.org/10.1039/c5fo01497b.

63. Guo Q., Liao C., Guan X., Xiao L., Xiang M., Long S., Liu J., Xiang M. Effect of chewing gum on orthodontic pain in patients receiving fixed orthodontic treatment: a systematic review and meta-analysis // Eur J Med Res. – 2023;28(1):491. doi:https://doi.org/10.1186/s40001-023-01467-y.

64. Hasegawa Y., Tachibana Y., Ono T., Kishimoto H. Flavour-enhanced cortisol release during gum chewing // PLoS One. – 2017;12(4):e0173475. doi:https://doi.org/10.1371/journal.pone.0173475.

65. Hashiba T., Takeuchi K., Shimazaki Y., Takeshita T., Yamashita Y. Chewing xylitol gum improves self-rated and objective indicators of oral health status under conditions interrupting regular oral hygiene Tohoku // J. Exp. Med. – 2015;235:39-46. doi:https://doi.org/10.1620/tjem.235.39.

66. Helm J.F. Role of saliva in esophageal function and disease // Dysphagia. – 1989;4:76-84. doi:https://doi.org/10.1007/BF02407149.

67. Helm J.F., Dodds W.J., Hogan W.J. Salivary response to esophageal acid in normal subjects and patients with reflux esophagitis // Gastroenterology. – 1987;93:1393-1397. doi:https://doi.org/10.1016/0016-5085(87)90270-8.

68. Imfeld T. Chewing gum - facts and fiction: a review of gum-chewing and oral health Crit. Rev // Oral Biol. Med. – 1999;10:405-409. doi:https://doi.org/10.1177/10454411990100030901.

69. Jagodzińska M., Zimmer-Nowicka J., Nowicki M. Three months of regular gum chewing neither alleviates xerostomia nor reduces overhydration in chronic hemodialysis patients // J Ren Nutr. – 2011;21:410-417. doi:https://doi.org/10.1053/j.jrn.2010.08.002.

70. Johnson L.F., DeMeester T.R. Twenty four hour pH monitoring of the distal esophagus // Am J Gastroenterol. – 1974;62:325-332. https://pubmed.ncbi.nlm.nih.gov/4432845/

71. Kaae J.K., Stenfeldt L., Eriksen J.G. Xerostomia after radiotherapy for oral and oropharyngeal cancer: increasing salivary flow with tasteless sugar-free chewing gum // Front Oncol. – 2016;6:111. doi:https://doi.org/10.3389/fonc.2016.00111.

72. Kaae J.K., Stenfeldt L., Hyrup B., Brink C., Eriksen J.G. A randomized phase III trial for alleviating radiation-induced xerostomia with chewing gum // Radiother Oncol. – 2020;142:72-78. doi:https://doi.org/10.1016/j.radonc.2019.09.013.

73. Kang M.S., Kim B.G., Chung J., Lee H.C., Oh J.S. Inhibitory effect of Weissella cibaria isolates on the production of volatile sulphur compounds // J. Clin. Periodontol. – 2006;33:226-232. doi:https://doi.org/10.1111/j.1600-051X.2006.00893.x.

74. Keller M.K., Bardow A., Jensdottir T., Lykkeaa J., Twetman S. Effect of chewing gums containing the probiotic bacterium Lactobacillus reuteri on oral malodour // Acta Odontol. Scand. – 2012;70:246-250. doi:https://doi.org/10.3109/00016357.2011.640281.

75. Kim H.J., Lee J.Y., Lee E.S., Jung H.J., Ahn H.J., Jung H.I. et al. Simple oral exercise with chewing gum for improving oral function in older adults // Aging Clin Exp Res. – 2021;33:1023-1031. doi:https://doi.org/10.1007/s40520-020-01606-z.

76. Kumbargere Nagraj S., Eachempati P., Uma E., Singh V.P., Ismail N.M., Varghese E. Interventions for managing halitosis // Cochrane Database Syst Rev. – 2019;12(12):CD012213. doi:https://doi.org/10.1002/14651858.CD012213.pub2.

77. Lew K.K. Attitudes and perceptions of adults towards orthodontic treatment in an Asian community // Community Dent Oral Epidemiol. – 1993;21:31-35. doi:https://doi.org/10.1111/j.1600-0528.1993.tb00715.x.

78. Libik T.V., Gileva O.S., Danilov K.V., Grigorev S.S., Pozdnyakova A.A. Management of cancer therapy-induced oral mucositis pain and xerostomia with extra- and intra oral laser irradiation // AIP Conference Proceedings. – 2017;1882(1):id.020044. doihttps://doi.org/10.1063/1.5001623.

79. Lin C.M., Preston J.F., Wei C.I. Antibacterial mechanism of allyl isothiocyanate // J. Food Prot. – 2000;63:727-734. doi:https://doi.org/10.4315/0362-028x-63.6.727.

80. Liu B., Dion M.R., Jurasic M.M., Gibson G., Jones J.A. Xerostomia and salivary hypofunction in vulnerable elders: prevalence and etiology // Oral Surg Oral Med Oral Pathol Oral Radiol. – 2012;114(1):52-60. doi:https://doi.org/10.1016/j.oooo.2011.11.014.

81. Locker D. Dental status, xerostomia and the oral health-related qualiity of life of an elderly institutionalized population // Spec Care Dent. – 2003;23:86-93. doi:https://doi.org/10.1111/j.1754-4505.2003.tb01667.x.

82. Ly K.A., Milgrom P., Rothen M. The potential of dental protective chewing gum in oral health interventions // J. Am. Dent. Assoc. – 2008;139:553-563. doi:https://doi.org/10.14219/jada.archive.2008.0215.

83. Lynge Pedersen A.M., Nauntofte B., Smidt D., Torpet L.A. Oral mucosal lesions in older people: relation to salivary secretion, systemic diseases and medications // Oral Dis. – 2015;21(6):721-729. doi:https://doi.org/10.1111/odi.12337.

84. Moazzez R., Bartlett D., Anggiansah A. The effect of chewing sugar-free gum on gastro-esophageal reflux // J Dent Res. – 2005;84(11):1062-1065. doi:https://doi.org/10.1177/154405910508401118.

85. Molek M., Florenly F., Lister I.N.E., Wahab T.A., Lister C., Fioni F. Xerostomia and hyposalivation in association with oral candidiasis: a systematic review and meta-analysis // Evid Based Dent. – 2022;24. doi:https://doi.org/10.1038/s41432-021-0210-2.

86. Muniz F.W., Vidal T., Rego R., Moreira M., Martins R., Carvalho R. Perception and level of knowledge about halitosis among students and patients // Full Dent. Sci. – 2016;7:99-103. https://editoraplena.com.br/wp-content/uploads/2016/05/99-103-perception-and-level.pdf

87. Nadeem M., Tariq J., Kamran M.A. et al. Effect of chewing gum on pain in fixed orthodontic treatment. 2016;21:94-99. https://www.researchgate.net/publication/320068700_Effect_of_Chewing_Gum_on_Pain_in_Fixed_Orthodontic_Treatment

88. Nagata H., Inagaki Y., Tanaka M., Ojima M., Kataoka K., Kuboniwa M., Nishida N., Shimizu K., Osawa K., Shizukuishi S. Effect of eucalyptus extract chewing gum on periodontal health: a double-masked, randomized trial // J. Periodontol. – 2008;79:1378-1385. doi:https://doi.org/10.1902/jop.2008.070622.

89. Nagata H., Inagaki Y., Yamamoto Y., Maeda K., Kataoka K., Osawa K., Shizukuishi S. Inhibitory effects of macrocarpals on the biological activity of Porphyromonas gingivalis and other periodontopathic bacteria Oral Microbiol // Immunol. – 2006;21:159-163. doi:https://doi.org/10.1111/j.1399-302X.2006.00269.x.

90. Nakagawa K., Matsuo K., Takagi D., Morita Y., Ooka T., Hironaka S. et al. Effects of gum chewing exercises on saliva secretion and occlusal force in community-dwelling elderly individuals: a pilot study // Geriatr Gerontol Int. – 2017;17:48-53. doi:https://doi.org/10.1111/ggi.12670.

91. Nasseripour M., Newton J.T., Warburton F., Awojobi O., Di Giorgio S., Gallagher J.E., Banerjee A. A Systematic Review and Meta-Analysis of the Role of Sugar-Free Chewing Gum on Plaque Quantity in the Oral Cavity // Front Oral Health. – 2022;3:845921. doi:https://doi.org/10.3389/froh.2022.845921.

92. Nathan C.O., Asarkar A.A., Entezami P., Corry J., Strojan P., Poorten V.V., Makitie A., Eisbruch A., Robbins K.T., Smee R., St John M., Chiesa-Estomba C., Winter S.C., Beitler J.J., Ferlito A. Current management of xerostomia in head and neck cancer patients // Am J Otolaryngol. – 2023;44(4):103867. doi:https://doi.org/10.1016/j.amjoto.2023.103867.

93. Navazesh M., Kumar S.K.S. Measuring salivary flow: challenges and opportunities // J Am Dent Assoc. – 2008;139:35S-40S. doi:https://doi.org/10.14219/jada.archive.2008.0353.

94. Nederfors T., Isaksson R., Mörnstad H., Dahlöf C. Prevalence of perceived symptoms of dry mouth in an adult Swedish population-relation to age, sex and pharmacotherapy // Community Dent Oral Epidemiol. – 1997;25:211-216. doi:https://doi.org/10.1111/j.1600-0528.1997.tb00928.x.

95. Newton J.T., Awojobi O., Nasseripour M., Warburton F., Giorgio S. Di, Gallagher J. E., Banerjee A. A Systematic Review and Meta-Analysis of the Role of Sugar-Free Chewing Gum in Dental Caries // JDR Clin Trans Res. – 2020;5(3):214-223. doi:https://doi.org/10.1186/s12903-021-01517-z.

96. Olsson H., Spak C.J., Axéll T. The efect of a chewing gum on salivary secretion, oral mucosal friction, and the feeling of dry mouth in xerostomic patients // Acta Odontol Scand. – 1991;49:273-279. doi:https://doi.org/10.3109/00016359109005919.

97. Ozen N., Aydin Sayilan A., Mut D., Sayilan S., Avcioglu Z., Kulakac N. et al. The effect of chewing gum on dry mouth, interdialytic weight gain, and intradialytic symptoms: a prospective, randomized controlled trial // Hemodial Int. – 2021;25:94-103. doi:https://doi.org/10.1111/hdi.12878.

98. Pham T.A., Ueno M., Shinada K., Kawaguchi Y. Factors affecting oral malodor in periodontitis and gingivitis patients // J. Investig. Clin. Dent. – 2012;3:284-290. doi:https://doi.org/10.1111/j.2041-1626.2012.00155.x.

99. Pham L.C., van Spanning R.J., Röling W.F., Prosperi A.C., Terefework Z., TenCate J.M., Crielaard W., Zaura E. Effects of probiotic Lactobacillus salivarius W24 on the compositional stability of oral microbial communities // Arch. Oral Biol. – 2009;54:132-137. doi:https://doi.org/10.1016/j.archoralbio.2008.09.007.

100. Popova N.S., Kiselnikova L.P., Oksentjuk O.A., Jakovleva J.N. The effectiveness of caries-prevention program above pregnant women // 10-th Congress of European Academy of Pediatric Dentistry jointly with the British Society of European Academy of Pediatric Dentistry. UK. Harrotage, 3-6 june. – 2010:45.

101. Porciani P.F., Grandini S. The effect of zinc acetate and magnolia bark extract added to chewing gum on volatile sulfur-containing compounds in the oral cavity // J. Clin. Dent. – 2012;23:76-79. https://pubmed.ncbi.nlm.nih.gov/23210417/

102. Reingewirtz Y., Girault O., Reingewirtz N., Senger B., Tenenbaum H. Mechanical effects and volatile sulfur compound-reducing effects of chewing gums: comparison between test and base gums and a control group // Quintessence Int. – 1999;30:319-323. https://pubmed.ncbi.nlm.nih.gov/10635286/

103. Risheim H., Arneberg P. Salivary stimulation by chewing gum and lozenges in rheumatic patients with xerostomia // Eur J Oral Sci. – 1993;101:40-43. doi:https://doi.org/10.1111/j.1600-0722.1993.tb01644.x.

104. Rosenberg M. Clinical assessment of bad breath: current concepts // J. Am. Dent. Assoc. – 1996;127:475-482. doi:https://doi.org/10.14219/jada.archive.1996.0239.

105. Rösing C.K., Gomes S.C., Bassani D.G., Oppermann R.V. Effect of chewing gums on the production of volatile sulfur compounds(VSC) in vivo // Acta Odontol Latinoam. – 2009;22:11-14. https://pubmed.ncbi.nlm.nih.gov/19601490/

106. Rossi S., Santamaria Junior M., Venezian G.C. et al. A doubleblinded randomized clinical trial of pain perception during orthodontic treatment // Rev Odontol UNESP. – 2022;51:e20220007. DOIhttps://doi.org/10.1590/1807-2577.00722

107. Said H., Mohammed H. Effect of chewing gum on xerostomia, thirst and Interdialytic weight gain in patients on hemodialysis // Life Sci J. – 2013;10:1767-1777. https://www.semanticscholar.org/paper/Effect-of-Chewing-Gum-on-Xerostomia%2C-Thirst-and-in-Said-Mohammed/610119644fcd30a1b68728e86bd6d550f6873ac4

108. Sarosiek J., Scheurich C.J., Marcinkiewicz M., McCallum R.W. Enhancement of salivary esophagoprotection: rationale for a physiological approach to gastroesophageal reflux disase // Gastroenterology. – 1996;110:675-681. doi:https://doi.org/10.1053/gast.1996.v110.pm8608875.

109. Simons D., Brailsford S.R., Kidd E.A.M., Beighton D. The effect of medicated chewing gums on oral health in frail older people: a 1-year clinical trial // J Am Geriatr Soc. – 2002;50:1348-1353. doi:https://doi.org/10.1046/j.1532-5415.2002.50355.x.

110. Smith B.G., Knight J.K. An index for measuring the wear of teeth // Br Dent J. –1984;156:435-438. doi:https://doi.org/10.1038/sj.bdj.4805394.

111. Smoak B.R., Koufman J.A. Effects of gum chewing on pharyngeal and esophageal pH // Ann Otol Rhinol Laryngol. – 2001;110:1117-1119. doi:https://doi.org/10.1177/000348940111001206.

112. Sreebny L.M., Valdini A. Xerostomia. Part I: Relationship to other oral symptoms and salivary gland hypofunction // Oral surgery, oral Med oral Pathol. – 1988;66:451-458. doi:https://doi.org/10.1016/0030-4220(88)90268-x.

113. Stewart C.M., Jones A.C., Bates R.E., Sandow P., Pink F., Stillwell J. Comparison between saliva stimulants and a saliva substitute in patients with xerostomia and hyposalivation // Spec Care Dent. – 1998;18:142-148. doi:https://doi.org/10.1111/j.1754-4505.1998.tb01136.x.

114. Suzuki N., Yoneda M., Tanabe K., Fujimoto A., Iha K, Seno K., Yamada K., Iwamoto T., Masuo Y., Hirofuji T. Lactobacillus salivarius WB21 - containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial // Oral Surg. Oral Med. Oral Pathol. Oral Radiol. – 2014;117:462-470. doi:https://doi.org/10.1016/j.oooo.2013.12.400.

115. Tabrizi R., Karagah T., Aliabadi E., Hoseini S.A. Does gum chewing increase the prevalence of temporomandibular disorders in individuals with gum chewing habits? // J. Craniofac. Surg. – 2014;25:1818-1821. doi:https://doi.org/10.1097/SCS.0000000000000993.

116. Tanaka M., Toe M., Nagata H., Ojima M., Kuboniwa M., Shimizu K., Osawa K., Shizukuishi S. Effect of eucalyptus-extract chewing gum on oral malodor: a doublemasked, randomized trial // J. Periodontol. – 2010;81:1564-1571. doi:https://doi.org/10.1902/jop.2010.100249.

117. Tanaka M., Yamamoto Y., Kuboniwa M., Nonaka A., Nishida N., Maeda K., Kataoka K., Nagata H., Shizukuishi S. Contribution of periodontal pathogens on tongue dorsa analyzed with real-time PCR to oral malodor // Microbes Infect. – 2004;6:1078-1083. doi:https://doi.org/10.1016/j.micinf.2004.05.021.

118. Tanasiewicz M., Hildebrandt T., Obersztyn I. Xerostomia of Various Etiologies: A Review of the Literature // Adv Clin Exp Med. – 2016;25(1):199-206. doi:https://doi.org/10.17219/acem/29375.

119. Thomson W. Dry mouth and older people // Australian Dental Journal. – 2015;60:54-63. doihttps://doi.org/10.1111/adj.12284

120. Thomson W.M. Issues in the epidemiological investigation of dry mouth // Gerodontology. – 2005;22:65-76. doi:https://doi.org/10.1111/j.1741-2358.2005.00058.x.

121. Tian M., Hanley A.B., Dodds M.W. Allyl isothiocyanate from mustard seed is effective in reducing the levels of volatile sulfur compounds responsible for intrinsic oral malodor // J. Breath Res. – 2013;7:026001. doi:https://doi.org/10.1088/1752-7155/7/2/026001.

122. Tian M., Hanley A.B., Dodds M.W., Yaegaki K. Chewing gum containing allyl isothiocyanate from mustard seed extract is effective in reducing volatile sulfur compounds responsible for oral malodor // Am. J. Dent. – 2013;26:180-184. https://pubmed.ncbi.nlm.nih.gov/24693626/

123. Torres S.R., Peixoto C.B., Caldas D.M., Silva E.B., Akiti T., Nucci M. et al. Relationship between salivary fow rates and Candida counts in subjects with xerostomia // Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. – 2002;93:149-154. doi:https://doi.org/10.1067/moe.2002.119738.

124. Van Strydonck D.A., Slot D.E., Van der Velden U., Van der Weijden F. Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review // J. Clin. Periodontol. – 2012;39:1042-1055. doi:https://doi.org/10.1111/j.1600-051X.2012.01883.x.

125. von Schonfeld J.V., Hector M.P., Evans D.F., Wingate D. Oesophageal acid and salivary secretion: is chewing gum a treatment option for gastro-oesophageal reflux? // Digestion. – 1997;58:111-114. doi:https://doi.org/10.1159/000201432.

126. Wagner A.E., Boesch-Saadatmandi C., Dose J., Schultheiss G., Rimbach G. Anti-inflammatory potential of allylisothiocyanate - role of Nrf2, NF-(κ) B and microRNA-155 // J. Cell. Mol. Med. – 2012;16:836-843. doi:https://doi.org/10.1111/j.1582-4934.2011.01367.x.

127. Wessel S.W., van der Mei H.C., Maitra A., Dodds M.W.J., Busscher H.J. Potential benefits of chewing gum for the delivery of oral therapeutics and its possible role in oral healthcare // Expert Opinion on Drug Delivery. – 2016;13(10):1421-1431. doihttps://doi.org/10.1080/17425247.2016.1193154

128. Wessel S.W., van der Mei H.C., Morando D., Slomp A.M., van de Belt-Gritter B., Maitra A., Busscher H.J. Quantification and qualification of bacteria trapped in chewed gum // PLoS One. – 2015;10(1):e0117191. doi:https://doi.org/10.1371/journal.pone.0117191

129. Wild J.E., Nelson B.J., Hubbard M.E., Bowman J.P. Oral malodor control afforded through the use of sodium bicarbonate-containing chewing gum // Compend. Contin. Educ. Dent. –2001;22:43-46. https://pubmed.ncbi.nlm.nih.gov/11913311/

130. Winocur E., Gavish A., Finkelshtein T., Halachmi M., Gazit E. Oral habits among adolescent girls and their association with symptoms of temporomandibular disorders // J. Oral Rehabil. – 2001;28:624-629. doi:https://doi.org/10.1046/j.1365-2842.2001.00708.x.

131. Xu F., Laguna L., Sarkar A. Aging-related changes in quantity and quality of saliva: where do we stand in our understanding? // J Texture Stud. – 2019;50:27-35. doi:https://doi.org/10.1111/jtxs.12356.

132. Yeung C.Y., Chu C.H., Yu O.Y. A concise review of chewing gum as an anti-cariogenic agent // Front Oral Health. – 2023;4:1213523. doi:https://doi.org/10.3389/froh.2023.1213523.