Abstract:
This monograph consists of 11 sections devoted to the diagnosis and prevention of precancer and malignant tumors of the oral cavity, their differential diagnosis, and the importance of oncological awareness in the work of dentists and maxillofacial surgeons. The monograph provides a brief history of the development of Russian oncology and the origins of the oncology service in the Middle Urals. It presents the experience of organizing preventive work in Yekaterinburg and the Sverdlovsk region on oral oncopathology. It describes the epidemiology, carcinogenesis, methods of early diagnosis and cancer screening, and the clinical features of various forms of precancer, carcinomas, inflammatory and neoplastic diseases of the oral mucosa in children and adults. The monograph is illustrated using the authors' photo archives. Recommended for expanding and deepening the knowledge of dentists and maxillofacial surgeons.

Keywords:
Oncoscreening, oncopathology, early diagnosis, diseases of the oral mucosa, history of the development of domestic oncology

1. Bahmudov B.R. Klinicheskie nablyudeniya za epulisami u beremennyh zhenschin, ih lechenie i prognoz / B.R.Bahmudov, M.B.Bahmudov, Z.B.Alieva // Klinicheskaya stomatologiya. – 2012. – № 2. – S.44-47.

2. Bahmudov B.R. Chastota razvitiya, klinicheskaya kartina, gistologicheskaya harakteristika i lechenie epulisa u beremennyh zhenschin / B.R.Bahmudov // Novoe v stomatologii. – 2015. – № 1. – S.54-59.

3. Berzin S.A. Onkologicheskoy shkole Ekaterinburga 75 let / S.A. Berzin // Vestnik Ural'skoy gosudarstvennoy medicinskoy akademii. – 2006. - № 15. – S.14-16.

4. Bykov V.L. Gistologiya i embrional'noe razvitie organov polosti rta cheloveka. – M.: GEOTAR-Media, 2014. – 624 s.

5. Vasil'ev A.G. Hirurgiya zubov s kursom chelyustno-licevoy travmatologii. - M., 1973. - 408 s.

6. Gazhva S.I. Rasprostranennost' zabolevaniy slizistoy obolochki krasnoy kaymy gub u vzroslogo naseleniya nizhegorodskoy oblasti / S.I.Gazhva, A.V.Dyatel // Fundamental'nye issledovaniya. – 2014. – № 10-6. – S. 1076-1080.

7. Gancev Sh.H. Onkologiya / Sh.H.Gancev. – 2-e izd., ispr. i dop. – M., 2006. – 488 s.

8. Glebova L.I. Izuchenie patologii slizistoy obolochki rta i krasnoy kaymy gub – odno iz osnovnyh napravleniy nauchnogo naslediya professora A.L.Mashkileysona / L.I.Glebova, E.V.Alekseeva // Materialy II Vserossiyskoy konferencii s mezhdunarodnym uchastiem «Istoriya stomatologii». - Moskva: MGMSU 2008. - S.46-49.

9. Gnatovskaya N.A. Povyshenie effektivnosti ranney diagnostiki i konservativnogo lecheniya erozivno-yazvennyh porazheniy slizistoy obolochki rta: Diss. kand. med. nauk: 14.04.14 / Gnatovskaya Natal'ya Andreevna. – Nizhniy Novgorod, 2019. – 201 s.

10. Davydov M.I., Gancev Sh.H. Onkologiya. – M., 2010. – 920 s.

11. Dannye terapevticheskogo monitoringa Ipsos: 500 onkologov i gematologov iz 32 gorodov Rossiyskoy Federacii, 13 onkopatalogiy. https://www.lvrach.ru/articles/15438395

12. Zabolevaniya slizistoy obolochki polosti rta i gub / Pod red. prof. E.V. Borovskogo, A.L. Mashkilleysona. – Moskva: MVDpress, 2001. – 320 s.

13. Zlokachestvennye novoobrazovaniya v Rossii v 2022 godu (zabolevaemost' i smertnost') / Pod red. A.D. Kaprina [i dr.] − M., 2023. − 275 s.

14. Ivina A.A. Sovremennye predstavleniya o ploskokletochnom rake slizistoy obolochki rta / A.A.Ivina // Arhiv patologii. – 2020. – T.82, № 3. – S.55–60.

15. Iskakova M.K. Udel'nyy ves zabolevaniy slizistoy obolochki polosti rta sredi chasto vstrechayuschihsya stomatologicheskih zabolevaniy / M.K.Iskakova, A.E.Zarkumova, G.K.Nurmuhambetova // Vestnik Kazahskogo Nacional'nogo medicinskogo universiteta. – 2018. - № 1. – S.188-192.

16. Istoriya onkologicheskih zabolevaniy. - https://scisne.net/a-2875

17. Istoriya onkologii. Istoriya razvitiya onkologii v Rossii i mire. - https://aptek-vt.ru/news/istoriya_onkologii_istoriya_razvitiya_onkologii_v_rossii_i_mire/

18. Kaprin A.D. K 70-letiyu onkologicheskoy sluzhby Rossiyskoy Federacii / A.D.Kaprin, V.V.Starinskiy, L.M.Aleksandrova // Onkologiya, zhurnal im. P.A.Gercena. – 2015. – T.4, № 2. – S.5 11.

19. Karapetyan I.S., Gubaydullina E.Ya., Cegel'nik L.N. Opuholi i opuholepodobnye porazheniya organov polosti rta, chelyustey, lica i shei. – M., 2004. – S.108-112.

20. K voprosu o papillomovirusnom geneze leykoplakii slizistoy obolochki rta / I.I. Babichenko, O.F. Rabinovich, A.A. Ivina, I.M. Rabinovich, A.A. Togonidze // Arhiv patologii. – 2014. – № 1. – S. 32–36.

21. Keratoakantoma / V.A.Molochkov, I.A.Kazanceva, Zh.S.Kuncevich, E.V.Bochkareva. – M.: Izdatel'stvo BINOM, 2006. – 176 s.

22. Kostina I.N. Stranicy istorii otdeleniya chelyustno-licevoy hirurgii / I.N.Kostina, O.V.Saliy // Vestnik Pervoy oblastnoy klinicheskoy bol'nicy. – 2018. – T.60, № 1. - S.26-30.

23. Kostina I.N. Struktura, lokalizaciya opuholevyh i opuholepodobnyh zabolevaniy polosti rta / I.N.Kostina // Problemy stomatologii. - 2014. - № 4. - S.33-39.

24. Mashkilleyson A.L. Predrak krasnoy kaymy gub i slizistoy obolochki rta / A.L. Mashkilleyson. – Moskva, 1970. – 272 s.

25. Novoobrazovaniya myagkih tkaney i kostey lica u detey i podrostkov // A.A.Kolesov, Yu.I.Vorob'ev, N.N.Kasparova - M., 1989. - 304 s.

26. Onlayn-opros Ipsos. 65 onkologov v gorodah RF s naseleniem >100 tys. https://www.lvrach.ru/articles/15438395

27. Ocherk ob istorii instituta. Vospominaya prof. G.B.Plissa. - https://www.niioncologii.ru/institute/institutehistory/pliss

28. Paches A.I. Opuholi golovy i shei: klinicheskoe rukovodstvo / A.I.Paches. – 5-e izd., dop. i pererab. – M: Prakticheskaya medicina, 2013. – 478 s.

29. Programma «Bor'ba s onkologicheskimi zabolevaniyami v Sverdlovskoy oblasti» na 2019-2024 gody // Pravitel'stvo Sverdlovskoy oblasti, rasporyazhenie № 310-RP. – 2019. – 99 s.

30. Programmy skrininga: kratkoe rukovodstvo. Povyshenie effektivnosti, maksimal'noe uvelichenie pol'zy i minimizaciya vreda. [Screening programmes: a short guide. Increase effectiveness, maximize benefits and minimize harm]. Kopengagen: Evropeyskoe regional'noe byuro VOZ; 2020. – 72 s.

31. Revmaticheskie bolezni: rukovodstvo dlya vrachey / pod red. V.A. Nasonova, N.V. Bunchuka. – Moskva: Medicina, 1997. – 520 s.

32. Simmetrichnyy gingival'nyy fibromatoz: redkoe klinicheskoe nablyudenie / I.N.Kostina, I.E.Valamina, S.E.Ioschenko, E.Yu.Bogdanova, S.V.Fominyh // Dental Yug. - 2009. - № 7. - S.32-34.

33. Skriningovye metody diagnostiki predrakovyh zabolevaniy slizistoy obolochki rta / O.O.Yanushevich, N.I.Kriheli, E.A.Volkov, L.V.Grishina, T.I.Pozdnyakova, N.N.Bulgakova. – M., 2017. – 68 s.

34. Sorkin Yu.E. Ocherki po istorii onkologii na srednem Urale: dis… kand.med.nauk. – Sverdlovsk, 1969. – 580 s.

35. Stomatologicheskaya dokumentaciya na specializirovannom prieme bol'nyh s zabolevaniyami slizistoy obolochki polosti rta / R.S.Gileva, A.Yu.Novikov, O.V.Pozdeeva, T.V.Libik, I.A.Malinina. – Perm', 2008. – 18 s.

36. Shahzadova A.O. Sostoyanie onkologicheskoy pomoschi naseleniyu Rossii v 2022 godu / A.O.Shahzadova, V.V.Starinskiy, I.V.Lisichnikova // Sibirskiy onkologicheskiy zhurnal. – 2023. - T.22, № 5. - S.5–13.

37. Advances in fluorescence imaging techniques to detect oral cancer and its precursors / D.Shin, N.Vigneswaran, A.Gillenwater, R.Richards-Kortum // Future Oncol. - 2010. – Vol.6, № 7. – P.1143-1154.

38. A genetic explanation of slaughter's concept of field cancerization: Evidence and clinical implications / B.J.Braakhuis, M.P.Tabor, J.A.Kummer, .CR.Leemans, RH.Brakenhoff // Cancer Res. – 2003. – Vol. 63. – P.1727–1730.

39. Allen K. Oral mucosal screening and referral attitudes of Australian oral health therapists and dental hygienists in Queensland / K.Allen, P.J.Ford, C.S. Farah // Int J Dent Hyg. – 2015. – Vol.13. – P.206–212.

40. Al-Mobeeriek A. Prevalence of oral lesions among Saudi dental patients / A. Al-Mobeeriek, A. M. AlDosari //Ann Saudi Med. - 2009. – Vol.29, № 5. – P.365–368.

41. Amagasa T. Oral premalignant lesions: from a clinical perspective / T.Amagasa, M.Yamashiro, N.Uzawa // Int J Clin Oncol. – 2011. – Vol.16, № 1. – P.5–14.

42. A multicenter study of oral malignant tumors from Thailand / K.Dhanuthai, S.Rojanawatsirivej, A.Subarnbhesaj, W.Thosaporn, S.Kintarak // J Oral Maxillofac Pathol. – 2016. – Vol.20. – P.462–466.

43. An analysis of peripheral giant cell granuloma associated with dental implant treatment / M.Cloutier, C.Makepace, R.P.Carmichael, G.K.B.Sándor // Oral Surg Oral Med Oral Pathol Oral Radiol Endod. – 2017. – Vol.103. – R.618–622.

44. Andreason A.R. A social marketing approach to changing mental health practices directed at youth and adolescents / A.R.Andreason // Health Marketing Quarterly. – 2004. – Vol.21, № 4. – P.51–75.

45. Anis R. Oral cancer in the UAE: A multicenter, retrospective study / R.Anis, K.Gaballah // Libyan J Med. - 2013 – Vol.8. – P.217-282.

46. A population-based study of factors associated with early versus late stage oral cavity cancer diagnoses / P.Groome, S.L.Rohland, S.F.Hall, J.C.Irish, W.MacKillop, B.O’Sullivan // Oral Oncol. – 2011. – Vol.47. – P.642–647.

47. Bednar's aphthae in neonates: incidence and associated factors / S.Nebgen, H.U.Kasper, D.Schafer, H.Christ, B.Roth // Neonatology. – 2010. – Vol.98. – P.208–211.

48. Betel-quid and areca-nut chewing and some areca-nut derived nitrosamines // IARC Monogr Eval Carcinog Risks Hum. – 2004. – Vol.85. – P.1–334.

49. Bittar M. CHILD syndrome avant la letter / M.Bittar, R.Happle // J Am Acad Dermatol. – 2004. – Vol.50, № 2. – P.34-37.

50. Cancer as an evolutionary and ecological process / L.M.Merlo, J.W.Pepper, B.J.Reid, C.C.Maley // Nat Rev Cancer. – 2006. – Vol 6. – R.924–935.

51. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / J.Ferlay, I.Soerjomataram, R.Dikshit, S.Eser, C.Mathers, M.Rebelo // Int J Cancer. – 2015. – Vol.136. – P.359–386.

52. Cancer treatment and survivorship statistics, 2014 / C.E. DeSantis, C.C. Lin, A.B. Mariotto, R.L. Siegel, K.D. Stein, J.L. Kramer, R. Alteri, A.S. Robbins, A. Jemal // CA Cancer J Clin. – 2014. – Vol.64. – P.252–271.

53. Chang J.Y. Localized juvenile spongiotic gingival hyperplasia / J.Y.Chang, H.P.Kessler, J.M.Wright // Oral Surg Oral Med Oral Pathol Oral Radiol Endod. – 2008. – Vol.106, № 3. – P.411–418.

54. Cheng Y-S.L. A review of research on salivary biomarkers for oral cancer detection / Y-S.L.Cheng, T.Rees, J.Wright // Clin Transl Med. - 2014. – Vol.3, № 1. – P.3.

55. Chidzonga M.M. Oral malignant neoplasia: A survey of 428 cases in two Zimbabwean hospitals / M.M. Chidzonga // Oral Oncol. – 2006. – Vol.42. – P.177–183.

56. Clinical and histopathologic parameters in survival of oral squamous cell carcinoma / W.L.Dissanayaka, G.Pitiyage, P.V.Kumarasiri, R.L.Liyanage, K,D.Dias, W.M.Tilakaratne // Oral Surg Oral Med Oral Pathol Oral Radiol. - 2012. – Vol.113. – P.518–525.

57. Clinical features of Bednar's aphthae in infants / S-W. Nam, S.H. Ahn, S-M. Shin, G.Jeong // Korean J Pediatr. – 2016. – Vol.59, № 1. – P.30-34.

58. Combination of inflammatory and amlodipine induced gingival overgrowth in a patient with cardiovascular disease / M.K.Pasupuleti, S.V.Musalaiah, M.Nagasree, P.A.Kumar // Avicenna J Med. – 2013. – Vol.3, № 3. – P.68-72.

59. Dalianis T. Human papillomavirus and oropharyngeal cancer, the epidemics, and significance of additional clinical biomarkers for prediction of response to therapy (Review) / T.Dalianis // Int J Oncol. – 2014. – Vol.44. – P.1799–1805.

60. Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions / J.L. Liu, T. Walsh, A.R. Kerr, M. Lingen, P. Brocklehurst, G.R. Ogden, S. Warnakulasuriya, C. Scully // Cochrane Database Syst. Rev. – 2012. – Vol.29. – P.56-63.

61. Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions / R. Macey, T. Walsh, P. Brocklehurst, A.R Kerr, J.L.Y. Liu, M.W. Lingen, G.R. Ogden, S. Warnakulasuriya, C. Scully //Cochrane Database Syst Rev. – 2015. – R. 70-76.

62. Do L.G., Spencer A.J., Dost F., Farah C.S. Oral mucosal lesions: findings from theaustralian national survey of adult oral health / Do L.G., Spencer A.J., Dost F., Farah C.S. //Aust Dent J. – 2014. – Vol.59. – P.114–120.

63. Efficacy of diode lasers in oral verrucous hyperplasia: A case series / A.M.Alwala, U.D.Arvind, K.S.Kumar, K,Kiran, B.H.Vinay, L.R.Babu // Nati J Maxillofac Surg. – 2022. – Vol.13, № 1. – P.121-124.

64. Eid R.A. Age and the architecture of oral mucosa / R.A.Eid, F.Sawair, T.Saku // Age (Dordr). – 2012. – Vol.34, № 3. – P.651-658.

65. Epstein J.B. The effi cacy of oral lumenoscopy (ViziLite) in visualizing oral mucosal lesions / J.B. Epstein, M. Gorsky, S. Lonky // Spec Care Dentist. - 2006. – Vol.26. – P.171-174.

66. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 / J.Ferlay, H.R.Shin, F.Bray, D.Forman, C.Mathers, D.M.Parkin // Int J Cancer. – 2010. – Vol.127, № 12. – P.2893‐2917.

67. Eurogin Roadmap: comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix / M.L.Gillison, X.Castellsagué, A.Chaturvedi, M.T.Goodman, P.Snijders, M.Tommasino // Int J Cancer. – 2014. – Vol.134. – P.497–507.

68. Farah C.S. Oral cancer in Australia 1982-2008: a growing need for opportunistic screening and prevention / C.S. Farah, B. Simanovic, F. Dost // Aust Dent J. - 2014. – Vol.59. – P.349–359.

69. Galvao-Moreira L.V. Screening and early detection of oral cancer: Current controversies / L.V. Galvao-Moreira, M. da Cruz // Acta Odontol Scand. - 2017. – Vol.75. – P.361–365.

70. Gathering data on oral mucosal diseases: a new approach / J.Ramanathan, M.H.Leclercq, B.R.Mendis, D.E.Barmes // World Health Forum. - 1995. - Vol.16, № 3. – R.299-304.

71. Global cancer statistics / A.Jemal, F.Bray, M.M.Center, J.Ferlay, E.Ward, D.Forman // CA Cancer J Clin. – 2011. – Vol.61, № 2. – P.69-90.

72. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / F. Bray , J. Ferlay , I. Soerjomataram , R.LSiegel, L.A. Torre , A. Jemal // CA Cancer J Clin. – 2018. – Vol.68, № 6. – P.394-424.

73. Global prevalence and incidence estimates of oral lichen planus: a systematic review and meta-analysis / Ch. Li, X. Tang , X. Zheng, Sh. Ge, H. Wen, X. Lin, Zh. Chen, L. Lu // JAMA Dermatol. - 2020. – Vol.156, № 2. – P,172-181.

74. Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines / S.B.Stanfill, G.N.Connolly, L.Zhang, L.T.Jia, J.E.Henningfield et al. // Tob Control. – 2011. - Vol.20. – R.2.

75. Granular cell tumor / L.Ayadi, A.Khabir, I.Fakhfakh et al. // Rev Stomatol Chir Maxillofac. - 2008. – Vol.109. – P.158–162.

76. Grimes D. Referral guidance for oral cancer: does it risk delay in diagnosis? / D. Grimes, J. Patel, C. Avery // Br J Oral Maxillofac Surg. – 2016. – Vol.55. – P.404–406.

77. Gupta B. Systematic review and meta-analysis of association of smokeless tobacco and of betel quid without tobacco with incidence of oral cancer in South Asia and the Pacific / B.Gupta, N.W.Johnson // PloS One. – 2014. – Vol.9, № 11. – P.113-121.

78. Hanahan D. The hallmarks of cancer / D.Hanahan, R.A.Weinberg // Cell. – 2000. – Vol.100. – R.57–70.

79. Hanahan D. Hallmarks of cancer: the next generation / D.Hanahan, R.A.Weinberg // Cell. – 2011. – Vol.144. – P.646–674.

80. Häkkinen L. Hereditary gingival fibromatosis: characteristics and novel putative pathogenic mechanisms / L.Häkkinen, A.Csiszar // J. Dent Res. - 2007. - Vol.86, № 1. - R.25- 34.

81. Hedstrőm L. Is there a connection between sublingual varices and hypertension? / L. Hedstrőm, M.Albrektsson, H.Bergh // BMC Oral Health. – 2015. – Vol.15. – P.78.

82. Hereditary gingival fibromatosis – a review / S.DeAngelo, J.Murphy, L.Claman, J.Kalmar, B.Leblebicioglu // Compend Contin Educ Dent. - 2007. - Vol.28, № 3. - R.138-143.

83. Hereditary gingival fibromatosis: review of the literature and a case report / LP.Bittencourt, V.Campos, L.F.Moliterno, D.P.Ribeiro, R.K.Sampaio // Quintessence Int. – 2000. – Vol.31. – P.415–418.

84. Huang S.H. Oral cancer: Current role of radiotherapy and chemotherapy / S.H.Huang, B.O'Sullivan // Med Oral Patol Oral Cir Bucal. – 2013. – Vol.18. – P.233–240.

85. Intercountry prevalences and practices of betel-quid use in south, southeast and eastern Asia regions and associated oral preneoplastic disorders: an international collaborative study by Asian betel-quid consortium of south and east Asia / C.H.Lee, A.M.Ko, S.Warnakulasuriya, B.L.Yin, N.Sunarjo et al. // Int J Cancer. – 2011. - Vol.129. – R.1741–1751.

86. Irani S. Distant metastasis from oral cancer: A review and molecular biologic aspects / S.Irani // J Int Soc Prev Community Dent. – 2016. – Vol.6. - 265–271.

87. Irani S. Oral health and related factors: an update / S.Irani // J Int Oral Health. – 2016. – Vol.8. – P.140–144.

88. Irani S. New insights into oral cancer—risk factors and prevention: a review of literature / S. Irani // Int J Prev Med. – 2020. – Vol.11. – P.202.

89. Juvenile spongiotic gingivitis / M.R.Darling, T.D.Daley, A.Wilson, G.P.Wysocki // J Periodontol. – 2007. – Vol.78, № 7. – P.1235–1240.

90. Kang H. Emerging biomarkers in head and neck cancer in the era of genomics / H.Kang, A.Kiess, C.H.Chung // Nat Rev Clin Oncol. – 2015. – Vol.12. – P.11–26.

91. Kessler H.P. Oral and maxillofacial pathology case of the month. Snuff dippers keratosis or snuff pouch / H.P.Kessler // Tex Dent J. – 2003. – Vol.120, № 12. – P.1181.

92. Koontongkaew S. The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas / S.Koontongkaew // J Cancer. – 2013. – Vol.4. – P.66–83.

93. Krishna Priya M. Evaluation of the prevalence of oral mucosal lesions in a population of eastern coast of South India / M.Krishna Priya, P.Srinivas, T.Devaki // J Int Soc Prev Community Dent. – 2018. – Vol.8. – P.396–401.

94. Laura Q.M. Head and neck cancer / Q.M.Laura, M.D.Chow // N Engl J Med. - 2020. – Vol.382. – P.60–72.

95. Lee J. Cigarette smoking and inflammation: cellular and molecular mechanisms / J.Lee, V.Taneja, R.Vassallo // J Dent Res. – 2012. – Vol.91. – P.142–149.

96. Lee P.N. Epidemiological evidence relating snus to health–an updated review based on recent publications / P.N. Lee // Harm Reduct J. – 2013. – Vol.6. – P.36.

97. Localized juvenile spongiotic gingival hyperplasia featuring unusual p16INK4A labeling and negative human papillomavirus status by polymerase chain reaction / P.P.Argyris, A.C.Nelson, S.Papanakou, S.Merkourea, K.I.Tosios, I.G.Koutlas // J Oral Pathol Med. – 2015. – Vol.44, № 1. – P.37–44.

98. Madurapperuma S.W. Spontaneously regressing neonatal oral aphthous ulceration of the palate / S.W.Madurapperuma, A.H. Jayaweera, R.D.Jayasinghe // Case Rep Pediatr. – 2021. – Vol.6. – P.66-70.

99. Management of medication-induced gingival hyperplasia: a systematic review / H.Mawardi, A.Alsubhi, N.Salem, E.Alhadlag, S.Dakhil, M.Zahran, L.Elbadawi // Oral Surg Oral Med Oral Pathol Oral Radiol. – 2021. – Vol.131, № 1. – P.62-72.

100. Management of mucocele of the glands of blandin-nuhn with a high-intensity laser: a case report / R.B.Kato, H.Jacome-Santos, A.P.Couto, L.G.Abreu, R.A.Mesquita, C.N.Kato // J Lasers Med Sci. – 2021. – Vol. 12. – P.27.

101. Mainville G.N. Non-HPV papillary lesions of the oral mucosa: clinical and histopathologic features of reactive and neoplastic conditions / G.N. Mainville // Head Neck Pathol. – 2019. – Vol.13, № 1. – P.71-79.

102. McCullough M. Oral mucosal malignancy and potentially malignant lesions: An update on the epidemiology, risk factors, diagnosis and management / M. McCullough, G.Prasad, C.Farah // Aust Dent J. - 2010. – Vol.55. - P.61–65.

103. Mighell A.J. Oral cancer - improving early detection and promoting prevention. Are you up to date? / A.J. Mighell, J.E. Gallagher // Br Dent J. - 2012. – Vol.213. – P.297–299.

104. Montero P.H. Cancer of the oral cavity / P.H. Montero, S.G. Patel // Surg Oncol Clin N Am. - 2015. – Vol.24, № 3. – R.491–508.

105. Mouth self-examination in a population at risk of oral cancer / P.L.Jornet, F.J. Garcia, M.L. Berdugo, F.P.Perez, A.P.Lopez // Aust Dent J. – 2015. – Vol.60. – P.59–64.

106. Mucocele of the glands of Blandin–Nuhn: Clinical and histopathologic analysis of 26 cases / Y.Jinbu, M.Kusama, H.Itoh, K.Matsumoto, J.Wang, T.Noguchi // Oral Surg Oral Med Oral Pathol Oral Radiol Endod. – 2003. – Vol.95. – P.467–70.

107. Mucocele of the glands of Blandin-Nuhn--clinical, pathological, and therapeutical aspects / P.Adachi, A.M.P.Soubhia, F.K.Horikawa, E.H.Shinohara // Oral Maxillofac Surg. – 2011. – Vol.15, №1. – P.11–13.

108. Munde A. Proliferative verrucous leukoplakia: an update / A.Munde, R.Karle // J Cancer Res Ther. - 2016. – Vol.12, № 2. – P.469-473.

109. Müller S. Frictional keratosis, contact keratosis and smokeless tobacco keratosis: features of reactive white lesions of the oral mucosa / S. Müller // Head Neck Pathol. – 2019. – Vol.13, № 1. – P.16-24.

110. Neville B.W. Oral and maxillofacial pathology. - Saunders/Elsevier; 2009. – 218 p.

111. Nico M.M. Mucocele in pediatric patients: Analysis of 36 children / M.M.Nico, J.H.Park, S.V.Lourenço // Pediatr Dermatol. – 2008. – Vol.25. – P.308–311.

112. Nikolov N. Effectiveness of Velscope and Vizilite Plus systems in diagnostics of oral lesions / N.Nikolov, E.Karaslavova, B.Yaneva // Acta Med Buldarica. – 2021. – Vol.48, № 1. -P.88-94.

113. Omar E. Current concepts and future of noninvasive procedures for diagnosing oral squamous cell carcinoma—A systematic review / E. Omar // Head Face Med. – 2015. – Vol.11. – P.6.

114. Oral cancer: A multicenter study / K.Dhanuthai, S.Rojanawatsirivej, W.Thosaporn, S. Kintarak, A.Subarnbhesaj, M.Darling, E.Kryshtalskyj, Ch.-P.Chiang, H-In.Shin, So-Y.Choi, S.-Shin Lee, P.-A.Shakib // Med Oral Patol Oral Cir Bucal. – 2018. – Vol.23, № 1. – P.23–29.

115. Oral cancer and precancer: a narrative review on the relevance of early diagnosis / S.Abati, C.Bramati, S.Bondi, A.Lissoni, M.Trimanchi // Int J Environ Res Public Health. – 2020. – Vol.17. – P.91-103.

116. Oral cancer in Libya and development of regional oral cancer registries: A review / E.BenNasir, M.El Mistiri, R.McGowan, R.V.Katz // Saudi Dent J. – 2015. – Vol.27. – P.171–179.

117. Oral mucosal lesions in childhood / L.H.Aleksijević, J.Prpić, M.M.Yrek, S.Pezelj-Ribarić, N.Ivančić-Jokić, R.P.Bukmir, M.Aleksijević, I.Glažar // Dent J (Basel). – 2022. – Vol.10, № 11. – P214.

118. Oral mucosal lesions in teenagers: a cross-sectional study / F.Amadori, E.Bardellini, G.Conti, A.Majorana // Italian J Pediatrics. – 2017. – Vol.43, № 1. - P. 50.

119. Oral squamous cell carcinoma in relation to field precancerisation: pathobiology / L.L.Feller, R.R.Khammissa, B.B.Kramer, J.J.Lemmer // Cancer Cell Int. – 2013. – Vol.13. – R.31.

120. Oral verrucous hyperplasia: histologic classification, prognosis, and clinical implications / Y-P.Wang, H-M.Chen, R-C.Kuo, C-H.Yu, A.Sun, B-Y.Liu, Y-S.Kuo, C-P.Chiang // J Oral Pathol Med. – 2009. – Vol.38, № 8. – P,651-656.

121. Oral verruciform xanthoma: a case report and literature review / Y.M.Marques, C.R. de Andrade, S.C. de Sousa, C.M.Navarro // Case Rep Pathol. – 2014. – P.64-67.

122. Oral verruciform xanthoma: a clinicopathologic and immunohistochemical study of 20 cases / B.A. de Andrade, M.Agostini, F.R.Pires, A.Rumayor, R.Carlos, O.P. de Almeida et al. // J Cutan Pathol. – 2015. – Vol.42, № 7. – P.489–495.

123. Oral verruciform xanthoma: report of 13 new cases and review of the literature / P. Tamiolakis, V.I. Theofilou, K.I. Tosios, A. Sklavounou-Andrikopoulou // Med Oral Patol Oral Cir Bucal. – 2018. – Vol.23, № 4. – P.429-435.

124. Overview of common oral lesions / E.Zahid, O.Bhatti, M.A.Zahid, M.Stubbs // Malays Fam Physician. – 2022. – Vol.17, № 3. – P.9-21.

125. Oxidative and antioxidative mechanisms in oral cancer and precancer: a review / S.K.Choudhari, M.Chaudhary, A.R.Gadbail, A.Sharma, S.Tekade // Oral Oncol. – 2014. – Vol.50. – P.10–18.

126. Patil S. Prevalence and distribution of oral mucosal lesions in a geriatric Indian population / S.Patil, B.Doni, S.Maheshwari // Canadian Geriatrics J. – 2015. – Vol.18, № 1. – P.11–14.

127. Peripheral giant cell granuloma associated with dental implants / A.Scarano, C.Lorusso, C.Mortellaro, L.Limongelli, A.Tempesta, G. Favia // J Craniofac Surg. – 2018. – Vol.29. – R.196–199.

128. Peripheral giant cell granuloma associated with dental implants: clinical case and literature review / M.A.Peñarrocha-Diago, J.Cervera-Ballester, L.Maestre-Ferrín, D. Peñarrocha-Oltra // J Oral Implantol. – 2012. – Vol.38. – R.527–532.

129. Persistence and stability of sublingual varices over time and their connection to underlying factors: an 8 year follow up study / H.Bergh, C.Kastberg, M.Albrektson, L.Hedstrőm // BMC Oral Health. – 2022. – Vol.22. – P.346.

130. Petersen P.E. Oral cancer prevention and control - the approach of the World Health Organization / P.E.Petersen // Oral Oncology. – 2009. – Vol.45, № 4-5. – P.454-460.

131. Pickup M.W. The extracellular matrix modulates the hallmarks of cancer / M.W.Pickup, J.K.Mouw, V.M.Weaver // EMBO Rep. – 2014. – Vol,15. – R.1243–1253.

132. Pinto A. Pediatric soft tissue oral lesions / A.Pinto, C.M.Haberland, S.Baker // Dent Clin North Am. – 2014. – Vol.58, № 2. – P.437–453.

133. Prevalence and distribution of oral mucosal lesions: a cross-sectional study in Shanghai, China / J.Feng, Z.Zhou, X.Shen et al. // J Oral Pathology. - 2015. – Vol.44, № 7. – P.490–494.

134. Prevalence and distribution of oral mucosal lesions by sex and age categories: A retrospective study of patients attending Lebanese school of dentistry / S.El Toum, A.Cassia, N. Bouchi, I. Kassab // Int J Dent. - 2018. – P.112-119.

135. Prevalence and distribution of oral mucosal non-malignant lesions in the western Sicilian population / S.Tortorici , S.Corrao, G.Natoli, P.Difalco // Minerva Stomatol. – 2016. – Vol.65, № 4. – P.191-206.

136. Prevalence of oral mucosal lesions among smokeless tobacco usage: A cross-sectional study / K.Hallikeri, V.Naikmasur, K.Guttal, M.Shodan, N.K.Chennappa // Indian J Cancer. - 2018. – Vol.55. – P.404–409.

137. Prevalence of oral mucosal lesions in geriatric patients living in lower Northern Thailand: a 10 years retrospective study / C.Intapa, C.C.Na Ayudhya, A.Puangsombat, B.Boonmoon, T.Janyasurin, U.Tonum // J Int Dent Med Research. – 2017. – T.10, № 3. – S.868–871.

138. Prevalence and risk indicators of oral mucosal lesions in adult population visiting primary health centers and community health centers in Kodagu district / S.Kumar, V.S.Narayanan, S.R.Ananda, A.P.Kavitha, R.Krupashankar // J Family Med Prim Care. - 2019. – Vol. 8, № 7. – P.2337–2342.

139. Primary malignant neoplasms of orofacial origin: A retrospective review of 256 cases in a Nigerian tertiary hospital / O.F.Ajayi, W.L.Adeyemo, A.L.Ladeinde, M.O.Ogunlewe, O.A.Effiom, O.G.Omitola // Int J Oral Maxillofac Surg. – 2007. – Vol.36. – P.403–408.

140. Primary malignant tumors of orofacial region at Benghazi, Libya: A 17 years review / K.Subhashraj, M.Orafi, K.V.Nair, R.El-Gehani, M.Elarbi // Cancer Epidemiol. – 2009. – Vol.33. – P.332–336.

141. Proliferative verrucous leukoplakia: diagnosis, management and current advances / D.L.Capella, J.M.Gonçalves, A.A.Abrantes, L.J.Grando, F.I.Daniel // Braz J Otorhinolaryngol. - 2017. – Vol.83, № 5. – P.585-593.

142. Pulte D. Changes in survival in head and neck cancers in the late 20th and early 21st century: a period analysis / D.Pulte, H.Brenner // The oncologist. – 2010. – Vol.15, № 9. – P.994–1001.

143. Pytynia K.B. Epidemiolog y of HPV-associated oropharyngeal cancer / K.B.Pytynia, K.R.Dahlstrom, E.M.Sturgis // Oral Oncol. – 2014. – Vol.50. – P.380–386.

144. Reactive Oral lesions associated with a dental implants: a sistematic review / F.Atarbashi-Moghadam, S.Atarbashi-Moghadam, M.Namdari, S.Shahrabi-Farahani // J Investig Clin Dent. – 2018. – Vol.10. – R.1–7.

145. Reidy J. A review of the relationship between alcohol and oral cancer / J.Reidy, E.McHugh, L.F.Stassen // Surgeon. - 2011. – Vol.9. – P.278–283.

146. Rivera C. Essentials of oral cancer / C.Rivera // Int J Clin Exp Pathol. – 2015. – Vol. 8, № 9. – P.11884-11894.

147. Rivera C. Histological and molecular aspects of oral squamous cell carcinoma (Review) / C.Rivera, B.Venegas // Oncol Lett. – 2014. – Vol.8. – P.7–11.

148. Rivera C. The challenge of the state of susceptibility to oral cancer / C.Rivera // J Oral Res. - 2015. – Vol.4. – P.8–9.

149. Retrospective survey of biopsied oral lesions in pediatric patients / Y.L.Wang, H.H.Chang, J.Y.F.Chang, G.F.Huang, M.K. Guo // J Formos Med Assoc. – 2009. – P.862–871.

150. Review of areca (betel) nut and tobacco use in the Pacific: a technical report. Regional Office for the Western Pacific // World Health Organization. - 2012.

151. Rioboo-Crespo M.R. Epidemiology of the most common oral mucosal diseases in children / M.R. Rioboo-Crespo, P.P. Pozo, R. Rioboo-Garcia // Med Oral Patol Oral Cir Bucal. – 2005. – Vol.10, № 5. - P.376-387.

152. Roed-Petersen B. A topographical classification of the oral mucosa suitable for electronic data processing. Its application to 560 leukoplakias / B. Roed-Petersen, G. Renstrup // Acta Odontol Scand. - 1969. – Vol.27, № 6. – P.681–695.

153. Rushton M.A. Hereditary or idiopathic hyperplasia of the gums / M.A.Rushton // Dent. Practit. - 1957. - Vol.7. - P.136-146.

154. Schafer D.R. A guide to yellow oral mucosal entities: etiology and pathology / D.R.Schafer, S.H.Glass // Head Neck Pathol. – 2019. – Vol.13, № 1. – P.33-46.

155. Screening programmes for the early detection and prevention of oral cancer / P.l Brocklehurst, O.Kujan, L.O'Malley, G.ROgden, S.Shepherd, A-M.Glenny // Cochrane Database Syst Rev. - 2013. – Vol.11. – P.67-79.

156. Shulman J.D. The prevalence of oral mucosallesions in US adults: data from the Third National Health and Nutrition Examination Survey, 1988-1994 / J.D.Shulman, M.M.Beach, F.Rivera-Hidalgo // J Am Dent Assoc. – 2005. – Vol.135, № 9. – P.1279–1286.

157. Siegel R. Cancer statistics / R.Siegel, J.Ma, Z.Zou // Cancer J Clinicians. - 2014. – Vol.64, № 1. – P.9–29.

158. Slebioda Z. Recurrent aphthous stomatitis: genetic aspects of etiology / Z.Slebioda, E.Szponar, A.Kowalska // Postery Dermatol Alergol. – 2013. – Vol.30, № 2. – P.96-102.

159. Smokeless tobacco and oral potentially malignant disorders in South Asia: a systematic review and meta-analysis / Z.Khan, S.Khan, L.Christianson, S.Rehman, O.Ekwunife, F.Samkange-Zeeb // Nicotine Tob Res. - 2017. – Vol.20, № 1. – P.12-21.

160. Spongiotic gingival hyperplasia synchronously involving multiple sites: case report and review of the literature / I.Siamantas, E-M. Kalogirou, K.I.Tosios, I.Fourmousis, A.Sklavounou // Head Neck Pathol. – 2018. – Vol.12, 4. – P.517-521.

161. Staines K. Oral leukoplakia and proliferative verrucous leukoplakia: a review for dental practitioners / K.Staines, H.Rogers // Br Dent J. - 2017. – Vol.223, № 9. – P.655-661.

162. Successful management of phenytoin and phenobarbitone induced gingival enlargement: A multimodal approach / V.Priyadharshini, V.V.Belure, M.G.Triveni, A.B.Kumar, D.S.Mehta // Contemp Clin Dent. – 2014. – Vol.5, № 2. – P.268-271.

163. Sugerman P.B. Mucocele of the anterior lingual salivary glands (glands of Blandin and Nuhn): report of 5 cases / P.B.Sugerman, N.W.Savage, W.G.Young // Oral Surg Oral Med Oral Pathol Oral Radiol Endod. – 2000. – Vol.90, № 4. – P.478–482.

164. Tanaka T. Understanding carcinogenesis for fighting oral cancer / T.Tanaka, R.Ishigamori // J Oncol. - 2011. – 60-67.

165. The betel quid dependence scale: replication and extension in a guamanian sample / T.A.Herzog, K.L.Murphy, M.A.Little, G.S.Suguitan, P.Pokhrel et al. // Drug Alcohol Depend. – 2014. - Vol.138. – R.154–160.

166. The immune hallmarks of cancer / F.Cavallo, C.De Giovanni, P.Nanni, G.Forni, P.L.Lollini // Cancer Immunol Immunother. - 2011. – Vol.60. – P.319–326.

167. The prevalence of oral mucosa lesions in pediatric patients / J.E.Owczarek-Drabinska, P.Nowak, M.Zimolag-Dydak, M.Radwan-Oczko // Int J Environ Res Public Health. – 2022. – Vol.19, № 18. – P.112-125.

168. Three cases of morsicatio labiorum / H.S.Kang, H.E.Lee, Y.S.Ro, C.W.Lee // Ann. Dermatol. - 2012. – Vol.24. – P.455–458.

169. Tobacco smoking and cancer: a meta-analysis / S.Gandini, E.Botteri, S.Iodice, M.Boniol, A.B.Lowenfels, P.Maisonneuve, P.Boyle // Int J Cancer. – 2008. – Vol.122. – P.155–164.

170. Toluidine blue aids in detection of dysplasia and carcinoma in suspicious oral lesions / N. Chainani-Wu, E. Madden, D. Cox, H. Sroussi, J. Epstein, S. Silverman // Oral Dis. – 2015. – Vol.21. – P.879–885.

171. Tumor microenvironment in head and neck squamous cell carcinoma / J.M.Curry, J.Sprandio, D.Cognetti, A.Luginbuhl, V.Bar-ad, E.Pribitkin, M.Tuluc // Semin Oncol. - 2014. – Vol 41. – R.217–234.

172. Verruciform xanthoma of the palatal gingiva: a report of two cases / D.J. Ryu, S.H.Lee, J.I. Yuk, H.J. Kim, J-K. Huh, K-H. Park // J Korean Assoc Oral Maxillofac Surg. – 2013. – Vol.39, № 6. – P.292-296.

173. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer / S.Warnakulasuriya // Oral Oncol. – 2009. – Vol.45. – P.309–316.

174. WHO, World Health Organization: Guide to epidemiology and diagnosis of oral mucosal diseases and conditions // Community Dent Oral Epidemiol. – 1980. - Vol.8, № 1. - R1-26.

175. Winstock A. Areca nut-abuse liability, dependence and public health / A.Winstock // Addict Biol. – 2002. - № 7. - R.133–138.

176. Wong T.S. Oral cancer / T.S.Wong, D.Wiesenfeld // Australion Dental J. - 2018. - № 3. – P.23-31.

177. Woo S-B. Keratosis of unknown significance and leukoplakia: a preliminary study / S-B.Woo, R.L.Grammer, M.A.Lerman // Oral Surg Oral Med Oral Pathol Oral Radiol. – 2014. – Vol.118, № 6. – P.713–724.

178. Woo S-B. Oral epithelial dysplasia and premalignancy / S-B.Woo // Head Neck Pathol. – 2019. – Vol.13, № 3. – P.423-439.

179. Zhang J. The Application of absolute ethanol in the treatment of mucocele of the glands of Blandin–Nuhn / J.Zhang, C.Wang // J Craniofac Surg. – 2016. – Vol.27, № 7. – P.641-642.