ASSESSMENT OF CYTOKINE BALANCE IN WOMEN WITH CHRONIC ODONTOGENIC INFECTION IN THE PERIAPICAL REGION OF THE TOOTH WITH CYCLIC CHANGES IN GONADOTROPIC AND STEROID HORMONES

Faniya Mirsaeva; Oskar Yakupov; Al'bina Bulgakova; Rasima Haybullina

doi:10.18481/2077-7566-2026-22-3-77-81

VAK Russia 3.1.7 UDC 616.31

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ASSESSMENT OF CYTOKINE BALANCE IN WOMEN WITH CHRONIC ODONTOGENIC INFECTION IN THE PERIAPICAL REGION OF THE TOOTH WITH CYCLIC CHANGES IN GONADOTROPIC AND STEROID HORMONES

Published in Actual problems in dentistry · Volume 22, Issue 3, 2026 · Pages 77–81 · Rubric: TERAPEUTIC DENTISTRY. ORIGINAL RESEARCH PAPERS

DOI: https://doi.org/10.18481/2077-7566-2026-22-3-77-81

Received: 16.07.2026 Accepted: 23.09.2026 Published: 23.09.2026 Language of publication: RUS

Authors

Faniya Mirsaeva

ORCID

Oskar Yakupov

Al'bina Bulgakova

Rasima Haybullina

Faniya Mirsaeva

Academic degree: doctor of medical sciences

Science rang: professor

Bashkirian State Medical University Head of Department · Department of Surgical Dentistry · Ufa

ORCID

Oskar Yakupov

Bashkir State Medical University Department of Surgical Dentistry · Russian Federation · Ufa

Al'bina Bulgakova

Academic degree: doctor of medical sciences

Science rang: professor

Bashkir State Medical University Head of the Department · Department of Propaedeutics of Dental Diseases · Russian Federation · Ufa

Rasima Haybullina

Academic degree: doctor of medical sciences

Science rang: professor

Bashkirian State Medical University Professor of The Department · Department of Therapeutic Dentistry · Ufa

ABSTRACT

Subject. In women of reproductive age with chronic odontogenic infection, pro- and anti-inflammatory cytokines were studied, taking into account changes in the hormonal background. The aim is to assess the cytokine balance in women of reproductive age with chronic odontogenic infection in periapical tooth tissues at different stages of the follicular phase of the menstrual cycle. Methodology. In the serum of three groups of women of reproductive age (control and two subgroups in the main group), levels of LH, FSH, progesterone and estradiol were determined in all stages of the follicular phase, and pro- and anti-inflammatory cytokines in the oral fluid. ELISA methods were used. The criteria for inclusion of patients in the study groups were: reproductive age, ovulatory menstrual cycle, the absence of chronic somatic diseases, the absence of chronic odontogenic infection in the periapical tissues of the tooth for the control group (its presence in two subgroups of the main group; in one subgroup in the stabilization stage, in the other - exacerbations), the absence of periodontal diseases, the absence of hormonal contraceptives. Results. A direct correlation between cytokines and the level of gonadotropic and steroid hormones was revealed. Conclusions. In women of reproductive age in the late stage of the follicular phase of the menstrual cycle, a change in estradiol levels affects the activity of pro- and anti-inflammatory cytokines. Chronic inflammation in the periapical tissues of the tooth is in a stage of stabilization with the active production of the anti-inflammatory cytokine IL-10 and a decrease in the activity of TNF- ᾳ, IL-1 β. Exacerbation of the chronic inflammatory process occurs with a decrease in both IL-4 and IL-10 levels.

KEYWORDS

cytokines, chronic odontogenic infection, gonadotropic hormones, steroid hormones, oral fluid, local immunity, systemic immunity

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GOST

Mirsaeva F. Z., Yakupov O. A., Bulgakova A. I., Haybullina R. R. ASSESSMENT OF CYTOKINE BALANCE IN WOMEN WITH CHRONIC ODONTOGENIC INFECTION IN THE PERIAPICAL REGION OF THE TOOTH WITH CYCLIC CHANGES IN GONADOTROPIC AND STEROID HORMONES // Actual problems in dentistry. 2026. no. 3. pp. 77-81. DOI: https://doi.org/10.18481/2077-7566-2026-22-3-77-81. (Date of access 22.10.2026).

MLA

Faniya Mirsaeva, Yakupov O. A., Bulgakova A. I., Haybullina R. R.. "ASSESSMENT OF CYTOKINE BALANCE IN WOMEN WITH CHRONIC ODONTOGENIC INFECTION IN THE PERIAPICAL REGION OF THE TOOTH WITH CYCLIC CHANGES IN GONADOTROPIC AND STEROID HORMONES." Actual problems in dentistry 22.3 (2026): 77-81. DOI: https://doi.org/10.18481/2077-7566-2026-22-3-77-81.

APA

Mirsaeva F. Z., Yakupov O. A., Bulgakova A. I., Haybullina R. R. (2026). ASSESSMENT OF CYTOKINE BALANCE IN WOMEN WITH CHRONIC ODONTOGENIC INFECTION IN THE PERIAPICAL REGION OF THE TOOTH WITH CYCLIC CHANGES IN GONADOTROPIC AND STEROID HORMONES. Actual problems in dentistry, 22(3), 77-81. https://doi.org/10.18481/2077-7566-2026-22-3-77-81

Chicago

Faniya Mirsaeva, Yakupov O. A., Bulgakova A. I., Haybullina R. R.. "ASSESSMENT OF CYTOKINE BALANCE IN WOMEN WITH CHRONIC ODONTOGENIC INFECTION IN THE PERIAPICAL REGION OF THE TOOTH WITH CYCLIC CHANGES IN GONADOTROPIC AND STEROID HORMONES." Actual problems in dentistry 22, no. 3 (2026): 77-81. https://doi.org/10.18481/2077-7566-2026-22-3-77-81.

WIKI

{{cite journal | author = Mirsaeva F. Z., Yakupov O. A., Bulgakova A. I., Haybullina R. R. | title = ASSESSMENT OF CYTOKINE BALANCE IN WOMEN WITH CHRONIC ODONTOGENIC INFECTION IN THE PERIAPICAL REGION OF THE TOOTH WITH CYCLIC CHANGES IN GONADOTROPIC AND STEROID HORMONES | journal = Actual problems in dentistry | year = 2026 | volume = 22 | issue = 3 | pages = 77-81 | doi = 10.18481/2077-7566-2026-22-3-77-81 }}

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