CEREBRAL PALSY: IMMUNOLOGICAL AND PHYSICOCHEMICAL INDICATORS OF ORAL FLUID

Sergey Chuykin; Kamila Yakupova; Natal'ya Makusheva; Elena Egorova; Guzel' Aflahanova; Tat`yana SNETKOVA

doi:10.18481/2077-7566-2026-22-1-165-168

VAK Russia 3.1.7 UDC 616.31

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CEREBRAL PALSY: IMMUNOLOGICAL AND PHYSICOCHEMICAL INDICATORS OF ORAL FLUID

Published in Actual problems in dentistry · Volume 22, Issue 1 · Pages 165–168 · Rubric: PEDIATRIC DENTISTRY, PROPHYLAXIS AND ORTHODONTICS. ORIGINAL RESEARCH PAPERS

DOI: https://doi.org/10.18481/2077-7566-2026-22-1-165-168

Received: 17.03.2026 Accepted: 19.04.2026 Published: 19.04.2026 Language of publication: RUS

Authors

Sergey Chuykin

ORCID

Kamila Yakupova

Natal'ya Makusheva

ORCID

Elena Egorova

et al.

Guzel' Aflahanova

Tat`yana SNETKOVA

Sergey Chuykin

Academic degree: doctor of medical sciences

Science rang: professor

Bashkir State Medical Universitey Head of the Department · Department of Pediatric Dentistry and Orthodontics · Russian Federation · Ufa

ORCID

Kamila Yakupova

Bashkir State Medical University Assistant of the Department · Department of Pediatric Dentistry and Orthodontics · Russian Federation · Ufa

Natal'ya Makusheva

Academic degree: candidate of medical sciences

Science rang: docent

Bashkir State Medical University assistant professor · Department of Children's Dentistry and Orthodontics · Russian Federation · Ufa

ORCID

Elena Egorova

Academic degree: candidate of medical sciences

Bashkirian State Medical University Docent of Department · department of Pediatric Dentistry and Orthodontics with IDPO course · Ufa

Guzel' Aflahanova

Academic degree: candidate of medical sciences

Bashkir State Medical University Associate Professor of the Department · Department of Pediatric Dentistry and Orthodontics · Russian Federation · Ufa

Tat`yana SNETKOVA

Academic degree: candidate of medical sciences

Science rang: docent

Bashkir State Medical University assistant professor · Department of Children's Dentistry and Orthodontics · Russian Federation · Ufa

ABSTRACT

Subject. Cerebral palsy (CP) is one of the most common neurological disorders in pediatrics, occurring in approximately 2–3 out of every 1,000 newborns. This condition remains a significant healthcare burden. Children with CP have impaired immune systems, which contributes to increased susceptibility to infections and exacerbates inflammatory processes. Analysis of immunological parameters of saliva allows for a better understanding of the mechanisms of inflammation and the characteristics of immune defense in the oral cavity. A comprehensive study of the composition and characteristics of oral fluid has important diagnostic and prognostic value in children with CP. Objectives. This study aimed to evaluate the main immunological and physicochemical characteristics of oral fluid in children diagnosed with cerebral palsy. Methodology. We examined the physicochemical and immunological indicators of oral fluid. The study included 108 children 9–18 years old. All respondents were divided into 2 groups: 1st - experimental group, diagnosed with cerebral palsy, consisting of 58 people; and the 2nd control, comprising 50 relatively healthy children. As part of the study, levels of secretory immunoglobulin A, lysozyme, salivation rate, kinematic viscosity and pH of mixed saliva were determined. Results. Children with infantile cerebral palsy are characterized by reduced levels of lysozyme and secretory immunoglobulin A in saliva, reflecting reduced local immunity in the oral cavity and increasing the risk of bacterial infections. At the same time, an increase in the kinematic viscosity of saliva is noted, which indicates a violation of its secretion and a change in composition, leading to a deterioration in the protective functions of saliva. Conclusion. The study demonstrated significant differences in immunological status and physical and chemical composition of oral fluid in children with cerebral palsy (CP) compared to healthy children. The identified deviations indicate the presence of a chronic inflammatory process, a decrease in local defense mechanisms and an increase in the likelihood of infectious diseases.

KEYWORDS

cerebral palsy, immunological parameters, oral fluid, physicochemical parameters, oral microflora

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GOST

Chuykin S. V., Yakupova K. I., Makusheva N. V., Egorova E. G., Aflahanova G. R., SNETKOVA T. V. CEREBRAL PALSY: IMMUNOLOGICAL AND PHYSICOCHEMICAL INDICATORS OF ORAL FLUID // Actual problems in dentistry. 2026. no. 1. pp. 165-168. DOI: https://doi.org/10.18481/2077-7566-2026-22-1-165-168. (Date of access 06.10.2026).

MLA

Sergey Chuykin, Yakupova K. I., Makusheva N. V., Egorova E. G., Aflahanova G. R., SNETKOVA T. V.. "CEREBRAL PALSY: IMMUNOLOGICAL AND PHYSICOCHEMICAL INDICATORS OF ORAL FLUID." Actual problems in dentistry 22.1 (2026): 165-168. DOI: https://doi.org/10.18481/2077-7566-2026-22-1-165-168.

APA

Chuykin S. V., Yakupova K. I., Makusheva N. V., Egorova E. G., Aflahanova G. R., SNETKOVA T. V. (2026). CEREBRAL PALSY: IMMUNOLOGICAL AND PHYSICOCHEMICAL INDICATORS OF ORAL FLUID. Actual problems in dentistry, 22(1), 165-168. https://doi.org/10.18481/2077-7566-2026-22-1-165-168

Chicago

Sergey Chuykin, Yakupova K. I., Makusheva N. V., Egorova E. G., Aflahanova G. R., SNETKOVA T. V.. "CEREBRAL PALSY: IMMUNOLOGICAL AND PHYSICOCHEMICAL INDICATORS OF ORAL FLUID." Actual problems in dentistry 22, no. 1 (2026): 165-168. https://doi.org/10.18481/2077-7566-2026-22-1-165-168.

WIKI

{{cite journal | author = Chuykin S. V., Yakupova K. I., Makusheva N. V., Egorova E. G., Aflahanova G. R., SNETKOVA T. V. | title = CEREBRAL PALSY: IMMUNOLOGICAL AND PHYSICOCHEMICAL INDICATORS OF ORAL FLUID | journal = Actual problems in dentistry | year = 2026 | volume = 22 | issue = 1 | pages = 165-168 | doi = 10.18481/2077-7566-2026-22-1-165-168 }}

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