MOLECULAR AND CELLULAR MECHANISMS OF PERIORODONTAL REMODELING IN TRAUMATIC OCCLUSION

Marina Lebedeva; Vitaly Parunov; Mikhail Deev; Igor' Lebedenko

doi:10.18481/2077-7566-2025-21-4-36-43

VAK Russia 3.1.7 UDC 616.31

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MOLECULAR AND CELLULAR MECHANISMS OF PERIORODONTAL REMODELING IN TRAUMATIC OCCLUSION

Published in Actual problems in dentistry · Volume 21, Issue 4 · Pages 36–43 · Rubric: LITERATURE REVIEW

DOI: https://doi.org/10.18481/2077-7566-2025-21-4-36-43

Received: 04.12.2025 Accepted: 29.01.2026 Published: 29.01.2026 Language of publication: RUS

Authors

Marina Lebedeva

ORCID

Vitaly Parunov

Mikhail Deev

Igor' Lebedenko

Marina Lebedeva

RUDN University Kafedra Ortopedicheskoy stomatologii · Russian Federation · Moscow

ORCID

Vitaly Parunov

Academic degree: doctor of medical sciences

Science rang: professor

Peoples' Friendship University of Russia named after Patrice Lumumba Department of Orthopedic Dentistry · Russian Federation · Moscow

Mikhail Deev

Academic degree: candidate of medical sciences

Science rang: docent

Peoples' Friendship University of Russia named after Patrice Lumumba Professor of the Department · Department of Orthopedic Dentistry · Russian Federation · Moscow

Igor' Lebedenko

Academic degree: doctor of medical sciences

Science rang: professor Russian Academy of Medical Sciences

Peoples' Friendship University of Russia named after Patrice Lumumba Head of the Department · Department of Orthopedic Dentistry · Russian Federation · Moscow

ABSTRACT

Objective. To systematize current data on the molecular and cellular mechanisms of periodontal tissue remodeling in response to traumatic occlusion, with a focus on key signaling pathways and promising therapeutic targets. Materials and Methods. A narrative literature review was conducted based on the analysis of publications from 2010 to 2025 in the PubMed, Google Scholar, eLibrary, and CyberLeninka databases. The selection criteria included original experimental and clinical studies, systematic reviews, and meta-analyses focusing on the pathophysiology of traumatic occlusion and related processes of mechanotransduction, bone remodeling, and impaired microcirculation. Results. The key pathogenetic factor was identified as specific pressure (force/area), rather than the absolute magnitude of the masticatory load. The tissue response is complex and phased: initial suppression of osteogenesis and metabolic imbalance are followed by the activation of osteoclastogenesis via the RANKL/RANK/OPG system, the NLRP3-IL-1β pathway, and oxidative stress mediated by the TRPM2 channel. Impaired microcirculation, ischemia, and hypoxia serve as a critical link between mechanical stress and biochemical disturbances, leading to the suppression of aerobic respiration and metabolic depression. Concurrently, compensatory and reparative processes are activated in the periodontal ligament, including the induction of heat shock proteins (HSP47, HSP70) and the remodeling of the collagen matrix involving type XII collagen. Conclusions. Traumatic occlusion is a multifactorial pathological process involving a complex cascade of molecular and cellular reactions. Effective treatment requires a comprehensive approach that combines the mandatory elimination of occlusal disorders and active anti-inflammatory therapy. Promising research directions include the development of methods targeting key molecular targets (RANKL, NLRP3, TRPM2, HSP47) and the implementation of personalized diagnostics based on biochemical markers and genetic features.

KEYWORDS

traumatic occlusion, periodontium, mechanotransduction, RANKL, bone resorption, periodontal ligament, HSP47, osteoclastogenesis, NLRP3

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GOST

Lebedeva M. A., Parunov V. A., Deev M. S., Lebedenko I. Y. MOLECULAR AND CELLULAR MECHANISMS OF PERIORODONTAL REMODELING IN TRAUMATIC OCCLUSION // Actual problems in dentistry. 2025. no. 4. pp. 36-43. DOI: https://doi.org/10.18481/2077-7566-2025-21-4-36-43. (Date of access 29.10.2026).

MLA

Marina Lebedeva, Parunov V. A., Deev M. S., Lebedenko I. Y.. "MOLECULAR AND CELLULAR MECHANISMS OF PERIORODONTAL REMODELING IN TRAUMATIC OCCLUSION." Actual problems in dentistry 21.4 (2025): 36-43. DOI: https://doi.org/10.18481/2077-7566-2025-21-4-36-43.

APA

Lebedeva M. A., Parunov V. A., Deev M. S., Lebedenko I. Y. (2025). MOLECULAR AND CELLULAR MECHANISMS OF PERIORODONTAL REMODELING IN TRAUMATIC OCCLUSION. Actual problems in dentistry, 21(4), 36-43. https://doi.org/10.18481/2077-7566-2025-21-4-36-43

Chicago

Marina Lebedeva, Parunov V. A., Deev M. S., Lebedenko I. Y.. "MOLECULAR AND CELLULAR MECHANISMS OF PERIORODONTAL REMODELING IN TRAUMATIC OCCLUSION." Actual problems in dentistry 21, no. 4 (2025): 36-43. https://doi.org/10.18481/2077-7566-2025-21-4-36-43.

WIKI

{{cite journal | author = Lebedeva M. A., Parunov V. A., Deev M. S., Lebedenko I. Y. | title = MOLECULAR AND CELLULAR MECHANISMS OF PERIORODONTAL REMODELING IN TRAUMATIC OCCLUSION | journal = Actual problems in dentistry | year = 2025 | volume = 21 | issue = 4 | pages = 36-43 | doi = 10.18481/2077-7566-2025-21-4-36-43 }}

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