DEVELOPMENT OF A NOVEL DESIGN FOR A CUSTOM REMINERALIZATION TRAY MANUFACTURED BY ADDITIVE MANUFACTURING: VALIDATION AND CLINICAL EFFICACY

Mark Grigorenko; Pavel Kravchenko; Elena Vakushina; Natalia Lapina; Aleksandr Bragin; Lolita Arzumanyan; Madina Mrikaeva

doi:10.18481/2077-7566-2025-21-3-170-177

UDC

616.31

VAK Russia

3.1.7

DEVELOPMENT OF A NOVEL DESIGN FOR A CUSTOM REMINERALIZATION TRAY MANUFACTURED BY ADDITIVE MANUFACTURING: VALIDATION AND CLINICAL EFFICACY

Published in Actual problems in dentistry · Pages 170–177 · Rubric: PEDIATRIC DENTISTRY, PROPHILAXIS AND ORTODONTICS

DOI: https://doi.org/10.18481/2077-7566-2025-21-3-170-177

Received: 15.10.2025 Accepted: 29.10.2025 Published: 29.10.2025 Language of publication: RUS

Authors

Mark Grigorenko

Pavel Kravchenko

Elena Vakushina

Natalia Lapina

Aleksandr Bragin

Lolita Arzumanyan

Madina Mrikaeva

Mark Grigorenko

Academic degree: candidate of medical sciences

Orthodontic practice of professor Vakushina dentist-orthopedist · Russian Federation · Stavropol

Pavel Kravchenko

Dental Polyclinic No. 1 orthodontist · Russian Federation · Stavropol

Elena Vakushina

Academic degree: doctor of medical sciences

Science rang: professor

Stavropol State Medical University Professor of the Department · Department of Orthopedic Dentistry · Russian Federation · Stavropol

Natalia Lapina

Academic degree: doctor of medical sciences

Science rang: professor

Kuban State Medical University Head of the Department · Department of Orthopedic Dentistry · Russian Federation · Krasnodar

Aleksandr Bragin

Academic degree: candidate of medical sciences

Science rang: docent

Stavropol State Medical University Associate Professor · Department of information and digital technologies · Russian Federation · Stavropol

Lolita Arzumanyan

Stavropol State Medical University Assistant Professor · Department of Pediatric Dentistry · Russian Federation · Stavropol

Madina Mrikaeva

Academic degree: candidate of medical sciences

North-Ossetian State Medical Academy Associate Professor of the Department · Department of Dentistry No. 1 · Russian Federation · Vladikavkaz

ABSTRACT

Objective: To develop and clinically evaluate an original design of a personalized remineralization tray fabricated using additive manufacturing in patients undergoing active orthodontic treatment with fixed appliances. Methodology: The study included 32 patients (aged 18–35 years, of both sexes) undergoing active orthodontic treatment with a fixed bracket system and exhibiting signs of initial enamel demineralization. The personalized dental tray was produced using CAD/CAM technologies and 3D-printed from a biocompatible photopolymer on individual digital jaw models with the fixed orthodontic appliance in place. Clinical efficacy of the original design of the personalized dental tray was assessed by the Remineralization Index (RI), oral hygiene (simplified oral hygiene index, OHI-S / Greene-Vermillion). Results: After completion of the remineralization course, which lasted 14 days, areas of initial demineralization disappeared completely in 93.5% of patients and were markedly reduced in the remainder. Statistically significant improvements were observed in all measured parameters: the Remineralization Index decreased from 2.15 ± 0.25 to 1.03 ± 0.18 (p < 0.001); OHI-S decreased from 2.35 ± 0.41 to 0.85 ± 0.29 (p < 0.001). The proposed original design of the personalized dental tray did not compromise the integrity or bonding of the fixed orthodontic hardware, and patient compliance remained high. Conclusions: The developed and clinically evaluated proposed original design of the personalized dental tray is an effective means of remineralization therapy for patients undergoing active orthodontic treatment with fixed bracket appliances at all stages of treatment. The proposed design ensures prolonged and uniform exposure of the remineralizing agent to sites of initial enamel demineralization. Individualized CAD/CAM 3D-design, subsequent 3D-digital modelling, and final photopolymer 3D-printing ensure precise retention and stabilization of the device intraorally.

KEYWORDS

remineralization, original design of a personalized personalized dental tray for remineralizing therapy, CAD/CAM, photopolymer 3D-printing, fixed orthodontic appliances, enamel demineralization, caries prevention

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GOST

Grigorenko M. P., Kravchenko P. S., Vakushina E. A., Lapina N. V., Bragin A. E., Arzumanyan L. V., Mrikaeva M. R. DEVELOPMENT OF A NOVEL DESIGN FOR A CUSTOM REMINERALIZATION TRAY MANUFACTURED BY ADDITIVE MANUFACTURING: VALIDATION AND CLINICAL EFFICACY // Actual problems in dentistry. 2025. no. 3. pp. 170-177. DOI: https://doi.org/10.18481/2077-7566-2025-21-3-170-177. (Date of access 06.09.2026).

MLA

Mark Grigorenko, Kravchenko P. S., Vakushina E. A., Lapina N. V., Bragin A. E., Arzumanyan L. V., Mrikaeva M. R.. "DEVELOPMENT OF A NOVEL DESIGN FOR A CUSTOM REMINERALIZATION TRAY MANUFACTURED BY ADDITIVE MANUFACTURING: VALIDATION AND CLINICAL EFFICACY." Actual problems in dentistry 21.3 (2025): 170-177. DOI: https://doi.org/10.18481/2077-7566-2025-21-3-170-177.

APA

Grigorenko M. P., Kravchenko P. S., Vakushina E. A., Lapina N. V., Bragin A. E., Arzumanyan L. V., Mrikaeva M. R. (2025). DEVELOPMENT OF A NOVEL DESIGN FOR A CUSTOM REMINERALIZATION TRAY MANUFACTURED BY ADDITIVE MANUFACTURING: VALIDATION AND CLINICAL EFFICACY. Actual problems in dentistry, 21(3), 170-177. https://doi.org/10.18481/2077-7566-2025-21-3-170-177

Chicago

Mark Grigorenko, Kravchenko P. S., Vakushina E. A., Lapina N. V., Bragin A. E., Arzumanyan L. V., Mrikaeva M. R.. "DEVELOPMENT OF A NOVEL DESIGN FOR A CUSTOM REMINERALIZATION TRAY MANUFACTURED BY ADDITIVE MANUFACTURING: VALIDATION AND CLINICAL EFFICACY." Actual problems in dentistry 21, no. 3 (2025): 170-177. https://doi.org/10.18481/2077-7566-2025-21-3-170-177.

WIKI

{{cite journal | author = Grigorenko M. P., Kravchenko P. S., Vakushina E. A., Lapina N. V., Bragin A. E., Arzumanyan L. V., Mrikaeva M. R. | title = DEVELOPMENT OF A NOVEL DESIGN FOR A CUSTOM REMINERALIZATION TRAY MANUFACTURED BY ADDITIVE MANUFACTURING: VALIDATION AND CLINICAL EFFICACY | journal = Actual problems in dentistry | year = 2025 | volume = 21 | issue = 3 | pages = 170-177 | doi = 10.18481/2077-7566-2025-21-3-170-177 }}

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