ASSESSMENT OF DENTAL PULP REGENERATIVE POTENTIAL AS THE MOST IMPORTANT ELEMENT OF PREVENTIVE ENDODONTICS PRINCIPLES REALIZATION

Ksenia Myasoedova; Irina Firsova; Sergej Krajnov; Alexandra Popova; Anatoliy Yakovlev; Irina Alekhanova; Natalia Trigolos

doi:10.18481/2077-7566-2024-20-4-89-96

UDC

616.31

VAK Russia

3.1.7

ASSESSMENT OF DENTAL PULP REGENERATIVE POTENTIAL AS THE MOST IMPORTANT ELEMENT OF PREVENTIVE ENDODONTICS PRINCIPLES REALIZATION

Published in Actual problems in dentistry · Pages 89–96 · Rubric: THERAPEUTIC DENTISTRY

DOI: https://doi.org/10.18481/2077-7566-2024-20-4-89-96

Received: 10.12.2024 Accepted: 28.12.2024 Published: 28.12.2024 Language of publication: RUS

Authors

Ksenia Myasoedova

Irina Firsova

Sergej Krajnov

ORCID

Alexandra Popova

Anatoliy Yakovlev

Irina Alekhanova

Natalia Trigolos

Ksenia Myasoedova

Volgograd State Medical University Assistant of the department · Department of Therapeutic Dentistry · Russian Federation · Volgograd

Irina Firsova

Volgograd State Medical University The head of Department · Department for Therapeutic Dentistry · Russian Federation · Volgograd

Sergej Krajnov

Academic degree: candidate of medical sciences

The Volgograd State Medical University assistant professor · Department for Therapeutic Dentistry

ORCID

Alexandra Popova

Academic degree: candidate of medical sciences

Science rang: docent

Volgograd State Medical University assistant professor · Department for Therapeutic Dentistry · Russian Federation · Volgograd

Anatoliy Yakovlev

Academic degree: doctor of medical sciences

Science rang: professor

Volgograd State Medical University Chief Researcher · Russian Federation · Volgograd

Irina Alekhanova

Academic degree: candidate of medical sciences

Volgograd State Medical University lecturer · Department for Therapeutic Dentistry · Russian Federation · Volgograd

Natalia Trigolos

Academic degree: candidate of medical sciences

Volgograd State Medical University Associate Professor of the Department · Department of Therapeutic Dentistry · Russian Federation · Volgograd

ABSTRACT

Subject of study. In the treatment of reversible forms of pulpitis, the principles of preventive endodontics aimed at preserving the vitality of the pulp are of great importance. For the realization of these principles, it is necessary to evaluate its regenerative potential, the verifier of which is the dynamics of transforming growth factor (TGF-β1) in gingival fluid (GF). Objectives. The purpose of the study was to optimize the assessment of tooth pulp regenerative potential in the treatment of reversible forms of pulpitis by analyzing the dynamics of TGF-β1 in GF. Materials and methods. 191 patients aged 19–29 years with reversible forms of pulpitis (K04.00 – “Pulp hyperemia” and K04.03 – “Chronic pulpitis”) were examined and treated, and were divided into 2 clinical groups: 1st – with pulp hyperemia and 2nd – with reversible form of chronic fibrous pulpitis. Each group was divided into subgroups (a, b, c), depending on the method of treatment: in subgroups 1a and 2a, a material based on calcium hydroxide was applied; in 1b and 2b, a preparation based on calcium silicate was applied; in subgroups 1c and 2c there combined the latter with laser therapy. The control group included 34 patients with intact pulp. To assess the regenerative potential of the dental pulp, the level of TGF-β1 in the GF was determined (at the initial examination, 7, 14, 21, and 30 days after the start of treatment of reversible pulpitis). Results. According to the data of the study, the combination of calcium silicate-based preparation and laser therapy demonstrated the highest clinical efficacy in comparison with calcium hydroxide-based material, harmonization of TGF-β1 activation processes in subgroups 1c and 2c came earlier (by the 7th day) (p < 0,05). At the same time, 2 patients (6.5%) of subgroup 2a were diagnosed with exacerbation of chronic fibrous pulpitis. Conclusions. Assessment of TGF-β1 concentration and its dynamics in GF allows to analyze reparative capabilities and processes occurring in the tooth pulp in pathological conditions and during various methods of conservative treatment to choose the most effective therapy.

KEYWORDS

reversible forms of pulpitis, preventive endodontics, Transforming growth factor (TGF-β1), gingival fluid, pulp capping (indirect and direct), laser treatment

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GOST

Myasoedova K. A., Firsova I. V., Krajnov S. V., Popova A. N., Yakovlev A. T., Alekhanova I. F., Trigolos N. N. ASSESSMENT OF DENTAL PULP REGENERATIVE POTENTIAL AS THE MOST IMPORTANT ELEMENT OF PREVENTIVE ENDODONTICS PRINCIPLES REALIZATION // Actual problems in dentistry. 2024. no. 4. pp. 89-96. DOI: https://doi.org/10.18481/2077-7566-2024-20-4-89-96. (Date of access 08.09.2026).

MLA

Ksenia Myasoedova, Firsova I. V., Krajnov S. V., Popova A. N., Yakovlev A. T., Alekhanova I. F., Trigolos N. N.. "ASSESSMENT OF DENTAL PULP REGENERATIVE POTENTIAL AS THE MOST IMPORTANT ELEMENT OF PREVENTIVE ENDODONTICS PRINCIPLES REALIZATION." Actual problems in dentistry 20.4 (2024): 89-96. DOI: https://doi.org/10.18481/2077-7566-2024-20-4-89-96.

APA

Myasoedova K. A., Firsova I. V., Krajnov S. V., Popova A. N., Yakovlev A. T., Alekhanova I. F., Trigolos N. N. (2024). ASSESSMENT OF DENTAL PULP REGENERATIVE POTENTIAL AS THE MOST IMPORTANT ELEMENT OF PREVENTIVE ENDODONTICS PRINCIPLES REALIZATION. Actual problems in dentistry, 20(4), 89-96. https://doi.org/10.18481/2077-7566-2024-20-4-89-96

Chicago

Ksenia Myasoedova, Firsova I. V., Krajnov S. V., Popova A. N., Yakovlev A. T., Alekhanova I. F., Trigolos N. N.. "ASSESSMENT OF DENTAL PULP REGENERATIVE POTENTIAL AS THE MOST IMPORTANT ELEMENT OF PREVENTIVE ENDODONTICS PRINCIPLES REALIZATION." Actual problems in dentistry 20, no. 4 (2024): 89-96. https://doi.org/10.18481/2077-7566-2024-20-4-89-96.

WIKI

{{cite journal | author = Myasoedova K. A., Firsova I. V., Krajnov S. V., Popova A. N., Yakovlev A. T., Alekhanova I. F., Trigolos N. N. | title = ASSESSMENT OF DENTAL PULP REGENERATIVE POTENTIAL AS THE MOST IMPORTANT ELEMENT OF PREVENTIVE ENDODONTICS PRINCIPLES REALIZATION | journal = Actual problems in dentistry | year = 2024 | volume = 20 | issue = 4 | pages = 89-96 | doi = 10.18481/2077-7566-2024-20-4-89-96 }}

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