USE OF THE RAT PERIODONTAL INDEX (PIoR) AS AN OBJECTIVE METHOD FOR STUDYING THE PERIODONTAL CONDITION OF WISTAR RATS. EXPERIMENTAL RESEARCH

Vyacheslav Popov; Lyubov Gorbatova; Aleksandra Dubinina; Semen Zhurba; Nikita Pozdeev; Yulia Zvezdina; Elena Preobrazhenskaya

doi:10.18481/2077-7566-2024-20-3-72-77

UDC

616.31

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76.29

VAK Russia

3.1.7

USE OF THE RAT PERIODONTAL INDEX (PIOR) AS AN OBJECTIVE METHOD FOR STUDYING THE PERIODONTAL CONDITION OF WISTAR RATS. EXPERIMENTAL RESEARCH USE OF THE RAT PERIODONTAL INDEX (PIoR) AS AN OBJECTIVE METHOD FOR STUDYING THE PERIODONTAL CONDITION OF WISTAR RATS. EXPERIMENTAL RESEARCH

АА Аа

Published in Actual problems in dentistry · Pages 72–77 · Rubric: PERIODONTIC DENTISTRY

DOI: https://doi.org/10.18481/2077-7566-2024-20-3-72-77

Received: 16.09.2024 Accepted: 30.09.2024 Published: 31.10.2024 Language of publication: RUS

Authors

Vyacheslav Popov

Lyubov Gorbatova

Aleksandra Dubinina

Semen Zhurba

Nikita Pozdeev

Yulia Zvezdina

Elena Preobrazhenskaya

Vyacheslav Popov

Northern State Medical University Assistant at the Department · Department of Pediatric Dentistry · Russian Federation · Arkhangelsk

Lyubov Gorbatova

Academic degree: doctor of medical sciences

Science rang: professor

Northern State Medical University Head of the Department · Department of Pediatric Dentistry · Russian Federation · Arkhangelsk

Aleksandra Dubinina

Northern State Medical University clinical resident · Department of Pediatric Dentistry · Russian Federation · Arkhangelsk

Semen Zhurba

Northern State Medical University Faculty of Dentistry · Russian Federation · Arkhangelsk

Nikita Pozdeev

Northern State Medical University Faculty of Dentistry · Russian Federation · Arkhangelsk

Yulia Zvezdina

Northern State Medical University Junior Researcher · Diagnostic laboratory of the Central Research Institute · Russian Federation · Arkhangelsk

Elena Preobrazhenskaya

Northern State Medical University Clinical Resident · Department of Pediatric Dentistry · Russian Federation · Arkhangelsk

ABSTRACT

Relevance. Currently, there is a high prevalence of inflammatory periodontal diseases (hereinafter referred to as IPD). The development of pharmaceutical products for the prevention and treatment of IPD remains a promising task. Reliable methods are needed to evaluate the effectiveness of such tools, however, known methods are not always applicable in experimental modeling of IPD in laboratory animals. To solve this problem, we proposed the periodontal index of rats (hereinafter referred to as the PIoR). Goal. To evaluate the practical application of PIoR in modeling experimental gingivitis in Wistar rats. Materials and methods. 30 adult male Wistar rats were selected for the study. The animals are divided into 3 groups: 2 intervention groups and 1 control group. The experiment was conducted for 16 days. The first stage of the experiment is the simulation of experimental gingivitis. Dysbiosis of the mouth was created in animals and mechanical damage to the gums was inflicted in the area of the incisors of the lower jaw. The second stage is the treatment of gingivitis with drugs “Asepta”, “Stomatophyte”. On the 10th and 16th days, a visual and instrumental assessment of bleeding, color and consistency of the gum was performed using PIoR. Results. During the experiment, on the 16th day, a decrease in PIoR values was recorded in all groups. However, bleeding and gum consistency were higher in the Stomatophyte group. The average value of the indicator “Gum color” varied in the range of 0.6–1.2 and significantly differed in the observation groups. When analyzing the signs of IPD before and after gingivitis therapy, statistically significant differences in the "Gum consistency" sign were revealed within the groups (0.7 vs. 0) in the Asepta group. When studying the changes in the average indicators of signs in the Stomatophyte group, an increase in bleeding was noted from 0.8 to 1.2. In the control group of animals, normalization of gum color was noted. Conclusion. The proposed index can be an effective tool in evaluating new pharmaceutical products for the prevention and treatment of IPD.

KEYWORDS

inflammatory periodontal diseases, preclinical studies, periodontal index, Wistar rats, gingivitis

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GOST

Popov V. A., Gorbatova L. N., Dubinina A. S., Zhurba S. I., Pozdeev N. V., Zvezdina Y. M., Preobrazhenskaya E. S. USE OF THE RAT PERIODONTAL INDEX (PIoR) AS AN OBJECTIVE METHOD FOR STUDYING THE PERIODONTAL CONDITION OF WISTAR RATS. EXPERIMENTAL RESEARCH // Actual problems in dentistry. 2024. no. 3. pp. 72-77. DOI: https://doi.org/10.18481/2077-7566-2024-20-3-72-77. (Date of access 06.09.2026).

MLA

Vyacheslav Popov, Gorbatova L. N., Dubinina A. S., Zhurba S. I., Pozdeev N. V., Zvezdina Y. M., Preobrazhenskaya E. S.. "USE OF THE RAT PERIODONTAL INDEX (PIoR) AS AN OBJECTIVE METHOD FOR STUDYING THE PERIODONTAL CONDITION OF WISTAR RATS. EXPERIMENTAL RESEARCH." Actual problems in dentistry 20.3 (2024): 72-77. DOI: https://doi.org/10.18481/2077-7566-2024-20-3-72-77.

APA

Popov V. A., Gorbatova L. N., Dubinina A. S., Zhurba S. I., Pozdeev N. V., Zvezdina Y. M., Preobrazhenskaya E. S. (2024). USE OF THE RAT PERIODONTAL INDEX (PIoR) AS AN OBJECTIVE METHOD FOR STUDYING THE PERIODONTAL CONDITION OF WISTAR RATS. EXPERIMENTAL RESEARCH. Actual problems in dentistry, 20(3), 72-77. https://doi.org/10.18481/2077-7566-2024-20-3-72-77

Chicago

Vyacheslav Popov, Gorbatova L. N., Dubinina A. S., Zhurba S. I., Pozdeev N. V., Zvezdina Y. M., Preobrazhenskaya E. S.. "USE OF THE RAT PERIODONTAL INDEX (PIoR) AS AN OBJECTIVE METHOD FOR STUDYING THE PERIODONTAL CONDITION OF WISTAR RATS. EXPERIMENTAL RESEARCH." Actual problems in dentistry 20, no. 3 (2024): 72-77. https://doi.org/10.18481/2077-7566-2024-20-3-72-77.

WIKI

{{cite journal | author = Popov V. A., Gorbatova L. N., Dubinina A. S., Zhurba S. I., Pozdeev N. V., Zvezdina Y. M., Preobrazhenskaya E. S. | title = USE OF THE RAT PERIODONTAL INDEX (PIoR) AS AN OBJECTIVE METHOD FOR STUDYING THE PERIODONTAL CONDITION OF WISTAR RATS. EXPERIMENTAL RESEARCH | journal = Actual problems in dentistry | year = 2024 | volume = 20 | issue = 3 | pages = 72-77 | doi = 10.18481/2077-7566-2024-20-3-72-77 }}

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USE OF THE RAT PERIODONTAL INDEX (PIOR) AS AN OBJECTIVE METHOD FOR STUDYING THE PERIODONTAL CONDITION OF WISTAR RATS. EXPERIMENTAL RESEARCH USE OF THE RAT PERIODONTAL INDEX (PIoR) AS AN OBJECTIVE METHOD FOR STUDYING THE PERIODONTAL CONDITION OF WISTAR RATS. EXPERIMENTAL RESEARCH

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