THE USE OF METALLOPROTEINASE INHIBITORS IN DENTISTRY. TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES USING PROTEOLYTIC ENZYME INHIBITORS

Natalia Allush; Lubov Muchamedzhanova

doi:10.18481/2077-7566-2024-20-1-5-10

VAK Russia 3.1.7 UDC 616.31

2 more Collapse

THE USE OF METALLOPROTEINASE INHIBITORS IN DENTISTRY. TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES USING PROTEOLYTIC ENZYME INHIBITORS

Published in Actual problems in dentistry · Volume 20, Issue 1 · Pages 5–10 · Rubric: LITERATURE REVIEW

DOI: https://doi.org/10.18481/2077-7566-2024-20-1-5-10

Received: 25.04.2024 Accepted: 02.05.2024 Published: 02.05.2024 Language of publication: RUS

Authors

Natalia Allush

Lubov Muchamedzhanova

Natalia Allush

Kazan State Medical Academy - branch of the Russian Medical Academy of Continuing Professional Education Department of Therapeutic, Pediatric Dentistry and Orthodontics · Russian Federation · Kazan

Lubov Muchamedzhanova

Academic degree: doctor of medical sciences

Science rang: professor

Kazan State Medical Academy - branch of the Russian Medical Academy of Continuing Professional Education Head of the Department · Department of Therapeutic, Pediatric Dentistry and Orthodontics · Russian Federation · Kazan

Chuvash State University named after I. N. Ulyanov Professor of Department · Department of Propaedeutics of Dental Diseases and New Technologies · Russian Federation · Cheboksary

ABSTRACT

Periodontitis is the most common inflammatory disease that leads to the destruction of the supporting tissues of the tooth. Therapeutic treatments aimed at reducing the effects of matrix metalloproteinases (MMPs) may be an effective adjunct to the treatment of periodontitis. The review examines the role of proteolytic enzyme inhibitors in the treatment of inflammatory periodontal diseases. General information about the ability of tetracyclines to inhibit MMPs is discussed. The purpose of the study was to examine the use of MMP inhibitors as a treatment for periodontal disease. Material and research methods. A scientific review of studies was carried out in Russian and English using information portals and platforms eLIBRARY.ru, Web of Science, PubMed and Scopus. The search was carried out using the following keywords: matrix metalloproteinases; oral diseases; tissue inhibitors of metalloproteinases. Of the 55 initially identified articles, after the initial analysis, 19 publications devoted to the study of MMP inhibitors associated with periodontal diseases were selected. Results of the study. Analysis of the literature allows us to conclude that the elimination of local irritants of periodontal tissues, the use of a therapeutic and prophylactic complex of measures using MMP inhibitors will have an advantage over traditional methods of treatment, will contribute to longer remission and prevent the progression of the inflammatory process in periodontal tissues, positively influence its course and reduce treatment time. The use of metalloproteinase inhibitors is an effective therapeutic strategy in the treatment of periodontal diseases. Conclusions. The therapeutic potential of metalloproteinase inhibitors may help prevent tissue damage in inflammatory periodontal diseases.

KEYWORDS

matrix metalloproteinases, periodontal diseases, extracellular matrix anti-inflammatory treatment, tissue metalloproteinase inhibitors

1. Abdugaffarov S.O.U., Rahimzhonov S.S.U., Bobokulov A.U.U., Akromov A.R.U. Rol' matriksnyh metalloproteinaz v organizme cheloveka. Eurasia Science: sbornik statey XXXI mezhdunarodnoy nauchno-prakticheskoy konferencii. Moskva. 2020:55-57. [S.O.U. Abdugaffarov, S.S.U. Rakhimzhonov, A.U.U. Bobokulov, A.R.U. Akromov. The role of matrix metalloproteinases in the human body. Eurasia Science: collection of articles of the XXXI international scientific and practical conference. Moscow. 2020:55-57. (In Russ.)]. https://elibrary.ru/item.asp?id=43938210

2. Bakumova A.P., Rogova L.N. Matriksnye metalloproteinazy, ih rol' v fiziologicheskih i patologicheskih processah zubochelyustnoy oblasti. Stomatologiya - nauka i praktika, perspektivy razvitiya. Materialy yubileynoy nauchno-prakticheskoy konferencii, posvyaschennoy 55-letiyu stomatologicheskogo fakul'teta VolgGMU. Volgograd. 2017:33-36. [A.P. Bakumova, L.N. Rogova. Matrix metalloproteinases, their role in physiological and pathological processes in the dentofacial area. Dentistry - science and practice, development prospects. Materials of the anniversary scientific and practical conference dedicated to the 55th anniversary of the Faculty of Dentistry of Volgograd State Medical University. Volgograd. 2017:33-36. (In Russ.)]. https://elibrary.ru/item.asp?id=28976423

3. Grigorkevich O.S., Mokrov G.V., Kosova L.Yu. Matriksnye metalloproteinazy i ih ingibitory. Farmakokinetika i Farmakodinamika. 2019;(2):3-16. [O.S. Grigorkevich, G.V. Mokrov, L.Yu. Kosova. Matrix metalloproteinases and their inhibitors. Pharmacokinetics and Pharmacodynamics. 2019;(2):3-16. (In Russ.)]. https://doi.org/10.24411/2587-7836-2019-10040

4. Davydov B.N., Domenyuk D.A., Kochkonyan T.S. Analiz profilya sistemy matriksnyh metalloproteinaz i ih endogennyh ingibitorov u detey s zabolevaniyami parodonta i razlichnymi displasticheskimi fenotipami. Parodontologiya. 2023;8(4):323-335. [B.N. Davydov, D.A. Domenyuk, T.S. Kochkonyan. Analysis of the profile of the matrix metalloproteinase system and their endogenous inhibitors in children with periodontal diseases and various dysplastic phenotypes. Periodontology. 2023;8(4):323-335. (In Russ.)]. https://doi.org/10.33925/1683-3759-2023-814

5. Dzampaeva Zh.V. Osobennosti etiologii i patogeneza vospalitel'nyh zabolevaniy parodonta. Kubanskiy nauchnyy medicinskiy vestnik. 2017;5:103-110. [Zh.V. Dzampaeva. Features of the etiology and pathogenesis of inflammatory periodontal diseases. Kuban Scientific Medical Bulletin. 2017;5:103-110. (In Russ.)]. doi: 10.25207 / 1608-6228-2017-24-5- 103-110.

6. Zalivskaya A.V., Zhilyakova E.T. Analiz osnov stomatologicheskih geley dlya lecheniya gingivita. Nauchnye rezul'taty biomedicinskih issledovaniy. 2016;2(1):53-58. [A.V. Zalivskaya, E.T. Zhilyakova. Analysis of the fundamentals of dental gels for the treatment of gingivitis. Scientific results of biomedical research. 2016;2(1):53-58. (In Russ.)]. doi:https://doi.org/10.18413/2313-8955-2016-2-1-53-58

7. Kazeko L.A., Benesh Yu.D., Zaharova V.A. Osobennosti ekspressii tkanevyh ingibitorov matriksnyh metalloproteinaz v bioptatah zdorovoy slizistoy obolochki polosti rta. Global Science and Innovations: Central Asia. 2021;2(12):133-135. [L.A. Kazeko, Yu.D. Benesh, V.A. Zakharova. Features of the expression of tissue inhibitors of matrix metalloproteinases in biopsy samples of healthy oral mucosa. Global Science and Innovations: Central Asia. 2021;2(12):133-135. (In Russ.)]. https://elibrary.ru/item.asp?id=46395950

8. Kandyba A.A., GrischenkoV.I., Hramcova K.A. Matriksnye metalloproteinazy. Student goda 2021. Sbornik statey XVII Mezhdunarodnogo nauchno-issledovatel'skogo konkursa. Penza. 2021:130-132. [A.A. Kandyba, V.I. Grishchenko, K.A. Khramtsova. Matrix metalloproteinases. Student of the Year 2021. Collection of articles from the XVII International Research Competition. Penza. 2021:130-132. (In Russ.)]. https://elibrary.ru/item.asp?id=44711281

9. Karahalis N.B., Karahalis M.N. Faktory riska tromboticheskih oslozhneniy i antitromboticheskaya terapiya kardiohirurgicheskih pacientov detskogo vozrasta. Acta Biomedica Scientifica. 2021;6(2):81-91. [N.B. Karahalis, M.N. Karahalis. Risk factors for thrombotic complications and antithrombotic therapy in pediatric cardiac surgical patients. Acta Biomedica Scientifica. 2021;6(2):81-91. (In Russ.)]. doihttps://doi.org/10.29413/ABS.2021-6.2.9.

10. Mardanov A.E. Diagnosticheskoe znachenie analiza matriksnyh metalloproteinaz u detey s rasschelinoy guby i neba : avtoreferat dis. … kandidata medicinskih nauk : special'nost' 14.01.14. Moskva, 2018:24. [A.E. Mardanov. Diagnostic value of matrix metalloproteinase analysis in children with cleft lip and palate : abstract dis. … candidate of medical sciences : specialty 01.14.14. Moscow, 2018:24. (In Russ.)]. https://elibrary.ru/item.asp?id=36430252

11. Orlova E.S. Etiopatogeneticheskie faktory vozniknoveniya i razvitiya vospalitel'nyh zabolevaniy parodonta. Universitetskaya medicina Urala. 2022;8(2):83-85. [E.S. Orlova. Etiopathogenetic factors in the occurrence and development of inflammatory periodontal diseases. University medicine of the Urals. 2022;8(2):83-85. (In Russ.)]. https://elibrary.ru/item.asp?id=49343197

12. Paterega N.I., Ogonovskiy R.Z., Pogranichnaya K.R., Lapovec L.E. Osobennosti dinamiki izmeneniya soderzhaniya provospalitel'nyh citokinov rotovoy zhidkosti posle udaleniya retenirovannyh nizhnih molyarov na fone primeneniya aprotinina i flyuktuiruyuschego toka. Laboratornaya diagnostika. Vostochnaya Evropa. 2019;8(1):58-63. [N.I. Paterega, R.Z. Ogonovsky, K.R. Pogranichnaya, L.E. Lapovets. Features of the dynamics of changes in the content of pro-inflammatory cytokines in the oral fluid after removal of impacted lower molars against the background of the use of aprotinin and fluctuating current. Laboratory diagnostics. Eastern Europe. 2019;8(1):58-63. (In Russ.)]. https://elibrary.ru/item.asp?id=38237023

13. Samsonova N.N., Andreev N.V., Klimovich L.G., Kozar E.F., Seregin K.O. Issledovanie effektivnosti i bezopasnosti traneksamovoy kisloty pri operaciyah na serdce v usloviyah iskusstvennogo krovoobrascheniya. Grudnaya i serdechno-sosudistaya hirurgiya. 2009;6:63-70. [N.N. Samsonova, N.V. Andreev, L.G. Klimovich, E.F. Kozar, K.O. Seregin. Study of the effectiveness and safety of tranexamic acid during heart surgery under artificial circulation. Thoracic and cardiovascular surgery. 2009;6:63-70. (In Russ.)]. https://elibrary.ru/item.asp?id=13571368

14. Haydarova N.B. Analiz sovremennyh metodov lecheniya hronicheskogo generalizovannogo parodontita. Aktual'nye nauchnye issledovaniya v sovremennom mire. 2020;7:55-59. [N.B. Khaidarova. Analysis of modern methods of treatment of chronic generalized periodontitis. Current scientific research in the modern world. 2020;7:55-59. (In Russ.)]. https://elibrary.ru/item.asp?id=43837649

15. Shadrina A.S. Matriksnye metalloproteinazy: struktura, funkcii i geneticheskiy polimorfizm. Patogenez. 2017;15(2):14-23. [A.S. Shadrina. Matrix metalloproteinases: structure, functions and genetic polymorphism. Pathogenesis. 2017;15(2):14-23. (In Russ.)]. Doi:https://doi.org/10.25557/GM.2017.2.7297.

16. Sherstobitov V.A. Analiz nauchnyh dannyh vzaimosvyazi polimorfizma genov matriksnyh metalloproteinaz s atrofiey kostnoy tkani chelyustey. Sovremennye dostizheniya hirurgicheskoy stomatologii. Cbornik materialov II Vserossiyskoy nauchno-prakticheskoy konferencii studentov i molodyh uchenyh. Moskva. 2021:75-78. [V.A. Sherstobitov. Analysis of scientific data on the relationship between matrix metalloproteinase gene polymorphism and jaw bone atrophy. Modern achievements of surgical dentistry: a collection of materials from the II All-Russian Scientific and Practical Conference of Students and Young Scientists. Moscow. 2021:75-78. (In Russ.)]. https://elibrary.ru/item.asp?id=47485826

17. Abramić M., Agić D. Survey of dipeptidyl peptidase III inhibitors: from small molecules of microbial or synthetic origin to aprotinin // Molecules. – 2022;27(9):3006. doi:https://doi.org/10.3390/molecules27093006.

18. Aggarwal N.K., Subramanian A. Antifibrinolytics and cardiac surgery: The past, the present, and the future // Ann Card Anaesth. – 2020;23(2):193-199. doi:https://doi.org/10.4103/aca.ACA_205_18.

19. Bassiouni W., Ali M.A.M., Schulz R. Multifunctional intracellular matrix metalloproteinases: implications in disease // FEBS J. – 2021;288(24):7162-7182. doi:https://doi.org/10.1111/febs.15701.

20. Bharadwaj P., Chouhan A.S. Periostat as a host modulating agent in the downregulation of matrix metalloproteinase (MMP) activity: A review // IP International Journal of Periodontology and Implantology. – 2021;4(4):192-194. scholar.google.ru

21. Chan D., Ooi E., Khalid O. A systematic review and meta-analysis of the role of doxycycline in chronic rhinosinusitis // J Laryngol Otol. – 2023;137(5):474-483. doi:https://doi.org/10.1017/S0022215122001803.

22. Cekici A., Kantarci A., Hasturk H., Van Dyke T.E. Inflammatory and immune pathways in the pathogenesis of periodontal disease // Periodontol 2000. – 2014;64(1):57-80. doi:https://doi.org/10.1111/prd.12002.

23. Cui N., Hu M., Khalil R.A. Biochemical and biological attributes of matrix metalloproteinases // Prog. Mol. Biol. Transl. Sci. – 2017;147:1-73. doi:https://doi.org/10.1016/bs.pmbts.2017.02.005.

24. Da Rocha H.A., Silva C.F., Santiago F.L., Martins L.G., Dias P.C., De Magalhães D. Local drug delivery systems in the treatment of periodontitis: a literature review // J. Int. Acad. Periodontol. – 2015;17(3):82-90. https://pubmed.ncbi.nlm.nih.gov/26373225/

25. Fischer T., Senn N., Riedl R. Design and structural evolution of matrix metalloproteinase inhibitors // Chemistry. – 2019;25(34):7960-7980. doi:https://doi.org/10.1002/chem.201805361.

26. Franco C., Patricia H.R., Timo S., Claudia B., Marcela H. Matrix metalloproteinases as regulators of periodontal inflammation // Int J Mol Sci. – 2017;18(2):440. doi:https://doi.org/10.3390/ijms18020440

27. Ivachtchenko A.V., Ivashchenko A.A., Shkil D.O., Ivashchenko I.A. Aprotinin-Drug against Respiratory Diseases // Int. J. Mol. Sci. – 2023;24(13):11173. doi:https://doi.org/10.3390/ijms241311173.

28. Keestra J.A., Grosjean I., Coucke W., Quirynen M., Teughels W. Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis // Journal of Periodontal Research. – 2015;50(3):294-314. doi:https://doi.org/10.1111/jre.12221.

29. Könönen E., Gursoy M., Gursoy U.K. Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues // J Clin Med. – 2019;8(8):1135. doi:https://doi.org/10.3390/jcm8081135.

30. Lisman T., Adelmeijer J., Huskens D., Meijers J.C.M. Aprotinin inhibits thrombin generation by inhibition of the intrinsic pathway, but is not a direct thrombin inhibitor // TH Open. – 2021;5(3):363-375. doi:https://doi.org/10.1055/s-0041-1735154.

31. Ma E., Chen W., Zhang C., Liu C., Lan J., Yan X. Ulinastatin in combination with aprotinin improves systemic inflammation in patients undergoing cardiac surgery with cardiopulmonary bypass // Am J Transl Res. – 2023;15(11):6505-6513. https://pubmed.ncbi.nlm.nih.gov/38074829/

32. Tilakaratne A., Soory M. Anti-inflammatory actions of adjunctive tetracyclines and other agents in periodontitis and associated comorbidities // Open. Dent. J. – 2014;8:109-124. doi:https://doi.org/10.2174/1874210601408010109.

This work is licensed under Creative Commons Attribution 4.0 International

JATS XML

Editor in Chief

Sergey Zholudev

zholudev_se@mail.ru

Deputy editor

Yuliya Mandra

jmandra@mail.ru

1051

downloads

This work is licensed under Creative Commons Attribution 4.0 International Creative Commons

GOST

Allush N. S., Muchamedzhanova L. R. THE USE OF METALLOPROTEINASE INHIBITORS IN DENTISTRY. TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES USING PROTEOLYTIC ENZYME INHIBITORS // Actual problems in dentistry. 2024. no. 1. pp. 5-10. DOI: https://doi.org/10.18481/2077-7566-2024-20-1-5-10. (Date of access 25.10.2026).

MLA

Natalia Allush, Muchamedzhanova L. R.. "THE USE OF METALLOPROTEINASE INHIBITORS IN DENTISTRY. TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES USING PROTEOLYTIC ENZYME INHIBITORS." Actual problems in dentistry 20.1 (2024): 5-10. DOI: https://doi.org/10.18481/2077-7566-2024-20-1-5-10.

APA

Allush N. S., Muchamedzhanova L. R. (2024). THE USE OF METALLOPROTEINASE INHIBITORS IN DENTISTRY. TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES USING PROTEOLYTIC ENZYME INHIBITORS. Actual problems in dentistry, 20(1), 5-10. https://doi.org/10.18481/2077-7566-2024-20-1-5-10

Chicago

Natalia Allush, Muchamedzhanova L. R.. "THE USE OF METALLOPROTEINASE INHIBITORS IN DENTISTRY. TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES USING PROTEOLYTIC ENZYME INHIBITORS." Actual problems in dentistry 20, no. 1 (2024): 5-10. https://doi.org/10.18481/2077-7566-2024-20-1-5-10.

WIKI

{{cite journal | author = Allush N. S., Muchamedzhanova L. R. | title = THE USE OF METALLOPROTEINASE INHIBITORS IN DENTISTRY. TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES USING PROTEOLYTIC ENZYME INHIBITORS | journal = Actual problems in dentistry | year = 2024 | volume = 20 | issue = 1 | pages = 5-10 | doi = 10.18481/2077-7566-2024-20-1-5-10 }}

Copy

Export: BibTeX EndNote RefMan RusMARC

THE USE OF METALLOPROTEINASE INHIBITORS IN DENTISTRY. TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES USING PROTEOLYTIC ENZYME INHIBITORS

Confirmation