SURGICAL TREATMENT OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH CANDIDA FUNGI

Faniya Mirsaeva; Timur Hanov; Alla Baykova

doi:10.18481/2077-7566-2022-18-2-131-138

VAK Russia 3.1 UDC 616 CSCSTI 76.29 Russian Classification of Professions by Education 31.05.03 Russian Library and Bibliographic Classification 566

5 more Collapse

SURGICAL TREATMENT OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH CANDIDA FUNGI

Published in Actual problems in dentistry · Volume 18, Issue 2 · Pages 131–138 · Rubric: SURGICAL DENTISTRY AND IMPLANTOLOGY

DOI: https://doi.org/10.18481/2077-7566-2022-18-2-131-138

Received: 12.08.2022 Accepted: 18.08.2022 Published: 18.08.2022 Language of publication: RUS

Authors

Faniya Mirsaeva

ORCID

Timur Hanov

Alla Baykova

Faniya Mirsaeva

Academic degree: doctor of medical sciences

Science rang: professor

Bashkirian State Medical University Head of Department · Department of Surgical Dentistry · Ufa

ORCID

Timur Hanov

Bashkirian State Medical University assistant of the department · Department of Surgical Dentistry · Ufa

Alla Baykova

Academic degree: candidate of medical sciences

Bashkirian State Medical University Docent of Department · Department of Surgical Dentistry · Ufa

ABSTRACT

Subject. The article presents the results of the complex treatment of chronic generalized periodontitis associated with fungi of the genus Candida, developed by the authors. The relevance of the study is associated with the prevalence of the disease and the lack of effective treatment. The aim of the study – increasing the efficiency of surgical treatment of patients with chronic generalized periodontitis associated with fungi of the genus Candida, using non-invasive laser blood irradiation in the early postoperative period. Methodology. The study was conducted in two groups of patients (main and comparison group). In the main group at the preoperative stage, a two-component probiotic was included in the complex of anti-inflammatory therapy. Surgical treatment was carried out according to the method developed by the authors, where a plate was used to replace the bone cavity, including collagen and the probiotic Bacillus subtilis 3H immobilized in it. In patients in the comparison group, preoperative anti-inflammatory, as well as surgical treatment, was performed according to a well-known method. The results were evaluated by clinical, immunological and functional research methods. Results. In patients of the main group, a significant improvement in the indicators of clinical, immunological and functional research methods was noted three months after the operation and stably persisted up to 12 months after the operation. In patients of the comparison group, three months after the operation, a negative trend was observed. Findings. Inclusion in the complex of treatment of patients with chronic generalized periodontitis associated with fungi of the genus Candida, a two-component probiotic followed by surgical treatment according to the method developed by the authors using a plate, including collagen and the probiotic Bacillus subtilis 3H immobilized in it, allows achieving stable results in the long-term after surgery. Key words: chronic generalized periodontitis, Candida fungi, probiotics, collagen, immunoglobulins, oral fluid, periodontal pockets, bone optical density. The authors declared no conflict of interest.

KEYWORDS

chronic generalized periodontitis, Candida fungi, probiotics, collagen, immunoglobulins, oral fluid, periodontal pockets, bone optical density

1. Grudyanov A.I., Fomenko E.V. Etiologiya i patogenez vospalitel'nyh zabolevaniy parodonta. Moskva : MIA. 2010:90. [A.I. Grudyanov, E.V. Fomenko. Etiology and pathogenesis of inflammatory periodontal diseases. Moscow: MIA. 2010:90. (In Russ.)]. https://e-stomatology.ru/pressa/literatura/grudyanov/etiologiya.htm

2. Puzin M.N., Kiparisova E.S., Vagner V.D. i dr. Etiopatogeneticheskie aspekty hronicheskogo generalizovannogo parodontita. Rossiyskiy stomatologicheskiy zhurnal. 2010;1:28-33. [M.N. Puzin, E.S. Kiparisova, V.D. Vagner. Etiopathogenetic aspects of chronic generalized periodontitis. Russian Dental Journal. 2010;1:28-33. (In Russ.)]. https://www.elibrary.ru/item.asp?id=14341364

3. Melehov S.V. Rol' drozhzhepodobnyh gribov roda Candida v razvitii patologii parodonta. Maestro stomatologii. 2009;2:72-75. [S.V. Melekhov. The role of yeast-like fungi of the genus Candida in the development of periodontal pathology. Maestro of dentistry. 2009;2:72-75. (In Russ.)]. https://www.elibrary.ru/item.asp?id=30691003

4. Artushkevich V.G. Vliyanie sistemnogo osteoporoza na razvitie generalizovannogo parodontita. Lechenie i profilaktika. 2012;2(3):42-47. [V.G. Artushkevich. Influence of systemic osteoporosis on the development of generalized periodontitis. Treatment and prevention. 2012;2(3):42-47. (In Russ.)]. https://www.elibrary.ru/item.asp?id=18755219

5. Bulkina N.V., Vedyaeva A.P. K voprosu etiologii i patogeneze bystroprogressiruyuschego parodontita. Rossiyskiy stomatologicheskiy zhurnal. 2012;5:50-52. [N.V. Bulkina, A.P. Vedyaeva. To the question of the etiology and pathogenesis of rapidly progressive periodontitis. Russian Dental Journal. 2012;5:50-52. (In Russ.)]. https://www.elibrary.ru/item.asp?id=18757561

6. Torabinejad M., Eby W.C., Nai-dorf I.J. Inflammatory and immunological aspects of the pathogenesis of human chronic periapical lesions // J. Endodond. - 2015;11(6):479-484. doi:https://doi.org/10.1016/S0099-2399(85)80221-1.

7. Uspenskaya O.A., Kachesova E.S. Rol' obschih i mestnyh faktorov v vozniknovenii i razvitii hronicheskogo generalizovannogo parodontita tyazheloy stepeni. Sovremennye problemy nauki i obrazovaniya. 2017;5:188. [O.A. Uspenskaya, E.S. Kachesova. The role of general and local factors in the occurrence and development of severe chronic generalized periodontitis. Modern problems of science and education. 2017;5:188. (In Russ.)]. https://www.elibrary.ru/item.asp?id=30457991

8. Rams T.E., Slots J. Candida biotypes in human adult periodontitis // Oral. Microbiol. - 2014;6(3):191-192. doi:https://doi.org/10.1111/j.1399-302x.1991.tb00476.x.

9. Beybulatov G.D., Ostrovskaya L.Yu., Lepilin A.V. Faktory, vliyayuschie na razvitie kandida-associirovannogo parodontita. Rossiyskiy stomatologicheskiy zhurnal. 2014;4:36-38. [G.D. Beibulatov, L.Yu. Ostrovskaya, A.V. Lepilin. Factors influencing the development of Candida-associated periodontitis. Russian Dental Journal. 2014;4:36-38. (In Russ.)]. https://www.elibrary.ru/item.asp?id=22566127

10. Chepurkova O.A. Vybor antimikrobnyh, antisepticheskih i antimikoticheskih preparatov v kompleksnoy terapii hronicheskogo generalizovannogo parodontita, associirovannogo s drozhzhevymi gribami roda Candida. Rossiyskiy stomatologicheskiy zhurnal. 2008;6:48-51. [O.A. Chepurkova. The choice of antimicrobial, antiseptic and antimycotic drugs in the complex therapy of chronic generalized periodontitis associated with yeast fungi of the genus Candida. Russian Dental Journal. 2008;6:48-51. (In Russ.)]. https://www.elibrary.ru/item.asp?id=23094045

11. Chepurkova O.A., Chesnokova M.G., Nedoseko V.B. i dr. Principy terapii kandida-associirovannogo parodontita. Stomatolog. 2011;2:21-27. [O.A. Chepurkova, M.G. Chesnokova, V.B. Nedoseko. Principles of therapy for Candida-associated periodontitis. Dentist. 2011;2:21-27. (In Russ.)]. https://www.elibrary.ru/item.asp?id=32250607

12. Perevoschikova O.A. Primenenie probiotikov v kompleksnom lechenii vospalitel'nyh zabolevaniy parodonta na fone somaticheskoy patologii : avtoref. dis. … kand. med. nauk. 14.01.14. Moskva, 2013:19. [O.A. Perevoshchikova. The use of probiotics in the complex treatment of inflammatory periodontal diseases against the background of somatic pathology : author. dis. … cand. med. Sciences. Moscow, 2013:19. (In Russ.)]. https://www.elibrary.ru/item.asp?id=30385949

13. Redinova T.L., Zorin A.Yu., Biktimerova O.O. i dr. Effektivnost' probiotikov v lechenii i profilaktiki stomatologicheskih zabolevaniy. Problemy stomatologii. 2016;12(1):50-56. [T.L. Redinova, A.Yu. Zorin, O.O. Biktimerova. Efficiency of probiotics in the treatment and prevention of dental diseases. Actual problems in dentistry. 2016;12(1):50-56. (In Russ.)]. https://www.researchgate.net/profile/Anatoly-Zhirkov/publication/302028364_Complex_interdistiplinary_aproach_in_temporomandibular_join_disfunction/links/5a23a01d0f7e9b71dd055f60/Complex-interdistiplinary-aproach-in-temporomandibular-join-disfunction.pdf

14. Biktimirova O.O., Redinova T.L. Dinamika klinicheskih, immunologicheskih i mikrobiologicheskih pokazateley polosti rta u pacientov s hronicheskim generalizovannym parodontitom legkoy i sredney stepeni tyazhesti pri lechenii probiotikami. Parodontologiya. 2016;2(79):10-15. [O.O. Biktimirova, T.L. Redinova. Dynamics of clinical, immunological and microbiological parameters of the oral cavity in patients with mild to moderate chronic generalized periodontitis in the treatment of probiotics. Periodontology. 2016;2(79):10-15. (In Russ.)]. https://www.elibrary.ru/item.asp?id=26139998

15. Bonifait L., Chandad F., Grenier D. Probiotics for Orai Heaith: Myth or Reality // JCDA. - 2009;75;8:58. PMID: 19840501

16. Moellering R.C. Tissue directed antibiotic therapy // Am. J. Med. - 2011;91(3):1-45. https:// docplayer/net/20903984Probiotics-for oral health-myth or reality.html

17. Waltimo T.M., Siren E.K., Torkko H.L., Olsen I., Haapasalo M.P. Fungi in therapy-resistant apical periodontitis // Int. Endod. J. - 2017;30(2):96-101. doi:https://doi.org/10.1046/j.1365-2591.1997.00058.x.

18. Jewtuchowicz V.M. et al. Subgingival distribution of yeast and their antifungal susceptibility in immunocompetent subjects with and without dental devices // Acta. Odontol. Latinoam. - 2017;20(1):17-22. PMID:18046966

19. Modina T.N., Maklakova I.S. Eksperimental'noe obosnovanie primeneniya gialuosta dlya zakrytiya kostnyh defektov v ambulatornoy hirurgii. Klinicheskaya stomatologiya. 2011;4:30-32. [T.N. Modina, I.S. Maklakova. Experimental substantiation of the use of hyaluost for the closure of bone defects in outpatient surgery. Clinical dentistry. 2011;4:30-32. (In Russ.)]. https://www.elibrary.ru/item.asp?id=22625387

20. Storozheva M.V. Primenenie preparata «Gialuost» v kompleksnom lechenii hronicheskogo parodontita. Visnik VDNZU «Ukrainska medichna stomatologichna akademiya». 2018;16;4(56):38-40. [M.V. Storozheva. The use of the drug "Hyaluost" in the complex treatment of chronic periodontitis. Visnik VDNZU "Ukrainian medical stomatological academy". 2018;16;4(56):38-40. (In Ukr.)]. https://www.elibrary.ru/item.asp?id=26737194

21. Zorina O.A., Boriskina O.A., Magomedov R.N., Prohodnaya V.A. i dr. Dinamika kostnogo metabolizma posle hirurgicheskogo lecheniya hronicheskogo generalizovannogo parodontita s podsadkoy razlichnyh kostno - plasticheskih materialov po pokazatelyam rotovoy zhidkosti. Stomatologiya. 2019;2:26-30. [O.A. Zorina, O.A. Boriskina, R.N. Magomedov, V.A. Prokhodnaya et al. Dynamics of bone metabolism after surgical treatment of chronic generalized periodontitis with implantation of various bone-plastic materials in terms of oral fluid. Dentistry. 2019;2:26-30. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37785543

22. Bychkova N.P., Skorikova L.A., Doeva E.T., Volkov V.A. Lechenie hronicheskogo generalizovannogo parodontita s primeneniem bakteriotoksicheskoy svetoterapii i posleduyuschim hirurgicheskim vmeshatel'stvom s primeneniem osteoplasticheskogo materiala biogen. Kubanskiy nauchnyy medicinskiy vestnik. 2018;25(2):52-58. [N.P. Bychkova, L.A. Skorikova, E.T. Doeva, V.A. Volkov. Treatment of chronic generalized periodontitis with the use of bacteriotoxic light therapy and subsequent surgical intervention with the use of biogen osteoplastic material. Kuban Scientific Medical Bulletin. 2018;25(2):52-58. (In Russ.)]. https://ksma.elpub.ru/jour/issue/viewFile/31/6

23. Mirsaeva F.Z., Hanov T.V., Kuznecova T.N., Usmanova I.N. Patent na izobretenie RU 2713959 C1. Sposob hirurgicheskogo lecheniya hronicheskogo generalizovannogo parodontita. № 2019126234. 11.02.2020. [F.Z. Mirsaeva, T.V. Khanov, T.N. Kuznetsova, I.N. Usmanova. Patent for invention RU 2713959 C1. A method of surgical treatment of chronic generalized periodontitis. № 2019126234. 11.02.2020. (In Russ.)]. https://www.elibrary.ru/item.asp?id=42478820

24. Mirsaeva F.Z., Hanov T.V. Dinamika klinicheskih i immunologicheskih pokazateley pri kompleksnom lechenii kandida-associirovannogo parodontita. Problemy stomatologii. 2019;15(2):128-134. [F.Z. Mirsaeva, T.V. Khanov. Dynamics of clinical and immunological parameters in the complex treatment of candida-associated periodontitis. Actual problems in dentistry. 2019;15(2):128-134. (In Russ.)]. https://www.elibrary.ru/item.asp?id=39165975

25. Moskvin S.V., Konchugova T.V., Hadarcev A.A. Osnovnye terapevticheskie metodiki lazernogo osvechivaniya krovi. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kul'tury. 2017;5:10-17. [S.V. Moskvin, T.V. Konchugova, A.A. Khadartsev. The main therapeutic methods of laser illumination of blood. Issues of balneology, physiotherapy and therapeutic physical culture. 2017;5:10-17. (In Russ.)]. https://doi.org/10.17116/kurort201794510-17 .

This work is licensed under Creative Commons Attribution 4.0 International

JATS XML

Editor in Chief

Sergey Zholudev

zholudev_se@mail.ru

Deputy editor

Yuliya Mandra

jmandra@mail.ru

973

downloads

This work is licensed under Creative Commons Attribution 4.0 International Creative Commons

GOST

Mirsaeva F. Z., Hanov T. V., Baykova A. Y. SURGICAL TREATMENT OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH CANDIDA FUNGI // Actual problems in dentistry. 2022. no. 2. pp. 131-138. DOI: https://doi.org/10.18481/2077-7566-2022-18-2-131-138. (Date of access 26.10.2026).

MLA

Faniya Mirsaeva, Hanov T. V., Baykova A. Y.. "SURGICAL TREATMENT OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH CANDIDA FUNGI." Actual problems in dentistry 18.2 (2022): 131-138. DOI: https://doi.org/10.18481/2077-7566-2022-18-2-131-138.

APA

Mirsaeva F. Z., Hanov T. V., Baykova A. Y. (2022). SURGICAL TREATMENT OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH CANDIDA FUNGI. Actual problems in dentistry, 18(2), 131-138. https://doi.org/10.18481/2077-7566-2022-18-2-131-138

Chicago

Faniya Mirsaeva, Hanov T. V., Baykova A. Y.. "SURGICAL TREATMENT OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH CANDIDA FUNGI." Actual problems in dentistry 18, no. 2 (2022): 131-138. https://doi.org/10.18481/2077-7566-2022-18-2-131-138.

WIKI

{{cite journal | author = Mirsaeva F. Z., Hanov T. V., Baykova A. Y. | title = SURGICAL TREATMENT OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH CANDIDA FUNGI | journal = Actual problems in dentistry | year = 2022 | volume = 18 | issue = 2 | pages = 131-138 | doi = 10.18481/2077-7566-2022-18-2-131-138 }}

Copy

Export: BibTeX EndNote RefMan RusMARC

SURGICAL TREATMENT OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH CANDIDA FUNGI

Confirmation