CYTOKINE PROFILE IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS

Ol&#039;ga Uspenskaya; Evgeniya Kondyurova; Irina Fadeeva

doi:10.18481/2077-7566-20-16-4-64-70

UDC

CYTOKINE PROFILE IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS

Published in Actual problems in dentistry · Pages 64–70 · Rubric: THERAPEUTIC DENTISTRY

DOI: https://doi.org/10.18481/2077-7566-20-16-4-64-70

Received: 03.12.2020 Accepted: 10.12.2020 Published: 28.12.2020 Language of publication: RUS

Authors

Ol'ga Uspenskaya

Evgeniya Kondyurova

Irina Fadeeva

Ol'ga Uspenskaya

Academic degree: doctor of medical sciences

Science rang: docent

Volga Research Medical University Head of Department · Department of Therapeutic Dentistry · Russian Federation · Nizhny Novgorod

Evgeniya Kondyurova

Academic degree: candidate of medical sciences

Science rang: docent

FGBOU VO «MGU im. N.P. Ogareva» zaveduyuschiy · Kafedra stomatologii · Russian Federation

Irina Fadeeva

Volga Research Medical University Department of Therapeutic Dentistry · Russian Federation · Nizhny Novgorod

ABSTRACT

Objective — improvement of methods of treatment of chronic generalized periodontitis based on the analysis of the cytokine profile of patients. Methodology. A study of 120 patients with chronic periodontitis of varying severity aged 30 to 50 years was conducted. All patients were randomized into 5 groups according to the severity of the disease and therapy. all patients received traditional anti-inflammatory therapy. In group 4, in addition to the main treatment, patients received laser therapy sessions. In group 5, patients with severe chronic periodontitis were administered remaxol along with laser therapy. Evaluation of the condition of periodontal tissues was carried out according to clinical indices. PMA, SBI, API, OHI-s, and periodontal indices were used. The serum levels of IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ, and TNF-α were studied by enzyme immunoassay. Results: In chronic generalized periodontitis of moderate and severe severity, the content of all studied proinflammatory cytokines in the blood serum increases, and more significantly in the group of patients with severe disease. At the same time, the content of anti-inflammatory mediators undergoes ambiguous changes: in group I, the content of IL-4 increases significantly, and in group II it does not change significantly. In turn, IL-10 in group I does not decrease significantly, but in group II it becomes significantly less than normal. The inclusion of laser therapy and remaxol in the complex of standard measures showed high efficiency in reducing the severity of the pathological process, which was expressed in a faster subsiding of inflammatory phenomena in periodontal tissues. Conclusions: An increase in the content of proinflammatory cytokines in the blood serum in chronic generalized periodontitis was revealed, and more significantly in the group of patients with a severe course of the disease. At the same time, an imbalance of the system of pro-inflammatory and anti-inflammatory cytokines is registered. The use of laser therapy and remaxol in the complex treatment of CPT was the most effective.

KEYWORDS

chronic generalized periodontitis, laser therapy, remaxol, cytokines, index assessment of the periodontal condition

1. Bahmet'ev O.A. Kondyurov I.M., Kurylev V.V., Potemina T.E., Uspenskaya O.A., Shevchenko E.A. Sovremennye osobennosti etiopatogeneza vospalitel'nyh zabolevaniy rotovoy polosti i virusno-bakterial'naya biota urogenital'nogo trakta. Medicinskiy al'manah. 2012;3(22).70-72. [O.A. Bakhmetyev, I.M. Kondyurov, V.V. Kurylev, T.E. Potemina, O.A. Uspenskaya, E.A. Shevchenko. Modern features of the etiopathogenesis of inflammatory diseases of the oral cavity and viral-bacterial biota of the urogenital tract. Medical almanac. 2012;3(22):70-72. (in Russ.)].

2. Bespalova N.A., Vorob'eva A.V., Durnovo E.A., Klochkov A.S., Marochkina M.S., Shashurina S.V. Diagnosticheskie vozmozhnosti dinamiki laktoferrina rotovoy zhidkosti dlya ocenki techeniya rannego posleoperacionnogo perioda pri operativnyh vmeshatel'stvah v polosti rta. Medicinskiy al'manah. 2012;2(21):242-246. [N.A. Bespalova, A.V. Vorobieva, E.A. Durnovo, A.S. Klochkov, M.S. Marochkina, S.V. Shashurina. Diagnostic capabilities of the dynamics of oral fluid lactoferrin to assess the course of the early postoperative period during surgical interventions in the oral cavity. Medical almanac. 2012;2(21):242-246. (In Russ.)].

3. Bespalova N.A., Durnovo E.A., Runova N.B. Sposob lecheniya parodontita. Patent RF2271769 C2, 20.03.2006. Zayavka № 2004118216/14 ot 15.06.2004. [N.A. Bespalova, E.A. Durnovo, N.B. Runova. Method for the treatment of periodontitis. RF patent 2271769 C2, 20.03.2006. Application No. 2004118216/14 dated June 15, 2004. (In Russ.)].

4. Beleva N.S., Gileva O.S., Krivcov A.V., Mozgovaya L.A.,Pozdin N.V., Sivak E.Yu., Sosnin D.Yu. NT-PROBNP v slyune i syvorotke krovi v norme i pri parodontite. Klinicheskaya laboratornaya diagnostika. 2018;63(3):164-168. [N.S. Beleva, O.S. Gileva, A.V. Krivtsov, L.A. Mozgovaya, N.V. Pozdin, E.Yu. Sivak, D.Yu. Sosnin. NT-PROBNP in saliva and blood serum in norm and in periodontitis. Clinical laboratory diagnostics. 2018;63(3):164-168. (In Russ.)]. https://www.elibrary.ru/item.asp?id=32782303

5. Bondarenko E.A., Gibadullina N.V., Gileva O.S., Gileva E.S., Pozdnyakova A.A., Sadilova V.A., Satyukova L.Ya. Novye podhody k lecheniyu vospalitel'nyh zabolevaniy parodonta. Ural'skiy medicinskiy zhurnal. 2011;5(83):22-27. [E.A. Bondarenko, N.V. Gibadullina, O.S. Gileva, E.S. Gileva, A.A. Pozdnyakova, V.A. Sadilova, L.Ya. Satyukova. New approaches to the treatment of inflammatory periodontal diseases. Ural Medical Journal. 2011;5(83):22-27. (In Russ.)].

6. Bragina O.M., Spiridonova S.A., Suhova A.V., Uspenskaya O.A. Izuchenie vliyaniya sostoyaniya polosti rta na psihoemocional'nyy status obuchayuschihsya stomatologicheskogo fakul'teta "privolzhskogo issledovatel'skogo medicinskogo universiteta" ministerstva zdravoohraneniya rossiyskoy federacii. Endodontiya Today. 2020;18(1). [O.M. Bragina, S.A. Spiridonova, A.V. Sukhova, O.A. Uspenskaya. Study of the influence of the state of the oral cavity on the psychoemotional status of students of the Faculty of Dentistry "Privolzhsky Research Medical University" of the Ministry of Health of the Russian Federation. Endodontics Today. 2020;18(1). (In Russ.)].

7. Gibadullina N.V., Gileva O.S., Daurova F.Yu., Korotin S.V., Sivak E.Yu., Sosnin D.Yu. Soderzhanie vaskuloendotelial'nogo faktora rosta v slyune i syvorotke krovi bol'nyh parodontitom. Klinicheskaya laboratornaya diagnostika. 2019;64(11):663-668. [N.V. Gibadullina, O.S. Gileva, F.Yu. Daurova, S.V. Korotin, E.Yu. Sivak, D.Yu. Sosnin. The content of vasculoendothelial growth factor in saliva and blood serum of patients with periodontitis. Clinical laboratory diagnostics. 2019;64(11):663-668. (In Russ.)]. https://www.elibrary.ru/item.asp?id=41272527

8. Gileva O.S. Konservativno-profilakticheskaya stomatologiya: sovremennye trendy razvitiya. Permskiy medicinskiy zhurnal. 2018;35(6):61-72. [O.S. Gileva. Conservative-preventive dentistry: modern development trends. Perm Medical Journal. 2018;35(6):61-72. (In Russ.)].

9. Gileva O.S., Leonova L.E., Sivak E.Yu., Sosnin D.Yu. Sravnitel'nyy analiz urovnya natriyureticheskih peptidov rotovoy zhidkosti pacientov s hronicheskim parodontitom. Stomatologiya. 2018;97(6-2). [O.S. Gileva, L.E. Leonova, E.Yu. Sivak, D.Yu. Sosnin. Comparative analysis of the level of natriuretic peptides in the oral fluid of patients with chronic periodontitis. Dentistry. 2018;97(6-2). (In Russ.)].

10. Gileva O.S., Sadilova V.A.Zabolevanie parodonta u VICh-inficirovannyh bol'nyh:rasprostranennost' i osobennosti klinicheskih proyavleniy v zavisimosti ot priverzhennosti antiretrovirusnoy terapii. Permskiy medicinskiy zhurnal. 2013;30(2):34-42. [O.S. Gileva, V.A. Sadilova. Periodontal disease in HIV-infected patients: prevalence and characteristics of clinical manifestations depending on adherence to antiretroviral therapy. Perm Medical Journal. 2013;30(2):34-42. (In Russ.)].

11. Grudyanov A.I. Bezrukova I.V. Agressivnye formy parodontita. Moskva: Medicinskoe informacionnoe agenstvo. 2002:126. [A.I.Grudyanov, I.V. Bezrukova. Aggressive forms of periodontitis. Moscow: Medical Information Agency. 2002:126. (In Russ.)].

12. Davtyan G.A., Spiridonova S.A., Uspenskaya O.A., Shevchenko E.A. Izmenenie gormonal'nogo fona u lic s hronicheskim generalizovannym parodontitom. Endodontiya Today. 2019;17(4):16-20. [G.A. Davtyan, S.A. Spiridonova, O.A. Uspenskaya, E.A. Shevchenko. Changes in hormonal levels in persons with chronic generalized periodontitis. Endodontics Today. 2019;17(4):16-20. (In Russ.)].

13. Durnovo E.A., Runova N.B., Furman I.V. Citohimicheskaya diagnostika nespecificheskoy rezistentnosti organizma u bol'nyh s ostrymi vospalitel'nymi processami chelyustno-licevoy oblasti. Allergologiya i immunologiya. 2003;2(4):192. [E.A. Durnovo, N.B. Runova, I.V Furman. Cytochemical diagnosis of nonspecific resistance of the organism in patients with acute inflammatory processes of the maxillofacial region. Allergology and Immunology. 2003;2(4):192. (In Russ.)].

14. Zadorina I.I., Gileva O.S., Islamova A.F., Plenkina V.A., Sintyurina A.A., Chuprakov M.A. Ocenka bolevogo simptoma u pacientov s vospalitel'nymi zabolevaniyami slizistoy obolochki rta, paro- i endodonta. Sovremennye problemy nauki i obrazovaniya. 2017;4:17. [I.J. Zadorina, O.S. Gileva, A.F. Islamova, V.A. Plenkina, A.A. Sintyurina, M.A. Chuprakov. Assessment of pain symptom in patients with inflammatory diseases of the oral mucosa, paro- and endodont. Modern problems of science and education. 2017;4:17. (In Russ.)].

15. Kachesova E.S., Uspenskaya O.A., Shevchenko E.A., Novaya shema kompleksnogo lecheniya agressivnyh form parodontita. Sovremennye tehnologii v medicine. 2017;4(9):209-216. [E.S. Kachesova, O.A. Uspenskaya, E.A. Shevchenko. A new scheme for the complex treatment of aggressive forms of periodontitis. Modern technologies in medicine. 2017;4(9):209-216. (In Russ.)]. DOI:https://doi.org/10.17691/stm2017.9.4.26

16. Spiridonova S.A., Ruzina K.A., Uspenskaya O.A. Izuchenie psihoemocional'nogo statusa i gigienicheskogo sostoyaniya polosti rta studentov, nahodyaschihsya na distancionnom obuchenii na fone covid-19. Dental Forum. 2020;4(79):59-60. [S.A. Spiridonova, K.A. Ruzina, O.A. Uspenskaya. Study of the psychoemotional status and hygienic state of the oral cavity of distance learning students against the background of covid-19. Dental Forum. 2020;4(79):59-60. (In Russ.)]. https://www.elibrary.ru/item.asp?id=44082057

17. Usmanova I.N., Bakirov A.B., Gerasimova L.P., Kabirova M.F., Farhutdinov R.R., Usmanov I.R., Masyagutova L.M., Husnarizanova R.F., Rybakov I.D. Sposob differencial'noy diagnostiki vospalitel'nyh zabolevaniy parodonta po sostoyaniyu lokal'nyh faktorov nespecificheskoy zaschity polosti rta. Patent na izobretenie RF2390775 C1, 27.05.2010. Zayavka № 2009108566/15 ot 10.03.2009. [I.N. Usmanova, A.B. Bakirov, L.P. Gerasimova, M.F. Kabirova, R.R. Farkhutdinov, I.R. Usmanov, L.M. Masyagutova, R.F. Khusnarizanova, I.D. Rybakov. A method for differential diagnosis of inflammatory periodontal diseases by the state of local factors of nonspecific protection of the oral cavity. Patent RU2390775 C1, 05/27/2010. Application No. 2009108566/15 dated 10.03.2009. (In Russ.)].

18. Uspenskaya O.A. Issledovanie biohimicheskih pokazateley kostnogo metabolizma rotovoy zhidkosti pri lechenii agressivnyh form parodontita. Problemy stomatologii. 2019;1(15):68-73. [O.A. Uspenskaya. Investigation of biochemical parameters of bone metabolism of the oral fluid in the treatment of aggressive forms of periodontitis. Actual problems in dentistry. 2019;1(15):68-73. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37602583

19. Uspenskaya O.A, Fadeeva I.I. Osobennosti stomatologicheskogo statusa u pacientov s onkologicheskimi zabolevaniyami. Problemy stomatologii. 2019;15(1):63-67. [O.A. Uspenskaya, I.I. Fadeeva. Features of the dental status in patients with cancer. Actual problems in dentistry. 2019;15(1):63-67. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37602582

20. Uspenskaya O.A., Fadeeva I.I. Izmenenie pokazateley krovi u pacientov s zabolevaniyami slizistoy obolochki polosti rta na fone onkopatologii. Endodontiya Today. 2020;18(1).82-86.

21. Yanushevich O.O. Zabolevaniya parodonta. Sovremennyy vzglyad na kliniko-diagnosticheskie i lechebnye aspekty. Moskva: GEOTARMedia. 2010:160. [O.O. Yanushevich. Periodontal disease. A modern view of the clinical, diagnostic and therapeutic aspects. Moscow: GEOTARMedia. 2010:160. (In Russ.)].

22. Uspenskaya O.A., Shevchenko E.A., Fadeeva I.I., Kazarina N.V. The influence of organ pathology on the development of diseases of the oral mucosa // Research journal of pharmaceutical, biological and chemical sciences. - 2019;10(6):228-236.

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Uspenskaya O. A., Kondyurova E. V., Fadeeva I. I. CYTOKINE PROFILE IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS // Actual problems in dentistry. 2020. no. 4. pp. 64-70. DOI: https://doi.org/10.18481/2077-7566-20-16-4-64-70. (Date of access 08.09.2026).

MLA

Ol'ga Uspenskaya, Kondyurova E. V., Fadeeva I. I.. "CYTOKINE PROFILE IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS." Actual problems in dentistry 16.4 (2020): 64-70. DOI: https://doi.org/10.18481/2077-7566-20-16-4-64-70.

APA

Uspenskaya O. A., Kondyurova E. V., Fadeeva I. I. (2020). CYTOKINE PROFILE IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS. Actual problems in dentistry, 16(4), 64-70. https://doi.org/10.18481/2077-7566-20-16-4-64-70

Chicago

Ol'ga Uspenskaya, Kondyurova E. V., Fadeeva I. I.. "CYTOKINE PROFILE IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS." Actual problems in dentistry 16, no. 4 (2020): 64-70. https://doi.org/10.18481/2077-7566-20-16-4-64-70.

WIKI

{{cite journal | author = Uspenskaya O. A., Kondyurova E. V., Fadeeva I. I. | title = CYTOKINE PROFILE IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS | journal = Actual problems in dentistry | year = 2020 | volume = 16 | issue = 4 | pages = 64-70 | doi = 10.18481/2077-7566-20-16-4-64-70 }}

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