IMPACT OF TOPICAL CYTOKINE THERAPY USING RECOMBINANT IL-2 (RONCOLEUKIN) ON THE CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS RECEIVED CLOSED SINUS-LIFTING WITH SINGLE-STAGE DENTAL IMPLANTATION

Larisa Latyushina; Il'ya Dolgushin; Aleksey Finadeev; Yuliya Pavlienko; A. V. Piotrovich

doi:10.18481/2077-7566-2018-000016

CSCSTI 76.29

IMPACT OF TOPICAL CYTOKINE THERAPY USING RECOMBINANT IL-2 (RONCOLEUKIN) ON THE CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS RECEIVED CLOSED SINUS-LIFTING WITH SINGLE-STAGE DENTAL IMPLANTATION

Published in Actual problems in dentistry · Volume 14, Issue 1 · Pages 83–88 · Rubric: SURGICAL DENTISTRY

DOI: https://doi.org/10.18481/2077-7566-2018-000016

Received: 20.06.2018 Accepted: 28.11.2025

Authors

Larisa Latyushina

Il'ya Dolgushin

Aleksey Finadeev

Yuliya Pavlienko

et al.

A. V. Piotrovich

Larisa Latyushina

Academic degree: doctor of medical sciences

Science rang: professor

Ural State Medical University Professor of the Department · Department of Dental and Maxillofacial surgery Department · Russian Federation · Yekaterinburg

Il'ya Dolgushin

Academic degree: doctor of medical sciences

Science rang: professor

Yuzhno-Ural'skiy gosudarstvennyy medicinskiy universitet Russian Federation

Aleksey Finadeev

South Ural State Medical University Chelybinsk

Yuliya Pavlienko

South Ural State Medical University Chelybinsk

A. V. Piotrovich

klinika «Vsya medicina» med. centra ChTPZ, g. Chelyabinsk

ABSTRACT

Predmet. Primenenie topicheskoy immunomoduliruyuschey terapii pri provedenii metodiki zakrytogo sinus-liftinga s odnomomentnoy dental'noy implantaciey. Cel' — izuchit' vliyanie lokal'nogo deystviya ronkoleykina (rekombinantnogo IL-2) u pacientov, poluchivshih implantologicheskoe lechenie. Metodologiya. Metodom prostoy randomizacii bylo sformirovano dve sopostavimyh po gendernym i vozrastnym priznakam gruppy: osnovnaya, n=35 (pri provedenii hirurgicheskogo vmeshatel'stva osuschestvlyalas' topicheskaya citokinoterapiya ronkoleykinom) i sravneniya, n = 35 (ustanovleny implantaty s manipulyaciey zakrytogo sinus-liftinga po standartnoy metodike). Gruppu kontrolya (n=10) sostavili klinicheski zdorovye dobrovol'cy, sopostavimye po polu i vozrastu s pacientami issleduemyh grupp. Ocenka klinicheskogo sostoyaniya i zabor biologicheskogo materiala osuschestvlyalis' na 3-i, 6-e, 12-i i 24-e sutki posleoperacionnogo perioda. Rezul'taty issledovaniya. Provedennyy sravnitel'nyy analiz klinicheskih pokazateley rannego posleoperacionnogo perioda i salivatornogo urovnya pro- i protivovospalitel'nyh citokinov u pacientov pri provedenii zakrytogo sinus-liftinga s odnomomentnoy dental'noy implantaciey svidetel'stvoval o neoslozhnennom techenii rannego posleoperacionnogo perioda i kupirovanii v rannie sroki vospalitel'nogo komponenta v gruppe bol'nyh, poluchavshih mestnoe lechenie ronkoleykinom. Vyvody. Izuchenie salivatornogo urovnya citokinov u pacientov, poluchavshih topicheskuyu citokinoterapiyu, vyyavilo, chto ronkoleykin privel k znachitel'nomu povysheniyu vyrabotki endogennogo IL-2, kotoryy usilival sekreciyu IFN-γ. Kak izvestno, eti citokiny aktiviziruyut tkanevye makrofagi i uchastvuyut v otvetnoy reakcii na patogennoe vozdeystvie infekcionnogo agenta, formiruya effektornye immunologicheskie mehanizmy zaschitnogo kletochnogo immuniteta, chto, veroyatno, sposobstvovalo blagopriyatnomu ishodu lecheniya.

KEYWORDS

dental'naya implantaciya, zakrytyy sinus-lifting, ronkoleykin

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Latyushina L. S., Dolgushin I. I., Finadeev A. P., Pavlienko Y. V., Piotrovich A. V. IMPACT OF TOPICAL CYTOKINE THERAPY USING RECOMBINANT IL-2 (RONCOLEUKIN) ON THE CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS RECEIVED CLOSED SINUS-LIFTING WITH SINGLE-STAGE DENTAL IMPLANTATION // Actual problems in dentistry. 2018. no. 1. pp. 83-88. DOI: https://doi.org/10.18481/2077-7566-2018-000016. (Date of access 07.10.2026).

MLA

Larisa Latyushina, Dolgushin I. I., Finadeev A. P., Pavlienko Y. V., Piotrovich A. V.. "IMPACT OF TOPICAL CYTOKINE THERAPY USING RECOMBINANT IL-2 (RONCOLEUKIN) ON THE CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS RECEIVED CLOSED SINUS-LIFTING WITH SINGLE-STAGE DENTAL IMPLANTATION." Actual problems in dentistry 14.1 (2018): 83-88. DOI: https://doi.org/10.18481/2077-7566-2018-000016.

APA

Latyushina L. S., Dolgushin I. I., Finadeev A. P., Pavlienko Y. V., Piotrovich A. V. (2018). IMPACT OF TOPICAL CYTOKINE THERAPY USING RECOMBINANT IL-2 (RONCOLEUKIN) ON THE CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS RECEIVED CLOSED SINUS-LIFTING WITH SINGLE-STAGE DENTAL IMPLANTATION. Actual problems in dentistry, 14(1), 83-88. https://doi.org/10.18481/2077-7566-2018-000016

Chicago

Larisa Latyushina, Dolgushin I. I., Finadeev A. P., Pavlienko Y. V., Piotrovich A. V.. "IMPACT OF TOPICAL CYTOKINE THERAPY USING RECOMBINANT IL-2 (RONCOLEUKIN) ON THE CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS RECEIVED CLOSED SINUS-LIFTING WITH SINGLE-STAGE DENTAL IMPLANTATION." Actual problems in dentistry 14, no. 1 (2018): 83-88. https://doi.org/10.18481/2077-7566-2018-000016.

WIKI

{{cite journal | author = Latyushina L. S., Dolgushin I. I., Finadeev A. P., Pavlienko Y. V., Piotrovich A. V. | title = IMPACT OF TOPICAL CYTOKINE THERAPY USING RECOMBINANT IL-2 (RONCOLEUKIN) ON THE CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS RECEIVED CLOSED SINUS-LIFTING WITH SINGLE-STAGE DENTAL IMPLANTATION | journal = Actual problems in dentistry | year = 2018 | volume = 14 | issue = 1 | pages = 83-88 | doi = 10.18481/2077-7566-2018-000016 }}

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IMPACT OF TOPICAL CYTOKINE THERAPY USING RECOMBINANT IL-2 (RONCOLEUKIN) ON THE CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS RECEIVED CLOSED SINUS-LIFTING WITH SINGLE-STAGE DENTAL IMPLANTATION

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