THE PROSPECTS AND POSSIBILITIES OF USE OF THE WARNERIN NIZKOMOLKULYARNY CATIONIC PEPTIDE IN PRACTICAL ACTIVITIES OF THE DENTIST (EXPERIMENTAL CLINICAL TRIAL)

Oksana Shulyatnikova; Gennadiy Rogozhnikov; Aleksey Rogozhnikov

doi:10.18481/2077-7566-2017-13-2-74-79

CSCSTI 76.29

THE PROSPECTS AND POSSIBILITIES OF USE OF THE WARNERIN NIZKOMOLKULYARNY CATIONIC PEPTIDE IN PRACTICAL ACTIVITIES OF THE DENTIST (EXPERIMENTAL CLINICAL TRIAL)

Published in Actual problems in dentistry · Volume 13, Issue 2 · Pages 74–79 · Rubric: ORTHOPEDIC DENTISTRY

DOI: https://doi.org/10.18481/2077-7566-2017-13-2-74-79

Received: 18.06.2018 Accepted: 27.11.2025

Authors

Oksana Shulyatnikova

Gennadiy Rogozhnikov

Aleksey Rogozhnikov

Oksana Shulyatnikova

Academic degree: doctor of medical sciences

Science rang: docent

Perm State Medical University named after Academician E. A. Vagner Professor of the Department · department of orthopedic stomatology · Russian Federation · Perm

Gennadiy Rogozhnikov

Academic degree: doctor of medical sciences

Science rang: professor

Perm State Medical University named after Academician E. A. Vagner Professor of the Department · Orthopedic Dentistry Department · Russian Federation · Perm

Aleksey Rogozhnikov

Academic degree: candidate of medical sciences

Perm State Medical University named after academician E.A. Wagner docent of the department · Department of Prosthetic Dentistry · Russian Federation · Perm

ABSTRACT

Predmet. Uvelichenie urovnya travmatizma i novoobrazovaniy chelyustno-licevoy oblasti opredelyaet aktual'nost' lecheniya dannyh pacientov. Poterya anatomicheskoy celostnosti chelyustnyh kostey vliyaet na izmenenie mikrobiocenoza polosti rta i privodit k hronizacii vospalitel'nyh processov. V stat'e rassmatrivaetsya vozmozhnost' ispol'zovaniya v prakticheskoy deyatel'nosti vracha-stomatologa nizkomolekulyarnogo kationnogo peptida varnerina dlya ingibirovaniya obrazovaniya mikrobnoy plenki na pervichnom etape bakterial'nogo prikrepleniya. Cel'. Eksperimental'no-klinicheskoe issledovanie vozmozhnosti ingibirovaniya plenkoobrazuyuschih svoystv mikro‑ organizmov. Metodologiya. Predvaritel'no provedeny issledovaniya rosta bioplenok na obrazcah dioksida titana s nanostrukturirovannoy poverhnost'yu i pri ego ispol'zovanii s peptidom varnerinom. Ocenivali obschuyu biomassu plenok i kolichestva zhiznesposobnyh kletok. Klinicheskoe izuchenie provodili na etape ortopedicheskogo lecheniya. Izuchali mikrobiologicheskiy status polosti rta bol'nyh do nachala eksperimental'noy chasti i posle putem issledovaniya smeshannoy stimulirovannoy slyuny i naleta. V kachestve primera konkretnogo vypolneniya priveden klinicheskiy sluchay. Rezul'taty. Nanostrukturirovannoe pokrytie dioksida titana v tri raza snizhaet kolichestvo zhivyh kletok i v dva raza snizhaet biomassu Staphylococcus epidermidis 33 v bioplenkah. Deystvie peptida varnerina effektivno na obrazcah s nanostrukturirovannym pokrytiem i bez nego. Klinicheskoe issledovanie mestnogo ispol'zovaniya peptida varnerina pokazalo snizhenie kolichestva Str. mutans i Lactobacillus v smeshannoy stimulirovannoy slyune i nalete. Vyvody. Rezul'taty nauchnogo issledovaniya sposobny uluchshit' kachestvo lecheniya bol'nyh s priobretennymi defektami i deformaciyami chelyustno-licevoy oblasti putem sokrascheniya ego srokov i material'nyh zatrat. Nizkomolekulyarnyy kationnyy peptid varnerin pozvolyaet snizit' risk razvitiya nozokomial'nyh infekciy, sposobstvuet resheniyu problem profilaktiki i lecheniya vospalitel'nyh oslozhneniy myagkotkannogo parodonta i slizistoy obolochki na etapah slozhno-chelyustnogo protezirovaniya

KEYWORDS

chelyustno-licevaya oblast', defekty, mikrobnaya plenka, ingibirovanie, peptid varnerin.

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GOST

Shulyatnikova O. A., Rogozhnikov G. I., Rogozhnikov A. G. THE PROSPECTS AND POSSIBILITIES OF USE OF THE WARNERIN NIZKOMOLKULYARNY CATIONIC PEPTIDE IN PRACTICAL ACTIVITIES OF THE DENTIST (EXPERIMENTAL CLINICAL TRIAL) // Actual problems in dentistry. 2018. no. 2. pp. 74-79. DOI: https://doi.org/10.18481/2077-7566-2017-13-2-74-79. (Date of access 23.10.2026).

MLA

Oksana Shulyatnikova, Rogozhnikov G. I., Rogozhnikov A. G.. "THE PROSPECTS AND POSSIBILITIES OF USE OF THE WARNERIN NIZKOMOLKULYARNY CATIONIC PEPTIDE IN PRACTICAL ACTIVITIES OF THE DENTIST (EXPERIMENTAL CLINICAL TRIAL)." Actual problems in dentistry 13.2 (2018): 74-79. DOI: https://doi.org/10.18481/2077-7566-2017-13-2-74-79.

APA

Shulyatnikova O. A., Rogozhnikov G. I., Rogozhnikov A. G. (2018). THE PROSPECTS AND POSSIBILITIES OF USE OF THE WARNERIN NIZKOMOLKULYARNY CATIONIC PEPTIDE IN PRACTICAL ACTIVITIES OF THE DENTIST (EXPERIMENTAL CLINICAL TRIAL). Actual problems in dentistry, 13(2), 74-79. https://doi.org/10.18481/2077-7566-2017-13-2-74-79

Chicago

Oksana Shulyatnikova, Rogozhnikov G. I., Rogozhnikov A. G.. "THE PROSPECTS AND POSSIBILITIES OF USE OF THE WARNERIN NIZKOMOLKULYARNY CATIONIC PEPTIDE IN PRACTICAL ACTIVITIES OF THE DENTIST (EXPERIMENTAL CLINICAL TRIAL)." Actual problems in dentistry 13, no. 2 (2018): 74-79. https://doi.org/10.18481/2077-7566-2017-13-2-74-79.

WIKI

{{cite journal | author = Shulyatnikova O. A., Rogozhnikov G. I., Rogozhnikov A. G. | title = THE PROSPECTS AND POSSIBILITIES OF USE OF THE WARNERIN NIZKOMOLKULYARNY CATIONIC PEPTIDE IN PRACTICAL ACTIVITIES OF THE DENTIST (EXPERIMENTAL CLINICAL TRIAL) | journal = Actual problems in dentistry | year = 2018 | volume = 13 | issue = 2 | pages = 74-79 | doi = 10.18481/2077-7566-2017-13-2-74-79 }}

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