THE EFFECT OF IMMUNOTHERAPY WITH RECOMBINANT IL-1β ON CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH COMPLICATED FRACTURE OF THE MANDIBL

Larisa Latyushina; Elena Berezhnaya; Il'ya Dolgushin

doi:10.18481/2077-7566-2017-13-2-49-53

CSCSTI 76.29

THE EFFECT OF IMMUNOTHERAPY WITH RECOMBINANT IL-1Β ON CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH COMPLICATED FRACTURE OF THE MANDIBL THE EFFECT OF IMMUNOTHERAPY WITH RECOMBINANT IL-1β ON CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH COMPLICATED FRACTURE OF THE MANDIBL

АА Аа

Published in Actual problems in dentistry · Volume 13, Issue 2 · Pages 49–53 · Rubric: SURGICAL DENTISTRY

DOI: https://doi.org/10.18481/2077-7566-2017-13-2-49-53

Received: 18.06.2018 Accepted: 28.11.2025

Authors

Larisa Latyushina

Elena Berezhnaya

Il'ya Dolgushin

Larisa Latyushina

Academic degree: doctor of medical sciences

Science rang: professor

Ural State Medical University Professor of the Department · Department of Dental and Maxillofacial surgery Department · Russian Federation · Yekaterinburg

Elena Berezhnaya

Yuzhno-Ural'skiy gosudarstvennyy medicinskiy universitet assistent, kafedry hirurgicheskoy stomatologii i chelyustno-licevoy hirurgii · Russian Federation

Il'ya Dolgushin

Academic degree: doctor of medical sciences

Science rang: professor

Yuzhno-Ural'skiy gosudarstvennyy medicinskiy universitet Russian Federation

ABSTRACT

Predmet. Lechenie oslozhneniy, voznikayuschih pri perelomah nizhney chelyusti v predelah zubnogo ryada, ostaetsya aktual'noy problemoy sovremennoy chelyustno-licevoy hirurgii. V stat'e rassmatrivaetsya vozmozhnost' primeneniya immunomodulyatora «Betaleykin» dlya profilaktiki transformacii oslozhnennogo techeniya perelomov v travmaticheskiy osteomielit. Cel'. Opredelit' kliniko-immunologicheskiy effekt ot primeneniya rekombinantnogo IL-1β u pacientov s oslozhnennymi perelomami nizhney chelyusti. Metodologiya. V hode provedennogo issledovaniya pacienty byli razdeleny na 3 gruppy: gruppa sravneniya i dve osnovnye gruppy, v kotoryh ispol'zovali dopolnitel'no preparat «Betaleykin». V 1-y osnovnoy gruppe lokal'no primenyali gidrogelevyy «Koleteks-Beta». Vo 2-y osnovnoy gruppe preparat vvodili parenteral'no. V kazhdoy iz grupp byli pacienty s ortopedicheskimi i hirurgicheskimi metodami fiksacii kostnyh otlomkov. Effektivnost' citokinoterapii ocenivali po klinicheskim (bol' v oblasti pereloma, normalizaciya temperatury tela, otek myagkih tkaney, giperemiya slizistoy, formirovanie svischey) i immunologicheskim kriteriyam, kotorye pozvolyali prosledit' dinamiku lecheniya pacientov. Provodilsya analiz obschego klinicheskogo balla i funkcional'noy aktivnosti neytrofilov smeshannoy slyuny, kotorye mogut ukazyvat' na adaptacionnyy potencial lokal'noy sistemy nespecificheskogo immunnogo otveta. Rezul'taty. U pacientov, kotorym provodilos' lechenie s primeneniem «Betaleykina», nezavisimo ot sposoba ego vvedeniya, v bolee rannie sroki kupirovalsya otek myagkih tkaney. Obschiy klinicheskiy ball u pacientov gruppy sravneniya zavisel ot sposoba fiksacii otlomkov i v gruppe prooperirovannyh bol'nyh byl statisticheski bolee vysokim, chem v ortopedicheskoy. V obeih osnovnyh gruppah etot pokazatel' svidetel'stvoval o bolee blagopriyatnom zazhivlenii kostnoy rany. U pacientov obeih osnovnyh grupp vyyavlen rost funkcional'nogo rezerva neytrofilov. Vyvody. Issledovanie vyyavilo kliniko-immunologicheskuyu effektivnost' lokal'nogo i parenteral'nogo primeneniya «Betaleykina» u pacientov s oslozhnennymi perelomami nizhney chelyusti. Rekombinantnyy IL-1β u pacientov dannoy kategorii sposobstvuet profilaktike razvitiya travmaticheskogo osteomielita.

KEYWORDS

perelom nizhney chelyusti, betaleykin, citokinoterapiya, neytrofily

Text

Text (PDF)

Read Download

1. Vernadskiy, Yu.I. Travmatologiya i vosstanovitel'naya hirurgiya chelyustno-licevoy oblasti / Yu.I. Vernadskiy. - Moskva: Medicinskaya literatura, 2006. - 456 c.

2. Chrcanovic B.R. Factors influencing the incidence of maxillofacial fractures. Oral. maxillofac. Surg, 2012, vol. 16, no. 3, pp. 17.

3. Malyshev, V.A. Perelomy chelyustey / V.A. Malyshev, B.D. Kabakov. - Sankt-Peterburg: SpecLit, 2005. - 224 c.

4. Kudlay, D. Uroven' provospalitel'nyh citokinov pri mnozhestvennoy travme / D. Kudlay // Vrach. - 2007. - №2. - S. 54-55.

5. Simbircev, A.S. Interleykin - 1. Fiziologiya. Patologiya. Klinika / A.S. Simbircev. - Sankt-Peterburg: Foliant, 2011. - S. 11-13.

6. Vernadskiy, Yu.I. Travmatologiya i vosstanovitel'naya hirurgiya chelyustno-licevoy oblasti / Yu.I. Vernadskiy. - Moskva: Medicinskaya literatura, 2006. - 456 c.

7. Durnovo, E.A. Sravnitel'nyy analiz funkcional'noy aktivnosti neytrofilov krovi i rotovoy polosti u bol'nyh s gnoyno-vospalitel'nym processom v polosti rta / E.A. Durnovo // Stomatologiya. - 2005. - №3. - S. 29-32.

8. Freydlin, I.S. Metody izucheniya fagocitiruyuschih kletok pri ocenkeimmunnogo statusa cheloveka: uchebnoe posobie / I.S. Freydlin. -Leningrad, 1986. - 37 s.

9. Mayanskiy, A.N. Sposob ocenki funkcional'noy aktivnosti neytrofilov cheloveka po reakcii vosstanovleniya nitrosineg tetrazoliya: metodicheskie rekomendacii / A.N. Mayanskiy, M.K. Viksman. - Kazan', 1979. - 11 s.

10. Kozlov, V.K. Citokinoterapiya: patogeneticheskaya napravlennost' pri infekcionnyh zabolevaniyah i klinicheskaya effektivnost': rukovodstvo dlya vrachey / V.K. Kozlov. - Sankt-Peterburg: Al'ter Ego, 2010. - 148 c.

This work is licensed under Creative Commons Attribution 4.0 International

PDF JATS XML

Editor in Chief

Sergey Zholudev

zholudev_se@mail.ru

Deputy editor

Yuliya Mandra

jmandra@mail.ru

5551

downloads

This work is licensed under Creative Commons Attribution 4.0 International Creative Commons

GOST

Latyushina L. S., Berezhnaya E. S., Dolgushin I. I. THE EFFECT OF IMMUNOTHERAPY WITH RECOMBINANT IL-1β ON CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH COMPLICATED FRACTURE OF THE MANDIBL // Actual problems in dentistry. 2018. no. 2. pp. 49-53. DOI: https://doi.org/10.18481/2077-7566-2017-13-2-49-53. (Date of access 07.10.2026).

MLA

Larisa Latyushina, Berezhnaya E. S., Dolgushin I. I.. "THE EFFECT OF IMMUNOTHERAPY WITH RECOMBINANT IL-1β ON CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH COMPLICATED FRACTURE OF THE MANDIBL." Actual problems in dentistry 13.2 (2018): 49-53. DOI: https://doi.org/10.18481/2077-7566-2017-13-2-49-53.

APA

Latyushina L. S., Berezhnaya E. S., Dolgushin I. I. (2018). THE EFFECT OF IMMUNOTHERAPY WITH RECOMBINANT IL-1β ON CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH COMPLICATED FRACTURE OF THE MANDIBL. Actual problems in dentistry, 13(2), 49-53. https://doi.org/10.18481/2077-7566-2017-13-2-49-53

Chicago

Larisa Latyushina, Berezhnaya E. S., Dolgushin I. I.. "THE EFFECT OF IMMUNOTHERAPY WITH RECOMBINANT IL-1β ON CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH COMPLICATED FRACTURE OF THE MANDIBL." Actual problems in dentistry 13, no. 2 (2018): 49-53. https://doi.org/10.18481/2077-7566-2017-13-2-49-53.

WIKI

{{cite journal | author = Latyushina L. S., Berezhnaya E. S., Dolgushin I. I. | title = THE EFFECT OF IMMUNOTHERAPY WITH RECOMBINANT IL-1β ON CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH COMPLICATED FRACTURE OF THE MANDIBL | journal = Actual problems in dentistry | year = 2018 | volume = 13 | issue = 2 | pages = 49-53 | doi = 10.18481/2077-7566-2017-13-2-49-53 }}

Copy

Export: BibTeX EndNote RefMan RusMARC

THE EFFECT OF IMMUNOTHERAPY WITH RECOMBINANT IL-1Β ON CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH COMPLICATED FRACTURE OF THE MANDIBL THE EFFECT OF IMMUNOTHERAPY WITH RECOMBINANT IL-1β ON CLINICAL AND IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH COMPLICATED FRACTURE OF THE MANDIBL

Confirmation