Prevalence and clinical features of drug-related osteonecroses of the jaws

Natal&#039;ya Vinogradova; Konstantin L&#039;vov; Marina Kharitonova

doi:10.18481/2077-7566-2017-13-4-38-42

CSCSTI

76.29

PREVALENCE AND CLINICAL FEATURES OF DRUG-RELATED OSTEONECROSES OF THE JAWS Prevalence and clinical features of drug-related osteonecroses of the jaws

АА Аа

Published in Actual problems in dentistry · Pages 38–42 · Rubric: SURGICAL DENTISTRY AND IMPLANTOLOGY

DOI: https://doi.org/10.18481/2077-7566-2017-13-4-38-42

Received: 25.12.2017 Accepted: 25.12.2017 Published: 25.12.2017 Language of publication: RUS

Authors

Natal'ya Vinogradova

Konstantin L'vov

Marina Kharitonova

Natal'ya Vinogradova

Academic degree: candidate of medical sciences

Ural'skiy gosudarstvennyy medicinskiy universitet vrach vysshey kategorii otdeleniya ChLH MAU CGKB № 23, assistent kafedry stomatologii obschey praktiki · Russian Federation

Konstantin L'vov

Central City Clinical Hospital No. 23, Yekaterinburg Head of the Department · Department of Maxillofacial Surgery · Russian Federation · Yekaterinburg

Marina Kharitonova

Academic degree: doctor of medical sciences

Science rang: professor

Ural State Medical University Professor of the Department · Department of orthopaedic dentistry and General practice dentistry

ABSTRACT

Subject of study. Bisphosphonate - related osteonecrosis of the jaw (BRONJ) is a severe complication, which may arise in patients, receiving BP therapy and also in patients taking designer drugs (desomorphine, methamphetamine). Urgency of the study is caused by broad bisphosphonate administration in patients with the proved bone metastasises, myelomatosis, Paget disease. Use of red phosphorus at clandestine production of desomorphine and methamphetamine in patients with drug abuse. Atypical forms of osteomyelitis develop at these two categories of people. Purpose - to study the prevalence and features of clinical and X-ray picture of the drug-related osteonecrosis. Methodology. The study is based on retrospective survey of records and X-ray examination of patients being on treatment in maxillofacial surgery’s unit in MAU “CGKB” (Central Clinical City Hospital) #23 in 2013-2017. Results. Drug - related osteonecrosis was diagnosed in 31.2% hospitalization cases with jaw osteomyelitis. In 50% designer drugs taking (desomorphine, methamphetamine) was the reason. In 50% was the administration of bisphosphonates therapy at bone metastasises in patients with malignant neoplasms and myelomatosis. The clinical picture is characterized by protracted disease course with frequent relapses. At X-ray examination the lack of sequesters with an accurate demarcation zone is characteristic. Conclusions. Prevalence of drug-related osteonecrosis is increasing due to widespread use of drugs called Zoledronic acid in patients with cancer. Detailed history taking on the outpatient reception hours plays the leading role at osteonecrosis diagnostics. Chemotherapy as well as continuing of designer drugs taking promotes progressing of osteonecrosis of a jaw and its relapses in spite of the treatment. Relapses nascency is the reason for rehospitalizations.

KEYWORDS

bisphosphonate - related osteonecrosis, osteomyelitis of the jaws.

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GOST

Vinogradova N. G., L'vov K. V., Kharitonova M. P. Prevalence and clinical features of drug-related osteonecroses of the jaws // Actual problems in dentistry. 2017. no. 4. pp. 38-42. DOI: https://doi.org/10.18481/2077-7566-2017-13-4-38-42. (Date of access 08.09.2026).

MLA

Natal'ya Vinogradova, L'vov K. V., Kharitonova M. P.. "Prevalence and clinical features of drug-related osteonecroses of the jaws." Actual problems in dentistry 13.4 (2017): 38-42. DOI: https://doi.org/10.18481/2077-7566-2017-13-4-38-42.

APA

Vinogradova N. G., L'vov K. V., Kharitonova M. P. (2017). Prevalence and clinical features of drug-related osteonecroses of the jaws. Actual problems in dentistry, 13(4), 38-42. https://doi.org/10.18481/2077-7566-2017-13-4-38-42

Chicago

Natal'ya Vinogradova, L'vov K. V., Kharitonova M. P.. "Prevalence and clinical features of drug-related osteonecroses of the jaws." Actual problems in dentistry 13, no. 4 (2017): 38-42. https://doi.org/10.18481/2077-7566-2017-13-4-38-42.

WIKI

{{cite journal | author = Vinogradova N. G., L'vov K. V., Kharitonova M. P. | title = Prevalence and clinical features of drug-related osteonecroses of the jaws | journal = Actual problems in dentistry | year = 2017 | volume = 13 | issue = 4 | pages = 38-42 | doi = 10.18481/2077-7566-2017-13-4-38-42 }}

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PREVALENCE AND CLINICAL FEATURES OF DRUG-RELATED OSTEONECROSES OF THE JAWS Prevalence and clinical features of drug-related osteonecroses of the jaws

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