employee
Krasnodar, Krasnodar, Russian Federation
employee
Tuapse, Krasnodar, Russian Federation
UDK 616.31 Стоматология. Заболевания ротовой полости и зубов
GRNTI 76.29 Клиническая медицина
Inflammatory periodontal disease is a worldwide disease of predominantly bacterial etiology characterized by dysregulation of the host inflammatory response. Currently, hyaluronic acid (HA)-based gels are used to treat periodontitis, as well as an innovative gel based on the extracellular matrix, which is a promising material used in regenerative medicine, tissue engineering and other areas of biomedical research. The extracellular matrix is a natural component of tissues that provides structural support to cells and plays a key role in cellular adhesion, proliferation and differentiation. The use of extracellular matrix (ECM)-based gels allows you to create a suitable microenvironment for cells, which promotes their functional activity and tissue regeneration. The purpose of the article. To study the benefits of extracellular matrix (ECM)-based gels and hyaluronic acid (HA)-based gels in the context of treating inflammatory periodontal disease, and to review the literature. Materials and methods: For comparative analysis of hydrogels, a detailed analysis of 35 literature sources in the electronic database PubMed, dLibrary for the last 10 years was carried out. The search is not limited to articles published in English, the use of keywords “hyaluronic acid”, “periodontitis” contributed to a successful search. The review included studies assessing the effectiveness and safety of using hydrogels in the treatment of various dental diseases. Conclusion: Gels based on extracellular matrix and hyaluronic acid as innovative technologies have significant potential for improving the treatment outcomes of various diseases, accelerating the recovery process of patients.
extracellular matrix-based gels, hyaluronic acid, dentistry, biocompatible gel, periodontitis, biomimetics
1. Eremin D.A., Krasnov N.M., Helminskaya N.M., Faustova E.E., Shen' P.A., Nikol'skaya I.A. Primenenie kompleksnogo preparata na osnove vnekletochnogo matriksa v kachestve strukturnomodificiruyuschey matricy pri hirurgicheskih stomatologicheskih vmeshatel'stvah. Medicinskiy alfavit. 2023;(30):47-50. [Eremin D.A., Krasnov N.M., Helminskaya N.M., Faustova E.E., Shen P.A., Nikolskaya I.A. Application of complex preparation based on extracellular matrix as a structure-modifying matrix in dental surgery. Medical alphabet. 2023:(30):47-50. (In Rus)]. https://doi.org/10.33667/2078-5631-2023-30-47-50
2. Tarasenko S.V., Kulaga O.I. Preparaty na osnove gialuronovoy kisloty dlya lecheniya pacientov s hronicheskim generalizovannym parodontitom. Rossiyskiy stomatologicheskiy zhurnal. 2016;20(6):340-343. [Tarasenko S.V., Kulaga O.I. Application of hyaluronic acid preparations for patients with a chronic generalized periodontal disease. Russian journal of dentistry. 2016;20(6):340-343. (In Rus.)]. https://www.elibrary.ru/download/elibrary_28358478_99420144.pdf
3. Efimovich O.I. Ispol'zovanie preparatov gialuronovoy kisloty v kompleksnom lechenii vospalitel'nyh zabolevaniy parodonta. Obzor literatury. Klinicheskaya stomatologiya. 2018;(1):28-33. [Efimovich O.I. Using hyaluronic acid preparations in complex treatment of inflammatory diseases of the parodont. Literature review. Clinical Dentistry. 2018;(1):28-33. (In Rus.)]. https://doi.org/10.37988/1811-153X_2018_1_28
4. Byalik V.E., Makarov M.A., Byalik E.I., Makarov S.A., Nesterenko V.A., Nurmuhametov M.R. Sravnenie effektivnosti preparatov gialuronovoy kisloty s razlichnoy molekulyarnoy massoy i v sochetanii s hondroitin sul'fatom v zavisimosti ot stadii osteoartrita kolennogo sustava. Nauchno-prakticheskaya revmatologiya. 2020;58(5):560-569. [Bialik V.E., Makarov M.A., Bialik E.I., Makarov S.A., Nesterenko V.A., Nurmukhametov M.R. Comparing the efficacy of hyaluronic acid products with various molecular weights as mono and combined with chondroitin sulfate regimens in treatment of patients with stage I–III knee osteoarthritis. Rheumatology Science and Practice. 2020;58(5):560-569 (In Russ.)]. https://doi.org/10.47360/1995-4484-2020-560-569
5. Hlusov I.A., Litvinova L.S., Yurova K.A., Melaschenko E.S., Haziahmatova O.G., Shuplecova V.V., Hlusova M.Yu. Modelirovanie mikrookruzheniya mezenhimnyh stvolovyh kletok kak perspektivnyy podhod k tkanevoy inzhenerii i regenerativnoy medicine (kratkiy obzor). Byulleten' sibirskoy mediciny. 2018;17(3):217-228. [Khlusov I.A., Litvinova L.S., Yurova K.A., Melashchenko E.S., Khaziakhmatova O.G., Shupletsova V.V., Khlusova M.Yu. Modeling of the mesenchymal stem cell microenvironment as a prospective approach to tissue bioengineering and regenerative medicine (a short review). Bulletin of Siberian Medicine. 2018;17(3):217-228 (In Russ.)]. https://doi.org/10.20538/1682-0363-2018-3-217-228
6. Sevast'yanov V.I., Perova N.V., Basok Yu.B., Nemec E.A. Biomimetiki vnekletochnogo matriksa v tkanevoy inzhenerii i regenerativnoy medicine dlya travmatologii i ortopedii. Opinion Leader. 2020;(6):36-46. [Sevastyanov V.I., Perova N.V., Basok Y.B., Nemets E.A. Biomimetics of extracellular matrix in tissue engineering and regenerative medicine for traumatology and orthopedics. Opinion Leader. 2020;(6):36-46 (In Russ.)]. https://elibrary.ru/item.asp?id=44084998
7. Islam A., Hansen A.K., Mennan C., Martinez-Zubiaurre I. Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures. European Cells and Materials. 2016;31:407-424. https://www.ecmjournal.org/papers/vol031/vol031a26.php
8. Sipkin A.M., Chenosova A.D., Modina T.N., Epifanov S.A. Primenenie nestabiliziro- vannoy gialuronovoy kisloty u pacientov s atrofiey al'veolyarnogo otrostka verhney chelyusti, al'veolyarnoy chasti nizhney chelyusti. Klinicheskaya stomatologiya. 2021;24(3):104-108. [Sipkin A.M., Chenosova A.D., Modina T.N., Epifanov S.A. Unstabilized hyaluronic acid in patients with maxillary alveolar atrophy, mandibular alveolar atrophy. Clinical Dentistry. 2021;24(3):104-108. (In Russ.)]. https://doi.org/10.37988/1811-153X_2021_3_104
9. Vega S.L., Kwon M.Y., Burdick J.A. Recent advances in hydrogels for cartilage tissue engineering. European cells & materials. 2017;33:59-75. https://www.ecmjournal.org/papers/vol033/vol033a05.php
10. Boere K.W., Blokzijl M.M., Visser J., Linssen J.E., Malda J., Hennink W.E., Vermonden T. Biofabrication of reinforced 3D-scaffolds using two-component hydrogels. Journal of Materials Chemistry B. 2015;3(46):9067-9078. https://doi.org/10.1039/c5tb01645b
11. Vriend L., Sinkunas V., Camargo C.P., van der Lei B., Harmsen M.C., van Dongen J.A. Extracellular Matrix-Derived Hydrogels to Augment Dermal Wound Healing: A Systematic Review. Tissue Engineering Part B: Reviews. 2022;28(5):1093-1108. https://doi.org/10.1089/ten.TEB.2021.0120
12. Agarwal G., Agiwal S., Srivastava A. Hyaluronic acid containing scaffolds ameliorate stem cell function for tissue repair and regeneration. International journal of biological macromolecules. 2020;165(Pt A):388-401. https://doi.org/10.1016/j.ijbiomac.2020.09.107
13. Olszewska-Czyz I., Kralik K., Prpic J. Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis. Biomolecules. 2021;11(10):1491. https://doi.org/10.3390/biom11101491
14. Kim Y., Ko H., Kwon I.K., Shin K. Extracellular Matrix Revisited: Roles in Tissue Engineering. International Neurourology Journal. 2016;20(Suppl 1):S23-29. https://doi.org/10.5213/inj.1632600.318
15. Zhai P., Peng X., Li B., Liu Y., Sun H., Li X. The application of hyaluronic acid in bone regeneration. International Journal of Biological Macromolecules. 2020;151:1224-1239. https://doi.org/10.1016/j.ijbiomac.2019.10.169
16. Rosales A.M., Anseth K.S. The design of reversible hydrogels to capture extracellular matrix dynamics. Nature Reviews Materials. 2016;1:15012. https://doi.org/10.1038/natrevmats.2015.12
17. Bhati A., Fageeh H., Ibraheem W., Fageeh H., Chopra H., Panda S. Role of hyaluronic acid in periodontal therapy (Review). Biomedical Reports. 2022;17(5):91. https://doi.org/10.3892/br.2022.1574
18. Asparuhova M.B., Kiryak D., Eliezer M., Mihov D., Sculean A. Activity of two hyaluronan preparations on primary human oral fibroblasts. Journal of Periodontal Research. 2019;54(1):33-45. https://doi.org/10.1111/jre.12602
19. Pilloni A., Schmidlin P.R., Sahrmann P., Sculean A., Rojas M.A. Effectiveness of adjunctive hyaluronic acid application in coronally advanced flap in Miller class I single gingival recession sites: a randomized controlled clinical trial. Clinical Oral Investigations. 2019;23(3):1133-1141. https://doi.org/10.1007/s00784-018-2537-4
20. Fujioka-Kobayashi M., Müller H.D., Mueller A., Lussi A., Sculean A., Schmidlin P.R., Miron R.J. In vitro effects of hyaluronic acid on human periodontal ligament cells. BMC Oral Health. 2017;17(1):44. https://doi.org/10.1186/s12903-017-0341-1
21. Fujioka-Kobayashi M., Schaller B., Kobayashi E., Hernandez M., Zhang Y., Miron R.J. Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential. Journal of clinical medicine. 2016;5(12):112. https://doi.org/10.3390/jcm5120112
22. Eliezer M., Imber J.C., Sculean A., Pandis N., Teich S. Hyaluronic acid as adjunctive to non-surgical and surgical periodontal therapy: a systematic review and meta-analysis. Clinical Oral Investigations. 2019;23(9):3423-3435. https://doi.org/10.1007/s00784-019-03012-w
23. Casale M., Moffa A., Vella P., Sabatino L., Capuano F., Salvinelli B., Lopez M.A., Carinci F., Salvinelli F. Hyaluronic acid: Perspectives in dentistry. A systematic review. International Journal of Immunopathology and Pharmacology. 2016;29(4):572-582. https://doi.org/10.1177/0394632016652906
24. Pilloni A., Zeza B., Kuis D., Vrazic D., Domic T., Olszewska-Czyz I., Popova C., Kotsilkov K., Firkova E., Dermendzieva Y., Tasheva A., Orrù G., Sculean A., Prpić J. Treatment of Residual Periodontal Pockets Using a Hyaluronic Acid-Based Gel: A 12 Month Multicenter Randomized Triple-Blinded Clinical Trial. Antibiotics (Basel). 2021;10(8):924. https://doi.org/10.3390/antibiotics10080924
25. Wang Y., Papagerakis S., Faulk D., Badylak S.F., Zhao Y., Ge L., Qin M., Papagerakis P. Extracellular Matrix Membrane Induces Cementoblastic/Osteogenic Properties of Human Periodontal Ligament Stem Cells. Frontiers in Physiology. 2018;9:942. https://doi.org/10.3389/fphys.2018.00942
26. Sharma V., Gupta R., Dahiya P., Kumar M. Comparative evaluation of coenzyme Q10-based gel and 0.8% hyaluronic acid gel in treatment of chronic periodontitis. Journal of Indian Society of Periodontology. 2016;20(4):374-380. https://doi.org/10.4103/0972-124X.183097
27. Olszewska-Czyz I., Kralik K., Prpic, J. Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis. Biomolecules 2021;11(10):1491. https://doi.org/10.3390/biom11101491
28. Kitamura N., Yokota M., Kurokawa T., Gong J.P., Yasuda K. In vivo cartilage regeneration induced by a double-network hydrogel: Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model. Journal of Biomedical Materials Research Part A. 2016;104(9):2159-2165. https://doi.org/10.1002/jbm.a.35745
29. Gibbs S., Roffel S., Meyer M., Gasser A. Biology of soft tissue repair: gingival epithelium in wound healing and attachment to the tooth and abutment surface. European Cells and Materials. 2019;38:63-78. https://doi.org/10.22203/eCM.v038a06
30. Boink M.A., Roffel S., Breetveld M., Thon M., Haasjes M.S.P., Waaijman T., Scheper R.J., Blok C.S., Gibbs S. Comparison of advanced therapy medicinal product gingiva and skin substitutes and their in vitro wound healing potentials. Journal of Tissue Engineering and Regenerative Medicine. 2018;12(2):e1088-e1097. https://doi.org/10.1002/term.2438
31. Wolff J., Farré-Guasch E., Sándor G.K., Gibbs S., Jager D.J., Forouzanfar T. Soft Tissue Augmentation Techniques and Materials Used in the Oral Cavity: An Overview. Implant dentistry. 2016;25(3):427-434. https://doi.org/10.1097/ID.0000000000000385
32. Monsuur H.N., Boink M.A., Weijers E.M., Roffel S., Breetveld M., Gefen A., van den Broek L.J., Gibbs S. Methods to study differences in cell mobility during skin wound healing in vitro. Journal of Biomechanics. 2016;49(8):1381-1387. https://doi.org/10.1016/j.jbiomech.2016.01.040
33. Theocharis A.D., Skandalis S.S., Gialeli C., Karamanos N.K. Extracellular matrix structure. Advanced Drug Delivery Reviews. 2016;97:4-27. https://doi.org/10.1016/j.addr.2015.11.001
34. Liang Y., He J., Guo B. Functional Hydrogels as Wound Dressing to Enhance Wound Healing. ACS nano. 2021;15(8):12687-12722. https://doi.org/10.1021/acsnano.1c04206
35. Surguchenko V.A., Ponomareva A.S., Kirsanova L.A., Skaleckij N.N., Sevastianov V.I. The cell-engineered construct of cartilage on the basis of biopolymer hydrogel matrix and human adipose tissue-derived mesenchymal stromal cells (in vitro study). Journal of Biomedical Materials Research Part A. 2015;103(2):463-470. https://doi.org/10.1002/jbm.a.35197
