employee
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
employee
Yekaterinburg, Ekaterinburg, Russian Federation
employee
Yekaterinburg, Ekaterinburg, Russian Federation
UDK 616.31 Стоматология. Заболевания ротовой полости и зубов
Subject In the traditional complex treatment of inflammatory periodontal diseases, antibacterial, antiseptic and anti-inflammatory agents are of paramount importance. These products allow you to obtain not only a positive clinical result, but can also manifest their negative properties, having an ambiguous effect on the microbiome of the oral cavity and periodontal tissue. The use of targeted biocorrection drugs and immunocorrectors has a significant local anti-inflammatory effect with minimal side effects. Their use in the complex treatment of chronic generalized periodontitis has not been studied enough. Aim. To evaluate the effectiveness of using a targeted biocorrection drug and a phytocomplex with lactoferrin in the complex treatment of chronic generalized periodontitis in patients with primary hypothyroidism. Material and methods. We observed 90 patients with the main diagnosis of primary hypothyroidism aged 44–59. The patients were divided into 3 groups: in group No. 1, 30 patients received traditional primary periodontal therapy, in group No. 2, 30 patients in whom this therapy was combined with a directed biocorrection drug, in group No. 3, 30 people for whom traditional primary periodontal therapy was combined with a directed biocorrection drug and a drug containing lactoferrin. The comparison group included 30 gender and age-matched patients with chronic generalized periodontitis without thyroid pathology. All patients underwent clinical, X-ray and index evaluation of periodontal tissues. Results. In patients of group No. 1, after traditional treatment, clinical and index evaluation data indicated the persistence of inflammatory processes in periodontal tissues. In groups No. 2 and No. 3 on the background of traditional treatment and additionally administered. Conclusions. The addition of a traditional treatment regimen for chronic generalized periodontitis with a targeted biocorrection drug and a drug containing lactoferrin is justified and effective.
chronic generalized periodontitis, hypothyroidism, periodontal index, biocorrection, lactoferrin
1. Bayazitova Yu.N., Filimonova O.I., Shishkova Yu.S. Nazad v buduschee ili primenenie bakteriofagov v stomatologii pri lechenii vospalitel'nyh zabolevaniy polosti rta u podrostkov. Ural'skiy medicinskiy zhurnal. 2020;8(191):21-23. [Yu.N. Bayazitova, O.I. Filimonova, Yu.S. Shishkova. Back to the future or the use of bacteriophages in dentistry in the treatment of inflammatory diseases of the oral cavity in adolescents. Ural Medical Journal. 2020;8(191):21-23. (In Russ.)]. DOI:https://doi.org/10.25694/URMJ.2020.09.23.
2. Bolsunovskiy S.M., Kazarina L.N. Sravnitel'naya ocenka sostoyaniya tkaney parodonta u bol'nyh s subklinicheskim gipotireozom i s eutireozom. The scientific heritage. 2021;63:13-15. [S.M. Bolsunovsky, L.N. Kazarina. Comparative assessment of the condition of periodontal tissues in patients with subclinical hypothyroidism and euthyroidism. The scientific heritage. 2021;63:13-15. (In Russ.)]. https://cyberleninka.ru/article/n/sravnitelnaya-otsenka-sostoyaniya-tkaney-parodonta-u-bolnyh-s-subklinicheskim-gipoteriozom-i-s-eutireozom-1.
3. Gannenko A.S., Miroshnichenko V.V., Masimov A.E. Primenenie bakteriofagov dlya lecheniya vospalitel'nyh zabolevaniy parodonta. Problemy stomatologii. 2020;16(1):64-69. [A.S. Gannenko, V.V. Miroshnichenko, A.E. Masimov The use of bacteriophages for the treatment of inflammatory periodontal diseases. Actual problems in dentistry. 2020;16(1):64-69. (In Russ.)]. DOIhttps://doi.org/10.18481/2077-7566-20-16-1-64-69.
4. Dzhafarov E.M., Edisherashvili U. B., Dolgalev A.A. i dr. Perspektivy primeneniya probiotikov pri lechenii zabolevaniy parodonta. Obzor literatury. Glavnyy vrach : prakticheskiy zhurnal dlya rukovoditeley zdravoohraneniya. 2022;3(82):25-30. [E.M. Jafarov, U.B. Edisherashvili, A.A. Dolgalev et al. Prospects for the use of probiotics in the treatment of periodontal diseases. Literature review. Chief Physician: a practical journal for healthcare managers. 2022;3(82):25-30. (In Russ.)]. https://www.elibrary.ru/item.asp?id=48725484.
5. Mironycheva K.V., Kipiani Sh.G., Maksyukova E.S. i dr. Diagnosticheskie vozmozhnosti kontrolya citokinovogo statusa desnevoy zhidkosti pri vospalitel'nyh i osteodestruktivnyh processah v parodonte. Ural'skiy medicinskiy zhurnal. 2019;9(177):28-32. [K.V. Mironycheva, Sh.G. Kipiani, E.S. Maksyukova et al. Diagnostic capabilities of monitoring the cytokine status of gingival fluid during inflammatory and osteodestructive processes in the periodontium. Ural Medical Journal. 2019;9(177):28-32. (In Russ.)]. https://www.elibrary.ru/item.asp?id=39539119.
6. Osipova Yu.L., Akimova S.A., Bulkina N.V. i dr. Vzaimosvyaz' pokazateley kletochnoy proliferacii, apoptoza tkaney parodonta i citokinovogo disbalansa rotovoy zhidkosti u bol'nyh bystroprogressiruyuschim parodontitom. Ural'skiy medicinskiy zhurnal. 2020;12(195):66-69. [Yu.L. Osipova, S.A. Akimova, N.V. Bulkina et al. Relationship between indicators of cell proliferation, apoptosis of periodontal tissue and cytokine imbalance oral fluid in patients with rapidly progressive periodontitis. Ural Medical Journal. 2020;12(195):66-69. (In Russ.)]. https://www.elibrary.ru/item.asp?id=44394433.
7. Yakusheva L.V. Gormonozavisimye mehanizmy razvitiya vospalitel'no-destruktivnyh processov v parodontal'nyh tkanyah. Acta medica Eurasica. 2019;2:29-43. [L.V. Yakusheva. Hormone-dependent mechanisms of development of inflammatory-destructive processes in periodontal tissues. Acta medica Eurasica. 2019;2:29-43. (In Russ.)]. https://cyberleninka.ru/article/n/gormonozavisimye-mehanizmy-razvitiya-vospalitelno-destruktivnyh-protsessov-v-parodontalnyh-tkanyah.
8. Morales A., Gandolfo A., Bravo J. et al. Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebocontrolled trial with 9-month follow-up // J. Appl. Oral Sci. - 2018;26:75. DOIhttps://doi.org/10.1590/1678-7757-2017-0075.
9. Cirino C.C. Clinical and Microbiological Evaluation of Surgical and Nonsurgical Treatment Of Aggressive Periodontitis // Braz Dent J. - 2019;30(6):577-586. doi:https://doi.org/10.1590/0103-6440201902930.
