employee
Ufa, Ufa, Russian Federation
Bashkir State University (Scientific Laboratory for the Study of Social and Economic Problems, Head of the Scientific Laboratory)
Ufa, Ufa, Russian Federation
employee
Ufa, Kazan, Russian Federation
employee
Ufa, Ufa, Russian Federation
graduate student
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Dental clinic “KREMLdenta”
Ufa, Ufa, Russian Federation
UDK 616 Патология. Клиническая медицина
Objective. This paper presents a comparative analysis of the effect of various diode lasers in the complex of local treatment of patients with recurrent oral aphthae on the background of inflammatory diseases of the digestive tract. Materials and methods. An examination and a complex of local treatment were carried out, as well as dynamic observation of 58 patients aged 25 to 45 years with the presence of aphthous rashes on the mucous membrane of the vestibulum and the oral cavity itself. The patients participating in the study were divided into 2 study groups. To relieve inflammation, diode lasers with different power and wavelength were used, as well as applications of various means with anti-inflammatory, antimicrobial, increasing epithelialization and regeneration of the mucous membrane in the area of the aphthous element. The estimation of the level of intensity of nociceptive pain level was assessed based on the data of the visual analog pain scale (VAS). Results and discussion. During the clinical observation of 1–5–7 days, the effect of a diode laser, regardless of the wavelength and intensity of radiation, contributed to a decrease in the intensity of inflammation, an increase in the rate of mucosal epithelialization and a leveling of the intensity of the pain level. A decrease in the intensity of pain was observed on average by 3.0 ± 0.8 and 3.5 ± 0.5 days, complete epithelialization of aphthous elements and leveling of all complaints was observed by 4.9 ± 0.4 and 4.7 ± 0.4 days of local treatment. Conclusions. The inclusion of various types of diode lasers in the scheme of local treatment of aphthous stomatitis in combination with applications are highly effective methods and contributes not only to the qualitative relief of pain, inflammation, but also contributes to the acceleration of epithelialization and regeneration of the mucous membrane in this group of patients. Summary. The effect of diode lasers and applications of powdered platelet autologous plasma, benzydamine hydrochloride and hyaluronidase 64 MU lyophilizate and Ora-Aid self-adhesive patch have high clinical efficacy in the complex of local treatment of recurrent ulcerative stomatitis against the background of inflammatory diseases of the digestive tract with symptoms of gastroesophageal reflux disease and chronic inflammatory bowel diseases.
aphthae, diseases of the digestive tract with symptoms of gastroesophageal reflux disease, Crohn's disease, chronic ulcerative colitis, diode laser, nociceptive pain, self-adhesive patch Ora-Aid, lidase, powdered form of platelet autologous plasma, chlorhexidine
1. Azimbaev N.M. Diagnostika i metody lecheniya hronicheskogo recidiviruyuschego aftoznogo stomatita polosti rta (obzor literatury). Nauka, obrazovanie i kul'tura. 2018;8(32):43-53. [N.M. Azimbaev. Diagnosis and treatment methods of chronic recurrent aphthous stomatitis of the oral cavity (review of literature). Science, education and culture. 2018;8(32):43-53. (In Russ.)]. https://www.elibrary.ru/item.asp?id=36366251
2. Akbarov A.N., Ziyadullaeva N.S., Irismetova B.D. Hronicheskiy recidiviruyuschiy aftoznyy stomatit: sovremennye podhody k lecheniyu. Re-Health Journal. 2021;2(10):196-202. [A.N. Akbarov, N.S. Ziyadullaeva, B.D. Irismetova. Chronic recurrent aphthous stomatitis: modern approaches to treatment. Re-Health Journal. 2021;2(10):196-202. (In Russ.)]. https://www.elibrary.ru/item.asp?id=46227940
3. Galimova I.A., Yunusova R.D., Usmanova I.N., Gerasimova L.P., Granot Igal', Borcova Yu.L., Ishmuhametova A.N., Kuznecova L.I., Muratov E.M., Usmanova D.I. Osobennosti kliniko-laboratornyh pokazateley u pacientov s recidiviruyuschimi aftami polosti rta na fone kislotozavisimyh zabolevaniy zheludochno-kishechnogo trakta. Problemy stomatologii. 2020;16(3):23-29. [I.A. Galimova, R.D. Yunusova, I.N. Usmanova, L.P. Gerasimova, Y. Granot, Y.L. Bortsova, A.N. Ishmukhametova, L.I. Kuznetsova, E.M. Muratov, D.I. Usmanova. Features of clinical and laboratory parameters at the patiens with recurrent oral afts and condomitant acid-dependent diseases of the gastrointestinal tract. Actual problems in dentistry. 2020;16(3):23-29. (In Russ.)]. DOIhttps://doi.org/10.18481/2077-7566-2020-16-3-23-29
4. Eshiev A.M., Azimbaev N.M., Abdykayymov A.T. Rezul'taty svetolecheniya v kompleksnoy terapii stomatitov. Mezhdunarodnyy zhurnal prikladnyh i fundamental'nyh issledovaniy. 2019;3:23-27. [A.M. Eshiev, N.M. Azimbaev, A.T. Abdykayymov. Results of lightning in complex therapy ofstomatitis. International journal of applied and fundamental research 2019;3:23-27. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37318710
5. Zhurbenko V.A., Lyaskina M.A. Izmeneniya slizistoy obolochki polosti rta pri zabolevaniyah zheludochno-kishechnogo trakta. Evraziyskoe Nauchnoe Ob'edinenie. 2019;12-2(58):132-136. [V.A. Zhurbenko, M.A. Lyaskina. Changes of the oral mucosa in diseases of the gastrointestinal tract. Eurasian Scientific Association. 2019;12-2(58):132-136. (In Russ.)]. https://www.elibrary.ru/item.asp?id=41827964
6. Kagramanova A.V., Mihaylova S.F. Knyaze O.V. i dr. Vnekishechnye proyavleniya vospalitel'nyh zabolevaniy kishechnika. Terapiya. 2017;4(14):107-118. [A.V. Kagramanova, S.F. Mikhailova, O.V. Knyazev et al. Extraintestinal manifestations of inflammatory bowel diseases. Therapy. 2017;4(14):107-118. (In Russ.)]. https://www.elibrary.ru/item.asp?id=29771052
7. Klyushnikova M.O., Klyushnikova O.N., Klyushnikov O.V. Diagnostika i lechenie hronicheskogo recidiviruyuschego aftoznogo stomatita. Teoriya i praktika sovremennoy stomatologii. Materialy XIV Vserossiyskoy nauchno-prakticheskoy konferencii, posvyaschennoy 30-letnemu yubileyu Stomatologicheskoy associacii Rossii, Irkutsk, 28 oktyabrya 2022 goda. Irkutsk : Federal'noe gosudarstvennoe byudzhetnoe nauchnoe uchrezhdenie "Irkutskiy nauchnyy centr hirurgii i travmatologii". 2022:98-101. [M.O. Klyushnikova, O.N. Klyushnikova, O.V. Klyushnikov. Diagnosis and treatment of chronic recurrent aphthous stomatitis. Theory and practice of modern dentistry. Materials of XIV All-Russian Scientific-Practical Conference devoted to the 30th anniversary of the Stomatological Association of Russia, Irkutsk, October 28, 2022. Irkutsk : Federal State Budgetary Scientific Institution "Irkutsk Scientific Center for Surgery and Traumatology". 2022:98-101. (In Russ.)]. https://www.elibrary.ru/item.asp?id=49723414
8. Starikova I.V., Radyshevskaya T.N., Pyslar' T.V., Dibceva T.S. Kompleksnoe lechenie hronicheskogo recidiviruyuschego aftoznogo stomatita. Nauchnyy al'manah. 2017;4-3(30):268-271. [I.V. Starikova, T.N. Radyshevskaya, T.V. Pyslar, T.S. Dibtseva. Complex treatment of chronic recurrent aphthous stomatitis. Scientific Almanac. 2017;4-3(30):268-271. (In Russ.)]. DOIhttps://doi.org/10.17117/na.2017.04.03.268
9. Kravchuk I.V., Bobkova I.L., Zinovenko O.G. Kompleksnoe lechenie hronicheskogo recidiviruyuschego aftoznogo stomatita s primeneniem nizkointensivnogo lazernogo izlucheniya. Stomatologiya. Estetika. Innovacii. 2021;5:3:269-276. [I.V. Kravchuk, I.L. Bobkova, O.G. Zinovenko. Complex treatment of chronic recurrent aphthous stomatitis with the use of low-intensity laser radiation. Dentistry. Aesthetics. Innovations. 2021;5:3:269-276. (In Russ.)]. DOIhttps://doi.org/10.34883/PI.2021.5.3.002
10. Makedonova Yu.A., Aleksandrina E.S., Vargina S.A., Sinenko T.A. Sravnitel'naya effektivnost' mestnogo lecheniya aftoznogo stomatita. Endodontiya Today. 2021;19(2):95-100. [Yu.A. Makedonova, E.S. Aleksandrina, S.A. Vargina, T.A. Sinenko. Comparative effectiveness of local treatment of afthous stomatitis. Endodontics Today. 2021;19(2):95-100. (In Russ.)]. DOIhttps://doi.org/10.36377/1683-2981-2021-19-2-95-100
11. Mezhdunarodnaya klassifikaciya orofacial'noy boli, 1-e izdanie (ICOP). Adaptirovannaya russkoyazychnaya versiya. Al'manah klinicheskoy mediciny. 2022;50:1-82. [International Classification of Orofacial Pain, 1st edition (ICOP). Adapted Russian-language version. Almanac of Clinical Medicine. 2022;50:1-82. (In Russ.)]. http://dx.doi.org/10.18786/2072-0505-2022-50-005
12. Nikitina E.A., Borisova E.G. Tradicionnye metodiki terapii hronicheskogo recidiviruyuschego aftoznogo stomatita (obzor literatury). Problemy stomatologii. 2021;1(17):26-31. [E.A. Nikitina, E.G. Borisova. Traditional methods of chronic recurrent afthous stomatitis therapy (literature review). Actual problems in dentistry. 2021;1:26-31. (In Russ.)]. DOIhttps://doi.org/10.18481/2077-7566-20-17-1-26-31
13. Hapsirokova Z.Z., Ponomarev A.A., Grigoryan A.S., Luchnikova D.V. Osnovnye principy lecheniya hronicheskogo recidiviruyuschego aftoznogo stomatita. Stomatologiya slavyanskih gosudarstv. Sbornik trudov HIV Mezhdunarodnoy nauchno-prakticheskoy konferencii, Belgorod, 08-12 noyabrya 2021 goda. Belgorod : Izdatel'skiy dom "Belgorod". 2021:306-307. [Z.Z. Khapsirokova, A.A. Ponomarev, A.S. Grigoryan, D.V. Luchnikova. Basic principles of treatment of chronic recurrent aphthous stomatitis. Stomatology of Slavic States. Proceedings of XIV International Scientific and Practical Conference, Belgorod, November 08-12, 2021. Belgorod : Publishing house "Belgorod". 2021:306-307. (In Russ.)]. https://www.elibrary.ru/item.asp?id=49047646
14. Usmanova I.N., Gerasimova L.P., Galimova I.A. i dr. Patent № 2707654 C1 Rossiyskaya Federaciya. MPK A61N 5/067, A61K 31/155, A61K 35/16. Sposob lecheniya recidiviruyuschih AFT polosti rta s primeneniem diodnogo lazera i applikaciy poroshkoobraznoy formy trombocitarnoy autologichnoy plazmy. № 2019110663. zayavl. 09.04.2019. 28.11.2019. [I.N. Usmanova, L.P. Gerasimova, I.A. Galimova et al. Patent No. 2707654 C1 Russian Federation, MPK A61N 5/067, A61K 31/155, A61K 35/16. Method for treatment of recurrent oral AFTs using diode laser and applications of powdered form of platelet-derived autologous plasma. No. 2019110663. application. 09.04.2019. 28.11.2019. (In Russ.)]. https://www.elibrary.ru/item.asp?id=41459070
15. Popova A.N., Kraynov S.V. Lazeroterapiya pri lechenii zabolevaniy slizistoy obolochki polosti rta. Colloquim-Journal. 2018;11-2(22):57-58. [A.N. Popova, S.V. Krajnov. Photoradiotherapy in patients with oral mucosa diseases. Colloquim-Journal. 2018;11-2(22):57-58. (In Russ.)]. https://www.elibrary.ru/item.asp?id=36429870
16. Robakidze N.S. Sovremennye predstavleniya o patogeneze sochetannyh zabolevaniy polosti rta i zheludochno-kishechnogo trakta. Institut stomatologii. 2020;4(89):64-65. [N.S. Robakidze. Modern concepts of the pathogenesis of combined diseases of the oral cavity and gastrointestinal tract. The dental institute. 2020;4(89):64-65. (In Russ.)]. https://www.elibrary.ru/item.asp?id=44287052
17. Usmanova I.N., Galimova I.A., Al' Mohamed M.A., Ishmuhametova A.N., Lakman I.A., Akopyan A.P., Tiunova N.V., Starceva E.Yu. Povyshenie effektivnosti mestnogo lecheniya recidiviruyuschih aft polosti rta u pacientov Na fone klinicheskih proyavleniy klassicheskih i oposredovannyh gipersekretornyh zabolevaniy zheludochno-kishechnogo trakta. Problemy stomatologii. 2022;4:40-46. [I.N. Usmanova, I.A. Galimova, M.A. Al Mohamed, A.N. Ishmukhametova, I.A. Lakman, A.P. Akopyan, N.V. Tiunova, E.Y. Startseva. Improving the effectiveness of local treatment of recurrent oral aphtae in patients with clinical manifestations of classical and mediated hypersecretory diseases of the gastrointestinal tract. Actual problems in dentistry. 2022;4:40-46. (In Russ.)]. http://dx.doi.org/10.18481/2077-7566-2022-18-4-40-46
18. Hapsirokova Z.Z., Ponomarev A.A. Sravnitel'naya ocenka effektivnosti razlichnyh metodik lecheniya hronicheskogo recidiviruyuschego aftoznogo stomatita. Klinicheskaya stomatologiya. 2022;25(3):120-125. [Z.Z. Khapsirokova, A.A. Ponomarev. Comparative evaluation of the efficiency of different treatment methods of the chronic recurrent aphthous stomatitis. Clinical dentistry (Russia). 2022;25(3):120-125 (In Russ.)]. DOIhttps://doi.org/10.37988/1811-153X_2022_3_120
19. Chizhikova T.S., Dmitrienko S.V. i dr. Primenenie apparata «Fotosan» v kompleksnom lechenii zabolevaniy slizistoy obolochki polosti rta i gub. Farmaciya i farmakologiya. 2015;1(8):54-58. [T.S. Chizhikova, S.V. Dmitrienko, R.D. Yusupov, T.V. Chizhikova, O.N. Ignatiadi, L.M. Abdulpatakhova. Fotosan device implementation in complex treatment of oral and labial muscosa diseases. Pharmacy & Pharmacology. 2015;1(8):54-58. (In Russ.)]. DOIhttps://doi.org/10.19163/2307-9266-2015-3-1(8)-54-58
20. Liu C., Zhou Z., Liu G. et al. Efficacy and safety of dexamethasone ointment on recurrent aphthous ulceration // The American Journal of Medicine. - 2012;125(3):292-301. DOIhttps://doi.org/10.1016/j.amjmed.2011.09.011
21. Ślebioda Z., Dorocka-Bobkowska B. Low-level laser therapy in the treatment of recurrent aphthous stomatitis and oral lichen planus: a literature review // Postepy Dermatol Alergol. - 2020;37(4):475-481. DOI:https://doi.org/10.5114/ada.2020.98258
