Kazan, Kazan, Russian Federation
Kazan, Kazan, Russian Federation
Kazan, Kazan, Russian Federation
Kazan, Kazan, Russian Federation
Kazan, Kazan, Russian Federation
Kazan, Kazan, Russian Federation
Subject of study. The development of new approaches to early diagnosis and identification of predisposition to the formation of gingival recession in children is an urgent task of modern dentistry. It is known that vitamin D plays an important role, affecting, among other things, the immune system and calcium-phosphorus homeostasis through the vitamin D receptor (VDR). In connection with the above, a promising direction is the study of polymorphisms of the vitamin D receptor gene to determine markers of gingival recession in a removable bite. Purpose: to study the relationship of the polymorphic marker Bsm I (rs1544410 T/C) of the VDR gene with a predisposition to gingival recession in children in a removable bite living in the Republic of Tatarstan. Methodology. We examined 81 children with gingival recession in a removable bite (8 ± 1 years old) living in the Republic of Tatarstan. DNA was isolated from buccal epithelial cells. Genotyping of the rs1544410 polymorphism of the VDR gene was performed using a real-time PCR. Results. A positive relationship was found for the rs1544410 T allele of the VDR gene with class II gingival recession in a removable bite according to Miller's classification (p = 0.021, r = 0.258), and recession depth (p = 0.029, r = 0.24). Conclusions. 1. A positive correlation was found between the risk allele T of the BsmI (rs1544410) polymorphism of the VDR gene and clinical manifestations of gingival recession in a removable bite in a sample of the population of the Republic of Tatarstan. 2. The distribution of alleles and genotypes of the BsmI (rs1544410) polymorphism of the VDR gene did not differ between the observation and control groups.
gingival recession, removable bite, children, vitamin D receptor (VDR) gene, BsmI polymorphism, rs1544410
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