Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
The subject. Clinical manifestations of dependence on synthetic narcotic substances have been thoroughly studied by specialists in the field of psychiatry, narcology, therapy, immunology at the tissue, organ and system levels. Unfortunately, the same cannot be said about dentistry. When receiving a drug-dependent patient, most dentists cannot determine drug addiction and, accordingly, competently draw up a treatment plan for such patients. Objectives. To study the features of the management of dental diseases in patients taking synthetic narcotic substances, according to the literature. Methodology. Within the framework of this article, the analysis of publications from the databases PubMed, Google Scholar, eLibrary and Cyberleninka describing the toxicological properties and clinical manifestations of synthetic narcotic substances is carried out. The search included full-text articles for the last 5 years. Informational letters were excluded from the analysis. Results. The fight against the spread and use of narcotic substances throughout the world is not slowing down. However, the creation of analogues of studied and illicit drugs by correcting their chemical structures, as well as new narcotic substances with known properties, reduces the effectiveness of this struggle. The dental status of patients taking synthetic narcotic substances has been little studied, since they rarely seek dental care, arriving, as a rule, for urgent indications, or by referral from a narcological institution. Conclusions. The analyzed literature data suggest that in patients taking synthetic "designer" substances, the most studied are the manifestations of drug addiction in terms of their effect on the central nervous system. This problem is relevant for doctors of narrow specialties, since knowing the signs of drug use, it is possible to correctly plan treatment tactics, preventing the occurrence of complications during the administration of drugs. Since the manifestations of drug addiction in dental patients are practically not described in the scientific literature, this topic requires further research.
synthetic drugs, dental manifestations of drug addiction, synthetic cannabinoids, synthetic cathinones, designer drugs, new psychoactive substances
1. Adams A.J., Banister S.D., Irizarry L., Trecki J., Schwartz M., Gerona R. "Zombie" outbreak caused by the synthetic cannabinoid AMB-FUBINACA in New York // N Engl J Med. - 2017;376(3):235-242. DOI: 10.1056 /NEJMoa1610300
2. Alon M.H., Saint-Fleur M.O. Synthetic cannabinoid induced acute respiratory depression: Case series and literature review // Respir Med Case Rep. - 2017;22:137-141. DOI: 10.1016 / j.rmcr.2017.07.011
3. Ancyborov A.V., Mryhin V.V. Sinteticheskie katinony «soli dlya vann»: mehanizm deystviya, toksikologicheskie aspekty, klinika, formirovanie zavisimosti. Interaktivnaya nauka. 2017;5(15):29-39. [A.V. Antsyborov, V.V. Mrykhin. Synthetic cathinones "bath salts": mechanism of action, toxicological aspects, clinic, addiction formation. Interactive science. 2017;5(15):29-39. (In Russ.)]. https://elibrary.ru/item.asp?id=29112773
4. Asadullin A.R., Ancyborov A.V. Novye psihoaktivnye veschestva: konec evolyucii narkotikov ili pervaya stupen'? Medicinskiy vestnik Bashkortostana. 2017;4(70):98-103. [A.R. Asadullin, A.V. Antsyborov. New psychoactive substances: the end of drug evolution or the first step? Medical Bulletin of Bashkortostan. 2017;4(70):98-103. (In Russ.)]. https://elibrary.ru/item.asp?id=30637485
5. Aygün A., Katipoğlu B., İmamoğlu M., Kılıç M., Karapolat B. S., Türkyılmaz A. Acute respiratory distress syndrome and pneumothorax after synthetic cannabinoid intoxication // Eurasian Journal Of Case Report Emergency Medicine. - 2017;16:86-87. DOI:https://doi.org/10.5152/eajem.2017.00719
6. Bali P., Kenny P.J. Transcriptional mechanisms of drug addiction // Dialogues Clin. Neurosci. - 2019;21(4):379-387. DOI:https://doi.org/10.31887/DCNS.2019.21.4/pkenny
7. Belenova I.A., Mitronin A.V, Azarova O.A., Podoprigora A.V., Kudryavcev O.A. Konfliktologiya v stomatologii. Endodontiya today. 2020;18(2):51-55. [I.A. Belenova, A.V. Mitronin, O.A. Azarova, A.V. Podoprigora, O.A. Kudryavtsev. Conflict management in dentistry. Endodontics today. 2020;18(2):51-55. (In Russ.)]. DOI:https://doi.org/10.36377/1683-2981-2020-18-2-51-55.
8. Golovko A.I., Ivanov M.B., Reynyuk V.L., Ivnickiy Yu.Yu., Barinov V.A., Borodavko V.K. Toksikologicheskaya harakteristika dizaynerskih narkotikov iz gruppy sinteticheskih opioidov. Toksikologicheskiy vestnik. 2019;1(154):3-11. [A.I. Golovko, M.B. Ivanov, V.L. Rejniuk, Yu.Yu. Ivnitsky, V.A. Barinov, V.K. Borodavko. Toxicological characteristic of designer drugs from the group of synthetic opioids. Toxicological bulletin. 2019;1(154):3-11. (In Russ.)]. https://elibrary.ru/item.asp?id=37033360
9. Danilova N.B., Curkan I.V., Solov'eva P.Yu., Vindorf S.A., Kopylova E.A. Rannee vyyavlenie zloupotrebleniya psihoaktivnymi veschestvami u pacientov na stomatologicheskom prieme. Medicina: teoriya i praktika. 2019;S(4):184-185. [N.B. Danilova, I.V. Tsurkan, P.Yu. Solovieva, S.A. Vindorf, E.A. Kopylova. Early detection of substance abuse in patients at a dental appointment. Medicine: theory and practice. 2019;S(4):184-185. (In Russ.)]. https://elibrary.ru/item.asp?id=39199102
10. Dubatova I.V., Stoyakin I.V., Karnauh K.A., Safronenko A.V. Analiz klinicheskih proyavleniy i osobennosti terapii psihoticheskih rasstroystv u potrebiteley dizaynerskih narkotikov. Glavnyy vrach Yuga Rossii. 2018;1(59):52-56. [I.V. Dubatova, I.V. Stojakin, K.A. Karnauh, A.V. Safronenko. The analysis of clinical manifestations and peculiarities of psychotic disorders therapy in consumers of designer drugs. Chief Physician of the South of Russia. 2018;1(59):52-56. (In Russ.)]. https://elibrary.ru/item.asp?id=32322154
11. Evstratenko V.V., Sevbitov A.V., Platonova V.V. Osobennosti okazaniya stomatologicheskoy pomoschi narkozavisimym pacientam. Rossiyskiy stomatologicheskiy zhurnal. 2018;1(22):55-57. [V.V. Evstratenko, A.V. Sevbitov, V.V. Platonova. Features of providing dental care to drug-addicted patients. Russian Dental Journal. 2018;1(22):55-57. (In Russ.)]. http://dx.doi.org/10.18821/1728-2802-2018-22-1-55-57
12. Izmaylova Z.M., Smirnova L.E., Vagner V.D. Ekspertnaya ocenka zapolneniya medicinskoy karty stomatologicheskogo bol'nogo na ambulatornom stomatologicheskom hirurgicheskom prieme. Rossiyskiy stomatologicheskiy zhurnal. 2018;22(1):57-60. [Z.M. Izmaylova, L.E. Smirnova, V.D. Vagner. Expert assessment of medical records maintenance for out-patient oral surgery procedures. Russian Dental Journal. 2018;22(1):57-60. (In Russ.)]. http://dx.doi.org/10.18821/1728-2802-2018-22-1-57-60.
13. Larchenko A.V., Suvorov M.A., Andryuhin V.I., Kaurov Ya.V., Suvorov A.V. Sinteticheskie katinony i kannabinoidy - novye psihoaktivnye veschestva (obzor). Sovremennye tehnologii v medicine. 2017;9(1):185-197. [A.V. Larchenko, M.A. Suvorov, V.I. Andryukhin, Ya.V. Kaurov, A.V. Suvorov. Synthetic cathinones and cannabinoids are new psychoactive substances (review). Modern technologies in medicine. 2017;9(1):185-197. (In Russ.)]. https://doi.org/10.17691/stm2017.9.1.23
14. Lyubchenko D.A. Biohimicheskoe obosnovanie sovershenstvovaniya medicinskoy pomoschi licam, zavisimym ot psihostimulyatorov : dis. … k.m.n. Krasnodar, 2020:171. [D.A. Lyubchenko. Biochemical justification for improving medical care for people dependent on psychostimulants : master’s thesis. Krasnodar, 2019:171. (in Russ.)]. https://www.elibrary.ru/item.asp?id=48214063
15. Malyshko E.V., Myslivceva A.V. Osobennosti klinicheskih priznakov «dizaynerskih» narkotikov pri medicinskom osvidetel'stvovanii na sostoyanie op'yaneniya. Glavnyy vrach Yuga Rossii. 2017;1(53):32-34. [E.V. Malyshko, A.V. Myslivtseva. Features of clinical signs of "designer" drugs during medical examination for intoxication. Chief Physician of the South of Russia. 2017;1(53):32-34. (In Russ.)]. https://elibrary.ru/item.asp?id=27700441
16. Martinotti G., De Risio L., Vannini C. et al. Substance-related exogenous psychosis: a postmodern syndrome // CNS Spectrums - 2020;1:8. DOI:https://doi.org/10.1017/S1092852920001479
17. Medeiros De F.C.F.L., Kudo G.A.H., Leme B.G. et al. Dental implants in patients with osteoporosis: a systematic review with meta-analysis // International journal of oral and maxillofacial surgery. - 2018;47(4):480-491. DOI:https://doi.org/10.1016/j.ijom.2017.05.021
18. Mryhin V.V., Ancyborov A.V. Dizaynerskie narkotiki: kratkaya istoriya, popytka sistematizacii na primere «spaysov» i «soley» (obzor). Nevrologicheskiy vestnik. 2017;1(49):97-100. [V.V. Mrykhin, A.V. Antsyborov. Designer drugs: a brief history of the attempt to systemize on the examples of "spice" and "salts". Neurological Bulletin. 2017;1(49):97-100. (In Russ.)]. https://elibrary.ru/item.asp?id=28770028
19. Mryhin V.V., Ancyborov A.V. Psihiatricheskie aspekty upotrebleniya dizaynerskih narkotikov i novyh psihoaktivnyh veschestv. Interaktivnaya nauka. 2017;2(12):64-74. [V.V. Mrykhin, A.V. Antsyborov. Psychiatric aspects of the use of designer drugs and new psychoactive substances. Interactive science. 2017;2(12):64-74. (In Russ.)]. https://elibrary.ru/item.asp?id=28995574
20. Nestler E.J., Lüscher C. The Molecular basis of drug addiction: linking epigenetic to synaptic and circuit mechanisms // Neuron. - 2019;102(1):48-59. DOI: 10.1016 / j.neuron.2019.01.016
21. Orsolini L., Chiappini S., Papanti D. et al. The bridge between classical and “synthetic”/chemical psychoses: towards a clinical, psychopathological, and therapeutic perspective // Frontiers Psychiatry. - 2019;10:851. DOI:https://doi.org/10.3389/fpsyt.2019.00851
22. Rao P.S.S., O'Connell K., Finnerty T.K. Potential role of extracellular vesicles in the pathophysiology of drug addiction // Mol. Neurobiol. - 2018;55(8):6906-6913. DOI: 10.1007 / s12035-018-0912-4
23. Priluckaya M.V., Molchanov S.N. Ostrye effekty novyh psihoaktivnyh veschestv v klinicheskoy praktike. Obzor literatury. Nauka i zdravoohranenie. 2018;1(20):131-152. [M.V. Prilutskaya, S.N. Molchanov. Acute effects of novel psychoactive substances in clinical practice: a literature review. Science and Health. 2018;1(20):131-152. (In Russ.)]. https://elibrary.ru/item.asp?id=32651978
24. Sumnaya D.B., Iksanov A.V., Shkarednyh V.Yu., Sadova V.A., Kuleshova M.V. Prognosticheskoe znachenie izmeneniya lipidnoy peroksidacii pri ostryh otravleniyah bytovymi narkotikami «soli dlya vann». Kazanskiy medicinskiy zhurnal. 2019;100(4):557-564. [D.B. Sumnaya, A.V. Iksanov, V.Yu. Shkarednykh, V.A. Sadova, M.V. Kuleshova. Prognostic value of lipid peroxidation changes in acute poisoning with household drugs "bath salts". Kazan Medical Journal. 2019;100(4):557-564 (In Russ.)]. https://elibrary.ru/item.asp?id=39198584.
25. Fedorova N.S., Saleev R.A., Urukov Yu.N., Saleeva G.T., Vasil'ev Yu.L. Psihologicheskie aspekty okazaniya stomatologicheskoy pomoschi pacientam pozhilogo i starcheskogo vozrasta. Endodontiya Today. 2018;4;64-66. [N.S. Fedorova, R.A. Saleev, Yu.N. Urukov, G.T. Saleeva, Yu.L. Vasiliev. Psychological aspects of dental care for elderly and senile patients. Endodontics today. 2018;4:64-66. (In Russ.)]. DOI:https://doi.org/10.25636/PMP.2.2018.4.15.
26. Ciciashvili A.M., Panin A.M., Zabarovskiy A.V., Yunina D.V., Gabidullina V.R. Antibakterial'naya terapiya pri lechenii pacientov s primeneniem dental'nyh implantatov v usloviyah ogranichennogo ob'ema al'veolyarnoy kosti. Endodontiya today. 2019;17(4):21-24. [A.M. Tsitsiashvili, A.M. Panin, A.V. Zabarovsky, D.V. Yunina, V.R. Gabidullina. Antibacterial therapy in the treatment of patients using dental implants in the limited alveolar bone volume conditions. Endodontics today. 2019;17(4):21-24. (In Russ.)]. DOI:https://doi.org/10.36377/1683-2981-2019-17-4-21-24.
27. Shamrey V.K., Markov A.V., Kurasov E.S., Kolchev A.I. Fenomenologicheskie osobennosti psihoticheskih rasstroystv u potrebiteley sinteticheskih katinonov. Social'naya i klinicheskaya psihiatriya. 2022;1(32):102-109. [V.K. Shamrey, A.V. Markov, E.S. Kurasov, A.I. Kolchev. Phenomenology of mental disorders in users of synthetic cathinones. Social and clinical psychiatry. 2022;1(32):102-109. (In Russ.)]. https://elibrary.ru/item.asp?id=48653711
28. Wise R.A., Robble M.A. Dopamine and addiction // Annu. Rev. Psychol. - 2020;71:79-106. DOI: 10.1146/ annurev-psych-010418-103337
